Glucocorticoids: Mechanisms and Side Effects

Glucocorticoids constitute a major drug class in treating inflammation and autoimmune disease. These include endogenous hormones that can be administered exogenously, but also synthetic alternatives with a variety of functions. These drugs interact with the glucocorticoid receptor, but what happens then? Let's find out!
Script by Michael Keith
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[@eldestisland4520]

These videos are gold. You will probably indirectly save a person's life by teaching this information

[@robert7622]

Umm unlikely.. But if your skin starts turning brown and you feel tired and weak you might have Addison disease which means your body isn’t making cortisol. Go to the hospital ASAP because that can kill you in days!

[@rupjit27]

Is there any subject left you dont know? You are unbelievably a brilliant teacher sir. We all love YOU, respect you.

[@rickkwitkoski1976]

Yeah. Many subjects he doesn't know. For many of his very good videos, he gets good experts to write up a script for him and then he creates the videos and narrates them. He is very good at that. AND I am quite sure that he learns a lot about the subjects too.

[@spvillano]

@@rickkwitkoski1976 the best way to learn a subject is to teach that subject. :)

[@wesley-vh7qj]

OmG, this is so so good. Thanks a lot Prof Dave

[@MissesSaschaMSP]

Every time we discuss something in school the next day you post about that specific topic.

[@supdawgydawgboi]

I'm saying!!!!

[@client1547]

😎

[@sir.bendover3299]

He's in your class yet you haven't noticed

[@arturo7926]

Professor Dave, thank you so much for holding my hand through organic chemistry! Do you play video games?

[@ProfessorDaveExplains]

Sometimes!

[@arturo7926]

@@ProfessorDaveExplains Which ones? Do you like Metroid?

[@ProfessorDaveExplains]

Super Metroid is dope! I like a lot of classic NES and SNES and N64. These days I mainly play my oculus.

[@arturo7926]

@@ProfessorDaveExplains That is so awesome that you played super metroid. The retro games are my jam too. I used to listen to lofi while doing my chemistry and math homework, but, I found this amazing music which helps even more. kzbin.info/www/bejne/hnTEYoedr6iLeNU I know you're a busy man, but if you get the time to play metroid dread, you really should, it feels like super metroid but it plays better. The game is super short too, which is a huge plus for us older students.

[@epicmusic9029]

@@arturo7926 retro console games are gold

[@guyonamandnicolashofman6040]

I have used prednison for over a year now, I have UC. I am not studying medicine or biology but thank you for this video very interesting!

[@kingcos19]

Love these videos thank you

[@smokeydops]

Great stuff. Had no idea that this stuff was involved in gene expression.

[@glennpearson9348]

Professor Dave, I lost my last pet dog to something he called Cushing's Disease. Is this the same phenomenon that you describe as Cushing's Syndrome in humans? A quick Google search suggests they may be similar; I was just wondering. Thanks for another great talk on pharmaceuticals. I'm enjoying this series a lot! Cheers.

[@JJPMaster]

Cushing’s disease is a type of Cushing’s syndrome, but it is caused by a tumor in the pituitary gland that produces the hormone that stimulates the adrenal glands, as opposed to chronic use of corticosteroid medications.

[@paul715]

FIRST! Can you do a video on Cryonics?

[@Hippopothanos]

Sir can you make some videos on solid state in physical chemistry because my jee advance exams are near and i want to build concept There is no one on KZbin who thought physical chemistry in deep level Plz help

[@shadoweaglebear]

Hey Dave, here's a good one for ya... The Shikimic Acid pathway!

[@teDDy_127]

Can you explain whole about the solid state??

