Rapamycin’s Anti-Alzheimer’s Promise: An Autophagy Story

[@MetricZero]

My grandma has dementia, I wish this was available for her. The worst is when she has these fleeting moments of consciousness where she's aware of her own condition.

[@Physionic]

Ah, I'm sorry, MZ. That's not an easy thing to endure.

[@MetricZero]

@@Physionic Another reason why I love what you're doing. You're one of the people who go through studies and help educate people towards what's possible with science and technology. I hope humanity continues to move towards a more positive future. It'll require all of us.

[@forscythe4284]

I've noticed rapamycin becoming more available lately. Though I think doctors (mostly online clinics) are prescribing it for longevity, rather than Alzheimers

[@evergreenrose427]

I'm so sorry about your grandma. You can get rapa online without a prescription. It's expensive and takes a long time to arrive, but it's worth the effort. My anti-aging doc is prescribing it for me now for longevity, but since I'm ApoE3/ApoE4 and both my mother and her mother died of dementia, this study is very encouraging for me.

[@lauraw.7008]

@@evergreenrose427good to know! I’m same, and I’ll ask my doc this week. I’m having what I call “Swiss-cheese” brain. Not remembering some recent events, word finding difficulty, mom, grandmom, aunt, uncle all had Alzheimer’s

[@hightierplayers2454]

Any significant progress on treating this disease is welcome. We lost several people to Alzheimer's from the silent/greatest generation in our family and none of that generation's kids want to either go through it themselves or put their kids through the long degrading years.

[@paulhailey2537]

A CARNIVORE DIET CAN REVERSE TYPE 3 DIABETES 🥩🐟🧈🥓🥚

[@joe2341]

You've been uploading great vids none stop! Keep it up!

[@Physionic]

Thanks Joe!

[@Floating-Cows]

I’m 27 now, my grandpa and grandma adopted me and they were my parents by choice and still my blood. Unfortunately, he got it. He stayed in shape and would sometimes think that I’m an intruder in the house. Attempting to kill me in various ways while I was maybe 11ish into my teenage years. Usually, minutes later he’d tell me how much he loves and adores me. It’s worse than a zombie apocalypse. It’s worse than a living corpse. It’s one of the worst diseases to exist because it forces those who you trust the most in the world to betray you against their own wishes. I never hated him nor did I ever resent him. I only complained about him trying to kill me a few times and sucked it up. I still love him. It wasn’t his fault and you don’t want to be the reason he gets sent to a away. You downplay the danger and do your best. Before people give me advice from years ago. I was just a kid who didn’t want to lose my dad. You just felt bad for him and your grandma who wanted nothing more than to be there for you. They are the most loving, loyal, and respectful people.

[@Physionic]

I’m really sorry you had to endure that. Thank you for sharing. It puts reality to science. Anyway, wishing you the best.

[@TheCookiecupcakes]

So that's why Dr. Brad Stanfield is so interested in Rapamycin. (I have heard a lot about it but didn't really know what it meant - until now - thank you!) I am looking forward to part 2! I do have to say your version of the β-Amyloid protein is the cutest so far that I have seen (too bad they are so disruptive). I am also pleased that the lighting level has returned to its peak opulence. Such a beautiful glow.

[@livephysiology]

It makes it seems as if Alzheimer's is like lactose intolerance. The problem in lactose intolerance isn't the eating process but that the digestion can't be completed. Similarly, Alzheimer's Disease may be fine at initiating autophagy, but cannot complete autophagy. Thus, the answer may lie in finding what causes autophagy to be left incomplete.

[@jenxsj3902]

The black T-shirt is giving me LIFE.

[@ludwigbear]

Bryan Johnson just announced that he's stopped taking rapamycin due to the side-effects (intermittent skin/soft tissue infections, lipid abnormalities, glucose elevations, and increased resting heart rate).

[@Physionic]

I've seen someone else mention that, too. He's also consuming upward of 13 milligrams, which is on the higher end. He probably should have considered simply dropping the dose, but either way, I wish him well!

