RESVERATROL & David Sinclair: Shocking Detail and Big Mistake - episode 1

Resveratrol.
A molecule. A supplement. Resveratrol, popularized by Dr. David Sinclair, is one of the most controversial yet fascinating supplements and molecules for longevity and health.
This is the thing providing red wine its supposed health benefits.
Is it truly so? Or is the supplement a hoax?
It’s a serious question that could impact our long-term health, longevity, and our pockets - especially if we reach the wrong conclusions.
This series investigates whether Dr. David Sinclair’s conclusions on resveratrol were wrong, whether resveratrol helps your body stay young, and the secret mechanisms by which it works.
I hope you'll like it!
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Study References:
I'm working on a website to include each video with all links, with each page per video.
In the meantime, I ALWAYS show the exact study titles & years and read them aloud. Go to GoogleScholar.com, put the first 4 words only, and the study will come out as the top search, guaranteed. Please double-check me!
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• Longevity Favorites
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The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast.
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Credits: 'Adrift Among Infinite Stars' by Scott Buckley - www.scottbuckley.com.au
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.

[@WellnessMessiah]

✅ Check the special deal of habits creation app + my routine for longevity: wellnessmessiah.com/app Disclaimer: I'm an affiliate of the company - I trust their product. Buying will support my channel

[@mikelangele]

Thank you so much for your video. Can't wait till the next one. Hope your wife is ok. Still watching 2 and 3 minutes ads to help you as much as possible. (letting it run on mute)

[@WellnessMessiah]

@@mikelangele Thank you, it really helps. Truly!

[@samirahusain855]

​@mikelangele

[@dcjohnson2208]

As an old retired scientist (octogenarian) I appreciate the efforts you expend in your research and interpretation of same. Your presentation level is excellent! I too have been taking David Sinclair’s protocol. I immediately backed down from 1 gram to 250 mg and then moved to 500 mg every other day. I have found from my own body reactions, tests etc. That a mostly vegan diet + 500mg NMN daily + 500mg Resveratrol every other day gives me the best results over the past 19 months. I’m forming an opinion that 36 hour fasting is going to be best for me. I usually have 2-3 tablespoons of EVOO when I break my fast. I have never smoked, drank alcohol or used illicit drugs. Today is my father in law’s 103rd birthday. He still gets around by himself. He played tennis 2-6 hours/ day for 82 years before he stopped at age 92 because he couldn’t keep up with the younger men!

[@bryanspicer90]

Great stuff. How’s your social/ dating life with the no alcohol/ drugs?

[@dcjohnson2208]

@@bryanspicer90 I’ve been married for more than half a century. My wife enjoys margaritas and wine occasionally. We reared five children and now have 10 grandchildren with more on the way. Prior to marriage I have the great privilege and good luck to have had my choice of 9-10 scale women. Some people have all the luck. Not me. I just have more than I probably deserve. I have blue eyes, white hair. I am 6’3” 196 lbs with a great body and I am still approached by good looking women in their 40s-70s. Thanks for asking!

[@bryanspicer90]

@@dcjohnson2208 haha great stuff! Keep it up .

[@christopherellis2663]

Well, I'm 73 and have eschewed carbohydrates because they are innessential for human nutrition. Good luck with the vegan muck. This includes alcohol, which is just another toxin. So-called social life is a nonsense.

[@bignige]

Hey DC, thanks for this.

[@llacerda1982]

Following up on my last comment: Besides dose (low or high), it seems that the bioavailability of free resveratrol between rodents and humans needs to be taken into consideration to achieve the same benefits that have been found in the different studies. 38% bioavailability of Resveratrol in rodents, and < 1% in humans is a significant difference that, from my understanding, shouldn't be neglected, therefore needing a higher dose in humans to achieve a similar outcome to the ones referred in the studies.

[@Jacob-uv1kh]

Please keep making content. You're one of the very few people who can put out a 40 minute video that I can watch every minute of. Thank you

[@WellnessMessiah]

Wow what a compliment!

