Polycythemia vera - causes, symptoms, diagnosis, treatment, pathology

[@jawahirsaif]

One of my goal in life is after finishing med school and being licensed doctor is to support u guys as much as i can in every aspect ... u make so much difference in our life as students , there were moments where i was so frustrated from certain topics i couldn't fully understand , u were my BACKBONE that i rely on ❤ . Thank u !

[@jawahirsaif]

Goals*

[@osmosis]

Thanks for making us part of your medical journey, Jawahir! 💕

[@misslyss9270]

Thank you!!! I want to be here with my son!

[@ballisbulat5512]

If i ever become a lecturer, the first thing before starting a lesson i will show a short osmosis video for my students. Its so helpful to people who struggle to understand books.

[@miss.conduct8083]

A random question but does anyone have Lyme Disease? Aka B-cell complete take over! The sad part about this? Is that I JUST found out I have thus by reading my medical records?? I don't know about the rest of you but, something about this ABSOLUTELY doesn't sit right within my soul.

[@anamikabharti3486]

Thanks a lot osmosis... M watching your videos just before 5 days for my university exam.... U have made videos on almost all imp topics...... Thanking you is just a small thing we can do...i am so addicted to your videos... That i find difficult to study from other videos on youtube....my huge huge love to osmosis

[@Mukeshkumar-re6tq]

Wow... I'm in love with ur cmnt 😍

[@benji2530]

Had a patient once with this disease. her blood had become so thick that, when outside of her body where like a paste of blood! it was so surreal

[@sandyb2391]

my blood was so thick n it would take over more than n hour to get a bag of blood out of me. which i had to do every 2 weeks but a nurse told me to take 4 baby aspirin before i come in that day. wholla 15 minutes later i would be finished. so i would just take 3 aspirin then 2 and none after 5 months n it worked to get it out n thin it better

[@lucylulusuperguru3487]

Could've also mentioned that this is classified in a class of Myeloproliferative Neoplasms and considered a rare blood cancer within the "leukemic state" classification as recognized by the World Health Organization since 2008.

[@woundedsaint8684]

Right. My father developed it.

[@evgeniiaivolga6272]

Right ? I am shocked they Don t mention that it’s a a blood cancer , people should know

[@thehobbyisttries]

is it bad?

[@howtomedicate]

The complications caused by polycythemia vera can be devastating! I have seen several strokes and heart attacks.

[@lucylulusuperguru3487]

I've had 9 Pulmonary Embolisms, 2 intracardiac embolisms, kidney failure, and umpteen different complications all resulting from this cancer. I'm JAK2+, Lupus Anticoag+, Factor 8 issues, and MTHFR+ as well as other screwy gene quirks. It SUCKS and has completely and utterly up-ended my life since I was diagnosed.

[@LastTrump7]

@@lucylulusuperguru3487 how are you doing now and what is your treatment?

[@thehobbyisttries]

@@lucylulusuperguru3487 how did you find out?

[@alexandremello6913]

Very nice. Could have mentioned that one of the possible outcomes of PV is transformation to acute myeloid leukemia.

[@OfoeNelson]

So the moment your red blood count is high you have this disease? Everything is normal or low except my rbc count.

[@herusaleron6793]

@@OfoeNelson that can just be dehydration. you would need multiple things to be off like hematocrit and hemoglobin, etc.

[@matildaarava2355]

@@OfoeNelson ABSOLUTE PCV - idiopathic cause or u r in a hypoxic state or u have a tumour causing increased erythropoietin. RELATIVE PCV - dehydration and decrease in plasma level giving u false reading of increased paced cell volume

[@gailaspinall1688]

My RBC count is "slightly" elevated. The parameters as set by Life Labs is 4.00-5.10. My result was 5.29. Again, slightly elevated, but also my Hematocrit is slightly elevated too. The parameters is 0.350-0.450 and mine was 0.473. Hemoglobin is fine. I'm told that I could have been dehydrated the day I had blood testing done. Again, the elevations I've mentioned are very slight & I will be meeting with my Dr. to discuss the matter. When I received the results, I checked with her office & was told not to worry, the elevations are very minor & could be caused by just about anything. For PV all blood cells are affected...red,white & platelets.