[@ColinMorrison-z6r]

Many thanks for your work and presentations. Some folks have had great success with treating Alz/cognitive decline - Dr. Perlmutter, Dr Bredesen, Hal Cranmer. Their approach is more diet, lifestyle, habits, supplements etc. Your research blends with this approach. The more we understand and can add to the 'toolbox' of treatment, the better. I do have someone in the midst of decline and it is distressing.

[@Kfjebfu65]

Thanks that was very informative and interesting

[@HSLSFirst]

Very interesting subject. I am 62. Alzheimer/dementia is a prominent disease on my father side. Who knows if it is due to genetics or lifestyle. Mitigation for me is healthy lifestyle and diet, with hard workout (cardio & weight lifting) 6 days/wk. So far, this works for me as I count on this to get the same benefits of Rapamycin and alike, to stimulate autophagy and mitochondria functions. Medicines altering mTor production is a concern to me. I can't wait to see studies compairing effects of promising medicine to exercise and, interactions.

[@wildcsgotactics]

Your channel is amazing!!!

[@Physionic]

Thanks - kind of you :)

[@joe2341]

Thank you so much!! Ive been looking inro this earlier!

[@paulhindle3961]

Drugs like rapamycin are mainly preventative and not nearly as effective if used as a curative. How do you expect to treat Alzheimer's when half your brain has already melted away? I have been taking rapamycin weekly for a few years now, but here in Canada I still can't get it through my doctor despite it's well established safety record.

[@LOLINC2010]

If not through a doctor, how are you able to get it?

[@paulhindle3961]

@@LOLINC2010 direct sale labs in China or India, powder to be mixed or pre-made tablets.

[@katgod]

I wonder why you trust your source for these drugs?

[@paulhindle3961]

@@katgod testing done by independent labs in north america

[@VeganLinked]

Meat, eggs, & dairy increase mTOR. Plant based diets decrease mTOR activity :) So does fasting... A good balance may be ideal, so some mTOR activity for repair can be achieved through high protein whole plant foods like legumes and some nuts...

[@paulhailey2537]

ONLY A CARNIVORE DIET REVERSES TYPE 3 DIABETES A VEGAN DIET LOW IN SATURATED FATS DIRECTLY IS A DIRECT CAUSE OF TYPE 3 DIABETES

[@AwesomeFDO789]

A plant based diet inhibits mtor likely through methionine restriction. As well as the restriction of a number of other aging associated amino acids. Methionine restriction also switches on autophagy. So as long as it's not on a high protein vegan or high protein plant based diet you're likely triggering autophagy without calorie restriction or fasting. Though calorie restriction is often achieved unintentionally due to fiber well known ability to suppress appetite.

[@VeganLinked]

@@AwesomeFDO789 yip! Dr Campbell has spoke on the benefits methionine restriction for a long time. Dr Greger has a fascinating video on mTOR you'd probably like. It's an old video but he released an update on it today just an hour or so ago. Dr Brad Stanfield released a video 3 days ago also on not dying 6.4 early that mentions mTOR, it's a hot topic all the sudden. Dr Greger has videos dating back 2014, 2016 and 2023 talking about it. Mostly it was about suppressing cancer. So the potential for Anti-Alzheimer's too is exponentially awesome!

[@VeganLinked]

@@AwesomeFDO789 Dr Greger also has a video somewhere talking about excess methionine causing amyloid plaques... the pieces are all coming together... Meat, eggs, and dairy are "rich" in methionine...

[@paulhailey2537]

@AwesomeFDO789 LOL THAT IS KNOWN AS MALNUTRITION

[@awjay9670]

Oh thank you i was interested in this

[@AnatomyDotCity]

I heard about Microtubules in reference to the ORC theory of consciousness Penrose is associated with. It’s almost like sci-fi but I love that theory so much 😅. But since reading about it every couple weeks it seems like Microtubules come up in something I’m watching. I guess I just never noticed the word before.

