Mechanisms of DNA Damage and Repair

[@maria1239876]

I like the preschool vibes i get from the background while I'm learning stuff in my junior year of college :D it makes me feel all warm and fuzzy.

[@naturegirl1999]

Imagine how smart preschoolers would be by watching this

[@noblevenom2858]

@@naturegirl1999nah preschoolers are pretty dumb. They can’t do shit

[@dr.bibaswan]

Correct. We are all little kids deep inside. Our official age may be 20 - 30 but we love the vibes of age 2-3 😇

[@BishoujoMegami]

Professor Dave, I'm still using your videos at Uni😂 They are so helpful. My genetics lectures are really confusing so far but this is helping consolidate my understanding. Genetics was always my week point in biology🙏🏾

[@alaazein7147]

Me too

[@geetugupta7244]

I don't even have to take biology next year, but I'm forced to learn it this year ...stupid school rules...😭😭

[@hamzazaqut1315]

It seems spelling is your “week” point too.

[@BishoujoMegami]

@hamzazaqut1315 omg, you need to quit your day job and become a stand up comic... you'd be a millionaire...

[@Eagles883]

@@hamzazaqut1315you’re harsh, I was thinking to myself “I’m not going to correct it.”

[@ComandaKronikk]

Dude thanks for getting directly to the point and not fluffing about like so many other youtube videos. U just feed me facts that I CRAVE!!! Professor Dave 4 prime minister 2019

[@Youssef-zo3ls]

Paris Coroneos exactly! He gets directly to the point

[@EpicSelenium34]

Thank you professor...another fabulous video. I like how you go deep down into the molecular structures of the mutant amino acids and the pyrimidine dimers (and other such things) instead of just glossing over them. Getting to the chemistry at the heart of what we observe makes the learning experience so much more intuitive!

[@personalacc4352]

"Now that we are sufficiently terrified of genetic mutations" 😂

[@sroydetroy6404]

Where did he say this lol?

[@memoryloop5816]

@@sroydetroy6404 5:39

[@anusphoorthi9anuradha968]

Àyy

[@furkaan346]

Dave, I suggest you first present a summarized outline using a flowchart classifying different mutations and its subtypes. This way it'll be easier to grasp and make notes at the same time. I suggest you apply it to other videos too

[@VinodGupta-hj8hu]

thank you, Professor Dave your explanations make me learn more. Thank you for producing this videos.

[@MrLaTEchno]

For a layman like me this series is fairly easy to follow and understand. I am therefore very grateful and hope to be able to use your work here on Y-T a lot. Greetzzz from Holland [sorry for my bad grammar]

[@mirarizqah]

This video is great. easy to understand and have a very clear explanation! I love it

[@MyMorghy]

Thank you so much Professor Dave I have an exam of Genetics this Tuesday and you have explained me about half of the themes of the exam in 11 minutes. Fantastic

[@samlynn7681]

Thank you so much! I couldn't understand mismatch or NER for the life of me for the entire semester. I really needed this explanation for my exam tomorrow!!

[@iluvbeef11]

hey professor dave. great video! your graphics really illustrate concepts that I've been struggling to grasp since high school. this is honestly the best explanation of mutations I've ever seen. I do have one thing I wanna clarify tho. so in the frame shift mutations, it was one whole base pair that you had deleted. let's say you showed an insertion. would it be an insertion of a whole base pair? or could you have an insertion of a nucleotide on one strand but not on the other strand opposite to that added nucleotide? let me know if my question is confusing lol I'd be happy to rephrase it as best as I can

[@ProfessorDaveExplains]

ooh that's a good question! you know i'm not too sure, i'll have to look into that

[@iluvbeef11]

@@ProfessorDaveExplains awesome, lemme know when ya know! and thanks again for the great vids

[@yikotao]

He knows all about science stuff and he is professor dave explains. This song is like gangnam style. I only watched several videos and start singing when I was cooking my dinner!

[@tomservo5007]

cooking and singing will increase dna mutations. good luck.

[@jwh5505]

just keep on cooking

[@thebigtricky9156]

Overtly, I find it annoying, but each to their own.

[@renkei7596]

Love your videos to sum up what i learned in biochem :) But could you do a video about molecular cloning and PCR?

[@e.c.2215]

Thank you for all your tutorials! From Chemistry to Bio they all have the exact content that I need.

[@clent444]

your videos are so clear and easy to understand. Thank you so much 🙏 😊

[@Surgtari]

thank you jesu.. I mean prof. Dave this was beyond mind blowing

[@patricksarama4963]

Don’t be shy, call him biology Jesus

[@ravikumarkommareddy3723]

Easy to understand and informative. Thank you very much. Great job

[@napojusticeramothokoane5536]

Thank you Prof. um thinking, I may as well stop paying my school fees and start paying R5.00 per month for joining your channel, this feels great

[@DanyalLaghari7]

your videos are still being used after 7 years. Thanks

[@alwaysambitious]

I love how clearly you talk! great Videos

[@henrynyirongo8761]

Professor Dave is one of the very few that take time to respond to the various comments😊

[@reemsjourney9070]

Thank you prof Dave, you made me survive my journey in premed 🙏❤️

[@fathimashahabudeen3477]

This video is great now u are my professor.. it’s easy to understand yr videos so simple and made with dedication and love 💕

[@GurpreetSingh-jr8kk]

U r fabulous professor ..... u teach better than my teachers in my tutions.... Lots of love from INDIA

[@lezanibrahim8327]

You saved my life by this video ,thank you

[@nesrineemira6381]

sir u are a life saver..and that intro sends ...

