Pharmacokinetics: How Drugs Move Through the Body

[@gunp0wderr0cks]

as a second year pharmacy student, I really thank you for all of your organic chemistry videos and these, keep them up

[@Hisheartlongsforyou]

Same pharmacy technician here he’s really helping me out!

[@halamikkawii]

as a second-year pharmacy student, I thank you for literally all your videos since they helped me a lot!! keep up the great work! ily

[@beefnoodlles]

I am watching your videos since my GSCEs; I moved to the UK when I was younger and it was really hard to study in English. But your videos made so much sense to me, that I was able to get into the uni. Now I am in my last year of Biochemistry course (bachelors) and I am still watching you! I cannot thank you enough. The impact you make is unbelievable

Thank you for your educational content. I dropped out of school in 10th grade to pursue a life of drugs and delinquency. Im now 29, spending the last 4 years re-educating myself on subjects I never even learned. Some of this wouldnt be possible for people like me without wonderful people like yourself making this content.

I just found out you lived in wilton,ct at one point by the way. So do i haha

[@hannahcrandall8415]

thank you for posting content like this! us nursing students appreciate it since pharm is only taught briefly but we're expected to know so much of it!

[@sasuxsakuxfan]

so true... i'm basically teaching myself at this point

[@easy461]

I'm an Egyptian pharmacist and very interested in your lectures . You are amazing, go ahead

[@ThePBandJen]

I'm in pharmacy school. I loved your videos for my pre-req classes like organic chemistry and biology so I am thankful you did these as well! Thank you!

[@Zetsuke4]

im impressed by your postings of medical videos recently

[@CarineLucilia]

I’m in nursing and this videos are amazing!! Thank you!

[@li-an7700]

im a filipino nursing student in the US and your video is helping me get through pharmacology

[@b14548]

I absolutely LOVE this little song at the beginning!

[@andrewliu6592]

can you please talk about antibiotic resistance, how it is spreading, and other possible treatments that could be used for treating antibiotic resistance? (like MRSA, acinetobacter baumanii, etc.)

[@desislavarusekova9394]

Hello from Scotland :)! I don't comment much in here but I am so glad I found your videos! You did great work with them, thank you! Easy, understandable clear, and knowledgable! I only have one recommendation (I apologize if you did it and I did not see it).Thank you! Officially I am a follower!

[@natethedon10]

Prof Dave! I haven't seen you in a while. You got me through undergrad, thank you 😭💜

[@BeaverZer0]

Hey bud. Love your shit. Good to see ya dropping vids.

[@junaid2173]

This is incredible vedio for pharmacy students

[@nickydaviesnsdpharms3084]

that's great, i didn't realise you did pharmacology too, you're an all rounder. like it

[@laibaali2297]

Can you please teach pharmacology topics related to MBBS? Like in a systemic way , lippincott takes a long time to interpret and understand. Your videos are very easy to understand. Thankyou so much for the videos. They are very very helpful.

[@alreadymarked]

Im wondering, what would be your next series? I hope that you'll make many videos about medicine! haha

[@getrudephiri9538]

Thank you for your effort in trying to make learning easy

[@jowiolfers6812]

I study biomedical sciences and your video's are very informative, clear and easy to follow!! amazing!

[@tesawaluyaputri5797]

Hello from Indonesia. I just found your channel. Thank you for your pharmacology videos!

[@kevinmoore2501]

I’m super interested in this stuff. I liked this vid, and added it to my faves. 👍

[@kenivia]

You Simplified it all, thanks!

[@Jslav-jj2xq]

Pretty good overview. 1 comment, bioavailability is the Rate and extent of absorption, not just extent. Generic drugs must demonstrate identical rates and extent of absorption for approval.

[@avirah__5644]

Superb video professor

[@mustaffmaxamed5439]

Thanks

[@nneomaofo]

Thanks for the good work Prof. Please are their no transcript for these videos

[@shahabbaloch8338]

professor thanks for ur videos we cant get out of homes because of lockdown i hope ur videos suffice. but please teach us other branches of chemistry like nuclear chemistry and analytical chemistry

[@nicolecurtis7016]

Thank you for these vids! They help me a lot with me studies and exams. Thank you 🙏🏻

[@bellavita5308]

Thank you professor Dave. Great explanation

[@jasmincappal8730]

thank you for your educational content. love it ❤

[@dlinmu]

Professor Dave, could you please make a video explaining how enterohepatic recycling of drugs work?? Please and thank you!!

[@abdulkarimturay5667]

You're indeed a professor Sir

[@colletchitiyo2799]

Many thanks , this is great!!

[@tulmajok3562]

Second-year pharmacy student... Nice video sir

[@mohammadhmouz2563]

Really thank you , finally I've understood it after a long suffer , wish you all the best ❤❤❤😍😍😍

[@hoseakiruii]

Hi Prof. You're doing an amazing job!

[@WhdibAoqj]

Thank you professor

[@essameliwa2251]

Thanks a lot for your efforts

[@kunenethandie220]

Nice summary prof

[@parasiftikhar159]

Thank you!

[@favourchiazam9319]

Wow! This is beautiful 🥰 Thank you so much sir 👏

[@sabrango]

thx!

[@sumanamaity3105]

You are an amazing teacher ❤️

[@jonathanbailey8376]

Good videos dave!!!!!!

[@ravena.carvalho]

Thank you very much for your explanations!

