Mechanisms of DNA Damage and Repair

[@maria1239876]

I like the preschool vibes i get from the background while I'm learning stuff in my junior year of college :D it makes me feel all warm and fuzzy.

[@naturegirl1999]

Imagine how smart preschoolers would be by watching this

[@noblevenom2858]

@@naturegirl1999nah preschoolers are pretty dumb. They can’t do shit

[@dr.bibaswan]

Correct. We are all little kids deep inside. Our official age may be 20 - 30 but we love the vibes of age 2-3 😇

[@ComandaKronikk]

Dude thanks for getting directly to the point and not fluffing about like so many other youtube videos. U just feed me facts that I CRAVE!!! Professor Dave 4 prime minister 2019

[@Youssef-zo3ls]

Paris Coroneos exactly! He gets directly to the point

[@personalacc4352]

"Now that we are sufficiently terrified of genetic mutations" 😂

[@sroydetroy6404]

Where did he say this lol?

[@memoryloop5816]

@@sroydetroy6404 5:39

[@anusphoorthi9anuradha968]

Àyy

[@BishoujoMegami]

Professor Dave, I'm still using your videos at Uni😂 They are so helpful. My genetics lectures are really confusing so far but this is helping consolidate my understanding. Genetics was always my week point in biology🙏🏾

[@alaazein7147]

Me too

[@geetugupta7244]

I don't even have to take biology next year, but I'm forced to learn it this year ...stupid school rules...😭😭

[@hamzazaqut1315]

It seems spelling is your “week” point too.

[@BishoujoMegami]

@hamzazaqut1315 omg, you need to quit your day job and become a stand up comic... you'd be a millionaire...

[@Eagles883]

@@hamzazaqut1315you’re harsh, I was thinking to myself “I’m not going to correct it.”

[@EpicSelenium34]

Thank you professor...another fabulous video. I like how you go deep down into the molecular structures of the mutant amino acids and the pyrimidine dimers (and other such things) instead of just glossing over them. Getting to the chemistry at the heart of what we observe makes the learning experience so much more intuitive!

[@MrLaTEchno]

For a layman like me this series is fairly easy to follow and understand. I am therefore very grateful and hope to be able to use your work here on Y-T a lot. Greetzzz from Holland [sorry for my bad grammar]

[@mirarizqah]

This video is great. easy to understand and have a very clear explanation! I love it

[@yikotao]

He knows all about science stuff and he is professor dave explains. This song is like gangnam style. I only watched several videos and start singing when I was cooking my dinner!

[@tomservo5007]

cooking and singing will increase dna mutations. good luck.

[@jwh5505]

just keep on cooking

[@thebigtricky9156]

Overtly, I find it annoying, but each to their own.

[@napojusticeramothokoane5536]

Thank you Prof. um thinking, I may as well stop paying my school fees and start paying R5.00 per month for joining your channel, this feels great

[@furkaan346]

Dave, I suggest you first present a summarized outline using a flowchart classifying different mutations and its subtypes. This way it'll be easier to grasp and make notes at the same time. I suggest you apply it to other videos too

[@iluvbeef11]

hey professor dave. great video! your graphics really illustrate concepts that I've been struggling to grasp since high school. this is honestly the best explanation of mutations I've ever seen. I do have one thing I wanna clarify tho. so in the frame shift mutations, it was one whole base pair that you had deleted. let's say you showed an insertion. would it be an insertion of a whole base pair? or could you have an insertion of a nucleotide on one strand but not on the other strand opposite to that added nucleotide? let me know if my question is confusing lol I'd be happy to rephrase it as best as I can

[@ProfessorDaveExplains]

ooh that's a good question! you know i'm not too sure, i'll have to look into that

[@iluvbeef11]

@@ProfessorDaveExplains awesome, lemme know when ya know! and thanks again for the great vids

[@samlynn7681]

Thank you so much! I couldn't understand mismatch or NER for the life of me for the entire semester. I really needed this explanation for my exam tomorrow!!

[@Surgtari]

thank you jesu.. I mean prof. Dave this was beyond mind blowing

[@patricksarama4963]

Don’t be shy, call him biology Jesus

[@clent444]

your videos are so clear and easy to understand. Thank you so much 🙏 😊

[@VinodGupta-hj8hu]

thank you, Professor Dave your explanations make me learn more. Thank you for producing this videos.