[@gailaspinall1688]

You stated that multiple things need to be off like hematocrit and hemoglobin. If that person's RBC count is high, & he has a normal hemoglobin count, but a slightly elevated hematocrit, I wouldn't think that qualifies as having the "diseasse". Now we've mentioned the RBC count as being high. Just how high is high. A slight elevation hardly qualifies.

[@niharikapaliwal2383]

Keep posting osmosis... U made my medicine easy to understand

[@4estdweller4ever]

I was just diagnosed yesterday with Polycythemia, with leukocytosis and thrombocytosis after a bone marrow biopsy. Symptoms so bad I have a struggle with dressing, cooking a simple meal and trying not to fall from dizziness. I get out of breath just standing

[@NileshKumar-Dl1wli]

what kind of tests have you done.....and what is rengs of your hb hct...etc... please reply...I need to know for my brother...who is struggling very badly and we don't know what to do or not

[@khalidbazid9478]

@@NileshKumar-Dl1wli what happened to your brother?

[@NileshKumar-Dl1wli]

@@khalidbazid9478 his hb was increased

[@khalidbazid9478]

Did he got diagnosed with polycythemia vera? And how is his health now?

[@babumanu895]

@@NileshKumar-Dl1wli just do phlebetomies with daily aspirin and drink lots of water and be physically active maybe after 1 year u may need phlebetomy once in 3 months .... Start hydroxyurea immediately after family planning is over since u shud not father a kid taking hydroxyurea

[@moisesfernandes2371]

Well done, easily understandable in layman's terms. 👍

[@GodsFavourite771]

Osmosis. You guys don't know what you do for us Med Students. Thank you❤️❤️❤️❤️❤️❤️❤️❤️❤️

[@osmosis]

Happy to help! 💕

[@strizay]

Thank you for the simple explanation. I was dianosed with this yesterday, I am 50 years old

[@osmosis]

Hope our video was able to help! 🙏🏼

[@boriapao357]

My sister in law is also recently diagnosed polycythemia vera. May i know which medicine the doctor prescribed you?

[@NicoleBrown-ff1mg]

Was your b12 levels high when you got diagnosed?

[@pichonrodriguezcorp8468]

Im 33 and Im facing PV, Im getting blood withdrawals every 3 weeks it make feel so much better. Already did Jack2 test came back negative and Im schedule for the bone marrow biopsy in 3 weeks.

[@adamhp13]

I'm age 35 jak2 positive, tested and re-tested. having my first bloodletting next week. hoping i feel better

[@pichonrodriguezcorp8468]

@@adamhp13 good luck, you will feel better after blood withdrawal!

[@romybazan-gillis7861]

How did that go?

[@NileshKumar-Dl1wli]

Dear Adriano... please help me I need help.....I want to know something about it.... please help me

[@lh5375]

Hi. I am Lena 43 y.o.diagnosed yesterday with Polycythemia Try to be strong…

[@StR8uP254]

Extremely informative video & to the point. The ending was a bit of an awkward ending the way it ended with dead silence all the sudden 🤫

[@rosieposie7180]

Hahaha what did you expect 😂

[@amandamelendy9537]

Waiting on my dads results for this. Im horrified because his hemoglobin has been elevated for 4 YEARS and his doctor just now decided to have it tested.

[@Faemomi]

How is he doing now? What treatments is he taking?

[@somberwolf1]

This happened to me too, apparently my levels had been high since 2018 but no doctor took the time to let me know and now that I'm having more severe symptoms and cardiovascular problems.. I was finally told about it. Hope your dad is doing well ❤️

[@evakal9293]

@@somberwolf1 hi,Ana Marie same here,my doctors overlooked my numbers for more than 2 years when I started having joint pains I googled my symptoms and voila,now I'm waiting for answers.

[@miguelcardenas2413]

I have been living with High hb high rbc and high Mchc for the last 20 years finally I got tested for the results winch doesn’t scare me since I have been having a lot of those symptoms without explanation . Now if they find the cause finally I may throw a party. Many people gets scared from it but from all forms of cancer if you’ll get one it better be this one .

