Remyelination for MS: Remyelination Clincal Trials & more! - MS Exercise

[@FMD91]

Omg this is great news. Getting our hopes up even a tiny bit makes me so happy. I really want my life back. I wan t to be able to do what normal people do😢. Thank you so much Dr. Gretchen ...thank you for this detailed video.

[@DoctorGretchenHawley]

You're very welcome! I'm glad you enjoyed it!

[@susanagaliano5073]

Muchas gracias por compartir las últimas investigaciones y ser tan clara con tus explicaciones. Todos deseamos que pronto se pueda curar la Esclerosis múltiple, recuperar la mielina perdida y recuperar las funciones. Hay muchas investigaciones y eso brinda muchas esperanzas.

[@nazilakhademi3754]

Thank you so much ❤❤

[@julieb2033]

I am cautiously optimistic. I so want this to be available in the next couple years. I'd love to be able to walk normally again without a cane. It is good to hear that researchers are working on it, though.

[@mikaelaslak8808]

I'm in exactly the same situation. It's the walking that gets to me. Good luck to you also. :)

[@ankita210]

Yes m hvng same prob .. I wish d research gets successful nd Me wid odr patients of MS who hv lost d ability to walk normally,doing odr daily chores will get d BOON of normality again..😊😊

[@Gerbs601]

My wife has had MS for 35yrs. We have found the ATTO that helps us travel world wide and around the grocery store. Not for everyone, but perfect for us. We did the following PR to help others > kzbin.info/www/bejne/jqKQmIGiqN-ggsksi=M9cMjuUQfNFJPOKv

[@Gerbs601]

@@mikaelaslak8808 My wife has had MS for 35yrs. We have found the ATTO that helps us travel world wide and around the grocery store. Not for everyone, but perfect for us. We did the following PR to help others > kzbin.info/www/bejne/jqKQmIGiqN-ggsksi=M9cMjuUQfNFJPOKv

[@kevindonnelly7475]

I want this available before I have any walking issues. Luckily not too bad off so far. Trying my best to deal with it through pretty intense exercise and a ketogenic diet.

[@aluna_m888]

Is that Niacin as in B3??!! Imagine that!!! I agree with you, as when you go through the list of what B vitamins do, Niacin as in B3, is actually promoting myelin repair

[@evakumova966]

@DoctorGretchenHawley, thank you so much!!! I am also writing down notes because of exactly this niacin, vitamin B!! And the mobilization is surely true, I am the only paraTriathlonistin from my country Slovakia, there is an other MS paraTriathlete from Germany and these 3 sports help us very much♥️

[@Jo67983]

Also Lions Mane Mushroom

[@Jcr2446]

Does vitamin c help too? I heard it did.

[@EvenSoItIsWell]

Thanks Dr. Gretchen! I will be watching the research and continuing to exercise to my body moving. Feeling optimistic that exercise along with medication, diet, sleep, & mindfulness will keep me going. So far (18 years) it is helping!

[@DoctorGretchenHawley]

Absolutely!! There may not be a "fool proof" way to remyelinate nerves yet, but there are definitely proven things that can be done until then! You got this 🧡

[@helenfinaldi8645]

Thank you dr Gretchen for always keeping us “ms ers” informed and up to date on the latest 💞

[@DoctorGretchenHawley]

Always happy to share!

[@imadragnZ]

Please start sharing the technical termes as well this helps with research (also most of us MS fighters probably already know what you r talking about).

[@DoctorGretchenHawley]

Thanks for the feedback! I can definitely include them in future videos

[@cherylvl1036]

I have aggressive, progressive MS. My neurologist just prescribed metformin for me because she said it’s worth a shot and it’s a drug that’s already approved for use in Canada (not specifically for remyelination) and should be safe as long as it’s being monitored. I’m happily trying it.

[@GurpreetKaur-sx2fi]

Any change or improvement after trying it ?

[@DoctorGretchenHawley]

That's good news! I hope it works well for you!

[@Elem70]

Did she rx the extended or instant release?

[@cherylvl1036]

@@GurpreetKaur-sx2fi no change yet but it’s only been a couple months. I feel like I need to be more consistent with exercise to see any improvement.

[@cherylvl1036]

@@Elem70 I’m not sure how to tell if they’re the extended release pills. They look like they have that hard coating on them that suggests an extended release pill.

