RESVERATROL MYSTERY: Why Taking Too Much HURTS Your Longevity (ep. 2)

If you take resveratrol… did you know resveratrol works differently in your body depending on how much you take every day?
If you’re not careful about how you take resveratrol, you may achieve completely different benefits from the ones you intended!
I couldn’t believe it either until I saw it too. And it is one of resveratrol’s biggest secrets.
And it’s kept within its polyphenol family. Which includes fisetin, quercetin, pterostilbene, and others.
Today, we’ll hear Dr. David Sinclair explaining a mechanism that helps to stay younger for much longer. This mechanism is critical to deciphering how resveratrol works and what it does inside our bodies.
You will clearly see what these powerful molecules do to our bodies and even to our DNA after we take them.
We’ll answer the following questions:
1. If, in Sinclair’s study, the small dose resveratrol lived longer in both groups,why this sudden change of impact when going to high resveratrol?
2. What does resveratrol do to cancer cells?
Is resveratrol a good supplement to kill cancer?
Let’s continue with our investigation.
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Episode 1: • RESVERATROL & David Si...
Episode 3: • EXERCISE, Resveratrol ...
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Study References:
I'm working on a website to include each video with all links, with each page per video.
In the meantime, I ALWAYS show the exact study titles & years and read them aloud. Go to GoogleScholar.com, put the first 4 words only, and the study will come out as the top search, guaranteed. Please double-check me!
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Credits: Scott Buckley
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.

[@WellnessMessiah]

✅ Check the special deal of habits creation app + my routine for longevity: wellnessmessiah.com/app Disclaimer: I'm an affiliate of the company - I trust their product. Buying will support my channel Watch episode 3: kzbin.info/www/bejne/fnSZYnqdatGDepY P.s. Ironically, after 8 years I've just replaced my old laptop. This video was an honorable retirement party to an old 2015 friend. It's still alive though, supporting the longevity theory :)

[@georgechristoforou991]

What I understood from the research paper is that low dose resveratrol protects mice that eat a fatty diet. What I also understood with alternate fasting is that fasting activates the longevity genes and the resveratol protects against the mouse on the effect of feasting on the non fasting day. So, the mouse gets an extra bit of longevity on the eating day compared to mice not taking resveratrol on feasting day. What do you think? Is my thinking correct?

[@rashadsmith6624]

I think all of this is one part of aging you should look into TA65 Telomere activators the extension of Telomere caps Reverses aging

[@WellnessMessiah]

@@georgechristoforou991 Hi George I explain this exactly in episode 3. It's a very smart idea that you had!

[@kenergyinter]

Great Video,I am 50. I now understand why Dr. David Sinclair is taking resveratrol 1 gram daily, I too will start to take a gram a day in every other days. alone with Quercetin or Fisetn

[@akhileshp6419]

@@WellnessMessiah Hi Rimon, At 36:45 Regarding the link between high dose resveratrol and senescence. How does high dose leading to increased senescent cells make sense? Doesn't high dose resveratrol mimics a high stress scenario, leading to apoptosis? This explains why cancer cells die at high dose. Shouldn't this also mean that senescent cells die via apoptosis as well, since they are damaged/sub-optimal cells? Thanks

[@larsnystrom6698]

I think it's very simple: Reservatrol is a stressor! A little stress activates the cells response a little more than necessary. And this is the beneficial effect. But too much stress is harmful. Many poisons have this effect. So does other stressors, like heat and cold. Vegetables contains many poisons. But we know which vegetables stresses us just enough. In a way, exercise is also a stressor...

[@WellnessMessiah]

Yes, it stresses without causing damage, just perfect. And low dose doesn't stress us financially haah. You're right about vegetable toxins, too.

[@thehungergames8918]

This is called Hormesis 🙋‍♂️💁🏻😮

[@crimzdad]

Take resveratrol at your own risk is what I tske. Just my opinion.

[@davidtempest7175]

Move over Dr. Brad......this channel is now number one for unbiased detailed analysis.

[@WellnessMessiah]

You're very kind. Well, I try to compliment his videos by expansion

[@davidtempest7175]

@@WellnessMessiah dr Brad posted today stating resveratrol is basically toxic . Would love to hear your response to it

[@WellnessMessiah]

@@davidtempest7175 Check episode 1 which we cover the impact on our DNA and decide for yourself, High dose could be toxic to cells as I showed. Has Brad delved into the details of the dosage and how it changes resveratrol activity? This is episode 1 btw: kzbin.info/www/bejne/e16ldqBpgdyif9U

[@irenegardiner6857]

Thanks for putting this together Rimon. You put a lot of work into it.