[@mnhard508]

Think you

[@hendrawms3592]

Hi Professor, could you explain the steroid resistance mechanism? Thank you for the explanation

[@organizedbiology]

This article online explains this in the abstract: pubmed.ncbi.nlm.nih.gov/18682458/ If I am reading correctly, and summarizing well, glucocorticoids are a steroid-based molecule that can bind to receptors to illicit a cellular response, most often by going into the nucleus and binding to either promoter or repressor segments of DNA, which either upregulates protein synthesis or downregulates it, depending on what is necessary. Therefore, there's a whole slew of things that could be at play when discussing steroid resistance: 1. There could be too few receptors to mediate uptake of the glucocorticoids, due to some genetic factor or other damage to those receptors. 2. The lack of corepressor activity (if the glucocorticoid needed a 'helper' molecule to help repress gene activation) 3. Other inflammatory pathways that are disrupting this mechanism/cascade. Hope this helps

[@vetoedimpersonator4478]

the goat dave

[@Linguae_Music]

When I had Lyme disease they diagnosed me with mononucleosis even though the test was negative and said "the tests aren't always right" and didn't feel it was necessary to administer a second test. So they gave me prednisolone to reduce my immune response and thus, my symptoms as well... A month later I was in the ICU with a 3rd-degree heart block, and recovery took months. Oddly enough, i didn't notice any symptoms of my heart block until I happened to smoke weed one afternoon. And initially went to the doctor because I thought I'd simply had a seizure. But really my heart was about to stop functioning :D It was pretty great :D Woohooo!!!!

[@konnor9577]

What is Proffessor Dave degree? He knows a lot of everything and very deep. What Phd title is it?

[@berniethekiwidragon4382]

Dave actually answers this and many more questions viewers pose about himself. kzbin.info/aero/PLybg94GvOJ9E-MJS7mG32HiICr1r4CyLF

[@spvillano]

It's in his About page.

[@HakuCell]

hey Dave, physicist Sabine Hossenfelder has a youtube video titled "You don't have free will, but don't worry". What do you think? do we have free will?

[@ProfessorDaveExplains]

Probably. Maybe not. She makes clickbait kinda stuff though.

[@HakuCell]

@@ProfessorDaveExplains ty for giving ur opinion.

[@epicmusic9029]

@@ProfessorDaveExplains so when you say clickbait, do you mean stuff that isn’t relevant to modern day people, or factually incorrect? I mean some popular public science communicators go for the style of interesting fact trivia unlike yours and some other KZbinrs vids which do simplification of school to college level courses which students have trouble with. In some of these trivia videos there may or may not be good explanations of concepts but it’s hit or miss on whether they’re relevant and not clickbait.

[@-JA-]

👍

[@juicedelemon]

is this an april fool's joke?

[@ProfessorDaveExplains]

Um, no.

[@bertmathricks2024]

And I thought you were going to do an April fools joke...

[@sapy4124]

Who are you? Mathematician? Physicist?, chemist?, Biologist?, WHO?😲

[@claudelorrain-bouchard6941]

He also did an American history series....

[@sapy4124]

@@claudelorrain-bouchard6941 😳

[@glennpearson9348]

Professor Dave readily acknowledges that he has a team of researchers and writers for this channel. His claim is that he is, perhaps above all, a science communicator with particular knowledge and experience teaching college-level chemistry.

[@ambrosia1068]

He’s a cousin of Jesus.

[@palestine7456]

إنما المؤمنين إخوة مناشدة أم فلسطينية من قطاع غزة 🇵🇸 أناشد القلوب الرحيمة وفاعلين الخير انا أرملة وأم لأطفال أيتام اخوتي اطفالي بحاجة لكم انا أملي برب العالمين ثم فيكم ان ترحمو أطفالي بمساعدتكم بمصروف لهم وتامين حياة كريمة لهم وسداد ديني ولو بالقليل منها التي تراكمت عليا بسبب الظروف التي انا فيها أختي أخي الكريم بادر بفرحة يتيم امنحه الحياة أعطيه ابتسامة كن عونا وسندا له 🤲 حفظكم الله ورعاكم وسدد خطاكم وجعل اعمالكم في ميزان حسناتكم 🤲 لمن يريد مساعدتي التواصل واتساب الرقم موجود امامكم بصورة الملف الشخصي.