Psychedelic Research, Psilocybin Therapy and Mental Illness

[@Lizz7711]

I hope they do more studies on microdosing to lend more credibility to it - I have been microdosing for months and it is DEFINITELY actually helping me in a much different way than any prior medication or treatment, and it is not a placebo (trust me I've "believed" in lots of prior things that simply didn't work!). I am working through issues that are slowly being revealed as I continue microdosing, I have more patience in general for others, I am not so easily overwhelmed by basic tasks that used to cause major anxiety, and more.

[@BeefLoverMan]

Do you have a specific protocol?

[@Lizz7711]

@@BeefLoverMan Currently I dose 200 mg every other day Weds/Fri/Sun, and take Mon/Tues off. But occasionally will take a few days in a row, or skip more days depending on timing/work stuff etc.

[@katilyncolvin3134]

Do you microdose everyday? Im looking into this for my panic and depression disorder. Also how much is a microdose?

[@STEINYY]

@@katilyncolvin3134I would like an update

[@davisantos3431]

All the current research indicates that there is a dose-response relationship between psilocybin and mental health conditions like depression and PTSD up to around 40 mg of psilocybin (roughly equivalent to 4 grams of dried mushrooms). I'm glad that it's working for you, but just because you FEEL like it's not a placebo, it doesn't mean that it isn't. Science needs to be rigorous.

[@EmmaJohnson-ug4lv]

Psychedelic shrooms trips can be truly life-changing. It's amazing how they can bring about positive transformations and have a profound impact on our lives.

[@Vivian-eh5dh]

! It's fascinating how everyone's psychedelic experiences can be so unique, even when taking the same amount at the same time.

[@MarcoGosatti43]

A friend of mine went to Peru and tried Psilocybin with expert's around him, blindfolded lying down 6 hours it lasted. He told me he seen half humans half animals telling him how great he was and seen another universe. It was full on. I'd love to give it a go at the right place right people.

[@simonelemer6623]

Wasn't it Ayahuasca?? Usually on shrooms you rarely have other beings in the experience.

[@MarcoGosatti43]

@@simonelemer6623 Most probably was.

[@cathy7382]

What deep deception nobody who goes through this ceremony won't receive God's ways and wisdom only Jesus can give you true insight

[@smileykileykins]