[@semaaral2498]

Same here.Trust is main key here.. God Bless Rimon & His lovely wife🙏💙🙏💙

[@bilbyguy2389]

What a great video. I am fascinated. Well done on all your hard work.😀

[@Thaythichgiachanh262]

Thanks for all your great advice. I really enjoy watching your videos, they provide a lot of knowledge and are very helpful on a daily basis in choosing food when shopping, etc. Thank you ❤✨

[@bluffmaster4222]

Very engaging content ! One of the few people on social media who do their home work before opening their mouth. Keep going ! Lovin' your work brother!

[@harborgirl8877]

Thank you for explaining this subject in a way I could understand. Your research is appreciated!

[@jimsigrist5506]

Bravo! Very thorough explanation! Thank you very much. More longterm studies necessary. Need to know more about drug to drug (molecule) interactions with NMN, Metformin, Berberine, and Ficetin, etc.

[@aljosarojac8575]

Great investigative work. Well done 👍

[@NTMihaila]

I love your channel man! Keep the excellent content coming!

[@WellnessMessiah]

With comments like yours, what choice do I have?

[@TheMarczan]

Great job! Thank you so much for this video! :)

[@emilguste]

Really good work mister, looking forward to the next

[@WellnessMessiah]

You're very kind emil. the next episode this saturday.

[@dmpag7000]

excellent and very thought provoking

[@brazilchem]

I do low and intermittent resveratrol dosage in the form of 1 bottle of red wine at once, per week.

[@MrHlynskyy]

Wow you just converted my 2 month supply to 2 years supply.

[@tahsin95]

This is a great study, thank you so much. Subscribed.

[@Always-xl9db]

What a great podcast, and this makes perfect sense along with your other videos on resveratrol…I’ve been microdosing and pulsing it ever since!

[@WellnessMessiah]

Great to see you again!

[@semaaral2498]

I was confused and didn't hear from you for some time & worried. Needed an explanation about Resveratrol, especially in Google, Resveratrol says works like an estrogen hormone in the body. So I've lost my excitement & trust towards many things😟 It's scary. So need good detailed info. Thanks for this video, "every effort helps" Hope your wife's health is improving every day 🙏💙 My thoughts & prayers are with her🙏💖🙏 May God give you the strength to care for your wife🙏🙏🙏 God Bless you & your wife🙏💙🙏

[@shy-guy5544]

Fascinating well-researched video. I read that high doses of resveratrol blunts the benefits of exercise. I assume that if I exercise 4-5 times a week in the morning, engage in intermittent fasting with the main meal in the afternoon, along with a glass of wine about every other day, I will receive nearly the maximum benefits of all three. Thanks

[@Sunyataji]

Going by the graphs and estimating the number values, it seems that EODLR is an approx. 2.3% increase and HCLR is 1.4% increase in longer lifespan. Transposing that to a human lifespan of 80 yrs, would be 1.8 yrs and 1.1 yrs gain in lifespan respectively. Granted, we would all like as long a lifespan as possible and even 1 year is desirable, but given other factors effecting lifespan is the low vs high resveratrol question that significant?

[@CommanderRiker0]

Best presentation yet

[@MrCt40]

Thank you for doing the hard work on clarifying this confusing area - which brands of resveratrol do you like to take ?

[@MP-id2po]

Interesting how red wine as an explanation for the French paradox, has triggered thousands studies in resveratrol. Great job in abstracting and gathering relevant information from all the studies to create order, logic and relevance from all the "chaos"

[@christopherellis2663]

The French paradox arose from the hypothesis that cholesterol clogs the arteries. It doesn't.

[@Krunch2020]

The paradox is why anyone trusts American health information. It’s rotten from the top down. Sinclair is near the top.