[@helenh445]

Dr Gretchen, thank you! I just found you and I’m delighted. I have CIDP, please mention this type of demylenating condition in your videos too! It’s demyelination on the peripheral nervous system. My take away today was exercise and Niacin, will get started ASAP! Looking forward to your next video! I believe in complete recovery! 🙏🙏🙏🙏🌷🌸🌷🌸

[@DoctorGretchenHawley]

Thank you so much for sharing! I'm so glad that you are here!!🧡

[@chamberfield1]

Thank you for this great overview. My wife is currently on Kespimpta but suffering from constant UTI infections, so it's not really working out well. It sounds like BTK + a remyelination therapy would be a better way to go. I hope it comes soon.

[@ginacampbell2082]

Thank you so much. The new info is so exciting 😅

[@DoctorGretchenHawley]

Happy to share!

[@poojahm120]

That's great news

[@poojahm120]

Thank you so much for sharing the above mam❤❤❤

[@reneerojas2987]

Yes! Hope is on the horizon!

[@SMOOTHFUNKYONE]

Thank you for sharing. Some hope is better than no hope.

[@DoctorGretchenHawley]

I couldn't agree more!!

[@jamescoull8168]

⭐️ Amazing News ⭐️

[@kousercooks3147]

Thank you doctor God bless you my dear Doctor

[@DoctorGretchenHawley]

You're very welcome!

[@maryjsum]

Thanks

[@DoctorGretchenHawley]

Always happy to share!🥰

[@vidyatennety3186]

Super helpful. Thank you so much 😊

[@DoctorGretchenHawley]

Always happy to share!

[@robhruska7611]

Would love it if you could reference the studies on niacin. Thank you.

[@ketselaworku3745]

MS is unknown in Ethiopia. Thank you for the information and I will do physical exercise.

[@DoctorGretchenHawley]

I'm so glad you found my page and that it continues to be resourceful for you!

[@ketselaworku3745]

@@DoctorGretchenHawley thank you I have problem in MS. Your video is wonderful with a good skills of presentation.God bless you.

[@violetwonder7]

Thank you so much! This definitely gives me more hope🧡.

[@DoctorGretchenHawley]

You're welcome! I'm so glad you came across this video!

[@alrightwithms845]

Exciting times ahead-thanks so much for this information 😊

[@DoctorGretchenHawley]

You're very welcome!

[@marydeboda9581]

Love this! Thanks!

[@DoctorGretchenHawley]

Always happy to share!

[@katrienremory5721]

Thank you.

[@DoctorGretchenHawley]

You're welcome!

[@NYNC88]

It would be nice to have some hope.

[@sukranvural7465]

Thank you Dr Gretchen for your information and especially for mentioning the importance of exercise

[@DoctorGretchenHawley]

You're very welcome! I'm glad you enjoyed the video!

[@judehall2220]

Than you, Dr. Gretchen. This information does provide some hope ☺️

[@DoctorGretchenHawley]

I'm so glad! I'm always happy to share!

[@Pawel__M]

A very informative video (as usual on your channel 🙂). I have SPMS, with a 6.5 on "our" scale. I take Mayzent (DMT), and last year, after reading more about the ongoing clinical trials in Cambridge. UK, and after informing my doctor, I started to take Clemastine and Metformin, supplemented with vit. C, B3, liberal amount of B12, the usual exercises etc. Clemastine in itself is supposedly not very effective in adults over 25-30 (I'm 59), but preliminary tests suggest it works when combined with Metformin (a synergy effect). My results are not unequivocal, but my vision improved a bit. That is, I still can't see with my right eye after optic neuritis in 2014, but now the "fog" in the affected eye is less dense, and I now can read large letters (8 inches high) on my PC screen. Also, I don't have to stop every few steps when using my rollator (my EDSS is still at 6.5).

[@jyotiattri5937]

My brother is suffering from MS from last 8 yrs..He is 40 now..He is bed ridden..On EDSS scale he is between 7-8..Stem cell transplantation also did not bring any positive results..we are based in India Kindly let us know when this remylination therapy starts

[@Pawel__M]

@@jyotiattri5937 All the best for your brother and for you. The clinical trial continues in Cambridge and they say first results may be available next year.

[@realaudioreviews]

what can you do about bladder and pelvic pain, like a pinched nerve

[@DoctorGretchenHawley]

An in person physical therapist will have great exercise suggestions for pelvic pain and sciatica!

[@WilliamWallace-sc9cx]

Physical therapyst here 🙋 with MS. Dr.Terry Wahls protocol (and supplements) is by FAR the best option/guideline to follow if you want to improve your condition. 🙏

[@DoctorGretchenHawley]

Thank you for sharing what has been working for you!