[@MyMorghy]

Thank you so much Professor Dave I have an exam of Genetics this Tuesday and you have explained me about half of the themes of the exam in 11 minutes. Fantastic

[@ravikumarkommareddy3723]

Easy to understand and informative. Thank you very much. Great job

[@renkei7596]

Love your videos to sum up what i learned in biochem :) But could you do a video about molecular cloning and PCR?

[@DanyalLaghari7]

your videos are still being used after 7 years. Thanks

[@alwaysambitious]

I love how clearly you talk! great Videos

[@reemsjourney9070]

Thank you prof Dave, you made me survive my journey in premed 🙏❤️

[@nesrineemira6381]

sir u are a life saver..and that intro sends ...

[@GurpreetSingh-jr8kk]

U r fabulous professor ..... u teach better than my teachers in my tutions.... Lots of love from INDIA

[@fathimashahabudeen3477]

This video is great now u are my professor.. it’s easy to understand yr videos so simple and made with dedication and love 💕

[@lezanibrahim8327]

You saved my life by this video ,thank you

[@henrynyirongo8761]

Professor Dave is one of the very few that take time to respond to the various comments😊

[@e.c.2215]

Thank you for all your tutorials! From Chemistry to Bio they all have the exact content that I need.

[@belgacem_mehdi]

A question : 2:27 you said if the mutation happen outside the gene it does not cause any thing But we know that there many gene that are regulated and activated and deactivated by portions of DNA outside the gene ( epigenic )

[@TheAnnie121]

....am I the only one who ALWAYS sings the intro, even though this channel has been accompanying me since my Senior year? :D

[@reginadaka2335]

No u ain't the only one..

[@iseegoodandbad6758]

I love Dave so much!! The best teacher so far!!

[@OneWithTheOcean]

Very informative, Thank you!

[@jwh5505]

if this video is that informative to you, i recommend you not to take ap biology

[@Godessa9shrek]

"Now that we are sufficiently terrified of genetic mutations...", lol...a laugh I needed while late night studying. Thanks!

[@christopherreed2694]

Thank you Dave for taking 🙏 the time it is appreciated much 👍

[@innate-videos]

Another great vid and, as always, total clarity. Thank you.

[@henrydennis2199]

@ 5:39 Dave: Now that we are sufficiently terrified of genetic mutation.... Me: guuuuuuyyyy!!!😂😂

[@econguyph]

*you helped me in biochem class thank you professor I think thank you isn't enough so grateful ❤️*

[@floppy8568]

Deletion or insertion reminds me of a situation of a program I'm thinking of codons as instructions here when an opcode is read as an operand and vice versa In computers this gets fixed quickly since instructions aren't stored in a constant amount of bytes, could be one with "NOP" (0x00), could be 2 or even three. but genetic code is stored in a constant amount of nucleotides: 3, so this never gets fixed. Nonsense mutations gotten from that i like to think as 0xFF in the operand being read as the halt instruction

[@purkinje4248]

As a medical student, I appreciate you, sir. You're amazing. God sent u to teach us medical contents

[@breadbread8759]

This video was tooo good! so perfect!! Thank you!!

[@radhikabiraj5243]

U r amazing sir.....lots of love from india.....ur videos boost my knowledge🤗🙏🙏

[@nileflower9181]

you're information is very useful

[@roxannemacasinag761]

Thank you Prof! My Go To Guy! I’ve been passing my subjs, partly bc of u! And correctly answering activity sheets because of u! THANK U SO MUCH!

[@arovana82]

Very good explanation! Thank you!

[@ThePhoenixstar88]

He always makes me smile if he pops up while I’m scrolling by lol ☺️

[@jeannensantos4296]

brilliant. everything I needed in one video clearly explained

[@annestricker6917]

Thanks! Great presentation, much appreciated!

[@fredcalledbygod]

Very good teacher👌🏿👍🏿

[@raqimafarhad7745]

Very clear and concise 👍

[@ShiwanaGhai]

that binding of oxidized guanine with A happens when during repair or replication as there should be C there initially ?

[@joedart1465]

Nice job Dave.

[@citysbandaid]

Dave thanks so much for the videos ! Your lectures are complete and easy to understand. :)

[@ProfessorFrydman]

Hi Professor Dave! I'm an atheist from Brazil and I wonder how could such a complex mechanism exists without an inteligent mind to project this. I know the answer is very complex. Do you have any content about the origins of this part of biochemistry? It's well related to the origins of life, right? I just love your videos, thanks a lot for them!

[@ProfessorDaveExplains]

check my content debunking james tour

[@dannyfreeman2302]

so great this is awesome information thank you dave

[@johnbates3567]

This is excellent Dave, thank you!