[@TehKaiser]

French paradox might be because they eat better quality foods like milk and real butter, along with cultural limits on the schedule of eating. Butter does contain valuable vitamins like K2. Americans are willing eaters of industrial influence and are willing to eat bad quality foods and blindly trust big food's science saying veggie oils and trans fats were better.

[@Fearzero]

​@@christopherellis2663 It does along with saturated fats. The French paradox is nothing more than only including peasants living in small villages in the study who ate mostly grains and beans not the high fat meals that wealthy city dwellers were consuming. Look it up.

[@Michael_RareZebra]

Thanks for the in-depth review

[@jgs9911]

Another excellent video. Thank you. BTW: your English is perfect

[@es1653]

I absolutely love this continuing free education on ageing backwards and becoming younger. I started taking 400 mg. Resveratrol daily along with my other supplements and vitamins.

[@count_of_monty_crypto]

I wonder why the leading researcher on longevity and aging at Harvard takes 1000mg resveratrol if his own data on mice suggest lower doses are more effective for his needs. Just seems odd he that he would disregard all his own data and in fact from what you suggest earlier potentially shorten his life with a higher dose. Very odd need to clarify his exact reasons/arguments for personal/human 1000mg daily consumption. Great video but baffles me why Sinclair would ignore his own research if this is truly the case. Need to hear his own scientific reasons for 1g

[@507thug]

Insightful!!! Thank you

[@SeattleCondoSpecialistcom]

Bravo. Great Information!

[@harborgirl8877]

I am convinced that centenarians do have a genetic component. My family, especially on my paternal side, has consistently long life spans. My father (born in 1917) lived to be almost 100, but so did my grandfather, and great grandfather. We have gone back to the 1700’s, and were shocked to see how long people in our family line lived. This was during a time when life expectancy was far less. I am hoping good genes, and following a good anti aging lifestyle will get me to 110-120. As I said, both my parent died shortly before 100, and both were active and sharp minded.

[@dcjohnson2208]

Did they eat a lot of sugar or processed foods or fast food? My guess, due to their ages, they did not. Which begs the question: Do you eat lots of sugar, processed foods or fast food? If you do you may drive up the percentage of senescent cells faster than they did, thus, diminishing your genetic advantages.

[@harborgirl8877]

@@dcjohnson2208, no, they did not, and neither do I. I have never been a fast food person. I’ve also always watched ingredients in what I eat. They were born in 1917 and 1921 respectively, and both were raised on farms.

[@dcjohnson2208]

@@harborgirl8877 I’m happy for you. I too grew up on a farm in Illinois. I am an old retired scientist (octogenarian). I feel very good and am told by many I look 50-60. My father in law is 103 and played tennis until he was 92yo.

[@harborgirl8877]

@@dcjohnson2208, Wow! That is nice ;). My Dad grew up in Illinois. A small town at the time , called Harvard, but also spent time in Belvidere, as well as Poplar Grove.

[@dcjohnson2208]

@@harborgirl8877 our farm was in Lisle next to Downers Grove.

[@karinak3487]

Thank you sooo much for such a valuable info!!! ❤ blessings to you ❤

[@papyber]

Great job, thanks.

[@RestorationWatch]

I think you need to recheck your calculations at 10:23 where the low dose is stated as 4.9gms/kg which would equate to 490gms for a 100kg (220lb) individual (4.9 x 100 = 490) so a 160lb person would need to be taking 350mgs/day to be on an equivalent low dose. I take 400mgs/day. Also, Resveratrol should be taken with something that has fat in it as it is fat soluble. David takes his with his morning yoghurt, whereas I take mine with my morning glass of Bonsoy soy milk. NMN on the other hand should be taken with water on an empty stomach as it is water soluble. I take 1000mgs of NMN with a glass of water first thing in the morning.

[@jurgenpretsch1770]

A human is not a 80 kg mouse. At 7:49 there ist a calculation that converts the results of mice to humans. the numbers are divided by 12. In Germany the official number is 7 which means a of of 56 or 153 mg/d.

