Potential Risks of NAD Supplements | Iñigo San-Millán, Ph.D. & Peter Attia, M.D.

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The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 40 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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[@DrBradStanfield]

Can’t beat a great diet, regular exercise, and high quality sleep. Supplements/medications are interesting (particularly Rapamycin IMHO hence my clinical trial) but we need to proceed with caution as this video beautifully illustrates

[@jamdec123]

This KZbin Sporned Longevity NON_SENSE, ( including your Chanel ) Bifurcate, Science too it's detriment. Like trying a Moonshot because we found some Minerals ( Molecules, Metabolites and Compounds Beneficial to the Cause ), It took a hell of a lot more ENGINEERING than materials/materials science to land on the Moon. Pill Popper's and Patent Chasers like Sinclair are Lucky they are not testifying under oath. Anti ageing is a Laughable Industry. Shame Shame Shame

[@luckyhanger1326]

don't forget to throw in a little internet trolling like you did with your channel and the Sinclair-resveratrol controversy. Keeps you young with lots of troll youtube hits. Haven't been back to your channel since.

[@andreapinaroli974]

Agreed, but how do you balance the needed caution with the fact that we keep on aging? I think that taking some risk and making decisions based on current best science is advisable, even if there may be unknowns and undesired effects.

[@luckyhanger1326]

@@andreapinaroli974 You quote science, not bring up how Dr. Sinclair made money and discuss various nefarious actions. He needs to dissect the science and why it failed. He did some of that but it was not compelling, however I felt it trashed Dr. Sinclair along the way. Dr. Stanfield's debunk has been debunked several times. You have to review the science not the scientist.

[@andreapinaroli974]

@@luckyhanger1326 ? I was referring to the caution part of the comment, just honestly unsure how to balance the fact that aging doesn't stop with the unknown risks that one would take by ingesting supplements/medicines that haven't been extensively tested for safety but appear to be potentially benefitial.

[@2nkdav]

Nad therapy has been used in rehabs for two decades and the clinical obvs on humans are meaningful . So much more to talk about here. Better to look at the work of Ross Grant to get into the weeds not just gloss the top

[@dongrey8975]

What I do is have several supplements, but only take one or whichever, ever so often. I avoid to much of any one, for too long.

[@ScottSummerill]

Just a reminder that all of this is one big experiment. That said, there are way more longevity promotors and researchers in favor of supplementing with NAD precursors than not. I’m not sure why this guy’s opinion carries any more weight than others. For myself, I play with a lot of these supplements but not every day and not in the prescribed amounts. I prefer real food, exercise and quality sleep.

[@stevenr.2534]

I’m skeptical of any expert on longevity who is promoting NAD precursors or any other supplement where they have a financial interest in their sales.

[@lthoang101]

This guy is wrong about Resvetol and should know better. There were some research that 'debunked' its effectiveness, but then follow up research showed that it was in fact effective, so the debunking was itself debunked.

[@antonystringfellow5152]

@@lthoang101 You believe that? You believe that GSK scrapped the company they bought from David Sinclair for $720 million when they had a useful product? Try reading more papers on Resveratrol rather than relying to just two. Also, look at who funded the research, in each case.

[@antonystringfellow5152]

How many of these longevity researchers and promoters are making money from them? Answer: Most if not all. I know most KZbin promotors of supplements are profiting nicely from their videos. Nothing wrong with that but most of them are not medical professionals either. In fact, most of them have no medical training whatsoever.

[@Hmy8799]

@@antonystringfellow5152 this^^

[@marysmith4811]

I agree that one supplement is not the fountain of youth. But I do wonder if it can help some people who are struggling with certain health issues.

[@jeffhaggerty402]

I don't know if this is possible but I have read that niacin can cause a gout attack. I have used NMN twice now for several months both times....both times I ended up with horrible joint pain and very high uric acid. Could be chance as I do take other things, but it seems odd as NMN is the only new thing.

[@greggbambu411]

Interesting. Still so much that we don't know . people run out and buy these molecules without considering the long-term affects.