[@GhYaAan]

Thank you sir better than my md teacher ❤️Love you

[@fartuunxuseenxasan4662]

Thank you for your help me

[@Zetsuke4]

this is good

[@ruhidyusifov5106]

Thank you for great video context

[@sabazargarzadeh]

Thank you so much for your videos, they are really helpful 🙏🏽❤️

[@richricogranada9647]

The way drugs reach their destination is fascinating

[@dindafaara]

THANK YOU SO MUCHH

[@sachinmasan8574]

So easy explain ❤

[@arshisiddiqui7657]

Thanks a lot sir😊...its helpfull👍

[@afifahatikasari3337]

that so helpful sir thanks u so much!

[@Randomthought222]

Sir you are really amazing 😍

[@3la7e]

Thank u Dr ♥️

[@techgautam422]

To some extent it cleared but couldn't completely clear my doubt. My question is, if liver detoxifies any toxin in blood does it see drug as toxin? If so, how drugs work in our body if liver detoxifies it?

[@chirazcharzou8610]

Could u please make videos about medicine chemistry * therapeutic chemistry* I'll appreciate that so much, 🙏💓 and thank u so much for all those videos 🙏💕

[@bravonline3052]

When exactly the metabolism occurs?is it after the drug acted on the organ or before it?

[@michaelberman3648]

With all due respect, I do not agree with this definition of "bioavailability". The way I actually define "bioavailability" is the fraction of drug which reaches its targeted receptors and the active site of enzymes whether the enzymes are located on the cell membrane's surface or inside those targeted cells. When a drug reaches systemic circulation, not all of the drug will clearly reach the target receptors or enzymes at those targeted cells because the drug may bind to some extent to proteins or fatty acids within the systemic circulation of the blood and some of it will not be released by those binding proteins or fatty acids within the blood stream. And if these enzymes are in those targeted cells, then it will depend on the polarity and size of the drug molecule whether it can pass through those cellular membranes or not. Thus, based upon my definition of "bioavailability", the fraction of drug becoming truly "bioavailable" should be even lower than the more popular definition which states "the fraction of drug which reaches systemic circulation"!

[@joefarrow1599]

Serum concentration is easy to measure by a blood test. If I use your definition, how would I measure this quantity?

[@alfiethelabrador9692]

You summarised a 2 hour lecture in 8 minutes.... come work at my uni please 😆

[@anirbandutta3273]

I just understood the entire pharmacokinetic ( portal circulation) in my final year 😅😅 dont know why i didnt find this one b4

[@jpgnt5721]

Thnq so much

[@abdallaabdelrahim8949]

does the drug metabolize in the liver and kidney before entering the bloodstream? or enter the circulation then reach the target tissue then end up in the liver & kidney

[@hamadafd9730]

If you give the drug orally it will enter the portal circulation before it reach blood stream so it will undergo metabolism so the amount of drug reach the blood stream less than same drug if you give it intravenously and the kidney has no thing with metabolism it is responsible for elimination of the drug I hope you understand me

[@arlix6845]

i have a question do drugs (medication) activate the immune system if so the body will attack the drug and there will be memory cells then the next time the drug is being adminstered the bioavailablity will decrease right cause so of it will be destroyed ???

[@beautyofislam9688]

fantastic

[@dariustaylor6983]

0:20

[@kondwanibanda7819]

Thumbs up for the intro 😂😂❤

[@Code3chef]

Hello! Any chance I could contact you and discuss a skin absorption problem

[@jakubd3426]

New here. Replayed intro like 100 times now xDDDD

[@riveraraissajoyce9131]

hello, where did you get those photos from the slides?

[@dgmickley]

Do the kidneys help keep metals and carcinogens from the brain when you get a vaccination?

[@nicc8230]

Awesooome!

[@akosuaanointed6561]

Please i want to no from the beginning of pharmacology

[@reneferdinandfilip2202]

you forgot about liberation

[@anasalabd6515]

Adsorption not absorption

[@ProfessorDaveExplains]

They are two different words with different meanings. I used the correct one.

[@janinemaemacaraig4889]

What about liberation? I thought it is LADME

[@ascharyabalaji5888]

OMG he got a haircut whatttt

[@akshaygullapalli6500]

Sir where are your hair

[@erikjohansson1814]

You are good and pleasant to listen to. Subscribed. Oh, love your funny bashing of the flat earth idiots.

[@midend]

nice

[@YahawahshiIsTrueGOD]

Does pooping get rid of the drug

[@mujib4466]

🙏🏽

[@queenzelika8269]

Woooow very fruitful 💉💊👍

[@mari_6163]

Please translation to Arabic

[@mirad7014]

First year medical student cries over there in the corner

[@Mrgowds009]

How drugs ex., paracetamol know that they have to move to targets Hoe do they know

[@CabdifataaxCardio]

May Allah guides u to the light of Islam from the dark of non Islamic beliefs

[@syedarizvi7290]

In Sha Allah Ameen

[@glydeldetubio336]

I have watched a lot of your videos but this is my first time seeing you with a short hair you look so hot hahaha by the way thank you very much, you really a big help for my board exam review. Hope I will pass!!

[@LashZhvania-Movies-MMA-Science]

intro is very ennoying

[@natethedon10]

Prof Dave! I haven't seen you in a while. You got me through undergrad, thank you 😭💜

[@quenniepacaldo4714]

Amazing!!! Thank you!