[@WellnessMessiah]

Hi Steph, you forgot to divide to convert from mice into humans. by 12.3 exactly. Google mice to human conversion.

[@morgenstern8945]

NMN wird besser aufgenommen, wenn Du ihn unter die Zunge für 20 Minuten zergehen lässt

[@maitregab4997]

Soy is an endocrinian disruptive so its bad for your health and your hormone

[@rossnrice]

Thank you for the update.

[@elliottrubenstein1746]

Great information.

[@lynamine]

Excellent podcast!

[@masterjstory7887]

Absorption is key. Our body chemistries are unique. We were taught at medical school that B3 (NMN) must be taken in conjunction with the vitamin B group for it to be metabolized, otherwise it is excreted.

[@petermiller4434]

were you taught that b3 is the same as nmn?

[@stevecrawfordpianodreams5167]

Thank you very much for this in depth analysis of the available data. I'm glad you are doing the episode 2 on this topic because I kept thinking why is Dr. Sinclair taking 1 gram a day when the analysis so far points to a lower dose being the most effective dose. I look forward to the upcoming episode.

[@WellnessMessiah]

The next episode is coming this Saturday. Great to meet you, you're very kind.

[@bigguy130]

@@WellnessMessiah Wouldn't it be cool if you could get the man himself, David Sinclair to discuss with you the topic of resveratrol supplementation and what dose is best and why? 😯

[@mixalis6168]

@@bigguy130 He would lie all day long @

[@kiwiingrid]

@@bigguy130 he takes it himself. Look for a video done by 60 minutes Australia about longevity and he says in that interview. It on KZbin btw.

[@paj6757]

Very well explained and practical.

[@ash9x9]

So, What is the crux? Haven't had the time to go thru the entire stuff..!

[@MP-id2po]

@@ash9x9 Get a life.

[@jeannineosorio6566]

Good evenig Rimon! I have recently added NMN and TMG. I currently weigh 125 lbs. How much resveratrol could I begin taking? Thank you and I look firward to your next video.

[@Sublimer79]

I take knotroot as an natural source (I grind the root into a powder, its also sold in powder form now which would be a lot easier) I would assume its safer since its not just isolated resveratrol. I could be wrong. But that is my source. I only drink 1 bottle of wine a month. I'm sure it does something.

[@094340]

Japanese Knotweed is my source as well. I'm taking it daily, it's included in an herbal support supplement for Lyme Disease.

[@llacerda1982]

Great content, thanks for putting it together! What's your view on the bioavailability of resveratrol in mice vs humans? Could humans need a higher dose to factor in a possible lower bioavailability of resveratrol in humans, but still achieve similar results to the ones achieved with the mice on every other day feeding with low resveratrol?

[@MyMy-tv7fd]

rather too complicated for me I am afraid, but I am excited to see that resveratrol is still being researched

[@WellnessMessiah]

Hi there, just check the end of the next episode, it's all you need to know, really.

[@kisha_music]

When is the next episode coming?

[@vickypoulimenou-tesdorpf2746]

@@kisha_music Saturday

[@drieman]

Sorry, busy person here. Maybe you can summarize your findings, and not have your viewers struggle through the data and your interpretations. However, keep your findings coming. Thanks

[@JaxObsessed]

Thank you Rimon!! This is useful information. ... On a side note, I hope your wife is continuing to recover.

[@WellnessMessiah]

Thank you Jax, she had a backslide with another clot. I hope I could update soon.

[@reikiandrew]

Can you please tell me if NR/NMN + resveratrol and GlyNac work in similar or complementary way? is it ok to take both combos?

[@joannsmith9]

Bravo! Brilliant!!

[@slidecatch]

Great video, thanks! The only solution to the mystery that I can think of is that Sinclair believes that taking high-dose Resveratrol with NMN combined confers some synergistic benefit that low-dose Resveratrol with NMN would not.