[@jasonhearn5818]

Same can be said about meditation

[@nsudatta-roy8154]

I wonder what would happen when intracellular glutathione percursor(s) is consumed along with NAD+ precursor(s). Intracellular glutathione raises the requsite t-cells to shrink tumors or otherwise reverse cancers. Just a thought.

[@sales_coach_ai]

Taking Tru Niagen but may stop because I eat healthy, exercise daily and sleep well. 34 y.o here.

[@NomadicLiving]

Perhaps NAD could favor' a tumor but it's not gonna cause it, lack of NAD isn't going to cure it; the tumor will be a problem no matter what. I guess the question is pros vs cons, not either-or and it is a combination of circumstances that is most likely the real question, not separating out on supplement and expect that is the only factor.

[@mana9a]

I think part of being alive is running the risk of growing tumors, i think they are contending the fact that maybe it is helpfil, but as of now you dont have any concrete evidence (which is really hard in those type of things) about the dose for humans and how to supplement it, aside from the question, does raising plasma levels mean increase NAD in the cell? So what i understood is not to jump on such conclusions that NAD is essential and without it life ceases to exist, i think alot of things could be categorized as essential to the cell integrity but you cant say that supplementing them at x dose makes you live longer

[@TheHorrorsPersistButSoDoI]

It really does make sense, as we get older greater the chance we get cancer,if we are young and already have cancer we know it spreads faster than it does in older people, so if we want to reduce cancer by aging we take nmn, but we must be careful not to cause cancer in other ways, careful that we don't already have it, and if we have some suspect gene for cancer not sure to take or not to take nmn

[@antonystringfellow5152]

@@mana9a "does raising plasma levels mean increase NAD in the cell?" If it increases the rate of tumour growth, then yes. That is confirmation.

[@nsudatta-roy8154]

​@@mana9aThe tumor can be reversed with intracellular glutathione therapy. Id like to see how these two can work together.

[@rashedusman9717]

The real results will come from human studies only. I respect David Sinclair for actually trying his methods on himself and I think that a lot of people don't apreciate his work. It's easy to find problems in any inovation, but it's hard to inovate. Ok, why not 100 mice, why not other tipes of tumors, why not see how those tumors react to treatment in both groups, etc. because, after all, they suspect that a substance that starts to be widely used can promote cancer.

[@rodrigosanchez7539]

Excelente informaciòn Peter, Gracias.

[@marcog951]

Peter, does this support that NAD increases happen inside the cells as well then, and not only in plasma? It it increases in cancer cells it should increase in others..

[@antonystringfellow5152]

That's true!

[@judesterification]

Would a severe niacin deficiency, like having pellagra cause someone to have very fragile, weak and thin connective tissue. Like ligament and tendon?

[@Maveric78]

I’d love you to get David Sinclair back on and directly call him out on both Resveratrol and NMN. Imo he undermines the entire longevity field by propagating poor science.

[@ScottSummerill]

GOOD FREAKING LUCK. Sinclair prefers to live in his own world and not be challenged. And if you push too hard he’ll block your access to his Twitter feed. That says it all.

[@maarten7]

I'm beginning to think he's a fraud. I'm becoming very concerned.

[@maarten7]

@@ScottSummerill True. He did that to me for questioning him.

[@nsiebenmor]

It would undermine his book sales.

[@BarsandNightclubsAU]

David Sinclair doesn't have affiliate links in his videos, he doesn't recommend supplement brands and is pioneeeing epigenetic reprogramming. The main people criticising him literally sell supplements or worse yet, have affiliate links to supplements in their videos.

[@A123-d8o]

Thanks for posting this video Dr. Attia. I genuinely appreciate you and your content. I see a lot of people who already drank the Kool-aide and cannot question something they want to believe in (pop a pill and live forever). I'm gonna focus on eating healthy, fasting, getting enough sleep, and exercising instead of taking NMN, NR, NAD, any of that.

[@markvoelker6620]

We can each decide to be in the control group or the experimental group, provided we know the experiment is being run. Absent that knowledge, a person is automatically in the control group.