[@Fermentedbiome]

You should take a look at Tom LaRocca's research out of Colorado State looking at repetitive elements of the DNA being transcriptionally active and activity abundance having relationships with cognitive health. Definitely has a potential role impacting development of chronic diseases

[@roberto4188]

Lithium can both activate and inhibit mammalian target of rapamycin (mTOR) activity, depending on the context Lithium can activate mTOR signaling in the renal collecting ducts of mice, as shown by increased phosphorylation of rS6, p-TSC2, and p-mTOR. Lithium can also activate mTOR phosphorylation to improve spatial cognitive impairment in mice. Lithium can decrease mTOR signaling, as shown by inhibited GSK3β activity. Lithium can also induce autophagy independently of mTOR inhibition.

[@rohitrathi4552]

Do taurine and/or aspirin help in autophagy?

[@cachaça_baby]

Bryan Johnson is watching your content like a crazy

[@edl653]

About 10 seconds before you mentioned it, I was thinking "mitochondria" and how it is impacted by Rapamycin. 😉

[@Physionic]

Coming on Wednesday...

[@mrmacguffin6886]

Hi Nic! Can we have a video on how to activate the mTOR pathway instead so as to achieve more muscle hypertrophy from the gym? I remember reading that leucine is quite powerful in that regard, but is there anything else that we can do, like take certain supplements? And is it even going to make a noticeable difference at all?

[@Mario-forall]

How are Tau and B amyloid proteins related to the impairment of glucose metabolism seen in AD?

[@jtetteroo2919]

So, does fasting have a similair benefit?

[@Physionic]

It probably works through similar mechanisms, but I don't think fasting is necessary (for example, energy deficit does the same).

[@VeganLinked]

I have seen where caloric restriction is advantageous for mTOR activity, like most mechanistic things speculatively. But, fasting has all kinds of other incredible benefits as well. I have a great talk by Dr Goldhamer I released a few weeks ago. He runs a fasting center that he started 40 years ago and has helped over 25,000 people with all kinds of conditions. What's awesome is it may even help healthy people get even healthier! It's important to do extended fasts under clinical supervision though. Dr Goldhamer just released a new book called "Can Fasting Save Your Life" very recently. If I recall correctly the book is based on over 20 or 25 scientific peer reviewed papers from his teams research. I really want to get that book, heck, I might get it today. I think it would be so cool to stay at his clinic, it's basically a retreat. I know a lot of people that have gone through there, sick or healthy just to do it. :)

[@Slayer666th]

From what ive learned and experienced over the years, dementia seems to be highly linked to diabetes. I know 3 people who all had diabetes for a rather long time before developing dementia. 1 person i knew didnt have diabetes, but dementia and i asked the family of my gf to test him for diabetes… turned out to be a diabetic too. I personally read up on this and it seems that dementia often is conmected with metabolic problems. Studies like this just confirm my bias that it is tightly connected, hopefully my bias isnt too wrong or can be corrected with new evidence. Either way, drugs like rapamycin or creatin seem to help. Also fasting improved the mental state a bit. Sadly all of this only improved the condition a bit and did not cure it.

[@Franky2A3]

Some people use to describe Alzheimer's disease as "Type 3 diabetes”

[@VeganLinked]

Will Rapamycin bring back Tupac & Fatman Scoop?

[@jeffhutjens]

Sarcasm font "Isn't it nice that rapamycin is so cheap and readily available !"

[@paulcervenka]

Have there been any studies you are aware of that has looked at Rap along with/compared to fasting and/or exercise (both causing autophagy)

[@AnilSingh-rn3kx]

Thanks my mom has alzheimer's

[@nebojsa1976]

How do I remember to take Rapamycin if I have dementia?

[@stargazerbird]

An issue with treating the already frail and elderly is compliance. My mother in law has vascular dementia and I am sure some days she just forgets to take her regular meds, let alone pulsing Rapamycin. Also fasting for her is not advisable as she has already dropped so much weight.

[@Physionic]

Excellent points. Different problems to also hurdle. Wishing you and your mom the best.

[@fbomb7184]

I know a lot of fasting proponents tout its ability to stimulate autophagy but I wonder if that has any effect on MTOR. I’d like to see some research on whether fasting could achieve similar results as rapamycin for as you said, we need MTOR to live so inhibiting it could be detrimental to our health.