[@jayasriramani6718]

John Bates

[@Lalita_Chevaliere_108]

Thank you, Professor! Does this mean that if you avoid sunlight, you will be healthier? Say if you just go in the morning sun for a few minutes, and then stay inside all the time? Or do we need sunlight so much that we can't avoid it, though it comes at a price?

[@ProfessorDaveExplains]

well you need some! but excessive exposure increases the risk of skin cancer certainly. sunscreen!

[@Lalita_Chevaliere_108]

Thank you! I'll remember that ;)

[@jasonl4237]

@@ProfessorDaveExplains What sunscreen type/spf should I choose? Do I need to apply sunscreen to all skin areas (face, neck, hands, arms, legs) exposed to sunlight or only the face? How long should I stay in the sun each day to be healthy? Thanks.

[@geraldwise335]

wow amazing proff Dave

[@nikokallio8650]

It´s very calming that he talks like for baby to me, after being on lectures where you have 20 seconds time for one dia while professor is speaking,,, to read and understand one dia takes 2 minutes and to listen and understand professor takes another 2 minutes which end up you learning nothing and just skip the lectures and try to find what the hell are we supposed to learn and then find how to learn it.

[@mymonamkeess6516]

Thanks for the wonderful explain ♡ I loved the song at beginning ^_^

[@jacobguenette273]

Dude I understand everything so well now. Thanks!

[@camilasousa5853]

Thank you so much!! I was really looking for a class like this

[@sciencenerd7639]

very good information, thanks so much

[@omaimah7366]

thanks.. you explain it so clearly

[@MrMagic-bl3ew]

lol aced my genetics final by watching these videos... didn't go a single day to class loooool

[@klutz3955]

College or high school?

[@4everanjan]

Fantastic !!! really helpful

[@TutunChanda]

Awesome video proffessor

[@maschinenraum]

sunscreen is only good for preventing a serious sun burn. but beside that i do not use sun screen because it reduces the vitamin d level in the body. and with a high vitamin d level there is maybe more DNA repair going on.

[@AyushPramanik]

Could you gimme the details regarding the repairing enzymes? I mean, not all of them. But the main ones.

[@joshmemarrynagdey1639]

It's very nice helpful. Thank you

[@ipanemasalinas]

ily dave 💖

[@themillennialpa]

I love you PROFESSOR DAVE!!!

[@TupeDavid]

This video is great. easy to understand and have a very informative.

[@witty_me]

Thanks, Professor, for explaining it.

[@littlelulu5675]

so professor Dave is it true the number of mutations in human DNA makes it highly unlikely that man is as ancient a creation as we are taught and that we also have an expiration date coming up pretty soon because of those mutations?

[@ProfessorDaveExplains]

No, that's not true, or remotely intelligible.

[@yusuphajallow5646]

thank you Professor its well explained indeed

[@prembhattarai7365]

you're genius. thanks for saving my life

[@whisperingsage]

One big cause of gene damage is minerals and vitamin deficiencies. Too bad he left that one out. Weston Price did work in showing vitamin A deficiencies cause lack of eye development in pigs and puppies, there are pictures of this in his free online book, Nutrition and Physical Degeneration. He also showed where soil mineral deficiencies caused double faced calves and partial absorption of a twin which showed as calves with extra limbs. He even showed where calcium and Magnesium deficient soils caused proud upright horns of an ox to gradually fall when he was moved to an area of poor soil. These are things that are preventable, by supplementation, and soil supplementation. So it's sad that more isn't done in this area as it's an easy and usually cheap fix. Dolomite has calcium and magnesium, much needed by the soil for good crop production (ideal soil needs 68% calcium and 12-20% magnesium) and limestone has calcium and 60 trace minerals (found in the soils of the centenarian cultures) (soilminerals dot com). A"simple" magnesium deficiency can cause multiple illnesses and maladies including death. William Albrecht was the father of soil minerals. He discovered this and helped this farm resolve their high mortality rate. Also missing was a discussion of fetal alcohol and tylenol, and smoking and any number of drugs taken in pregnancy. There is enormous chance of damage in pregnancy when ingesting these things. So easy to prevent.

[@Phoenix-np1iu]

is the polymerase used dna polymerase iii? I can never remember which polymerase is which

[@maryamsediqi3625]

Many thanks, was great explanation.

[@RandomNooby]

One of the greatest mysteries of modern science, is how does Dave have such a derpy haircut and yet manage to ooze cool from every fiber of his being?