[@jochemlaurenssen9440]

Yes it is said that resveratrol acts as an accelarator for nmn. Maybe that is why Sinclair takes a higher dose. I dont know if there are any studies done to corroborate this.

[@WellnessMessiah]

Hi there, resveratrol activates SIRT-1, not NMN. NMN should raise NAD+ (hopefully, inside the cell, not just the blood), which can be used for fuel by sirtuins (not just sirt1). Not a very strong case with zero data to take more than 100-120mg. Remember he has been taking high dose a decade before he started NMN.

[@33Crazydude]

Wow, what a great video 💗

[@WellnessMessiah]

You're very kind, thank you!

[@33Crazydude]

@@WellnessMessiah ❤

[@KTPurdy]

excellent video

[@fwdolphin]

You are very thorough and so much so it made my head spin. I just wanna know how much to take for someone that weighs about 200 pounds.

[@carloscarion1748]

Pinot noir has the highest concentration of resveratrol. It has the hardest working grape. also muscadine grapes and açaí berries, as well as organic peanut butter, or boiled green peanut( a southern delicacy), and the common knot weed

[@havad3938]

Excellent analysis! Did they compare the mice, or people to those that did not take any reseveratrol? Perhaps im missing something. thanks

[@dontaylor8912]

I really liked this presentation, Rimon. You revealed plenty of useful info. David Sinclair has repeatedly stated that resveratrol is needed to fully activate NMN. He gives the analogy of accelerator and fuel. Low dose resveratrol is helpful for lowering insulin and glucose but is 50 to 120 mg enough to effectively activate NMN?

[@WellnessMessiah]

Hi Don resveratrol activates SIRT-1, not NMN. NMN should raise NAD+ (hopefully, inside the cell, not just the blood), which can be used for fuel by sirtuins (not just sirt1). Not a very strong case with zero data to take more than 100-120mg. Remember he has been taking high dose a decade before he started NMN.

[@murrmurr765]

​@@WellnessMessiahThe question is if 50/120mg is enough to create the synergistic effect between Resveratrol and NMN he mentions. What do you think about it?

[@gloriagolemboski4515]

You talk so fast. For me. So per weight how much resveratral and how much nmn. Where do I get it.

[@mikec5544]

QUESTION. What about Trans-Resveratrol? My reading seems to indicate that Bioactive Trans is more effective. So if we buy into this 30-100mg low dose resveratrol, how would this translate to the Trans version in terms of dosage?

[@V_Dgt]

Great reseach and video! Thnx So, now, the question is, what Sinclair's thoughts on low dose according to these data?

[@0906mlynek0906]

Hi, I don't know English, tell me is it better to take a little Resveratrol or a lot? weighing 90 kg? And is it better every day or every other day?

[@cityinthesky1341]

Dr. David Sinclair said that determining human dosage based on mouse dosage involves total surface area for the calculation. It is not a simple weight ratio formula.

[@VXingxu]

Hello Rimon. What do you think about cycling resveratrol at comparatively lower doses to help with longevity and insulin levels i.e. 300 mg? You did mention cycling was used in the mouse studies. Furthermore, I am wondering if the bioavailability of resveratrol is different for mice as compared to humans?

[@CamiloVergaVideos]

Thank you very much for the video and analysis! It is very interesting! But I think there is something very important that is not being mentioned. When doing the test tube studies with cells, sugar and resveratrol there are no problems with bioavailability. The question, in the case of humans, is how long a capsule or powder reaches the cells after passing through the intestines. Maby a dose close to a gram is necessary for some of it to reach the cells. Thank you very much and greetings from Buenos Aires.

[@WellnessMessiah]

Very interesting Camilo, great to meet you here.

[@CamiloVergaVideos]

@@WellnessMessiah Thank you very much Rimon. I'm stay tuned to all the videos you upload. A hug!!!