[@stefan-cosmin.ionescu807]

If one would want to use rapamycin off-label, I'm guessing based on this tau and amyloid beta proteolysis in neurons via mTOR inhibition means that rapamycin it's lipophilic, which might explain why it tends to increase triglycerides, or maybe because it's delivered via liposomal technology. Did the authors mention the means and route of administration?

[@Zuluknob]

So does that mean that prolonged fasting also helps Alzheimer's as it flips mtor?

[@Physionic]

It probably works through similar mechanisms, but I don't think fasting is necessary (for example, energy deficit does the same).

[@Zuluknob]

@@Physionic I was under the impression that mtor wasn't just controled by insulin levels but also by the amino acids leucine and arginine. The pathway is a lot more complex than that but you need to reduce all 3 to inhibit mtor don't you?

[@livintnet]

i wonder if i should switch from rapamycin to everolimus - another mTOR inhibitor, but with a better BBB.

[@efsmiley1995]

So then fasting and creating autophagy naturally is equally as effective?

[@jacobdahl7747]

Mice to human is so controversial! My understandig is that people with amyloid deposits are more likley to develop Alzheimers... where mice with amyloid have deficits in spartial memory. Mice do not get alzheimers. ..is this usefull at all?

[@virgilkirschner5717]

I read Brian Johnson has discontinued his use of rapamycin. Do your research and you will understand why. It does have some negative effects.❤

[@Franky2A3]

Thanks. I just read that article. I'll stick with fasting since it's more natural.

[@marcus-b4x3h]

How do they induce diseases like cancer, Alzheimer's, and others in mice?

[@Minecraft34]

You feed them american diet for two days

[@Physionic]

Introduce genes that cause them to accumulate the protein - they're transgenic mice.

[@mark-c802]

rapa is great...esp if you like cold sores...🤡 good biomarkers are p-tau 181/217, NfL and a beta 42/40 ratio some say to target weakest organs with bioregulator peptides...🏆 also ghk-cu pep's

[@ozarkcyn1]

I think you would be interested in Dr. Abs video on this topic. He does NOT base his knowledge on studies and Dr. Saheel Dhand who is a VERY strongly outspoken doctor which is GREAT doesn't put much credence in studies.

[@eric3661]

Fasting...the cheap man's MTOR inhibitor.

[@VeganLinked]

And a plant based diet is an easy way to stay in a healthy caloric deficit or prevent getting too many calories since it tends to be low fat :)

[@thomasmuller1850]

Fasting has a negative cost, because you save money for food.

[@sparkybob1023]

Anti inflammatory to the brain?

[@ericmaclaurin8525]

Imagine that! Plaque triggers the body to clean and repair itself!!!?? 😂

[@OWill40]

❤

[@liamweavers9291]

Well done! Heart contractility is the key to avoiding Alzheimer's and dementia. You need the required arterial pressure and pulsations in the subarachnoid space to push cerebral spinal fluid through your perivascular system in the brain. Chronic reduction in heart contractility leads to a reduction in metabolite removal in the brain that over time can lead to both dementia and Alzheimer's, as well as other systemic diseases. Autophagy improves heart function, specifically mitophagy, and this improves contractility, which increases arterial pressure and pulsation to remove more metabolites from the system. However, mental coherence, that is to say a person's state of mind, is key in determining the success or failure of the intervention. If a person is not in the right mental state and you increase heart contractility you increase incoherence instead of coherence. So the key to using rapamycin will be combining it with a cognitive therapy or at least screening a patient's mental state before use.

[@liamweavers9291]

