Primary Myelofibrosis (PMF) | Myeloproliferative Neoplasm| Bone Marrow Fibrosis

[@MedicosisPerfectionalis]

🦠Antibiotics Lectures: www.medicosisperfectionalis.com/ 📝 Download Notes: www.medicosisperfectionalis.com/

[@ahmadaljazeeri9287]

You have the style, the knowledge and the spirit! You’re awesome man! The best medical channel in KZbin. Many thanks for your generosity!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@ramatouliebarry1007]

I came to subscribe and realized i already did long time ago😂. Thanks for your wonderful videos. I am working 8hours a day, 6days a week and a 4th year med student. Your videos are the ones keeping me going. After reaching home 12am, your videos are the only ones that can keep me awake to study. I can't put everything into words right now coz it will end up being a text book but just know that am grateful ❤❤

[@MedicosisPerfectionalis]

Wow! Thank you so much! You’re the best!

[@farahahmad8681]

Secondary myelofibrosis : 1_Metastasis to bone marrow from other tumors 2_Other myeloproliferative neoplasms polycythemia vera and essential thrombocythemia 3_ some types of leukemia and lymphoma 4_infections such as tuberculosis 5_chemotherapy and radiation

[@MedicosisPerfectionalis]

Excellent!

[@eleneendeladze6432]

Thank you for making my medical life easier

[@samanthers]

Your sense of humor is spot on. Keep making videos ❤️

[@MedicosisPerfectionalis]

Sure...Thank you, dear, for your nice words.

[@luqi01]

thank youuuuuuu! you have NO idea how helpful your videos are for my USMLE preparation, your style of explanation is so simple and to the point!

[@MedicosisPerfectionalis]

Thanks dear 😊😊

[@MedicosisPerfectionalis]

Please, help me reach 35,000 subscribers and I will start uploading videos on “bleeding and coagulation disorders” instantaneously. Thanks 🙏

[@MedicosisPerfectionalis]

😍

[@l.salcher7122]

And now 5 month later you have more than 60.000! AMAZING! You are great! Thank you

[@MedicosisPerfectionalis]

It’s thanks to great people like you 🤗

[@amjadbajudah]

You deserve more than the double of your subscribers now ❤️❤️❤️ YOU ARE A HERO

[@ΖωήΣωτηροπούλου-ζ3ο]

causes of secondary myelofibrosis : leukemia ,MDS, metastasis ,lupus and other diseases of connective issue ,toxins , granulomatosis (TB ,fungus ,sarcoidosis) ,gaucher disease

[@MedicosisPerfectionalis]

Excellent 👍

[@ammed9204]

C-kit mutation is also found in GIST(gastrointestinal stromal tumor).

[@MedicosisPerfectionalis]

Yup! What else?

[@DrSD-lu5lv]

gastrointestinal stromal tumor, seminoma, myeloid leukaemia , malignant melanoma- these are conditions with c-kit mutation!!!

[@manarsmaan2624]

Thank you for the great lecture . WHO classification more than 20% blast is AML . i think that what you mean to say AML in minute 11:15 . you are great as always .

[@helenTW]

Praying for my mom, hopefully her ET is not going to turn into this 😢

[@sarahjacobson929]

Thank you for saving lives

[@MedicosisPerfectionalis]

I appreciate you so much!

[@towlettepetatucci6067]

I heard "the marrow is shitting tears of red blood cells" and honestly that would be a valid explanation lmao

[@MedicosisPerfectionalis]

Haha 😂

[@alijaberi9852]

Many thanks for interesting dicreption about PV !

[@MedicosisPerfectionalis]

My pleasure 😇

[@alittledoctor_04]

أنت إنسان عبقري ❤

[@arshadhussain8797]

Pls make a video on bone marrow transplantation and stem cells therapy ...thanks 👍

[@MedicosisPerfectionalis]

Thank you! I added the topics to my ToDo list.

[@loknr9931]

Love your video very much especially the case at the end !!!

[@MedicosisPerfectionalis]

Thank you 🙏

[@ryansandy2433]

From the video, it sounds like primary myelofibrosis can present like polycythemia Vera in the beginning. How would you differentiate/make a diagnosis knowing megakaryocite numbers ?

[@paediatricspotcases5220]

Can u make a separate video for all treatment of malignancy

[@alangarfias6075]

This videos help me sooooo mucho thank you for your amazing work!!