[@andreasmarx4427]

Yes, will depend on the condition and capacity of the small intestine to assimilate the RSV.

[@its1me1cal]

Every other day for mice so what’s the equivalent for humans? I’m sure as mice live much shorter lifespans, it wouldn’t be every other day for humans.

[@mieciuuu506]

Hey, how much resveratrol to take for a person who weighs 90 kg? is Japanese Knotweed Extract or Pure Trans-Resveratrol Better?

[@EmilioS.-bs7ld]

I have downloaded the 10 Resveratrol Habits, which give very practical tips for cycling and Hit&Run supplementation. So far I have been using micronised resveratrol for its higher bioavailability, which I believe is what Sinclair used in his published research from which you derived the intermittent cycling human dose of about 100mg every other day. However, the suppliers mentioned in your habits have plant-based, non-micronised resveratrol. Does your recommended dosage apply to both forms of resveratrol, or should it be adjusted for the micronised form, and if so, what would you recommend?

[@lventer165]

What about SALVESTEROL? Please tell me your thoughts on this

[@michelekurlan2580]

More interested in Ramon's protocol. How to get this?

[@pepeponcela]

Rimon, here's the problem: videos 45mn long are a non starter, particularly when you start talking about some study in rats from Sinclair... more than 15 years ago. Take a leaf from Brad Stanfield: if you can't condense someone else's research in less than 10mn, might as well read the paper. Sinclair: it still amazes me how much credit this guy has. He made a fortune on a resveratrol research that was not replicable in 2006... and ignores all thr research since then. Great stuff.

[@WellnessMessiah]

Well my style is different. It's awesome for the viewer: if a person has the mood for a 4-minute video, he has brad. and when you're in the mood for 40 in-depth education you have me. What I can tell you is that this in-depth style achieves real results in humans = my clients. I witnessed it. The devil is in the details. Even if they take 40 minutes :)

[@pepeponcela]

Fair enough! I guess what I was trying to say is: I like what you do (that's why I'm here!) but don't have the time for 40mn videos! Probably the sweet spot for people wth busy schedules is somewhere in between (eg 20mn). And less focus on what Sinclair does, he made a tremendous contribution to the field but he's not at the forefront and no longer well respected in the scientific community. There's great research coming out continuously in the longevity field!

[@alexk48]

Saying what people want to hear is very lucrative + will get one a lot of attention.

[@pastamandjinka]

@@pepeponcela How come he is not respected no longer...?! Pls specify .

[@saralakushwaha1180]

Thank you

[@rebeccaortman4764]

Rimon, how can I measure resveratrol when I bought it in bulk? I have measuring spoons 1/8, 1/16, 1/32 of a teaspoon. I don't have a sensitive scale. Any ideas? Thank you for doing the math on dosage according to our body weight.

[@msplateaugal]

I believe that ½ tsp is about 1 gram

[@dontaylor8912]

Buy an inexpensive digital scale that measures in grains and grams. I just measured out 500 mg of resveratrol powder and it is a very small amount compared to what I have been taking.

[@msplateaugal]

@@dontaylor8912 I did exactly this and concluded that ½ t was a close approximation to 1 gram

[@rebeccaortman4764]

@@msplateaugal thank you for that info on 1/2 tsp. in 1 gram.

[@rolandbrecher4265]

So what is considered as "low" dose resveratrol? Most of the Supplements have at least 500mg of resveratrol, is this considered as "high" dose? Should I avoid taking them?

[@semaaral2498]

Thanks, a lot for this informative podcast. Yes like you've heard me. I've read these results and was worrying a lot. So hard to find a spoon with 80_100 gr to calculate but find a way to calculate. The original spoon is 250 mg which comes with the powder from # donotage I think of your wife & sending my prayers. Looking forward to seeing you together again. She is young so with your super care will heal one day, hopefully.🙏🌹 Thanks for this video. Very useful🙏💙💯🙌

[@semaaral2498]

🙏🙏🙏😔

[@gz625]

It's too late for ya😂

[@semaaral2498]

💅🙏💙🙏💙

[@supercal333]

Just eyeball it. Precision is not required. The optimal dose is different for everyone anyway based on how well we absorb it. Don't get too hung up on it.