[@TheAnnie121]

....am I the only one who ALWAYS sings the intro, even though this channel has been accompanying me since my Senior year? :D

[@reginadaka2335]

No u ain't the only one..

[@christopherreed2694]

Thank you Dave for taking 🙏 the time it is appreciated much 👍

[@iseegoodandbad6758]

I love Dave so much!! The best teacher so far!!

[@innate-videos]

Another great vid and, as always, total clarity. Thank you.

[@econguyph]

*you helped me in biochem class thank you professor I think thank you isn't enough so grateful ❤️*

[@OneWithTheOcean]

Very informative, Thank you!

[@jwh5505]

if this video is that informative to you, i recommend you not to take ap biology

[@purkinje4248]

As a medical student, I appreciate you, sir. You're amazing. God sent u to teach us medical contents

[@nileflower9181]

you're information is very useful

[@annestricker6917]

Thanks! Great presentation, much appreciated!

[@breadbread8759]

This video was tooo good! so perfect!! Thank you!!

[@Godessa9shrek]

"Now that we are sufficiently terrified of genetic mutations...", lol...a laugh I needed while late night studying. Thanks!

[@arovana82]

Very good explanation! Thank you!

[@belgacem_mehdi]

A question : 2:27 you said if the mutation happen outside the gene it does not cause any thing But we know that there many gene that are regulated and activated and deactivated by portions of DNA outside the gene ( epigenic )

[@omaimah7366]

thanks.. you explain it so clearly

[@jeannensantos4296]

brilliant. everything I needed in one video clearly explained

[@raqimafarhad7745]

Very clear and concise 👍

[@roxannemacasinag761]

Thank you Prof! My Go To Guy! I’ve been passing my subjs, partly bc of u! And correctly answering activity sheets because of u! THANK U SO MUCH!

[@jacobguenette273]

Dude I understand everything so well now. Thanks!

[@nikokallio8650]

It´s very calming that he talks like for baby to me, after being on lectures where you have 20 seconds time for one dia while professor is speaking,,, to read and understand one dia takes 2 minutes and to listen and understand professor takes another 2 minutes which end up you learning nothing and just skip the lectures and try to find what the hell are we supposed to learn and then find how to learn it.

[@joedart1465]

Nice job Dave.

[@johnbates3567]

This is excellent Dave, thank you!

[@jayasriramani6718]

John Bates

[@yusuphajallow5646]

thank you Professor its well explained indeed

[@ThePhoenixstar88]

He always makes me smile if he pops up while I’m scrolling by lol ☺️

[@citysbandaid]

Dave thanks so much for the videos ! Your lectures are complete and easy to understand. :)

[@raoulfulgos8536]

Nice job, would love a homologous and nonhomologous recombination video if you have it in you

[@witty_me]

Thanks, Professor, for explaining it.

[@MrMagic-bl3ew]

lol aced my genetics final by watching these videos... didn't go a single day to class loooool

[@klutz3955]

College or high school?

[@geraldwise335]

wow amazing proff Dave

[@camilasousa5853]

Thank you so much!! I was really looking for a class like this

[@prembhattarai7365]

you're genius. thanks for saving my life

[@sciencenerd7639]

very good information, thanks so much

[@maschinenraum]

sunscreen is only good for preventing a serious sun burn. but beside that i do not use sun screen because it reduces the vitamin d level in the body. and with a high vitamin d level there is maybe more DNA repair going on.

[@TutunChanda]

Awesome video proffessor

[@ProfessorFrydman]

Hi Professor Dave! I'm an atheist from Brazil and I wonder how could such a complex mechanism exists without an inteligent mind to project this. I know the answer is very complex. Do you have any content about the origins of this part of biochemistry? It's well related to the origins of life, right? I just love your videos, thanks a lot for them!

[@ProfessorDaveExplains]

check my content debunking james tour

[@joshmemarrynagdey1639]

It's very nice helpful. Thank you

[@mymonamkeess6516]

Thanks for the wonderful explain ♡ I loved the song at beginning ^_^

[@radhikabiraj5243]

U r amazing sir.....lots of love from india.....ur videos boost my knowledge🤗🙏🙏

[@themillennialpa]

I love you PROFESSOR DAVE!!!

[@windyanissarecita]

omg very helpful.. im a big fan

[@dannyfreeman2302]

so great this is awesome information thank you dave

[@4everanjan]

Fantastic !!! really helpful

[@divyatiwari4990]

Sir please start lecture on animal physiology subject.

[@ProfessorDaveExplains]

zoology tutorials are coming next year!

[@divyatiwari4990]

@@ProfessorDaveExplains thank you sir.