[@IftikharKhan-hc3oz]

​@@evakal9293hi

[@chrisp7336]

Would've been good to mention PV and association with RED BLOOD cells rather than just saying blood cells, can easily be confused with white blood cells

[@gailaspinall1688]

All the blood cells are affected with PV, particulary the red cells. If your white blood cells are fine, & your platelets are fine, it's doubtful you have PV. Hematocrit may be slightly elevated but if you haven't drank enough water that day, it could mean slight dehydration which would elevate the hematocrit.

[@julez_q]

I am surprised that interferon is not mentioned as a treatment

[@HOODSSWEETIE]

Very informative, thank you so much.

[@lillyrocks2011]

With these symptoms are doctors that would diagnose with fatigue chronic syndrome or fibromyalgia 😑😤 When I find that kind of doctors I know I have to run ASAP.

[@MeghanaK-lv6uj]

Very helpful for last minute preparation Thank you

[@osmosis]

Most welcome and best of luck! 😊

[@jetrastv9315]

I experience it right now. It’s hard for me to walk. My vertigo hits me always my hemoglobin ranging 19.4

[@IftikharKhan-hc3oz]

Hi

[@robertshrewsbury4241]

I had Polycythemia/cancer and my g/dl's was 62 g/dl's instead of 16 and I had to get a pint of blood (Phlebotomy) drained out of me a lot. So I started taking oxalate foods until my hemoglobin was back down to normal at 16 g/dl's Strawberries are good oxalated, but so is rhubarb, but I thought rhubarb was too much Oxalate, so I stuck with strawberries. I am aware that too much oxalic can also be harmful.

[@sandyb2391]

hi Robert i was have this too for past 5 months n was getting bag of blood out every 2 weeks. my hemoglobin when started was 277. now its 124 n haven't had to get the bag done 3 times so far. have to go every Monday n get 2 viles done to check hemoglobin level each week but i am happy it has gone down n not have to get that bag done again so far.

[@briankober9016]

So what are the normal ranges for hct and HB for men? Some people say >50.3%, >52%, and >54%.

[@hderby8576]

You should make a video on the “spent phase”

[@khawlacherif4486]

Raha dayra 3la myelofibrosis khoya ezanji

[@moustafazoudji6335]

@@khawlacherif4486 siyid mafham walo😂 3ayb 3lik zanji

[@khawlacherif4486]

@@moustafazoudji6335 🤣🤣🤣

[@ankitparjapati9102]

Very easy language..thnks😊😊

[@drbeardo6960]

Thanks for quick review Awesome channel

[@filipgheorghe3868]

learned more in 30 minutes if youtube than in a full day of reading class notes:))))))

[@osmosis]

Happy to help! ❤️

[@douglasschmidt2869]

I was diagnosed at 25. I ignored it and never sought treatment. I’m 42 now. Am I gonna live forever? I walk 15-20 miles a day. I recently got sober after 24 years. I’ve never felt better. I think all the PCBs I was exposed to the first 10 years of my life may have caused it. What do you think?

[@robertwilliams5618]

Nobody lives forever

[@xZekQzuneR]

yes. pv can be acquired via bad vices like alcohol and smoking.

[@beckyboo6767]

Please get checked to make sure. My dad had this and his spleen started to become enlarged and passed away not even a year after

[@Pure-Crystal-Fire]

@@robertwilliams5618 They do if they trust in Jesus and believe in him John.11 Verses 25 to 26 [25] Jesus said unto her, I am the resurrection, and the life: he that believeth in me, though he were dead, yet shall he live: [26] And whosoever liveth and believeth in me shall never die. Believest thou this? You may want to look up this too KEY WORD IS BELIEVE! 1 Corinthians Chapter 15 1Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand; 2By which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain. 3For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures; 4And that he was buried, and that he rose again the third day according to the scriptures:

[@Pure-Crystal-Fire]

