Pharmacokinetics for Students: Absorption, Distribution, Metabolism, and Elimination -Lect 1

[@saraw9317]

Thank you-thank you-thank you!!! I have been listening to a professor drone on for 3 weeks, bouncing all over the place, about these topics. You just cleared up 9 hours of his lectures in 2 videos that are fewer than 15 minutes long. I wish I could hug you right now, I am so grateful.

[@rebeccaross6206]

This video is unbelievably helpful. I studied those topics for about 4 hours, and a 15 minute video has taught me way more. I am so relieved. I need to give this guy a donation lol.

[@DrBleck35]

I have a Ph.D. in analytical chemistry, and my weakest point (in terms of career goals) is lack of knowledge regarding drug metabolism. Having worked in R&D at two contract labs, I am a pretty good plasma extraction and instrument method guy. But, without an understanding of how the drugs were being metabolized, I was severely limited. Thanks to you, I am actually starting to understand this stuff.

[@JuanJopZam]

if only every med school professor could teach half as good as you do.. A man can dream

[@medicalbiochemistryandmole3119]

And if only every viewer could comment just as you did, the world would have been far a better place to live 💓

[@meaganharris6589]

Thank you! Thank you! Thank you! Pharmacology in PA programs move very quickly, and the lecturers seem to have a difficult time explaining these topics to us in a language we understand. Keep them coming, for the sake of my future patients! ;)

[@abhiamarnani6771]

The dose response curve is a relative curve where the Y axis can be set from 0.0 - 1.0 as a the response. The full agonist defines the maximal response at 1.0. Partial agonists, though they may bind to sites as effectively as full agonists, do not always activate the drug target to its active state and can simply occupy that receptor location. Hence, on the dose response curve the partial agonist has a maximal response lower than the max. The overall shape is the same, it just hits a lower max.

[@Furious_Mage]

You are better than my Lecturer in the University of Greenwich who is 60 years old and who cant teach anything as well and perfected to go in as you do. Thumbs UP!!! :D

[@عزالدينالشيخسليمان]

you are literally making pharmacology easier, please continue this gold material, thanks a lot

[@davidphetteplace4769]

I teach EMS. Thanks for showing me a different way to explain this to my students. Many EMS text books fail this subject.

[@zaphod5589]

as a matter of fact most pharmacology-books just "steal" their stuff from other books. This "drug-motion" explanation is really a unique self-explaining method. perfekt for memorizing !

[@amitakaur882]

You are unbelievable. I wish you could give a lecture to other professors on how to teach subjects in school!! Hands off to you!

[@marioavalle6914]

I clicked on this video so I might learn how my cat absorbs insulin. I came away learning so much more. I'm a dumb grunt. And even I understood what you where saying. You're a great teacher!

[@Marwa-en5gf]

Honestly, the video series is awesome. I struggled so much with this material when I was reading and listening to my professor's lectures but this not only explains all the different parts to metabolism but also put everything in perspective rather than just throwing words at us. Thank you sooo much!

[@chiomaumeizudike9086]

Thank you for this video. My teacher posted it on Blackboard Learn and it helped me understand this topic. I am looking forward to learning pharmacology.

[@missireason8998]

Chioma: MY plan is to do the same thing. I'm an Instructor of Criminal Justice at a community college, and this video is going to be an excellent tool for my students in understanding how drugs enter-move-leave the body.

[@crystaltrasolinepac]

Incorporating your lecture series into my Pharmacology 1 course for PA students. Great stuff!

[@MrFishbaj]

Dr. Areo, Superb series. Studying for job interview and needed to re-familiarize myself with DMPK concepts. This was a great painless place to relax... a break from reading the texts! Dr. Jim

[@cintiasean]

Great explanation, it has helped me a lot to understand PK. I just started my BTEC in Pharmaceutical Science. I will watch the other videos you made... Thanks a million.:)

[@areosaf]

@Almas Bandeali - Very good explanation! Also thanks for helping a fellow KZbin learner out. Brings a smile to my face!

[@mayercalma1810]

I must say. He is a very good lecturer.

[@uyiosaidemudia4826]

This video is great! Better than what I'm taught in class... You're doing great Sir

[@ElMasmalobrrroo]

you are the best professor i ve ever had. thank you

[@BlackNaijaBeauty]

I've been looking for something to supplement my notes because I don't learn when I memorize. This was a nice breakdown of this topic. I also like the questions at the end. Thank you so much! Looking forward to future posts.