[@kirildimitrov3815]

Thank you!!!! Great news for us!

[@DoctorGretchenHawley]

Happy to share!

[@CSB012]

It's very encouraging!!

[@DoctorGretchenHawley]

I'm so glad you think so as well! ☺️

[@markgeleta1368]

Thank you so much for this and your book it's really helping me to try and get normality back. ❤

[@DoctorGretchenHawley]

You're very welcome! I'm always happy to share, and I'm so glad to hear that you enjoying the book!! Happy reading!

[@bibamakes]

Great news! And thank you for all your ongoing help. Now for my question, based on your comment of exercising as moving even if seated: does the act of crafting count? Like knitting, crocheting, embroidering, those kinds of movements. Because 1: if it counts, I'm set! and 2: all jokes aside, the spasticity in my right leg makes exercising very difficult and tiring on top of the high levels of fatigue, so if the crafting that is helping me mentally will also help me physically, I would be immensely happy.

[@DoctorGretchenHawley]

You’re very welcome! Crafting that requires upper body movement is great! The studies didn’t indicate what type of movement/exercise would be necessary (upper body, lower body, or both) but I’ll keep my eyes and ears open for more details on this.

[@bibamakes]

@@DoctorGretchenHawleythank you!!!

[@er8497]

🙏🏼🙏🏼🙏🏼🙏🏼🙏🏼 thank you so much for sharing this information! Gives us hope❤

[@DoctorGretchenHawley]

You're welcome☺️

[@dingosl9638]

Thank you God, hope that would be also for NMO.

[@wernervdz2710]

Can you use it next to Ocrevus? I am from Europe, The Netherlands. Thanks in advance

[@DoctorGretchenHawley]

Possibly! They haven’t tested that yet.

[@Pawel__M]

Hello from Poland, There are a number of clinical trials in Eutope for clemastin combined with metformin, for instance in Cambridge, UK. They recruit candidates who take a disease-modifying drug (a requirement), Google or search YT for more info:) I am on Mayzent and I started my own experiment a year ago, after talking to my doctor.1 mg Cl. plus 500 mg metformin per day. But metformin may lead to deficiency of vitamin B12, so supplement it. And ask your doctor to monitor your liver enzymes at the beginning!

[@vfnyc2005]

I am surprised that Pipe-307 and NVG-291 were not mentioned. They are both in clinical trials right now and have a lot of potential hopefully.

[@DoctorGretchenHawley]

I have videos on these coming out in the near future! Stay tuned :)

[@HeleneHultman]

Thank you so much for sharing useful information in a great way❤How long will it take before those of us who ned it can expect this medicine? Greetings from a hopeful patient in Norway

[@DoctorGretchenHawley]

My guess is several years, but there’s the possibility it could get “fast tracked” by the FDA which would speed up the process!

[@dougdnh]

Gretchen - good information. Just to add - have you any thoughts on N-Acetylglucosamine? I appears to be very promising from what I've read.

[@DoctorGretchenHawley]

I haven’t! I’ll look into it, thanks!

[@UNbalancedDogTrainer]

Woohoo! I'm already very good at de-mylenation ;)

[@aluna_m888]

@@UNbalancedDogTrainer 😆😆😆 same here, but I want to be very very good at re-myelination too. let’s find a way to build ourselves up, or at least try. Best of luck ❤️

[@annapov91pov92]

😂

[@yvonnemccullaghward361]

I would hope that this would also be significant for Transverse Myelitis also as all these issues are also experienced with TM as demyelination is exactly the cause

[@marshaholmes8412]

I have been diagnosed with transverse myelitis in 2011, I came across an article written about Clemastine , an antihistamine, and I have been on it since April 29th this year . I have seen significant improvement and strength as well as healing in the area of my spinal cord that has been damaged. I believe the combination of Metformin and Clemestine will help people with transverse myelitis.

[@yvonnemccullaghward361]

@@marshaholmes8412 WowI will ask my doctor about this. Wouldn’t it be great if anything helped!

[@deborahkaba4573]

Onward and Upwards I say.🧡

[@DoctorGretchenHawley]

Absolutely!

[@giorgos7six]

Very interesting news! Is it known when those clinical trials will end and hopefully bring out good news?

[@DoctorGretchenHawley]

one of the trials ended already and unfortunately didn’t yield the results we were hoping but there’s still 4 more in trial and there’s high hopes for them! Not sure when they’ll be finalized.