1 Corinthians ( this is The Gospel or good News, belive this below and you WILL live forever yes ! ) Chapter 15 1Moreover, brethren, I declare unto you the gospel which I preached unto you, which also ye have received, and wherein ye stand; 2By which also ye are saved, if ye keep in memory what I preached unto you, unless ye have believed in vain. 3For I delivered unto you first of all that which I also received, how that Christ died for our sins according to the scriptures; 4And that he was buried, and that he rose again the third day according to the scriptures:

[@aaa_9090]

رااااااائعة !!! Fantastic & Amazing Thanks alot from my heart

[@DoctorMinhaj]

Very brief end effective. Thank you

[@osmosis]

You're welcome! 😊

[@mikeclardy5689]

I've been having these symptoms for a year, but blood test came back having really high white blood cells and ebv... I also have enlarged lymphnodes around my neck and jaw. I'm worried I have this or some kinda of lymphatic cancer. I'm poor and can't afford treatments...

[@DominionMovementDotOrg]

is it possible that someone could live like 15 years after diagnosis without treatment?

[@sanjaysahu7828]

Please help! My dad is 63 and he is healthy apart and eating fine.But post covid getting frquent minor health issues. We get his body check up done. Everything is fine but there was elevated level of haemoglobin,RBC,WBC. We went to as Hematology oncologist and he suggested few tests. His tests reports came today His erythroprotein is 3.3(it should be in 5.4-33) , Jak 2 Exon 14-Positive. Is it PV now.Please suggest how severe it is ? Thanks in advance!

[@إيهابجمالصالحعبدالرزاق]

Osmosis is always the best,. Thank you dear for this amazing video.

[@osmosis]

Most welcome! 😊

[@iqra4397]

Wao u helped me with my problems

[@joellogsdon8061]

Was diagnosed in 2019

[@m.jamaluddin3235]

sir, My Himoglobin rate is 19.5 My diagnosis report as detected primary policythemia vera.... Please sir brief my pure treatment..... May Allah blessing for you and your family. Thanks

[@IftikharKhan-hc3oz]

Hi bro

[@rakhigupta5868]

Thank u osmosis u make medicos burden easier

[@osmosis]

Happy to help, Rakhi! 💖

[@4estdweller4ever]

My father had leukemia for 3 years when I was born. I wonder if that would have any connection with me having a blood cancer?

[@chrisoliver9442]

Yes more than likely so ! According to what I have investigated I have pv I was diagnosed 2 years ago I take hydrea for it ! I've been doing that for over a year now !

[@EMDS04]

My Granddad died today He had this illness Ruhe in Frieden Opa. ❤

[@osmosis]

Sorry for your loss, Leonard 🙏🏻

[@EMDS04]

@@osmosis thank you

[@sallylambert7552]

I am sorry for your loss. Prayers for peace.

[@Aviation_Professional]

How does one distinguish from erythrocytosis?

[@lillyrocks2011]

Good question. I have high erythrocytes but I don't know what to do next.

[@Jakien247]

Thank you

[@henrys1046]

how do you do that?

[@fionaapple4308]

Is this more common in young males 18-24 after getting COVID shots? My son entered the military at 18 yrs without any blood issues. Now after getting the mandatory COVID shots he was just disqualified from deployment next month due to his lab results because they think he has this PV. He's just turned 22. This is genetic so how is this possible??

[@mittag983]

I'm a girl, only 17 and I have it too. I've got many COVID shots too and I took the vaccine three times. I wonder if it's a coincidence.

[@zm1786]

My girlfriend is in the military, she got the vaccine and now shes having all these symptoms, I'm extremely concerned

[@432_mdaqueel9]

Me too I am 23 and I got this too 😅

[@LMW-ms7dw]

Yesss is this a coincidence

[@JaHm3sZ]

I have always have high RBC but normal hemoglobin, htc whc and platelet.

[@Sillysausage17]

Are you well?

[@estiakshakil2663]

It’s always save my time informative one.

[@osmosis]

Glad to help, Estiak! 😊

[@niharikapaliwal2383]

I really love osmosis studies

[@calmprince7231]

Osmosis is love

[@jgirish6549]

I have a doubt that there hemorrhages in polycythemia vera despite increase in platelets why it occurs?