Rapamycin will give variable results due to variable mental coherence within patients. The Role of Heart Contractility as an Amplifier in Drug Response: Understanding the Impact of Mental State Pharmaceuticals that enhance heart contractility, such as caffeine and rapamycin, have the potential to significantly influence both mental and physiological health. However, the effects of these drugs are not uniform across all individuals. Instead, they act as amplifiers of energy in the body, and the benefits or downsides of this amplification are largely dependent on the individual’s mental state at the time of drug administration. Additionally, the electromagnetic field generated by the heart is closely linked to its contractility, and this field can either promote systemic coherence or exacerbate incoherence depending on the state of mind. Heart Contractility as an Amplifier Heart contractility refers to the force with which the heart contracts to pump blood throughout the body. Drugs that increase contractility improve the heart's efficiency at delivering oxygen and nutrients to tissues, including the brain. But beyond this mechanical action, increasing heart contractility also amplifies energy within the system, which has both physiological and electromagnetic consequences. 1. Positive Mental State and Coherence: When a person is in a positive mental state, heart contractility increases systemic coherence. The heart and brain work together in harmony, improving mental clarity and cognitive function. The amplified arterial pulsations promote efficient circulation, enhanced cerebrospinal fluid (CSF) flow, and improved waste clearance in the brain. In this state, the increased energy flow supports both cognitive and emotional stability. 2. Negative Mental State and Incoherence: Conversely, when a person is in a negative mental state, amplifying heart contractility can worsen the situation. The sympathetic nervous system (SNS) is often more active in negative states, driving stress and anxiety. Amplifying heart contractility in such a state could lead to increased mental incoherence, as the additional energy flow exacerbates disorganised thought patterns, stress, or emotional dysregulation. The increased energy fails to synchronise effectively with the body's natural rhythms, creating further discord. Electromagnetic Implications: Coherent vs. Incoherent Fields The heart's electromagnetic field is the strongest field generated by the body, detectable several feet away. This field is a key player in the heart-brain connection, influencing how information is processed across the body. The strength of this field is closely tied to heart contractility, and it is crucial to understand how this field operates differently based on mental state: 1. Coherent Electromagnetic Field: In a positive mental state, the increased contractility of the heart strengthens its electromagnetic field, but this field remains coherent-meaning it is synchronised with the brain’s electromagnetic activity. This coherence promotes clear thinking, emotional regulation, and overall system harmony. The electromagnetic energy flows smoothly through the body, supporting efficient communication between the heart and brain. 2. Incoherent Electromagnetic Field: In a negative mental state, the amplified contractility also strengthens the heart’s electromagnetic field, but it becomes incoherent. The mismatch between the heart’s electromagnetic energy and the brain’s processing can lead to heightened stress, anxiety, or confusion. This discordant electromagnetic field may impair communication between different systems in the body, exacerbating both emotional and cognitive issues. Clinical Implications and Considerations Given the dual nature of heart contractility's effects-both mechanical and electromagnetic-it is important for drug researchers to consider the mental state of individuals when studying pharmaceuticals that impact heart contractility. A key recommendation would be to incorporate mental health evaluations into studies on such drugs to predict the outcomes more accurately. 1. Psychological Screening: Prior to administering heart contractility-enhancing drugs, researchers should assess the individual’s psychological state to determine whether the person is more likely to benefit or experience adverse effects. In individuals with positive mental states, the drugs are more likely to enhance system coherence, whereas in those with negative mental states, the drugs could worsen existing psychological symptoms. 2. Mental Health Interventions: For individuals in negative mental states, combining these drugs with mental health interventions (such as cognitive behavioural therapy or mindfulness) may help shift their mental state toward coherence. This could enable them to reap the cognitive and emotional benefits of increased heart contractility without the risk of exacerbating incoherence. Conclusion Heart contractility-enhancing drugs act as amplifiers of both mechanical and electromagnetic energy in the body. Their effects depend heavily on the individual’s mental state, with coherent mental states leading to positive outcomes, and incoherent states potentially amplifying stress and disorganisation. Understanding and incorporating these factors into drug research could significantly improve the predictability and efficacy of treatments, especially those aimed at improving both cardiovascular and cognitive health.