[@ozzyhouston2535]

When I do hours of yard work on hot Summer days, I have significantly more stamina when I have taken nicotinamide riboside.

[@Bshipbuilder]

You know when I bring up similar antidotes from my own personal experience I'm told that it's the placebo effect. But what a difference it seems to make for me also.

[@juliodumbobk]

Why risk it then? I would not be taking NAD for sure

[@jjrkroon]

They both don't know...

[@mickmack9333]

.... i dont like the way Atila pushes the dicussion towards a specific outcome..... nmn is mostly harmless.... when it comes to tumors u could then also argue that normal food intake speeds up cancer....... i hate this fake and sneaky approach...... this podcast is for ruining the Reputation of nmn, just dont

[@bernhardwalther]

Thanks for this video and sharing in a comprehensive way for neophyte. NR might increases cancer growth from your 8 mice pilot study. Did you measure other markers? If you are in better health, aren't you less prone to start a cancer at all? The probability of growing a cancer gets less scary?

[@ryanpagan1032]

I think we have to come up with a better matrix for health span.. .. I think you’re definitely administer NAD and a few other ways.. such as pre-loading one, and then discontinuing the see if it has a certain kind of affect on the cancer growth

[@HH-gv8mx]

So is it beneficial to take NAD Supplements on their own?

[@grasucat1720]

Funny when asked about ketogenic diets, Sinclair says "there is no long term evidence to support their adoption" while for NAD, there also is no long term evidence, yet he recommends taking a gram of it a day : ) probably because he owns a supplement company that sells it.

[@BalthazarBotbol]

Sinclair looks like a skinny vegan 50yo boy, if that man is supposed to represent health then i'm not interested.

[@arielmalanga]

He looks unhealthy and definitely not younger than his biological age, I agree.

[@steve9189]

Where are you getting this misinformation from? Sinclair does not recommend any supplements and he does not own a supplement company.

[@emjayel4509]

Sinclair literally says he does not recommend it. he is sharing what he does

[@louisvario1087]

NAD has been around along time..

[@thepatternforms859]

I’m a heavy binge drinker and just want to supplement with NAD oral supplements. Thoughts?

[@panagenesis2695]

Stop drinking. It's one of the worst risk-factors. Replace it with positive behavior(s). AA can help.

[@JB-qt3wo]

I was a binge drinker for years. Picked up the habit in college and maintained it throughout my career. My big problem was I drank to take away anxiety and so I could sleep. I finally found trazodone which is a RX drug which you take at night to help you relax and fall asleep. It helped reduce my need to drink significantly. I can just pop one of those and I relax and fall asleep within 30-45 mins. No negative sides as far as I can tell. The other thing that helped me almost entirely cut out alcohol is I started treating my ADD. I take ritalin 2X a day and it helps provide my brain with dopamine so i can focus and get things done which reduces stress. The fact that it supplies my brain with dopamine has the benefit of reducing my urge to drink. When you’re drinking, you are self-medicating. It’s never so easy as to “just stop” you can, but the untreated issue that caused you to drink will still be there causing you problems. Go to a psychiatrist. A real professional. Tell them your problems and that you’re drinking too much, want to stop and are seeking treatment for x,y,z. If you’re smart and guide your own care, and do your own research, you can heal yourself. I had to do most of it on my own though. All the docs did were run tests and write me prescriptions…but I had to guide them. It’s up to you! You just gotta own it.

[@jujufisherofmen]

🤣

[@fxn]

If it is claimed that resveratrol studies in mice did not translate to humans, why is a pilot with 8 mice relevant in the same conversation?

[@yorocco1]

FINALLY someone is addressing this!!

[@nutech1810]

Nmn is fantastic

[@ryananastasiaquinn5543]

Now; I do know that they have tested NMN on Mice and Tumours Reduced in Size.... Richard #ModernHealthspan

[@seanolivas9148]

I saw that study as well… there’s over a dozen human studies since this video came out

[@angeloselarja]

Basically "too much of a good thing"

[@Helcc]

What's nad?

[@smartturkey123]

Layman here... but NAD is higher in young people than in old people. Young people have lower rates of cancer.