[@WellnessMessiah]

You're too kind Irene

[@mikegatesyoutubb]

This video provides an INCREDIBLY helpful and cogent explanation of data on resveratrol’s effects and the mechanisms behind it, relying on numerous recent studies on the topic. Best out there; awesome!

[@WellnessMessiah]

You're too kind Michael

[@felicisimomalinao1981]

Much thanks Rimon for the meticulous research. Looking forward to epi 3.

[@WellnessMessiah]

You're very kind! thank you

[@Grythpyke]

I'm so grateful that Rimon takes the time to dig down into the research that would be beyond my ability and time. So well presented and balanced

[@WellnessMessiah]

Thank you Chris, great to see you here

[@gianpaolocosentino]

many of your videos are true masterpieces....finally someone who really studies scientific studies...thanks!

[@stephaniejohnson1450]

I absolutely love the way you break down and compare different data and opinions. Watched several of your videos and this has helped me sort through why there's conflicting studies and information. Can you do something like this for NMN?

[@lindaallen2412]

WOW, I just feel I have been to college, my brain hurts but in a good way, thank you so much for explaining all this in a way I can understand, this has to be one of the best and most comprehensive video, this is so important it really needs to be out there, thank you

[@WellnessMessiah]

Thank you Linda, you're awesome. If you like it, I will make sure episode 3 will take you on a similar journey, if that's possible.

[@lindaallen2412]

Yes would be great, definitely up for it learning so much

[@jgs9911]

Another excellent video. Looking forward to #3. Thank you

[@WellnessMessiah]

You're very kind, thank you

[@ConnieWobbles]

I posted an earlier question and then I realised you'd actually answered it in the video. The perils of trying to absorb science stuff whilst multi tasking. Anyhow, fantastic info as always and I'm adjusting my protocols accordingly.

[@WellnessMessiah]

Great to see you again, lots of love

[@adrgoo]

So Dr Sinclair is taking correct dose for his Age, great confirmation thanks for all the time you put into this

[@martinesantos6846]

Enfin une explication claire, merci pour votre travail😀

[@tobiaskevorkazito4072]

That was a tremendous presentation 🥊

[@WellnessMessiah]

Thank youTobias you're awesome :)

[@ccamire]

Thanks for the info. I expect to continue to drink my red wine without any stress.

[@joannsmith9]

Rimon I thank God for your wonderful brain and ability to explain extremely complicated things in a way lay people can understand THANK YOU!!!!!!!!

[@WellnessMessiah]

So nice of you Jo Ann, hope to hear from you again in the future 🙏

[@TheGeneticHouse]

Your analogies are great! Thanks for the video man a lot of good information very pertinent to my right now in life :-)

[@WellnessMessiah]

Thank you and happy new year, full of youth and love

[@pjaworek6793]

Love it, thanks! I'm eyeballing 50-100mg resveratrol every other day, 500mg quercetin on the alternate days, was taking 200mg fisetin once month but after this episode, I think I'll change that to quarterly until maybe my mid fifties, I'm now 47.

[@WellnessMessiah]

Yes makes sense. Though, I would be careful with quercetin, I believe I talk about why in episode 4.

[@mike.999]

Your Longevity Reports are THE BEST. Tnx 😁

[@WellnessMessiah]

You're very kind Mikael!

[@andreastchuente1643]

Thanks for your expertise and dedication. God bless you.

[@WellnessMessiah]

So nice of you Andreas, hope to hear from you again in the future 🙏

[@soniahaydee868]

Wow 👍❗️thank you for such and important information ❗️👍

[@Always-xl9db]

Your channel is so underrated! 😊👍

[@WellnessMessiah]

Thank you A T you're awesome :)

[@danielblanco8519]

Gracias por Toda ESTA informacion que lograste reunir y simplicar para El entendimiento de todos.😀

[@WellnessMessiah]

Gracias Daniel

[@azadehkhajeheian9430]

Great video , thank you Rimon. I hope your wife is doing better 💕

[@WellnessMessiah]

Thank you Azadeh

[@henvest3491]

I take fiestin 2 days per week , quercetin, resveatrol and pterostilbene 3 days per week. I had a full blood test. I was very happy with my results especially cholesterol. Only out of scope markers were shbg and testosterone both very high but had a normal free testosterone level. Doctor couldn't explain it and was surprised at my supplements....