🎯 Key points for quick navigation: 00:14 *🧠 Overview of Current Psychiatric Treatment Challenges* - Psychiatry lacks effective pharmacological cures for disorders like eating disorders and personality disorders. - Treatments for common disorders such as depression are often insufficiently effective. - Existing treatments have significant side effects, and there's a lack of new drug development in psychiatry. 04:02 *🍄 Historical Context and Modern Revival of Psychedelic Research* - Psychedelic research faced a significant setback post-1970 due to legal restrictions. - Recent years have seen a resurgence in psychedelic research at institutions like UCSF, Hopkins, and NYU. - Psilocybin, the active compound in hallucinogenic mushrooms, has been a focal point of modern research. 06:22 *🌀 Pharmacological Effects and Mechanisms of Psilocybin* - Psilocybin metabolizes into psilocin, which primarily affects serotonin receptors, particularly the 5HT2A receptor. - Typical effects of psilocybin include alterations in perception, mood, cognition, and behavior. - Its duration of effects allows for potential therapeutic use within a workday setting. 12:06 *🚫 Safety and Dependence Potential of Psychedelics* - Psychedelics like psilocybin have low potential for dependence compared to substances like heroin or nicotine. - Physiologically, psychedelics are generally well-tolerated even at higher doses. - The risk of overdose or lethal dose ratio is favorable compared to many other substances. 14:54 *🌱 Microdosing vs. Macrodosing: Applications and Evidence* - Microdosing involves taking sub-perceptual doses intermittently and lacks substantial clinical trial evidence. - Macrodosing, used in clinical trials, involves higher doses for therapeutic psychedelic experiences. - Existing research indicates placebo effects may significantly influence reported benefits of microdosing. 26:28 *🌌 Connecting with suppressed grief and trauma* - Exploring suppressed traumatic memories and emotions. - Engaging with intense feelings and finding comfort and liberation through psychedelic experiences. 29:22 *🌈 Psilocybin therapy for AIDS survivors* - Using psilocybin therapy to help HIV-positive individuals who survived the AIDS epidemic. - Addressing complex psychiatric issues stemming from traumatic experiences. - Group therapy format effectiveness and demographic considerations. 33:30 *🧠 Study design and outcomes in psilocybin therapy* - Group therapy integrated with individual dosing in a clinical trial setting. - Positive outcomes in reducing demoralization and enhancing quality of life. - Challenges and benefits of using an open-label study design. 36:20 *📈 Efficacy and durability of psilocybin treatment* - Rapid and enduring improvements in depression observed after psilocybin therapy. - Long-term benefits observed up to several weeks post-treatment. - Potential for single-dose treatment to manage depressive symptoms effectively. 39:11 *🌍 Hope, hype, and expectations in psychedelic therapy* - Managing expectations and understanding the balance between hope and reality in psychedelic treatments. - Addressing societal and individual hopes regarding the transformative potential of psychedelics. - Challenges in meeting expectations while maintaining scientific rigor. 46:12 *🕶️ Challenges of blinding in psychedelic clinical trials* - The importance and challenges of maintaining blinding in clinical trials involving psychedelics. - Impact of participant and researcher expectations on study outcomes. - Comparisons with traditional pharmacological trials and implications for study design. 52:29 *🧠 Psilocybin's Potential Risks in Bipolar Patients* - Psilocybin can induce manic episodes in individuals with underlying bipolar disorder. - A systematic review found cases where individuals without prior bipolar disorder developed mania post-psilocybin use. - Challenges include distinguishing whether psilocybin triggers bipolar disorder or merely unmasks latent symptoms. 54:24 *🌍 Global Survey on Psilocybin Use in Bipolar Disorder* - Over 500 respondents reported using psilocybin for mental health; about a third experienced worsening symptoms. - Geographic distribution of survey participants highlighted widespread interest in psilocybin therapy. - Despite adverse effects, users generally rated psilocybin's helpfulness highly while perceiving its harm as low. 58:12 *🧬 Psilocybin Research and Clinical Trials* - Ongoing clinical trials explore psilocybin's efficacy in treating conditions like depression, anxiety, Parkinson's disease, and more. - Research includes comparative studies on different psychedelic compounds and their mechanisms, particularly inflammation. - Challenges in integrating psychotherapy with drug treatments in clinical settings are being addressed in these trials. 01:16:28 *🌿 Psychedelic Culture and Ethics* - Psychedelic research acknowledges its roots in indigenous practices like ayahuasca ceremonies. - There's a sensitive balance between scientific exploration and cultural appropriation. - Cultural respect is maintained in settings like dosing rooms adorned with local California nature. 01:18:20 *🧠 Psychedelics and Adolescent Mental Health* - The adolescent brain's ongoing development raises concerns about psychedelic safety. - Research into conditions like anorexia nervosa in adolescents is crucial due to high mortality rates. - Balancing potential benefits with unknown risks guides decisions on researching psychedelics for youth. 01:22:10 *💊 SSRIs and Psychedelic Interactions* - There's a historical exclusion of SSRI users from psychedelic trials due to safety concerns. - Contrary to lore, actual research on SSRI interactions with psychedelics is limited. - Understanding these interactions is pivotal for future psychedelic therapy developments. Made with HARPA AI

[@cxvzf]

Thanks for posting this!

[@yashtomar1484]

Excellent in-depth analysis

[@dplj4428]

23:03 macrodosing combined with guidance and monitoring plus integration therapy followup.

[@mliittsc63]

Good to hear we are continuing to get back on track with this after 50 years. Someone should probably tell people to shut up about stopping war, or we'll have to wait another 50 years. Interesting and concerning about the BD issue. More concerned about people with fam hx of schizophrenia.

[@BuilderSpring]

IMO, unless you're feeling seriously unbalanced, save the dollars on therapy... Ask a trustworthy friend to stay with you, and begin with a tiny bit. You'll be just fine!❤

[@ChokeArtist411]

Terrible advice. Nothing about taking shrooms makes you an authority on mental health.

[@CanadianBear47]

did u find a therapist that felt the same things? as in the healing of it?

[@TheIgnacio777]

What's the mechanism that makes it last versus SSRIs that require daily dose?

[@CanadianBear47]

@@TheIgnacio777thats what most scientists are confused about. basically i wish i knew

[@ReetCZ108]

Doing therapy and doing psychedelics is both great for opening up and having new experiences and important revelations

[@sgill4833]

I did about 1.5 grams. Other than the stomach ache. It's amazing. My sleep and hunger improved significantly. I ate twice as much as I usually do and slept much more deeply. I have trouble otherwise with both. And I felt pain-free for a few days. But the initial stomach ache is upsetting.

