Myelofibrosis - causes, symptoms, diagnosis, treatment, pathology

What is myelofibrosis? Myelofibrosis is a disease in which the bone marrow gets replaced by connective tissue in a process called fibrosis. Find our full video library only on Osmosis: osms.it/more.
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[@701elie]

Haematology is my least favourite subject and you guys make it so simple and logical. Keep it up!

[@AhsanKhan1998]

HOW THE HELL CAN ANYONE LIKE HEMATOLOGY 😭😭😭😭

[@MBOsman]

@@AhsanKhan1998 Do you drink coffee?

[@psyche--]

@@MBOsman Why??

[@howtomedicate]

Often a splenectomy is part of the treatment as well. This is because myelofibrosis can also lead to splenomegaly, which will cause an massive anaemia.

[@vigneswaranvithushan8247]

Thank you so much! Very useful to Learn it within a short period 👍

[@jimip9755]

Great video, thanks so much for your work!. It might be worth noting that Calreticulin gene mutations are responsible for a significant portion of primary myelofibrosis (since JAK2 is only responsible for ~50%).

[@hbh7868]

Why are these so good?

[@TheRachelDJ]

great video. What causes the itching ?

[@Rhonda-a10]

Puritis is a histamine response.

[@cynthiaHernandez-bc4cc]

I have myleofibrosis i got diagnosed at 15 also I was born without a spleen

[@HBoi-md7yr]

Hello, I don't want to offend you. But I would like to find out more about the disease. On the Internet, life expectancy is reduced to around 15 years for non-risk patients. Did your doctor tell you anything more specific? Is the statement correct or is it not correct? I thank you in advance for your answer.

[@crxracer805]

​@@HBoi-md7yrMaybe she forgot to answer.

[@ghostintheshell1431]

Well done guys, thanks a lot😊

[@v.p_rathwa6312]

Nice Conceptwise Animation !!! It'll help to learn myelofibrosis easily within short time !!

[@swapniljain2175]

Any treatment?

[@vanessa-ul7nj]

such good explanation!!

[@osmosis]

Thank you! 🙏🏼

[@narjesalbazi7190]

Thank you for your help 😊

[@osmosis]

Happy to help! 💕

[@mitanshusharma5944]

Nice explanation Thankyou

[@osmosis]

Happy to help, Mitanshu! 🙌🏼

[@Chaudharys1]

great summary.

[@yesicaalejandratolay6742]

Puede poner los subtítulos en español? Plis

[@bayareamacaddict]

"dry tap": on bone marrow aspiration attempt

[@muze1114]

Thanks 😊

[@osmosis]

You're welcome! ❤️

[@ireneadrian-kalchhauser4837]

Another treatment is interferon.

[@DinushanChathumal]

🎉Thank you❤

[@d.k.b1354]

Thanks Amazing 👏

[@osmosis]

Welcome! 😊

[@anava84]

Amazing!

[@sreejithmg9101]

thank u

[@katblack7625]

How did you get thee John Mulaney to do this? 🥰

[@kikikilo8341]

love u gys !

[@eiithais]

muito bom

[@sandeepodak8589]

Is it curable?

[@artgalleryfidelio]

sadly not

[@DinushanChathumal]

Also need a video about Essential Thromnocythemia...😇

[@paulmcdermott4285]

My mother’s spleen took over from the bone marrow she survived 15 years died with every organ in her body had cancer the brain was the last to be infected the inhibitors etc she was taking masked thesymptoms of the other cancers

[@luvjesuslee2033]

My Deepest Condolences. So sorry for your Loss.

[@HBoi-md7yr]

So sorry for you. How old was she?

[@madhankrishna7527]

Sorry for your loss bro

[@_madbunny]

I hate the fact that I'm here because my friend has myelofibrosis. She's currently at the hospital:

[@tongoctuan8937]

the video image is too poor, you need to fix it more

[@osmosis]

Hi! Thanks for letting us know. The video quality seems great on our end, so this might a network connectivity issue. You might want to try playing the video using a different internet connection. 😊

[@fadeskywards1245]

What about imatinib?

[@S1830367]

FadeSkywards imatinib is used to treat conditions where there is over-activity of a tyrosine kinase receptor, e.g. in C-kit positive GI stromal tumors, or CML t(9,22) where you get the formation of the Philadelphia chromosome, and the BCR-ABL fusion protein as a result (constitutively active tyrosine kinase receptor). Myeloproliferative disorders (like myelofibrosis, essential thrombocytosis, polycythemia Vera, etc.) are caused by a JAK mutation, which is different, so it needs a different inhibitor (ruxolitinib) :)

[@skandhansai9079]

Superrrrr

[@osmosis]

⚡️⚡️⚡️

[@jesicamacron9142]

❤❤❤❤❤❤

[@julesneville3113]

Doesn't really causes....

[@elizabethCorkins83]

👍🏻

[@rexcel2193]

my father survived for 3 years, then came leukemia...

[@egyptianpharaoh3721]

My his soul Rest In Peace , 3 years from discovering myelofibrosis?

[@masoomesadraei6695]

😍

[@indefat]

Look at em' cute immature wbc. hehehe...