[@thebigtricky9156]

Most likely his knowledge of his area of expertise and indeed the subject of the content, I think he uses that to stimulate people's interest and become and thus become charismatic.

[@geetugupta7244]

Really urgent doubt : Are cytosine and cytobine the same ?

[@raoulfulgos8536]

Nice job, would love a homologous and nonhomologous recombination video if you have it in you

[@rayadopsmanguito]

Do you think that if you change the dna artificialy in order to obtain a new desired characteristic (like in OMGs) the organism could try to repair the "damage" changing their structure in non certain consequences?

[@ProfessorDaveExplains]

I'm not sure I understand the question, if you modify the genome, what precisely?

[@rayadopsmanguito]

Professor Dave Explains By a gene gun, blasting DNA into other organism. Or, if I am sure, using plasmids with one or more genes that improve, for example, the resistance to some insect or extreme climate. A lot of thanks for your answers 😀

[@rayadopsmanguito]

Professor Dave Explains I am trying to understand if we change artificialy a characteristic in the expresion of the DNA in order to improve our food we will have a undesirable consequence because there are is fact in the nature of the fenomena that is still not clear. For example the epigenetic or something else, maybe the relation with other microorganisms. I thought, also, that a fenotype is expresed not only with a single linear section of the code also by other parts of the code like jumps. Sorry, I hope to be enough clear. English is not my first language.

[@windyanissarecita]

omg very helpful.. im a big fan

[@abidemitoluwaniosho5571]

THANKS MAN, THIS WAS Helpful

[@divyatiwari4990]

Sir please start lecture on animal physiology subject.

[@ProfessorDaveExplains]

zoology tutorials are coming next year!

[@divyatiwari4990]

@@ProfessorDaveExplains thank you sir.

[@duolchol3262]

the greater teacher ever

[@mfuhvaldes2404]

Is it legal to know that much 😅😅, wonderful lecture

[@myazed1]

can the silent mutation make any phenotypic, effect ?

[@ProfessorDaveExplains]

they shouldn't, no.

[@myazed1]

@@ProfessorDaveExplains silent mutation can happen in non codon mutation, right? and the non codon can be affect gene expression by up and down promoter mutation , is this not considered phenotype effect ?

[@ProfessorDaveExplains]

well that's not what's implied by a silent mutation, it implies it is within a codon, but certainly mutations can occur within a promoter as well, which could potentially be devastating.

[@nikhilratna9421]

Did he miss out Single/double strand breaks due to ionising radiation etc?

[@pastimepursuit7212]

video really starts at 5:49

[@melvyncarrot4741]

What about DNA damaged by antibiotics such as fluroquinolone antibiotics? Can it repair by itself?

[@basmah7837]

Thank you so much you are a life saver😟💕💕💕

[@mapuliclavery9883]

Very nice professor

[@bumblebee434]

Thank you sir ❤️

[@victoriakathleen9993]

Do you offer worksheets to practice and review the things you teach?

[@ProfessorDaveExplains]

enough people have requested this that i'm thinking of doing it at some point

[@mohe6327]

hello sir I have a question I would like to know if cancer is a gene mutation how does chemo and radiation therapy work on cancer how does it stop replication even in the begin of cancer and why after the apoptosis from chemotherapy patient has life duration depend on the stage of the cancer

[@ProfessorDaveExplains]

So the way chemo works is we just blast a tumor with radiation, giving all the cells huge amounts of DNA damage. This will inevitably result in messing up tons of enzymatic activity and the cells won't be able to reproduce so they die. The only problem is that it's very difficult to hit only the tumor so inevitably some of our regular cells also get hit, which does harm us, which is why chemo is so rough on the body. It's really a last resort. And if the tumor metastasizes, then it's not a feasible strategy.

[@mohe6327]

So isn’t there like way so it’s local treatment and is it true cancer get faster and stronger by sugar I know nucleotide synthesized of sugar + base+ phosphate . But that doesn’t make it reason to metastasis faster

[@mohe6327]

Professor Dave Explains waiting your response prof

[@The-Anonymous.]

Here for 0:09

[@abdullahhelal5413]

Informative video.

[@zollingerellison1998]

thank you,professor👍

[@MONGTRAN11]

Mutations are classified by heredity or environment factors ?

[@ProfessorDaveExplains]

i think typically by the mechanism of repair as i've done here, but you can certainly classify them by the means you've mentioned as well. i'm not too familiar!