[@duolchol3262]

the greater teacher ever

[@whisperingsage]

One big cause of gene damage is minerals and vitamin deficiencies. Too bad he left that one out. Weston Price did work in showing vitamin A deficiencies cause lack of eye development in pigs and puppies, there are pictures of this in his free online book, Nutrition and Physical Degeneration. He also showed where soil mineral deficiencies caused double faced calves and partial absorption of a twin which showed as calves with extra limbs. He even showed where calcium and Magnesium deficient soils caused proud upright horns of an ox to gradually fall when he was moved to an area of poor soil. These are things that are preventable, by supplementation, and soil supplementation. So it's sad that more isn't done in this area as it's an easy and usually cheap fix. Dolomite has calcium and magnesium, much needed by the soil for good crop production (ideal soil needs 68% calcium and 12-20% magnesium) and limestone has calcium and 60 trace minerals (found in the soils of the centenarian cultures) (soilminerals dot com). A"simple" magnesium deficiency can cause multiple illnesses and maladies including death. William Albrecht was the father of soil minerals. He discovered this and helped this farm resolve their high mortality rate. Also missing was a discussion of fetal alcohol and tylenol, and smoking and any number of drugs taken in pregnancy. There is enormous chance of damage in pregnancy when ingesting these things. So easy to prevent.

[@maavaishno2198]

AWESOME EXPLANATION

[@maryamsediqi3625]

Many thanks, was great explanation.

[@TupeDavid]

This video is great. easy to understand and have a very informative.

[@floppy8568]

Deletion or insertion reminds me of a situation of a program I'm thinking of codons as instructions here when an opcode is read as an operand and vice versa In computers this gets fixed quickly since instructions aren't stored in a constant amount of bytes, could be one with "NOP" (0x00), could be 2 or even three. but genetic code is stored in a constant amount of nucleotides: 3, so this never gets fixed. Nonsense mutations gotten from that i like to think as 0xFF in the operand being read as the halt instruction

[@skynabendera7854]

Super helpful

[@ipanemasalinas]

ily dave 💖

[@fredcalledbygod]

Very good teacher👌🏿👍🏿

[@AyushPramanik]

Could you gimme the details regarding the repairing enzymes? I mean, not all of them. But the main ones.

[@bumblebee434]

Thank you sir ❤️

[@abidemitoluwaniosho5571]

THANKS MAN, THIS WAS Helpful

[@holden2966]

Thanks Dave

[@shikhavats8920]

Sir I m from India I want that the caption written below should be right bcs I can't understand ur language properly bt through caption I should understand your Language in better way. Nice vedio.

[@ProfessorDaveExplains]

there are captions! i wrote them myself so they should be accurate.

[@abdullahhelal5413]

Dave sir you r great!

[@mohammedjobarafadlallah6144]

شرح ظريف وممتع بالتوفيق وللامام دومااا

[@mapuliclavery9883]

Very nice professor

[@Lalita_Chevaliere_108]

Thank you, Professor! Does this mean that if you avoid sunlight, you will be healthier? Say if you just go in the morning sun for a few minutes, and then stay inside all the time? Or do we need sunlight so much that we can't avoid it, though it comes at a price?

[@ProfessorDaveExplains]

well you need some! but excessive exposure increases the risk of skin cancer certainly. sunscreen!

[@Lalita_Chevaliere_108]

Thank you! I'll remember that ;)

[@jasonl4237]

@@ProfessorDaveExplains What sunscreen type/spf should I choose? Do I need to apply sunscreen to all skin areas (face, neck, hands, arms, legs) exposed to sunlight or only the face? How long should I stay in the sun each day to be healthy? Thanks.

[@zollingerellison1998]

thank you,professor👍

[@abdullahhelal5413]

Informative video.

[@sarahward5974]

Really great thank you!

[@RandomNooby]

One of the greatest mysteries of modern science, is how does Dave have such a derpy haircut and yet manage to ooze cool from every fiber of his being?

[@thebigtricky9156]

Most likely his knowledge of his area of expertise and indeed the subject of the content, I think he uses that to stimulate people's interest and become and thus become charismatic.

[@henrydennis2199]

@ 5:39 Dave: Now that we are sufficiently terrified of genetic mutation.... Me: guuuuuuyyyy!!!😂😂

[@AR-rf9hc]

Thank you professor

[@mfuhvaldes2404]

Is it legal to know that much 😅😅, wonderful lecture

[@geetugupta7244]

Really urgent doubt : Are cytosine and cytobine the same ?

[@littlelulu5675]

so professor Dave is it true the number of mutations in human DNA makes it highly unlikely that man is as ancient a creation as we are taught and that we also have an expiration date coming up pretty soon because of those mutations?

[@ProfessorDaveExplains]

No, that's not true, or remotely intelligible.

[@satyabantasanjenbam]

I was searching for SOS response.

[@Twix_loves_domo]

What about Trauma? I rad a recent study that said trauma can effect your DNA

[@The-Anonymous.]

Here for 0:09

[@chunellemariavictoriaespan8752]

Is this what happens in the formation of Cancer cells?