[@vetmedicinekp]

Thank you. Thank you so much. I am in a self-paced online program and although it is great for my work schedule, essentially teaching myself some of these more complex topics is incredibly difficult at times. You just made something a little easier for me, and I can't thank you enough.

[@nfidzni]

better lecture than what I got on class :)

[@atoosab2160]

You are a gifted educator. God bless you!

[@kukuaparker1341]

This is just amazing!!! Mwuah! I could just watch these videos, pair them with my notes fromnlectures and write my exams with full assurance of distinction. Thanks a lot!

[@nanateng8285]

+kukua parker which school are in ?

[@kukuaparker1341]

+Nanateng I'm at Kwame Nkrumah University of Science and Technology, Ghana.

[@ososisyasub8656]

+Nanateng hi there, I was looking for a group that discuss pharmacokintics principles and willing to share their knowledge. I am also struggling with understanding basic PK. Could you please let me know if I can join your group??

[@kukuaparker1341]

Okay dear, I'll mail u soon

[@ososisyasub8656]

+kukua parker Thanks a lot my dear!!I will wait for your email!!

[@OJASVIVYAS]

just fantabulous.....loads of appreciation....please load more as fast as possible so that....we can study well and get good grades...thanks a lot

[@greymeshmask551]

Can you do a lecture on Plasma Protein Binding of Drugs, How it affects plasma concentration of Drugs & clinically significant implications of plasma Protein Binding.

[@MysticMD]

Yes please!!!!!

[@MrNakedWizard]

OK let's think of two local anaesthetics, Lidocaine and Levobupivacaine. Levobupivacaine is 95% protein bound and lidocaine is far less than this. This means that the fraction available to work in the tissue is far less. It is part of the reasons (not completely as the pka and concentration is also important) why levobupivacaine takes longer to act but also why it lasts for a longer time. As the levobupivacaine is metabolised, more is released from the protein which is Then able to exert its effect. There are other considerations as drugs may bind to the same protein so giving one drug may cause another to release and get to toxic levels. Also why does often are readuced in liver failure as the liver makes so many proteins

[@suenaidu3996]

Thanks for making it so simple. You are an amazing teacher.

[@RanulfoKnox]

Veery Useful! from a 1st year Anesthesiology resident this is great for my pharmacology module. Thanks a lot! I hope you consider doing these kind of lessons for TIVA, opioids or anesthetic gas hehe =) Cheers

[@heidischultz2473]

Your videos are fantastic. Incredibly helpful to me for the pharmacology portion of my graduate work!

[@cricketworld1428]

You are amazing sir why not you making more vedios on pharmacology

[@SANJEYARAJ]

Excellent work lots of appreciation, God bless u.

[@kukuaparker1341]

I downloaded all your lectures on pharmacokinetics

[@MiriamGonzalez-wz5nh]

in our lessons : Elimination =Metabolism+Excretion

[@DinaAwd]

Good

[@parfoisbaker]

same

[@valle5169]

Could you please make a video series for pharmacodynamics :( I understood pharmacokinetics with your videos. You are so cool

[@MuhammadSaidKamel]

Thank you for this interesting video. I am a medical translator and I would like to know the software you used while explaining. Thanks again.

[@aspinat]

this is very helpful for my class, thanks so sooo much and bless u for this timely lecture..

[@samham7787]

excellent work .. very clear .. simple to understand .. appreciated

[@dadalacks]

Hi guys anyone know when lectures 14 and 15 will be posted? Great work so far, and I'd like MORE.

[@AallthewaytoZ2]

You are a brilliant teacher!

[@virendraagrawal8054]

thanks for making matter crystal clear

[@Sherirose1]

love you explanation and your voice. pleasant and well explained

[@JHong270]

Elimination and Excretion made clear cut,thanks!

[@pearlsky4026]

Thanksss Alooot sir ! This videos helped me a lot in my exam you summed up everything I needed to know in these videos. And you have a brilliant way of delivering an information

[@PSCLKL]

Watched all your lectures! Thanks a lot, they´re awesome....but seems like you stopped :(

[@annatarasenko9041]

the best explanation ever!

[@gafratoga]

Great lecture. But the CCs are not in sync with the voice of the video

[@walterbroekema]

Nice lectures and good voice.

[@aijazmehran906]

very impressive and helpful sir.thanks

[@monzii3969]

Thanks ! This video just made my day !

[@bloomprinceton]

YOU ARE A LIFE SAVERRRRR

[@engwasechimwemwembewe1525]

Can you make a playlist on pharmacodynamics too🥺

[@lakmalrath]

very nicely explained.thank you.may i know the software that you use...please

[@sebbe91]

Could you (or someone else) tell me how the elimination/metabolisation rate change if you first take a drug 400 mg once a day, and then change to taking it 200 mg twice a day instead. ^ In this case, I understand that the steady state will be the same, but will the elimination also be the same?