[@tgifford4]

What percentage of population with the JAK2V617F mutation do not go on to develop a myeloproliferative neoplasm?

[@purely_goan7749]

Hb levels at 17.1

[@gayathriswedhika2442]

Thanks for the Video❤

[@osmosis]

You're welcome! 😊

[@gailaspinall1688]

This condition is considered RARE. It affects approx. 50 people in 100,000.

[@moirangthemwilson8651]

Can bone marrow transplant can cure polycythemia vera ?

[@fahadnadeem7599]

Helpful vedio...

[@nocstindolly1010]

Is it fatal?

[@mahiehussein]

Thank you!

[@mahoulo612]

hope you make more rare disease videos!

[@seymss15]

EPO is usually low due to negative feedback in here

[@harshanidissanayake4466]

Very nice explanation.

[@MarysZenDoodleArt]

thank you :-)

[@donmulder8061]

Nice video -- does anyone have some specific diagnostic criteria currently being used to help distinguish between ET and PV? It seems like sometimes they overlap a bit and HCT and HgB levels can be within universally accepted normal ranges but high for an MPN. For example, a JAK 2+ male patent with HgB of 15.8 and HCT of 49 and platelets stable at 450,000. How to distinguish between ET and PV?

[@sanasaqib6036]

WHO has made criterias for both of these. And mainly they are differentiated on bone marrow biopsy rather than a CBC or even a Peripheral blood film. Hope it helps

[@johndobb8239]

Are you a doctor? But you were talkin way over my head 🤣 it was diagnosed is polycythemia vera. And as of right now the only treatments are phlebotomist once a month or twice a month

[@donmulder8061]

@@johndobb8239 No I am diagnosed with JAK2 ET but now have a new hematologist oncologist who says that my HCT and HgB and RBC levels, while always in the normal range, are too high and that means that I have PV, not ET despite stable high platelets my whole life at 450,000. Sorry if it was a mouthful. I have seen videos now that suggest relooking the diagnosis criteria. But nothing firm that would put me in the PV box. And my doc wont do phlebotomies -- only HU which I have not started and dont really wish to.

[@johndobb8239]

@@donmulder8061 yeah I hope you don't have to start them. They kind of sux

[@curiousc9259]

​@@donmulder8061did go get your diagnosis figured out? I hope you're ok.

[@eacahilig3797]

4:00 summary

[@farzanajaveri7204]

I have routine CBC My hgb is 11 RBC's are 6.2 Is it normal I am 63 yrs old Female

[@babumanu895]

Erythrocytosis noted ... Check for ferritin levels and epo if both are low take iron supplements for 4 months and do retest for cbc if hb is increased drastically it might be polycythemia , if ferritin and epo are normal nothing to worry

[@robertwilliams5618]

@@babumanu895 my hct is 50.1, RBC 5.73 and hb 16.9 I haven't had ferritin checked in a while but years ago it was low. I'am male

[@divyasathish4814]

Polycythemia vera ,polycythemia rubra vera are same or not 🤔

[@yousraadly7341]

My life nightmare medical condition. 😐

[@lucylulusuperguru3487]

Same here!

[@yousraadly7341]

@@lucylulusuperguru3487 i hope God grants us both healing , Amin .

[@lucylulusuperguru3487]

@@yousraadly7341 Amen!

[@Les4717]

Any foods not drugs

[@johndobb8239]

I was diagnosed with polycythemia vera, it's been a few months now. I've had multiple phlebotomies. It's unfortunate that it's such a rare blood cancer. Well I guess that came out a little bit wrong. 😂

[@johndobb8239]

@@Yvettep777 Hello Mona, through a blood test. The blood test will show you have too many red blood cells and then they'll do further test. That's how mine was diagnosed

[@johndobb8239]

@@Yvettep777 since mine was diagnosed in a blood draw, and I really wouldn't have any idea how else to diagnose. Just ask your doctor to check your blood levels and see what's going on

[@johndobb8239]

@@Yvettep777 if you doubt his diagnosis could always go to another doctor and have him ever look at your. Fatigue has a very big part of this.