[@estellar.367]

do you still ake them and which mg or mcg?

[@oolala53]

I am going to start asking on all of your videos that I come across to. Please share with us the protocol you used to put on so much muscle in just four weeks. I know it might not work for an older person but I’ve been eating a lot of protein over the last year and a half and I want to cut back on it. But I lost a lot of muscle over the last 10 years and I feel like I need to push to get some of it back before I Curtale my protein intake and concentrate more on maintenance.

[@christopherellis2663]

Thank you for your work 🙏

[@WellnessMessiah]

Good to see you Christopher

[@davidzeal8915]

Dear Rimon, I would like to express my heartfelt appreciation for your wonderful and informative video. For over a year now, I have been taking 1g of resveratrol per day, being in my early forties and with a history of heart disease. Although I am unsure whether I have any tumors or cancer, I believe that I do not. After watching your insightful video, I find myself in a dilemma whether to alter my resveratrol dosages or not. I would appreciate any recommendations you may have on this matter. Once again, thank you for sharing your valuable insights.

[@WellnessMessiah]

So nice of you David, hope to hear from you again in the future 🙏The medical situation you're at prevents me from directly giving an advice (the laws where I live prevent that - believe me if I could I would). The recommendation at the end of episode 2 are for most healthy people, but people vary. I take 50 mg 3 times a week.

[@davidzeal8915]

@@WellnessMessiah Hi Rimon, thank you very much for your reply. I fully appreciate your position regarding the provision of medical advice. Nonetheless, the insights you have shared are exceedingly valuable to me.

[@TPMaverick2022]

Great content. Thank you 🙏

[@WellnessMessiah]

So nice of you TP, hope to hear from you again in the future 🙏

[@antoniozisa]

Thanks so much for this additional video, you are making our life much easier. I have a question though: if resveratrol represents also a fasting mimicking tecnique, why fasting is good both on killing cancer cells and extending lifespan while resveratrol can do either of the effects?

[@WellnessMessiah]

Hi Antoion, resveratrol only mimics part of fasting effect. Fasting reduces mTOR which targets cancer. Resveratrol can't do that.

[@emil8367]

Thanks for informative video. Good to do an interview with some other specialist in this matter, to make sure about your investigation, I think it is important to confirm, to not overlook anything. Also, worth to analyse the absorption, which you didn't mention. Maybe it's important when you consider low dose 🙂

[@WellnessMessiah]

Yes, absorption in epidose 3. I want to have Sinclair one day and others.

[@MixtrisUFOimages]

very informative. thanks

[@WellnessMessiah]

You're very kind!

[@geraldk1445]

Great episode!... Would love to hear your comments on the latest Modern Healthspan channel episode where Dr. M. Zemel talks about SIRT1 activation with regards to leucine, resveratrol (low dose 100mg) and NMN. Is it consistent with the findings of your current model?

[@WellnessMessiah]

Good question. If this is the study, from 2012, from a quick look, they took a small group of mice, not humans (10 each group). They were obese (not like our healthy community), and gave resveratrol for 6 weeks. It tells so little about longevity, and it's only a short-term mechanistic study on obese mice of specific strain that may only measure short-term effect. similar to my muscle growth experiment. ncbi.nlm.nih.gov/pmc/articles/PMC3506499 "At the end of the treatment period (6 weeks) all animals were humanely euthanized" *I couldn't find the human study* send it to me. Leucine itself is anti-longevity but helps with recovery from intense exercise or muscle growth. I've used it to grow 8 pounds of muscles in 4 weeks (Check the intro video in my channel). I took about 3 grams a day. 1.1 grams... not that high. By the way, it's the first time in my life I had a spurt of white hair, proving the point. I find it difficult to believe that leucine can have a longevity effect when combined with another supplement, but I'm open to it. The only interaction I can imagine between Res. and Leu is that Res may counteract the aging effect of leucine. Send me the study if you find it.

[@AshtasticAcrobat]

This makes sense. Just like any other vitamin such as A or iron etc, at certain doses are beneficial but at higher doses become toxic.

[@birgittadevlin4206]

Thank you Rimon. Dosage is complicated by differing purities/concentrations as well as micronisation and liposomal preparations. Do the two latter really increase absorption and must be taken into account?

