How effective is NAD and its precursors for longevity?

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This clip is from episode 300 ‒ Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, & more.
In this clip, they discuss:
- Peter's current thoughts on NAD
- What we still need to study about NAD to know if it's effective
- Promising data supporting the efficacy of NAD
- And more
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
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[@tdichow]

I'd like to know the opinion on GlyNac, rather then NAD

[@Ryan-wx1bi]

Tried it, gave me a headache every time. No thanks. People lived to 100+ without it. Ill just stick to a clean diet and lifestyle

[@2thdoctom]

I have NMN powder from Renue. Figured I’d play human chemistry set with it and look for a single (self) case outcome. Wondering about bioavailability after 2nd pass metabolism. Too bitter for sublingual (and too much powder). Ruins coffee, and heat may denature the compound. So, I bought some cellulose capsules and filled them with the powder (2 caps/500mg). Renue instructions suggest 500mg BID. Is that an appropriate dose according to most recent data?

[@theancientsancients1769]

I wouldn't put it in a hot drink . Start at 500mg and see how you get on before increasing to 1000mg . Different people use the dosage they tolerate . But you must take TMG with for it to work

[@judesterification]

Would a severe niacin deficiency, like having pellagra cause someone to have very fragile, weak and thin connective tissue. Like ligament and tendon?

[@marwanhagar7196]

There's good data to support the use of NMN for endurance training, it has been shown to significantly improve cardiopulmonary metrics in several trials (within a short time period, appears to have a cute ergogenic effects like a pre-workout). With this knowledge, I think NMN should be taken in proximity to is cardiovascular exercise to get the most benefits from this ingredient.

[@TheBriarCottage]

Dr. Attia, I would like your opinion on red light therapy.

[@user-fy9rr7wi7f]

He would get mad and say, are you doing 45 minutes of ejercice every day???

[@junu0507]

Lifespan probably not, but healthspan-wise, why not?

[@rtypepe]

NMN has made a differance for me..... I am almost 60 years old and will continue. Also taking it with TMG

[@liutasx]

NMD doesn't help, you have wishful thinking

[@sn0wfir3_]

And TMG only helps for working out

[@pauln8503]

This is why it’s the most re-ordered supplement in the world- it works

[@mattstanbridge]

I've been taking it for 5 years. What benefits have I gained from it? It's hard to know what the 'me' without it would be like. All I can say is what I'm capable of and my appearance. I'm 55, people assume I'm about 15 years younger, I'm still very agile, very strong, and even though I've lost speed, I'm still fast. As well as going to the gym, I skateboard several times a week. Some of that may be down to genes or simply never allowing myself to grow old or even consider I'm ageing, basically maintaining a young mindset. The only hard evidence I have is when I used to play football ⚽️, I would need some good pre season training to start the season being able to do, according to my tracker, 40 or so flatout sprints, general jogging and some walking for 90 minutes a game. Covering around 8 km a game. The last season I played before, I decided to retire and just skateboard, I did no pre season training, but my first game it felt like I was 2 months into the season, I was running around and sprinting effortlessly, it was weird, and the only difference was nmn. Other than that, I can skate non-stop for 2 hours, probably more, without getting tired, I'm ready for breakfast after a couple of hours, though.

[@nattyfatty6.0]

After listening to the entire episode, "geroprotective" is now the most annoying word I've ever heard

[@whatthefunction9140]

Als is proof there is no god.

[@pr1ce213]

Okay lol

[@tommydinob]

Nonsense. But, obviously this place is a work in progress.

[@irenekuznet847]

Aging "anti-aging " "doctor" tells us what to take. Nothing is more pathetic than...