[@liamweavers9291]

The Role of Heart Contractility as an Amplifier in Drug Response: Understanding the Impact of Mental State Pharmaceuticals that enhance heart contractility, such as caffeine and rapamycin, have the potential to significantly influence both mental and physiological health. However, the effects of these drugs are not uniform across all individuals. Instead, they act as amplifiers of energy in the body, and the benefits or downsides of this amplification are largely dependent on the individual’s mental state at the time of drug administration. Additionally, the electromagnetic field generated by the heart is closely linked to its contractility, and this field can either promote systemic coherence or exacerbate incoherence depending on the state of mind. Heart Contractility as an Amplifier Heart contractility refers to the force with which the heart contracts to pump blood throughout the body. Drugs that increase contractility improve the heart's efficiency at delivering oxygen and nutrients to tissues, including the brain. But beyond this mechanical action, increasing heart contractility also amplifies energy within the system, which has both physiological and electromagnetic consequences. 1. Positive Mental State and Coherence: When a person is in a positive mental state, heart contractility increases systemic coherence. The heart and brain work together in harmony, improving mental clarity and cognitive function. The amplified arterial pulsations promote efficient circulation, enhanced cerebrospinal fluid (CSF) flow, and improved waste clearance in the brain. In this state, the increased energy flow supports both cognitive and emotional stability. 2. Negative Mental State and Incoherence: Conversely, when a person is in a negative mental state, amplifying heart contractility can worsen the situation. The sympathetic nervous system (SNS) is often more active in negative states, driving stress and anxiety. Amplifying heart contractility in such a state could lead to increased mental incoherence, as the additional energy flow exacerbates disorganised thought patterns, stress, or emotional dysregulation. The increased energy fails to synchronise effectively with the body's natural rhythms, creating further discord. Electromagnetic Implications: Coherent vs. Incoherent Fields The heart's electromagnetic field is the strongest field generated by the body, detectable several feet away. This field is a key player in the heart-brain connection, influencing how information is processed across the body. The strength of this field is closely tied to heart contractility, and it is crucial to understand how this field operates differently based on mental state: 1. Coherent Electromagnetic Field: In a positive mental state, the increased contractility of the heart strengthens its electromagnetic field, but this field remains coherent-meaning it is synchronised with the brain’s electromagnetic activity. This coherence promotes clear thinking, emotional regulation, and overall system harmony. The electromagnetic energy flows smoothly through the body, supporting efficient communication between the heart and brain. 2. Incoherent Electromagnetic Field: In a negative mental state, the amplified contractility also strengthens the heart’s electromagnetic field, but it becomes incoherent. The mismatch between the heart’s electromagnetic energy and the brain’s processing can lead to heightened stress, anxiety, or confusion. This discordant electromagnetic field may impair communication between different systems in the body, exacerbating both emotional and cognitive issues. Clinical Implications and Considerations Given the dual nature of heart contractility's effects-both mechanical and electromagnetic-it is important for drug researchers to consider the mental state of individuals when studying pharmaceuticals that impact heart contractility. A key recommendation would be to incorporate mental health evaluations into studies on such drugs to predict the outcomes more accurately. 1. Psychological Screening: Prior to administering heart contractility-enhancing drugs, researchers should assess the individual’s psychological state to determine whether the person is more likely to benefit or experience adverse effects. In individuals with positive mental states, the drugs are more likely to enhance system coherence, whereas in those with negative mental states, the drugs could worsen existing psychological symptoms. 2. Mental Health Interventions: For individuals in negative mental states, combining these drugs with mental health interventions (such as cognitive behavioural therapy or mindfulness) may help shift their mental state toward coherence. This could enable them to reap the cognitive and emotional benefits of increased heart contractility without the risk of exacerbating incoherence. Conclusion Heart contractility-enhancing drugs act as amplifiers of both mechanical and electromagnetic energy in the body. Their effects depend heavily on the individual’s mental state, with coherent mental states leading to positive outcomes, and incoherent states potentially amplifying stress and disorganisation. Understanding and incorporating these factors into drug research could significantly improve the predictability and efficacy of treatments, especially those aimed at improving both cardiovascular and cognitive health.

[@donregister4904]

@@liamweavers9291 thank you for that explanation. One more reason to keep a positive outlook. I have one copy of the APOE 4 And I have heart failure. I’m beginning to feel the effects of AD. I’m wondering if cranial sacral therapy would help clear the plaque.