[@ktakashismith]

Layman here…your immune system is what puts the brakes on tumor growth (part of the reason why your thymus is so large/active right up until you’re done with puberty - lots of growth and replication, hopefully without cancerous growth and replication). Your immune system degrades as you age, hence why cancer is more prevalent in older individuals.

[@brandonyoung4910]

@@ktakashismith I love that you said what the original person said, just in a much more comprehensive manner lol

[@tnov2242]

There is no shortage of paediatric cancers unfortunately. If the immune system slips on tumour surveillance, NAD is going to explode the growth and shorten the lifespan… talking of longevity

[@user-vi9iu7er8p]

What's the point of doing the experiment involving 4 rats instead of a lot? Anyways, it's been 2 years now and NMN sales are growing substantially. So I conclude that your mini experiment results failed drastically.

[@deadwalking100]

Interesting interview thankyou to you both. I think... and by all means shoot me down on this; is not the body in a constant state of repairing such aberrant cells, I mean cancer is just a matter of time. I digress, well that's a problem. If indeed NAD does increase the ability of a cancer cells glycolysis process.

[@motivationseeker60]

Interesting take on this

[@Vam1500]

Cool Tadej Pogačar jersey on his wall!

[@ah64Dcoming4U]

If NAD made your body behave younger and healthier than perhaps that's why cancer can grow faster with higher NAD?

[@MrNapcsi]

cos NR and NMN is B3 type,and all B vitamin give you energy your all cell,and may be your tumor is it will grow!No one knows this for sure, but in general they don't dare recommend B vitamins to cancer patients!!

[@larsnystrom6698]

The body thinks cancer out of control belongs to it. So, feeding the body feeds the cancer. The way to avoid cancer is to have an immune system that's not fooled or overwhelmed. Some of our cells would become cancers if they weren't killed by the immune system. They appear all the time, but as long as they are handled, nothing happens. The immune system probably need a good NAD+ level to function properly. It seems likely that we should start with NAD precursor before the immune system has been weakened. Giving mice a cancer which it can't handle doesn't give the immune system any chance to work against it. Wouldn't it be more appropriate to use mice with a risk to develope cancer NAD and see if the risk increases or decreases? That pilot study showed that we shouldn't give NAD to cancer patients. Nothing else!

[@popothebright]

One must note that David Sinclair promoted resveratrol (and still does) despite the lack of clinical evidence. Now he promotes NMN and his results are already facing criticism and serious questions.

[@gabymalembe]

Study on 4 mice with cancer raises questions about NAD supplements.

[@TheHorrorsPersistButSoDoI]

It really does make sense, as we get older greater the chance we get cancer,if we are young and already have cancer we know it spreads faster than it does in older people, so if we want to reduce cancer by aging we take nmn, but we must be careful not to cause cancer in other ways, careful that we don't already have it, and if we have some suspect gene for cancer not sure to take or not to take nmn

[@natalias1212]

They both need NAD for hair growth.

[@KenzXYZ]

😂

[@carmyvasquez318]

😂😂😂

[@Johnmyork23]

Wow all 4 mice got cancer. If you're Phd is real it should be reviewed if you're quoting results based on 8 subjects total.

[@JuliMoodyStunts]

I am always skeptical on Mice studies I understand are important but Mice are not humans The amounts of whatever they testing gets implemented in large doses. Is hard to really make any accurate determinations . Adults take a small amount of NAD+ injectable not everyday you can't make any assumptions on anything is basically your opinion Nothing in the filed of aging is great yet, I believe is in the infancy stage and it will be for a long time.

[@josiaghylnd2024]

Exactly. Mice tend to have higher levels of certain markers in some organs. For example, the possibility of thyroid cancer from taking semaglutide is severely higher in mice because they have more of chemical in their thyroid than humans which causes a rare type of thyroid cancer. So, doctors are hesitant to prescribe it to diabetic patients because they don't know this information, and it could be such a great help to those it was designed for.

[@JulieBeal-Hutchison]

Zzzzzzzz…..