[@Morgan-c9v]

What is the protein that you speak of which inhibits new myelin growth???? Is this something they test for in your blood to confirm MS?

[@DoctorGretchenHawley]

There’s actually lots of proteins - but to my knowledge they aren’t currently treated as part of an MS diagnosis.

[@katana9072]

How many Times a day do you do exercise on video fast track Neuroplasticity last year

[@DoctorGretchenHawley]

Hi there! I saw your recent comment from a few days ago, and just responded!

[@karrinleecasper-bryan1685]

How do you feel about chemo when first diagnosed?

[@DoctorGretchenHawley]

I haven’t had any patients go this route so I’m unable to speak on its effects.

[@karrinleecasper-bryan1685]

@@DoctorGretchenHawley seems scary. It’s Briumvi

[@rogerkelley5008]

The evidence on clemastine is not as clear cut as you indicated. One study showed that it did restore some optic nerve function- the latest one (which was pretty small, and not done all that well) said it made people get worse. It needs to be looked at better, IMO. I have been taking it for 2 years, and have restored some (not all, not even 50%) function in my affected hand. I am waiting for the metformin/clemastine study at Oxford to be completed, which I believe will be next year. Also, you forgot Freximilab, which is now going to phase 3 trials, and may be more promising than BTK.

[@annapov91pov92]

What dosage are you on?

[@DoctorGretchenHawley]

Thank you for sharing your experience and insight!

[@rogerkelley5008]

@@annapov91pov92 1.34, taken at night. I believe Oxford was using twice that, but I didn’t want to be groggy in the morning.

[@DoctorGretchenHawley]

There are components from the clemastine studies that paved the way for some newer medications currently in clinical trial for remyelination! I’ll be sharing a video on that soon :)

[@rogerkelley5008]

@@DoctorGretchenHawley I assume that is the PIPE study, targeting a specific receptor. I hope that does work!

[@jodifeltham3859]

Niacin has been my little miracle pill for several years. It allows me to move and exercise like I don’t have MS. However, the benefits wear off once the flush leaves. However, I did end up overdosing and having to stay in the hospital. I started out with 500 mg and went to 3500 mg. The overdose was no joke and my heart rhythm was thrown out of balance. The flashing effects from niacin can be overwhelming initially and some people think they are having a heart attack from the intensity.

[@DoctorGretchenHawley]

Thank you so much for sharing your experience!!

[@ernietollar407]

Thanks Dr. Hawley! TAKEAWAY FOR 2024.. EXERCISE FOR MYELIN, NIACIN. I look forward to BTK inhibitor updates

[@DoctorGretchenHawley]

Happy to share!

[@tedteddy1802]

How many milligrams of niacinamide do you think somebody with primary progressive MS should be taking per day ?

[@DoctorGretchenHawley]

That would be a great question for your neurologist!

[@tedteddy1802]

@@DoctorGretchenHawley I haven’t seen a neurologist in seven years, the last time I saw him through his hands up in the air and said there’s nothing more I can do for you so then politely I said you can go fuck yourself. I’ll take care of myself thank you and excuse my language.

[@tedteddy1802]

@@DoctorGretchenHawley thank you for all that you do. God bless you.

[@ntm0272PoPs]

CPM Central Pontine Myelin-osis*, what my case?

[@pauladesida]

Are BTK inhibitors good for other conditions that affect the Nervous System aside from MS?

[@DoctorGretchenHawley]

Yes, BTK inhibitors have been around for a while and are used in other conditions like other autoimmune conditions and blood cancers

[@pauladesida]

@@DoctorGretchenHawley Thank you !🙏🏻

[@lenamafalda]

Have you heard/read of PIPE-307 medicine that is now being tested on a 2nd phase? News broke about it earlier this month with quite positive and promising results of remyelination. Thank you for your video. From experience, I can see how exercise can help, since a friend who also has MS feels better after exercising.

[@DoctorGretchenHawley]

I have! I’ll be recording a video on PIPE 307 soon ☺️

[@lenamafalda]

@@DoctorGretchenHawley Awesome! I can't wait for it.

[@tennisfan6343]

Is there a way to get better visiob if you some due to ms?