[@willowraine5514]

…or get a milligram scale…

[@dantwister5106]

I only care about resveratrol and quercetin because they increase the effects of caffeine. The idea is taking low dose caffeine every other day to prevent tolerance. What does caffeine do? It makes running and working out easier. Why working out? To be healthier and to live longer. Probably I will also need piperline (black pepper) to increase the bioavailability of resveratrol.

[@jackd9820]

Rimon, I am 71 years old and one of those seniors who exercises every day ... elliptical, resistance, swimming. Since taking Revesterol before exercise is not advised am I OK with taking it after exercise on each of the 5 days with a breakfast meal?

[@jackd9820]

Rimon, I assume I could do the same with metformin??

[@WellnessMessiah]

Hi Jack sorry for the later repones. Not medical/personaized advice - yes taking after should be fine - with meal. Meformin, it's in the system for 17 hours. It won't prevent exercise benefits, just muscle "growth". If you maintain muscle mass, like me, than you shouldn't be worried about it. Make more sense to take metformin i the evening, as exercise will burn sugar anyhow, and so metformin ill have 16 hours before exercise to do its magic

[@jstntowner11089]

What is your opinion on Resveratrol vs Trans-Resveratrol? Is one gonna make a difference over the other or is that just supplement manufacturers trying to market their products to sell more?

[@vapeking466]

I don't get why Trans-Pterostilbene hasn't replaced resveratrol. From my research its superior in absorption and nearly identical otherwise. Maybe I missed something or it hasn't been tested yet. I been taking 200mg daily for a year or more now.

[@josephshawa]

So what exactly are aging genes? How is it resveratrol stopping their expression specifically? Did I just miss it?

[@dude861]

I wouldn't consider red wine as "low dose Resveratrol". Considering the studies on mices etc as well as your interpretation you would consider the optimal dose roughly around 100 mg Resveratrol a day for fat/unhealthy people or every 2nd day for healthy, normal people. Red wine has roughly around 1mg per glass. So putting them into the same group does not make sense to me since it has FAR LESS Resveratrol than all the other studies (were i think the lowest doeses were around 33mg).

[@pjaworek6793]

Thank you, so much detailed information. I'm eyeballing for about 50mg every other day from a 600mg (50%) pill.

[@WellnessMessiah]

That's exactly what I do today, good catch!

[@bilbyguy2389]

A quick question; Is the low dose a daily dose or every second day? I think I heard Dr Stanfield saying he does not take it on the days he exercises. Do you have any info' in this regard. Thank you so much. This ride in like a Tom Cruise movie! But your video has more longevity 😄

[@WellnessMessiah]

Yes, this is episode 3. Deep dive as usual!

[@1fires1]

Isnt it about absorption rate? So a higher dose would at least somewhat guarantee the lower titration rate?

[@mysimon2003]

Can someone post a summary here 🙏

[@NeuroNate24]

so just to confirm we’re supposed to take resveratrol every other day? And we have to go based off of the calculation provided to us for our body weight?

[@NTMihaila]

Didn't you already make a video talking about how low-dose cycled resveratrol is ideal? Around 100 mg daily, a few days on, a few days off. I recall you talking about how low-dose resveratrol restores senescent cells.

[@WellnessMessiah]

Yes Nicholas, go to the community tab on my channel to see how inquired about integrating past videos into 4 episodes. the first 2 are based on published information, and the 2 after are completely new.

[@NTMihaila]

@@WellnessMessiah I, gotcha. And thank you for the response. :)

[@kesiamolina9927]

So how much is the intake?

[@fishnski9211]

Has anything been discussed on astaxanthin?