[@North-my7kr]

sebbe91 I think because this is the same amount of drug daily the elimination would be the same overally but the steady state would be different because by the time the other dose is taken later on the other 200mg might have been past the steady state stage and has started or already been eliminated by the body

[@ameenal-modaffer7268]

Thanks for your efforts. Would it be possible to know the software you're using as l like to make such video for engineering students

[@klaymonkey9073]

when you say enzymes "add to" the drug to make it more polar - would this be the same process as enzyme "activation" by the addition of a substrate?.

[@SeemaSharma-cb9gd]

Sir i have a doubt Sir what if we inject aur drug directly into the the blood stream in that case your definition of absorption is not applicable Coz it is already is in the systemic circulation

[@ranamutaz6786]

Seema Sharma true, an IV drug isn't absorbed because it doesn't really involve too compartments, the compartment from which drug is transported by absorption (which depends upon permeation), and final compartment (circulation)

[@mynnzero]

Excellent lecture!

[@mngames514]

Plz make more pharmacology lactures 🙏

[@sarakulsoom401]

Plz make video on pharmacodynamic

[@kennethjeffreyarinze450]

This is amazing.. Thank you Sir

[@ph0asmaa]

thanks for your simple wonderful style

[@joanndiaz6736]

Phenomenal job!!! Thank you so much!!!!

[@chibialex7]

Thank you so much! You helped me a lot :) May I know the book source you are using?

[@murthy245]

i need more videos .......this is awesome

[@nabilanusrath9190]

you explain so well!! Thank God I bumped into your channel!! :D

[@arnelquenrickvillacorta1572]

Please continue on making video

[@zainabadel8775]

thank God for your existence!!!

[@jaquesfrancais3030]

thank u bro, nice video and voice

[@linseychacko7970]

you're awesome! thank you so much for your explanations!

[@hammadpasha2179]

thank you so much. but i need lecture on ion traping

[@BARKAT06]

whats the absorption route of ORALLYplase? i didnt catch what he said thank u doct...

[@a2ashopping260]

VERY nice keep it up sir

[@docbry2443]

Thank you doc. Im having hard time understanding katzung.

[@mohamedtarekeldemerdash4192]

You are amazing teacher thank you

[@MrCanadatony]

I need steady state concentration and peak and trough calculation

[@marenzakh1310]

you are the best to me . thanks a lot

[@hamdamultivlog9425]

Amazing

[@toyinadejimi7987]

Have got any video on pharmacodynamics

[@DancingDansHomebrew]

Thankyou. Great for my prescribing revision

[@huwguyver4208]

Great videos. Very helpful, thanks!

[@asraphrazack3705]

Very good video mate!! :) keep up the good work cheers zack

[@murthy245]

superb video

[@YokaiTetsuiga]

Hi there, I was wondering what you meant by "more Polar". How do you mean more polar. Thank you for helping

[@katzmeow5468]

+YokaiTetsuiga Polar or nonpolar are not like a toggle (on/off) switch. It is more of a gradient. Making small changes to a molecule may affect its degree of polarity. Increasing or decreasing the polarity of a molecule will impact how it behaves with regard to diffusion across membranes, etc.

[@normadicn5700]

More polar= more water solution

[@hafsatanvir7607]

Thanks for making it soo easy.😀

[@thurayae]

you are just awesome

[@canabmuktar102]

nice definition

[@seapearlie]

Why is it that with first order kinetics clearance is constant but with zero order kinetic it is not constant?

[@geropsychnp]

I wondered the same thing.....

[@gaferg1]

Is metabolism the same thing as chelation? Thanks

[@arnelquenrickvillacorta1572]

Rooting for more videos 😭😭😭

[@ntemene]

Thanks for helping me understand.

[@ishratzerin2490]

need a lecture about residual method........pls help........

[@anankpijoel517]

worth watching. Thanks

[@God0fCows]

Thank you so much for posting this!!!

[@sztv1223]

i want the videos of pharmacodynamic.....

[@sameerasarwarkhil9307]

wow 👌 love it

[@alejandranoemimarroquinbor7596]

Me fascino. (y) pero en verdad me encantaría que lo pudieran hacer en español, se me complica un poco, ir escuchando en ingles :D pero de ahí muy bien, muchas gracias.

[@cheema719]

thank u SIR U Are doing a AWSome job

[@saleemaly3764]

excellent