[@liamweavers9291]

@donregister4904 Hi Don, I'm sorry to hear about your health situation. Cranial sacral therapy, I believe would help significantly and I think it would be a great idea. I've written about this recently and come at it from an engineering perspective but I am not a doctor - so this isn't medical advice lol Here’s a protocol to support heart contractility and systemic coherence, particularly for individuals with dementia, Alzheimer’s, or those looking to take preventive measures. The focus is on integrating specific supplements, lifestyle practices, and social engagement. 1. Core Supplements for Cardiovascular and Cognitive Health - Taurine (500-1000 mg daily): This amino acid supports heart contractility, regulates calcium levels, and offers antioxidant protection, aiding both cardiovascular and cognitive resilience. - Creatine (3-5 grams daily): Creatine helps increase cellular energy, especially in heart and brain cells, supporting energy production, reducing oxidative stress, and enhancing cellular function. - Coenzyme Q10 (CoQ10) (100-200 mg daily): CoQ10 is essential for energy production within the heart, improving heart contractility and reducing oxidative stress. It also provides antioxidant support that is beneficial for aging cells. - Omega-3 Fatty Acids (1-2 grams EPA/DHA daily): These fatty acids reduce inflammation, support cardiovascular function, and improve blood flow, which are vital for heart health and brain function. - Vitamin D (1000-2000 IU daily): Vitamin D plays a role in muscle and heart function by aiding calcium regulation, which is critical for heart contractility and vascular health. - Magnesium (200-400 mg daily): Magnesium is essential for proper muscle and heart rhythm by helping regulate calcium, potassium, and sodium. It may help reduce arrhythmias and improve muscle function. - L-Carnitine (500-1000 mg daily): L-carnitine assists in energy production, especially within the heart, by transporting fatty acids to mitochondria. It supports cellular health and heart muscle function. 2. Lifestyle Practices to Support Cardiovascular and Cognitive Resilience - Regular Physical Exercise: Engage in varied forms of exercise, including aerobic activities (like brisk walking, swimming) and strength training. Aim for 3-5 times per week to enhance heart contractility, improve circulation, and support brain resilience. - Sauna Sessions: Regular sauna use (15-20 minutes, 3-4 times per week) increases heart rate, improves circulation, and stimulates the release of heat-shock proteins, which protect neurons and support both cardiovascular and brain health. - Quality Sleep: Aim for 7-8 hours of quality sleep each night. Sleep supports brain health by aiding in the clearance of metabolic waste and enhancing cellular repair throughout the body. 3. Social Engagement and Oxytocin Release for Systemic Coherence - Regular Social Interaction: Meaningful connections with friends, family, or pets encourage oxytocin release, which can improve heart function, reduce stress, and enhance systemic coherence. Oxytocin's benefits on emotional health and heart contractility are critical for maintaining resilience. - Community-Based Activities: Engaging in group activities, like volunteer work or hobby clubs, promotes social coherence, neuroplasticity, and emotional well-being, reducing stress factors associated with cognitive decline. 4. Mindfulness and Relaxation Techniques - Mindfulness Practices: Incorporating meditation or yoga (20 minutes daily) can reduce stress, improve focus, and increase oxytocin levels, supporting both heart health and mental coherence. This approach combines supplements, lifestyle adjustments, and social engagement to create a supportive network for heart and brain health. Each element contributes to systemic resilience, providing a proactive framework for reducing neurodegenerative risks. References: 1. Parminder Singh et al., “Taurine deficiency as a driver of aging,” Science, 2023. 2. ColumbiaDoctors, “Taurine May Be a Key to Longer and Healthier Life,” Columbia University. 3. PLOS ONE, “Rapamycin Ameliorates Kidney Fibrosis by Inhibiting the Activation of mTOR Signaling.” 4. Clinical Kidney Journal, “Rapamycin and kidney function,” Oxford Academic.

[@ljalpena3552]

One good thing about dementia is you can’t remember how bad your Government is. Food and drug administration is the cause.

[@virgilkirschner5717]

Hope RFK can help fix this mess.

[@keng7758]

With Trump and his psychotic picks for national office, we are truly doomed.

[@nebojsa1976]

@@keng7758 Doomed??? Go outside and look at people. We are already doomed under guidance of real "EXPERTS". 60% fat people. Diabetes through the roof. We must replace current "Experts" 100%.