Pyrimidine Synthesis

This video explains the synthesis of pyrimidine synthesis from the metabolic intermediates. Pyrimidine biosynthesis involves condensation of CO2 with glutamine and further condensation with aspartate. Pyrimidine synthesis pathway involves some important enzymes carbomylphosphate synthetase II, aspartate transcarbomylase, UMP synthase, thymidylate synthase. Pyrimidine synthesis is one of the high yield topic for usmle.
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[@stargirl7963]

Whoever watching this don't confuse synthase with synthetase. Synthase enzyme doesn't require energy to form its product but synthetase requires energy. So it is **ctp synthetase** which convert utp to ctp not **synthase** .

[@WhyNot-si4pj]

Great point ! few scholars worldwide know that difference ! BTW a water molecule required for the ATP hydrolysis is missing in the equation !

[@yasirmohammedali]

Hi .. thanks for the video

[@sitinurfamelia5947]

Thank you, thank you.. a billion thank for your video.. very understandable and really helpful with my biochemistry subject

[@naveenmvnaveenmv270]

Nice ❤️

[@abubakarsadiqmahmud2691]

Thanks so much Professor. Your videos help me lot. However, I'm not clear about the pyrimidine metabolism. Please do you have videos on pyrimidine metabolism?

[@naveenmvnaveenmv270]

Super

[@uttaragupta898]

Very well explained Sir. Thank you

[@user-es8lk4mh4t]

Wow really you are good sir....keep it up sir....

[@DrMungli]

I'm glad you liked the video.

[@streamapinkimsosick5392]

Thank you so much sir

[@hassinayazid99]

Thank you so much!

[@silentnight8346]

thanks sir for helping us ..😁

[@DrMungli]

You are most welcome. Glad to be helpful.

[@WhyNot-si4pj]

00:58 An exception for the cytoplasmic enzymes involved in the De Novo biosynthesis of pyrimidines is the dihydro orotate dehydrogenase (DHORD) ; which is a mitochondrial enzyme !

[@TheDiscover000]

Tq sir

[@SrikanthSrikanth-gr8fk]

Thank you sir

[@DrMungli]

You are most welcome

[@jagadeeshkumar1715]

For dna replication process have u put any video sir

[@mirashahh789]

Thank you so much:)

[@DrMungli]

You are most welcome.

[@ravinaa315]

Informative. But too many ad's. Makes it hard to concentrate

[@mdmuzakeermuzakeer5453]

Tysm sir

[@snehareddy1333]

isnt cps2 the rate limiting enzyme??

[@p.s.krishna2242]

Thank you sir

[@DrMungli]

You are most welcome.