[@MedicosisPerfectionalis]

My pleasure 😇

[@mowsey321]

I appreciate this breakdown as a patient. I have recently been diagnosed with Primary Myelofibrosis, they indicated it is prefibriotic. However the bone marrow aspirate and tissue sample were quite suboptimal for testing, leading me to wonder about the reliability of prefibriotic assessment. Particularly since the challenges they had in getting a good sample could be a direct result of fibrosis from what I gather. I also have teardrop cells, and increased reticulocyte. My CBC counts for the most part are within the normal range other than when I had an esophageal bleed and I think I have one or two white blood cells that are on the low end. As for symptoms it’s a little hard to judge as I am also in menopause and generally have very poor sleep hygiene, so might sweats and fatigue could be related to these things as well. They have ordered a myeloid panel, will this assist them in confirming the prefibriotic diagnosis since they couldn’t get a reliable bone marrow specimen. Should I be getting any second opinions, pushing for any sort of treatment, especially when my CBC counts are relatively normal? They are suggesting it is in the watch and wait phase of the disease

[@laurafedorowicz3357]

Is the tear drop cell an easy giveaway for Myleofibrosis/bone marrow fibrosis

[@powerplayer9150]

Superb explanation.

[@MedicosisPerfectionalis]

Thanks 🙏

[@JayRazah]

How to know when pv has transformed to mylophrobosis ?

[@alpr1864]

Hey medicosis! You said ALP is for mature WBCs; then why is it high in PV and PMF?

[@laeradelrazonamiento9390]

do you have a stem cell transplant video for leukemia?

[@mostafakhamis6978]

You are amazing ..thanks for this easy videos ❤❤

[@MedicosisPerfectionalis]

My pleasure 😇

[@drhemamalathiaravind8117]

C-kit mutation is also found in GIST

[@Sunshine-zi7oy]

such an amazing teacher! thank you sir!

[@MedicosisPerfectionalis]

My pleasure 😇

[@rawaa2501]

Thank you 😭❤️

[@MedicosisPerfectionalis]

You’re very welcome ☺️

[@naz674]

Ur videos are AMAZING thhaankks alot

[@MedicosisPerfectionalis]

My pleasure 😇

[@alexherbert11]

Gastrointestinal stromal tumor and testicular seminomas

[@Billguz978]

Imetelstat is the best treatment

[@YouMJ8]

Mastocytosis associated with mutations in c-kit gene

[@loyaltyesmaeel5656]

excellent as usual 👏👏🤗🤗 but plz add some hint about WHO 2016 classification of myeloid proliferation disorders bec it classified the PF acc to types of fibers retucllin or collagen fibers not retucllin only

[@林詩恩-r9b]

c-Kit is also seen in GIST.

[@MedicosisPerfectionalis]

Excellent...What else?

[@林詩恩-r9b]

@@MedicosisPerfectionalis In seminoma, c-Kit is often amplified or overexpressed. c-kit is expressed in some melanoma, as well.

[@MedicosisPerfectionalis]

You’re the best!

[@pari020]

Thank you so much!

[@MedicosisPerfectionalis]

You’re very welcome 😊

[@jorgevillacis8127]

Great great video - question: what is the difference between essential thrombocytosis ans essential thrombocythemia?

[@MedicosisPerfectionalis]

Nope...Also no difference between secondary thrombocytosis and secondary thrombocythemia.

[@doctorofmedicine1113]

Difference in spleaning 😎👌

[@ivansantiago1568]

So CML can also having more >20% blast cell? or is it

[@MedicosisPerfectionalis]

Less than 10% -> CML Between 10-15% -> MDS More than 20% -> AML. This is true most of the time, but not always. Moreover, thank you so much for joining the channel by clicking on the “join” button :)

[@drmohammadbasha6797]

Thank you very much bro Likely to discuss You as you mentioned in the case at the end of the video myeloid blast > 20% >>>> this may be CML as he is old age !!! I think it should be less than 10% !!

[@rajibkumar2026]

bro, which software are you used for making this video ? please say

[@ayeshamehak752]

Waooo it's awesome lectures

[@maryamgolshiri8107]

your Question: CML/ M7/myeloma/ granulomatous ds/ hyper and hypoparathyroidism

[@marionnella1217]

c KIT mutation in Gastrointestinal stromal tumor(GIST)

[@MedicosisPerfectionalis]

Yes!

[@420Gold]

What other diseases have a ckit mutation?? I got one for you… I have essential thrombocythemia with eosinophilia, and the only mutation they have found is a KIT r888q variant of “undetermined significance”. Curious if you know of anything similar, as I cannot find another similar case.

[@LewisJulian-l1e]

Virgil Common

[@jabizebadi6982]

c kit in GIST

[@MedicosisPerfectionalis]

Excellent!

