Pharmacokinetics 3 - Distribution

[@BBBBBBBBBBBBBB_992]

I just wanted to say a massive thank you for these videos!! They are so great, perfect speed of speaking ( hate it when they are 100 miles an hour) not over simplified, still containing the correct level of academic understanding, and are so clear and easy to understand. Its so good to be able to draw out what you have to further my understanding of these concrete concepts. Many thanks! Keep up the fab work, will share this around!

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This channel is fantastic! I study this in my university course of Pharmacology in Italy but i was in trouble because my university professor doens't explain it well. Now i'm starting to understand him, thank u

[@moxi_floxi]

Currently in pharmacy school, studying for the PCOA, you're doing god's work, good sir

[@falented2]

3:53 Volume of Distribution

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These videos are more helpful to me than any other video aid. Thank you so much for providing these!

[@user-vq7es7mz3j]

Your vids are really helpful for consolidating what I’ve learned in those drug chemistry things , even way better than my uni I would say👍 has got all the key points here in this 5 min length video

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couldn't wrap my head around this during lectures but in 5mins u helped me understand. tyvm!

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All those lectures I wasted attending when I could have just looked At this video

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+Joe B I hear that. :(

[@hiranyakumarsonowal1336]

amazing ,the hand written tutorial really cleared my doubt on pharmacokinetics

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Thanks for uploading.... In one word your lectures r awesome.....

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why am i just knowing about this channel now! I needed it for the last 2 years! T_T I failed anatomy1 and 2 ,physiology1 and 2 , Biochem1 and embryo. because i wasn't having fun taking those lectures with those boring drs T_T. thank u so much!

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[@32f32f]

I've been waiting for other vids for endocrine hormones control such as reproductive, digestive etc etc. U've been doing really well and tbh way better than my physiology lecturer :P

[@kalawatinandan]

Awesome videos by hand written tutorials !!!! Keep up the great work !!

[@mustabsheraahmed7265]

The volume of distribution part was so well described... Far better than Lippincott...👍🏻

[@danjbundrick]

OK, so if a drug is more protein bound, it will tend to pass more slowly into other compartments. Permeability of barriers also depends on pH of the compartment. Higher binding capacity means less movement into other compartments. I think I get it. Thanks for the overview! Oh, and it looks like you spelled permeability wrong. :-P

[@jagrutikirdak3210]

Sir, this is very helpful short tricks vedio on pharmacokinetics , thankyou sir.

[@Chelsea-gs7qj]

I also find your example of 3/70 mg/L very weird however conceptually, something just clicked. Thank you.

[@Vunami]

What size sharpie marker is that at 4:41. I want it

[@muskanty]

Extra Fine Point Sharpie. Box of 12 for $12.79 at Staples. This is the real takeaway from 4 years of post-secondary. Hope it's going well.

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[@ligitamontvilaite3123]

Amaaaaaazing! :) Absolutely love the explanations! :) Got back the hope to pass my test tomorrow!

[@kbsandeepgouda1264]

If u hav not commeted tat day..u would hav got 1 more marks atleast

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@@kbsandeepgouda1264 wbu would you have gotten that one mark ?

[@SlanderMonkey]

3:20 spelt *permeability

[@MikeyWahl01]

you mean *spelled...???

[@just_steve6122]

Does anybody know why the conc. drug in plasma is the only one discussed? Is that a standardized form of measurement for determining the effect of a drug? If so, are there any variables that might be overlooked, such as if a specific patient has abnormal permeability been one compartment and another? e.g. For a drug that's active in the CNF, and the patient has higher permeability between intracellular fluid and extracellular fluid?

[@jonashmallari]

I just find your example 3/70 mg/L very weird.

[@vijithroy3208]

What does it mean 3 by 70th ? Does it indicate that the plasma concentration ( known concentration ) is 3*70 = 210mg /liter ?

[@kbsandeepgouda1264]

Not known concentration...its wt he wanted to achieve...i mean tat amount of concentration

[@hawraalsofi4795]

just in ex , 3/70 ×5 =3/14 right ?or not I'm little confused 😑 but, it is very good and helpful tutorials thank you just need answer her please .?!

[@Beastie_TV]

Wow, really cleared some questions for me. Vd=dose/conc

[@17ReeM17]

oh god u make every thing easy! now I get it! I'v had no idea in the lecture at collage!

[@wajahatmahmood2081]

Simple but yet so better explained

[@monjurulkader9478]

wow...... awesome ,,, finally i have understand the compartment model ...... many many thanks for sharing this lecture

[@renut4877]

Thanks for knowledgeable videos plz describe more ....

[@zareenashaik5788]

would like to hear bout Elimination half time ,elimination half life, context sensitive halftime, time of recovery for iv anaesthetic drugs.kindly let me know once its on you tube.

[@uriaisNa4889]

But I didn't understand the calculation part. L/kg and mg/L. Any how thank you.

[@sciencekores139]

thank you this really helpful i was looking for it since a month ago

[@maramsin2341]

Thank you is never enough

[@melvinmathai5861]

I noticed that the units are different (5 L/kg and 3/70 mg/L). Can you just multiply different units like that? I feel like mathematically this is not right. Could someone please clarify?

[@juliescott317]

Although somewhat late... the Vd is = Dose/(Cp * kg). Dose is in mg and Cp is the peak concentration of the drug (mg/L) times the weight of the person (kg). So you have mg/(mg/L)(kg) or mg * L/mg * kg so mg cancels out and Vd is in L/mg units.

[@OlayinkaAwofodu]

Thanks for making understanding easy!

[@phanikumar4402]

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Thanks for sharing, It's very useful.

[@anandselva4879]

really nice...... very easy to understand......

[@kuromidori5573]

can you do the pharmacodynamics???

[@Roshanrahim2000]

Make life seem simple. Thank you

[@musicmania973]

whats wrong with audio volume...

[@lilianxavier2]

the sound is very low in this one. I can barely understand what you are saying :( Thanks for the tutorials!!

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at 5th yr i got this channel

[@aleenamaria1838]

Very helpful video...

[@frederikscience]

How does one find the VD of a drug? In the video he already knows the VD of morphine is 5L/kg bw

[@Dasanie]

assuming the drug facts are already given

[@Chem1917]

Thanks very much 🙏

[@fukyouisrael]

the final result in the demonstration of vd is 105mg not 15mg

[@PhoebeBrownpheebzequine]

I got 15mg, how did you get 105mg? Wondering if I did it incorrectly

[@fukyouisrael]

you're right i made a mistake

[@leojun2]

***** How did you get 15/10 mg/kg? You just start with 5 x 3/70 = 15/70. For the units, it's L/kg x mg/L, so you just take the "L" out, which leaves you with mg/kg. In the end, we have 15/70 mg/kg, or 15 mg/70 kg, or 15 mg of the drug for a 70 kg person. By the way, these tutorials are amazing! Thank you!

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Highly useful

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definitely!

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Soo many thanks ♥️🇮🇶

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Good and appreciated

[@muskduh]

thanks

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[@nasiruahmed7413]

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[@azariobeeh]

really nice... thx

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