[@Steger13]

Can we buy resveratrol over the counter pr need doctor prescribes ?

[@tutubedo]

Available on line. My Walmart carries it as well (over the counter and about $1 a day).

[@say6837]

Is fasting and taking low dose resveratrol on the same day more effective than just fasting?

[@longevitylover6273]

The new video, i think episode 3, speaks about fasting and how resveratrol isn't necessary when we fast

[@raibalama]

I think the basic problem is sugar which is new for humans so get rid of sugar and all carbs in your diet and you do not need any compounds that reduce sugar in your body. I advise my patients who are obese to avoid 4 items: bread, rice, basta, and all sweets.

[@alexk48]

What about starchy veg? If one replaced bread with a potato at mealtime this would simply be a carb replacement.

[@eyeswideopen7777]

If they are blood type O .. yea. They get fat easily if they don't get physically active. Asians with B blood type don't put on weight

[@alexk48]

@@eyeswideopen7777 Asians put on visceral fat. They don't put on a lot of subcutaneous fat so they don't appear fat. India + China have the highest rate of Type 2 Diabetes and associated diseases in the world. They have for a very long time, well before the diabetes epidemic in the west. Check out old WHO reports. Also look at the more recent pictures of abdominal CT scans on seemingly normal weight Indians.

[@eyeswideopen7777]

@@alexk48 India and China have adopted alot of western food style cuisines into their diet. Pizza, coke etc

[@edouarddebonneuil149]

Isn't resveratrol is quasi not absorbed by the body? In the specific study, isn't it the control that is short lived? If large doses of resveratrol lead to a lower lifespan, isn't it because some is absorved? My questions might be naive, but I prefer to make sure we get things right

[@jonathonperino8681]

Whar about Berberine or the prescriptuin Metformin..

[@KenjohaMedia]

I say an interview with David I think it was one of the Lifespan videos or Huberman Podcast he said the calculation of mice weight and human is not 1 to 1 based on our weight differences it was actually lower. I don't remember the percentage he said to use I am not totally sure but I think it was 4 to 1

[@unboximage1292]

your best video, I think. LOL

[@reinerheiner1148]

I highly doubt that we can simply convert dosage from animals to humans, because absorption of resveratrol is very different between humans and animals. Thats why we see a lot of positive data from animal studies but the picture is a lot worse for human studies. So unless you account for the difference in bioavailability between humans and animals the conversion is plain and simple wrong.

[@levondarratt787]

It's even different from Human to human.

[@Skiskiski]

Thank you. I stopped taking resveratrol.

[@drunvert]

Remember, mice have a 6x metabolism. So every other day is EVERY 12 DAYS for humans. That's almost a two-week fast

[@katewright632]

Pterostilbene is a more bioavailable stilbene that is fat soluble and has a longer half life in the body. It is highest in blueberries but potent in supplements. Resveratrol needs a certain amount of black pepper with it to increase its half life. I'm not sure if it can change from water soluble to fat soluble.

[@wpmitra7251]

You sound like a native English speaker when I watch the video at 2X speed XD. Not kidding. Please try that once. On a serious note, I got the answer to something I've been wondering about for some time. Which is whether non alcoholic red wine gives the same benefits as the alcoholic one. Thank you for clearing that up. Knowing this is very important to me because I don't want to drink alcoholic beverages.

[@constantinepatsalos2243]

I love your channel ❤ But why we waisting time try to prove Dr Sinclair wrong?

[@WellnessMessiah]

It's more about taking the viewer through a research journey that can make a huge difference to their longevity over a lifelong habit. The viewer longevity here is in the center, not Sinclair, despite the marketing of this video.

[@JenP2776]

Cannonau grapes/wine from Sardinia has the highest level of resveratrol!

[@markpappas9858]

Is Trans- Resveratrol fine to take???

[@SPX3455]

The mice graph says +7% longevity on low dose reseveratrol compared to no resveratrol. I.e. +5 human years