[@amandalynne9023]

I learn more on here than from my current Hematologist 🫤

[@azadkeerthi3510]

Seminoma dysgerminoma - ckit mutations

[@ashwaag73]

Thanks a lot 💕💕💕

[@MedicosisPerfectionalis]

My pleasure 😇

[@hannahrosa5485]

Will share. Thank you once again.

[@MedicosisPerfectionalis]

You’re always welcome 🙏 Thank You 😊

[@downtherabbithole02]

If you have a MPN at young age, how long before bone marrow scars permanently and turns into Myleofibrosis

[@dahis6763]

7:57 how AML can occur when bone marrow fibrosis there?

[@minahamdani3224]

Basophils are predominantly increased in CML not neutrophils.

[@doctorofmedicine1113]

Are u sure

[@michaeltogo99]

sure👍

[@jemy_tube]

awesome but we (non English speakers) hope that you speak slowly sometimes I can not follow

[@epstein1881]

Ruxolitinib.....jak kinase inhibitor for myelofibrosis

[@tcummin]

Great videos. I'm not sure Tm is quite right: hydroxycarbamide, ruxolitinib. Rarely see thalidomide used.

[@MrRafitows]

I believe GISTs are the result of a cKIT mutation

[@MedicosisPerfectionalis]

Excellent!

[@tuqa777]

Thanks🌸

[@MedicosisPerfectionalis]

My pleasure 😇

[@mjk9152]

I love your videws 😭😭💙💙💙💙💙💙😂

[@Sama7941]

Why is AML not a myeloproliferative neoplasm

[@MedicosisPerfectionalis]

Because WBCs and platelets are not elevated.

[@srirambhardwaj2343]

Thank.you.very.much.sir.

[@MedicosisPerfectionalis]

My pleasure 😇

[@tcummin]

Aquagenic pruritis rather than aquatic pruritis

[@zishanrahman7208]

You are awesome!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@loly7989]

Perfect

[@FrankJones-t3p]

Michelle Parkway

[@aaa203040]

HI DR i am from iraq i have mylofiprosis dicnostic from dr in iraq i have bone morow changes i have anemia i have ghigh esr i dont have wbc is normal plat normal no have larg liver no have larg spleen pls help me

[@MedicosisPerfectionalis]

What does your doctor suggest as treatment?

[@aaa203040]

@@MedicosisPerfectionalis no treatment i have just predselone and folic acid but now i take multi vitamin

[@baraaayman3783]

I can't see the platelets among your videos ? ?

[@MedicosisPerfectionalis]

Look 👀 no further, because they are here: goo.gl/Dt41Bg

[@filimimasthi1531]

How long can live with mpn

[@MedicosisPerfectionalis]

It depends on many factors.

[@eimanabedalhameed6396]

How can i get the pdf؟

[@MedicosisPerfectionalis]

On my website: www.medicosisperfectionalis.com/

[@AzulCelestex]

I cannot stay happy if a have to study hard

[@MedicosisPerfectionalis]

Haha 😂

[@moneebkhalid]

I do find your videos very useful. Thank you for that. Can you please stop calling MPN the disease of the elderly? I am currently 39 and was diagnosed with ET 3 years ago. I am currently part of a facebook support group for ET sufferers and there are people in FB group diagnosed with ET as young as 18 years old.

[@MedicosisPerfectionalis]

I appreciate you! There are exceptions to every rule. When you count all the patients with MPNs, the overwhelming majority of them is old. That’s all. No one claims that it doesn’t happen in the young! I wish you the best of luck! Don’t give up!

[@moneebkhalid]

@@MedicosisPerfectionalis Thank you. You are not wrong. When I went for another BMB and aspiration about 2 weeks ago, everyone else who came for the same procedure was at least 65+ years old. I do like your content, it’s very informative even for people like me who are not medical professionals.

[@MedicosisPerfectionalis]

You’re such a good person, Moneeb! I enjoyed the discussion!

[@kehkashannazrinansari1389]

"Normocellular bone marrow with 6% of plasma cells and erythroid hyperplasia" what does this indicate in a biopsy report .. if anyone can help

[@stillfindingmyself6869]

😊

[@MedicosisPerfectionalis]

:)

[@birhatyouns2004]

❤❤❤

[@AbrahamTodd-t7k]

40448 O'Keefe Lake

[@spacebound9665]

sorry.. im in love with you

[@anvifilms261]

perfect lecturism with humour minded doctor for lazy students 😂🫡.u r awesome 💥