[@johndobb8239]

@@Yvettep777 I think if the doctor told you you don't have it, then you probably don't have it perhaps your fatigue is coming from somewhere.

[@johndobb8239]

@@Yvettep777 all I do now is I have a blood draw once or twice a month, the doctor looks at it and decides if I need a phlebotomy that month. I was fortunate enough to not need one last month. So that was good. Otherwise the phlebotomies are pretty regular in my case.

[@imark2569]

Pretty sure I have this

[@jendavis2994]

did you find out if you have this

[@imark2569]

Jeniffer Davis yeah, like 2 years ago. I used to suffer massive nonstop headaches and discomfort. A doctor told me I had this. Just recommended exercising and regular donation of blood. I’ve only just started seeing how bad it is from the internet and now I don’t know if the doctor should’ve done a better job to alarm me or if I’m overreacting

[@robertwilliams5618]

@@imark2569 i think i have this :(

[@IftikharKhan-hc3oz]

​@@imark2569hi

[@rehababdelbagi]

thank u soo much

[@osmosis]

Happy to help! ❤️

[@ParticularlyBaptist]

Hydroxyzine is an antihistamine fyi

[@sayedaashiq962]

Super da dei nee vera level 🔥🔥🔥

[@NeonDynamics]

En bro ivlo puripu

[@ajasy.s5833]

Malayali

[@stayawayfromme4489]

Explaining complicated topic in 5 min. Is just genius not everyone can do it, including my professor who makes the topis even more complicated lol

[@osmosis]

We're glad that our video was able to help! 🙏🏼

[@p1dru2art]

I'm pretty sure there's a huge gray area that I'm stuck in....... my hematocrit level goes to 55 down to 49 and when 55 it's too high for me to donate plasma..... so no alcohol no caffeine,, OK,,...... I had to discover on my own no chocolate,,, typical things you do to lower your hematocrit...... now I'm down to the I hope is the last possible thing would be hard sugar candy hard candy sugar overeating sugar which I can do from time to time......

[@sangeynguedang6894]

My..HB(19.4)...RBC(5.73)normal to(5.8)..MCHC(37.5)high to(37.0)... Lymphocyte (60.0) high to(50).. Granulocyte (37.1)low to(70)..and other are at normal range can I have polycythemia please reply suggest me something..

[@osmosis]

Hi Sangey! Unfortunately, we don’t provide medical advice through this channel. We’d recommend reaching out to a local health professional for any consultation and diagnosis of your medical condition. 🙏🏻

[@bionium6976]

Yoo check out a doctor 19 hb aint normal

[@hayrettincosar871]

Gökçek şifa turkey çaresi var

[@Canseefornewchange]

Um...Why did I felt goosebumps when I saw the clip on 0:10?

[@seriousthing240]

Sir tell sperm analysis and ivf methif

[@DoctorRabi]

What do you mean by vera🙄

[@마이-b8r]

Vera is a female first name of Russian origin, and by folk etymology it has also been explained as Latin vera meaning true. In Russian, Vera means faith. according to Wikipedia

[@luandersoncosta3104]

@@마이-b8r In this case is from Latin. In Biology and medical Sciences we use Latin a lot in names.

[@sleepingknight9131]

Is Polycythemia Vera cancer?

[@patriciatimson1730]

ali hassan yes

[@cathyj8284]

the disease itself is not cancer , but it could turn into cancer after the spent phase as mentioned above, called myelofibrosis

[@abdullahkhansafi4500]

ali hassan hi bro

[@unclebrother6244]

Yes, it's a type of blood cancer.

[@ayazmemon1772]

@@cathyj8284 how myelofibrosis can be detected which test?

[@mahoooshmemo3787]

🌹🌹

[@leewilliam3417]

Mmmmmmm😊

[@thelegendtl]

First

[@KK-jb7rx]

Stfu you bitch

[@vibes7221]

Pray for me i have it😢😢😢 so dizzy daily