[@dominicannand8878]

the stomach upset is from the spores they are best harvested for consumption before the veil breaks to avoid the stomach problems and id avoid extracts you are missing out on the the full spectrum of constituents that work synergistically mild amounts of maoi and precursor alkaloids and whatever else complex carbohydrates fiber ect it all works together,kind of like cannabis and the different effects due to cannabinoids and terpenes taking pure thc is not good it can lead to addiction and further mental problems the terpenes and other cannabinoids like cbd are very important in reducing negative effects another example would be macuna pruriens velvet bean it can help with dopamine levels but taking L-dopa by itself isnt good its cutting out important enzymatic processes in the body and can actually make you worse , anyway maybe try grinding them too a powder and adding it to some chocolates measure out doses into the chocolate add other mushrooms powders such as lions mane mushroom works quite well with psilocybin bit more synergy at play and will help increase neurogenesis and neuroplasticity

[@SmileFreestyle-hx2rc]

Yes 6 hours but with certain strains that are stronger the next day you will feel like doing nothing - so wise to do on a day before a day off

[@Neighborhoodcarpetcleaners]

With someone with ptsd. Ive never said i will like to speak to someone with military ptsd. But ive always enjoyed it. So for him to sat is rare. Absolutely, question is approach on treatment pharmaceutically. Because of the fact a pharmaceutical employee is making a statement on the importance of group therapy

[@NarrelleChain]

They are mind expanding, but the stuff i took in 70s was something else, you won't know what hit you and it can be frightening but fun in a frightening way, i was 16, i took about 5 or 6 before i started having bad trips!

[@elisabethvdm9756]

hI, i have a question. I have bipolar ( one manic psychosis 20 years ago) and add and a bit ocd and currently following traumatherapy. Is there a risk that microdosing will cause psychosis? I 'm on Lithium and anti-depression medication.

[@dplj4428]

14:50 microdosing versus macrodosing.

[@SuraDoes]

Thank you!!!

[@DanielRietsma]

Can it help borderline personality disorder or help it?

[@DanielRietsma]

@mrs_Mccoy I could use some help with like options where to go or who to talk with. It’s been very tough dealing with this disorder. It’s ruining my life and others have hard time being by me or around me. I end up pushing the ppl I love the most away and I don’t want to. I hate being alone then I go push to hard and puff gone they go and alone I am. I’m also suffering from Abandonment issues and manic bipolar depression. I just need help.

[@DanielRietsma]

Does anyone know of any places looking for patients for study for psycodic treatment therapy for borderline personality disorders depression anxiety and chronic pain some what in or near Iowa like within a 8-10 hour drive. I’d be willing to participate. I want this like fixed well better

[@cxvzf]

@@DanielRietsmatry the Johns Hopkins Center for Psychedelic and Consciousness Research if youre in the northeast!

[@sleepstate1]

I did LSD once when I was about 21, I'm 59 now. I laughed all night, slept great and felt great for the next two weeks. Ever since I keep saying I need another brain reset. That's exactly what it felt like happened. I've asked around for the last 3 years here in Yuma and Tucson and nobody seems to know where to get it. You'd think it would be easy to find here. I won't send money over the internet. I have severe treatment resistant depression, severe anxiety and Narcolepsy. I pretty much have spent the last 25 years in bed, wasting everyday of my life. Why is it if a drug makes us feel good or better it's bad? Life is too short to go through it miserable especially when there is something that really helps

[@yelenamarycheva8175]

So, there's the question- why SSRI doesn't show the same placebo effect?

[@SacredVisions-]

Same thing I’m saying

[@gratefulkm]

We inherently know the government ban anything that makes you feel love

[@SuraDoes]

UCSF is looking for participants for psychedelic research. Anyone in the Bay Area, look it up so you can apply!

[@alfaalfa91]

Can psilocybin cure OCD? (Obssesive thoughts)

[@Sirstef12]

its crimes against humanity that psychedelics are illegal

[@anjilala]

There is a lot of anecdotal evidence of major mental health improvement on the carnivore diet. Are there ever going to be any real studies, or is that just not the answer that people want so they wont go there?