[@DoctorGretchenHawley]

Great question - I actually have a podcast episode that I think you'd enjoy with Dr. Rani Banik where we discuss MS and vision! Dr. Banik is a board-certified ophthalmologist and fellowship-trained neuro-ophthalmologist with additional training in Integrative and Functional Medicine. I hope you enjoy the episode: open.spotify.com/episode/7y8SlciQ7XPWfoHfVKESsG?si=NMVrYRHcSsefrr7eWYgW1Q

[@tedteddy1802]

I thought you were gonna say I hope it makes you feel inspired because it does

[@DoctorGretchenHawley]

That's wonderful! I agree!

[@d011p4rtz]

I feel like there's *ALWAYS* a trial or new meds being tested but never get released or are far too expensive for people so debilitated by this disease that they can't afford it and state insurance won't cover it so nobody ever gets to try it. people are suffering *NOW* . within our lifetime isn't fast enough😭

[@DoctorGretchenHawley]

This is a very valid statement, and I appreciate you sharing it!

[@ronaldinhogaucho5460]

Beautiful lady ❤❤❤❤❤

[@14sgs]

Would be nice.

[@gabrielecaredda90]

Doc don't you know Pipe-307?

[@DoctorGretchenHawley]

I do! I have a video on PIPE-307 coming out soon :)

[@wardensworld6308]

"That have worked in cats and mice. I am not saying to try these. Talk to-" and Amazon opened...JK

[@BasicBeachCommunity1]

My wife refuses to go to the DR........after 5 months with COVID no smell or taste my wife fell down and was refered to a Nuerologist for MS like symptoms....She is super angry and thinks i am lying to her....bizarre

[@DoctorGretchenHawley]

I'm so sorry to hear that!

[@BasicBeachCommunity1]

@@DoctorGretchenHawley me too. It wouldn't be such a big problem... But I have kids. 🙃

[@scores718]

Keep looking for fountain of youth

[@janbarriault4494]

stamets stack..

[@howardparks2083]

Is it cats and mice, or rats and mice? Not to be picky, but there is huge difference between rats (rodent) and cats (feline). Demylentation and Remylenation at the same time? That's something out of the book of Revelations!

[@DoctorGretchenHawley]

The studies that were presented were in cats and mice.

[@RickeyBobby-x2e]

Cc: CC: FYI/FYR: CC: FYI/FYR: November 12, 2024. Progress notes: The Rationale: Here, when I use Nicotine lozenges, they tend and do make me very dizzy, but if and were I to take Antivert, the dizziness symptoms, along with the benefits of my augmented Tincture, would likely work in the opposite way, ... in the same way, as to both Mitigate, Abate, and address the problem Dizziness, MS often causes; - all while adding the Clemestine in, say it's liquid form, (I've found some), ..to the Liquid Tincture, taken now 3 xs per day. I am now using.., " The regular and provided 1 ounce eyedroppesized eyedroppers that come [ in the 2 ounce bottles]. * I take 3 eyedropper squeezes; about a Third to a Quarter full when you squeeze for the liquid. I take it this way: I take: post 1.) Breakfast, 2.).Lunch, and lastly 3.) Dinnertime. All of this in order to address the MS typical symptoms caused by the microscopic, difficult to detect, that do hide inside red blood cells, that are obviously changing their pedestrian and normal red blood cell functions and behaviors; see book, Parasite Rex; ...eating /.feeding on the fatty and obviously Tasty and Preferred Protein lipids, that makeup the Meyelin Sheath, .... and I do believe, the new response; ordinary Clemestine, will now begin, - * to slowly begin 1.) rebuilding and 2.) regrowing the damage done previously to the obviously and rather delicate Meyelin Sheath. The goal: To Reverse neurological damage done by microscopic Parasitic Infection, and restore the subject person back to normal. ..*.. I think I will be adding the Clemestine, Antivert, and Neuriva soon, to the evolving Tincture for a [ Comprehensive Therapy Treatment ] . 👍❤❤❤❤ Note: on Nov 12, 2024, I found my Rx Antivert, took it, and it actually worked, for as the hours passed, I strangely began walking around as if I did during Year 3 of my MS diagnosis. Yes, very slight balance problem, but improvement enough to feel normal once again. Tomorrow, as planned, because the Antivert does cause a sense of fatigue and some drowsiness, I will purchase the Neuriva I mentioned, which should work to equalize the feelings of drowsiness, with a product which does Increase Alertness, thus the effect of Fatigue will likely cancel itself out. Wish me luck, for I don't have years to wait on studies, trials, and findings. My approach works because I am feeling like I am almost back to normal. Fact..Hope this helps. MDM, JD CANDIDATE ✌️❤❤❤