[@kerri5595]

Timestamps please

[@susanbalog8355]

Who is the speaker? he's excellent.

[@mikekuppen6256]

They show his name when he´s introduced: Josh Woolley.

[@arbez101]

@@mikekuppen6256 There's a lure used for fly fishing called the Olive Woolley Booger.

[@dplj4428]

Was that hijacking pilot self-administering mushrooms

[@smithz749]

MACROPAUL6

[@smithz749]

On Instagram..

[@smithz749]

His the best online drug store I know, he got DMT LSD and more

[@Sean-v1s]

You cant change the stripes on a zebra, but you can definitely feed that zeebra a mushroom to look at its stripes differently

[@poor_impulsive]

why cure disorders when you're getting paid so much every session? you want repeat customers, as long as they don't suicide, but there's always more traumatized children being developed every single second. medical professionals reliant on mental health disorders treated with patented drugs are worried for the future of their professions

[@amadeuscrossing7061]

How is alcohol even legal 😂 when it scores higher in addiction potential than MDMA 😂

[@joeldichter1320]

Because there’s methamphetamine in it. Alcohol versus methamphetamine what would have more damage potential? Honestly, alcohol for crashing cars but still with amphetamine destroys families. MDMA is a strong drug so yeah if you were to abuse it every day or use it every day you would be very depressed afterwards

[@amadeuscrossing7061]

@@joeldichter1320 I mean, I’m not advocating for MDMA but there are better drugs than alcohol. That don’t lead to brain damage, neuron degeneration, or the death of a whole ass family in a car or a living room

[@gratefulkm]

This is like Studying a Oak tree and only looking at the twigs and leaves, and pretending the Bough and roots do not exist!

[@arbez101]

Or like writing a comment that only you and the Bough of an Oak tree can understand.

[@Lizz7711]

Re pediatric use- magic mushrooms have almost zero side effect risks compared to the zillions of terrible side effects of the drugs they so flippantly prescribe to kids all the time. Microdosing is the way to go with kids IMO

[@davidm4677]

On Mushrooms you can trip for 12hrs not 6hrs for 6hrs you would have very middle douse.

[@motocydar]

Beware of many scammers on this thread. Direct you to a source on Telegram and/or Instagram. taking money and no delivery. Tell you the product was found by authorities or other excuse. You are out of luck and then they keep your money. Beware of Scammers You were warned! The same group of scammers has many names

[@alfaalfa91]

Can psilocybin cure OCD pure?

[@inwoodbutterflysanctuary]

Please refer me in NYC

[@lilianparle4822]

He's on instagram

[@pn2543]

in the old days before scientific materialism destroyed our inner powers, people achieved metanoia through faith, ritual, and prayer, now we just have faith in drugs, woe is us

[@moegreen5760]

Na psychedelics have been around for 1000’s of years. Don’t be ignorant

[@nancysands6130]

if you do to much, the mountains will laugh at you....

[@smithz749]

MACROPAUL6

[@smithz749]

On Instagram

[@smithz749]

His the best online drug store I know he got DMT LSD and more..

[@cathy7382]

Anyone who has bipolar disorder or suffers from schizophrenia should stay away from psychodelics

[@amadeuscrossing7061]

Use a sensory deprivation tank in a double blind study and you’ll mask and or create fake psychedelic experiences 😂. From experience 😂

[@CanadianBear47]

19:05 seems like kinda a openness to expirencee thing like we would be willing to try and attempt study on our selves with help of random ppl. and knowing. tho for me i am alright with ppl knowing even tho idk prison forever. same dude i think of it like i am lucky to eat them now and one day they will eat me again. even when i die i wont be useless and or lost i will continue. as life does. i also ask this why does it work the relief from mushrooms is much more whole then medication and therapy. magic mushrooms are hard to quantify. 1:10:48. more like a spirtual thing vs science thing. tho id still like to know why i can see colours and why i am able to have compassion for my self. and no more rushing everywhere i go. u guys need data tho people having that experiences is kinda a secondary i also notice even in places to experience everything is so sterile. unnaturally sterile and controlled unlike the experience or life. sterile doesnt make comfortable or safe. its just a way for u to control another thing u dont follow embrace.

[@CanadianBear47]

@spiders4540 hey would u delete so i dont need to report.

[@CanadianBear47]

@spiders4540 alright u made your choice

[@Hippyshrooms_Insta]

☝️🍄💊☝️