[@WellnessMessiah]

Yes, they could. But product quality matter and low-quality liposomal (which is very likely, as liposome are super expensive), may be equal to regular resveratrol.

[@arsononemwv]

Amazing show! What is considered a low dose of res ?

[@AlbertWeskerr_]

Entonce lo ideal es tomar resveratrol 3 o 4 veces por semana maximo y mejor si es los dias que no hacemos ejercicios?

[@davidgifford8112]

Initially it seemed that taking a senolytic daily in moderate doses didn’t make much sense to me, however many people seemed to be doing just that. I finally came to the conclusion that they know something I didn’t, but it seems from the studies you site, they don’t after all and the daily dose recommendations on most senolytic supplement labels should be ignored, which to be honest I always had.

[@WellnessMessiah]

Hi David you had the right intuition.

[@anetteccarlstrom4528]

Thank You for a great Channel! I just didnt understand the dose if we are a healthy Woman over 60. I really tried to follow your advice in video but not clear. I understand low dose, is it every day? Thank You for clarification! ✨

[@marklucas1898]

VIdeo says 50-60 mgs for thin/small people every other day (or skip 3 days a week). For larger people 60-120 mgs every other day.

[@anetteccarlstrom4528]

@@marklucas1898 Thank You!

[@demkal336]

So, from 50 years old and on perhaps an effective strategy would be: low-dose resveratrol+ polyphenol complex (i.e., red wine consumption) daily, punctuated every few months with several weeks of supplemental high-dose resveratrol.

[@cococgb5389]

That’s an interesting thought!! 💪

[@WellnessMessiah]

Hi Dem episode 3 is about timing. Episode 4 is about synergetic effect (including poly complex) :)

[@OgimaPotawatomi]

very good

[@milagrosroman9978]

i have diabetics and am off the pills, I have it under control through fasting and diet, can i take this pill?

[@chch6171]

Very interesting. I’ve watched this 3 times trying to understand it. 25:42 animals with healthy and younger body but with tumors? Wouldn’t a body with tumors be considered as unhealthy?

[@edenposh1890]

thanks fort the video. however I did not understand our statement at the end of the video...if you were old ypu ''would take every quarter for one day''???'what does it mean? high dose per day?

[@WellnessMessiah]

Yes. one day very high dose. It is still arguable if we need 2-3 days consecutively or just 1 day. 1 day works, 2 days may be working better.

[@thehungergames8918]

I am a bit confused 🥴

[@larsnystrom6698]

I wonder if daily Resveratrol supplement really is the way to go. I would like to know if intermittent higher doses, say once a week, wouldn't be better. By "higher doses", I mean 0.6 -- 1 g. Although, how can we translate once a week for humans into mouse times. Perhaps once a day for them? By low doses, I consider what we get from plants to be about the right ones. But that's just intuition...

[@WellnessMessiah]

Hi Lars I got your question nailed in episode 3 :)

[@mattcummings6131]

When I reread David Sinclairs' book, I had the impression that mice obsorb resveratrol differently than people do. I took it as maybe they have better bioavailability than us, so a weight conversion formula between us and mice might not be accurate.

[@WellnessMessiah]

Hi Matt, it makes little sense as resveratrol is absorbed via diffusion through the gut - they have the same gut tissues as ours. In addition, fatty meals increase absorption both in mice and humans, suggesting similarities. I read sinclair's book, and didn't remember that really. Do you have a page number?

[@NightFlight1973]

@@WellnessMessiah Lifespan - Pg 245/858 also footnote 36 is relevant. "As it turned out, resveratrol wasn’t very potent and wasn’t very soluble in the human gut, two attributes that most medicines need to be effective at treating diseases." Missing is any citation from where that conclusion came from.

[@gloriagolemboski4515]

What is low and how many days a week should we take it.

[@lja961953]

Thank you for excellent videos, I have just started taking 300mg of Resveratrol + Pterostilbene, 70 years old, any thoughts, keep up the good work !!!

[@WellnessMessiah]

Nice to meet you Lynton. My thoughts are basically what I do personally, at the end of this video around minute 40-42

[@georgekozub9803]

Let's hear more about human studies, please!

[@WellnessMessiah]

Hi George, I covered human studies in episode 1: kzbin.info/www/bejne/e16ldqBpgdyif9U

[@renatabarros1065]

Im a nutritionist from Rio de Janeiro. ❤

[@supercal333]

At 32:00 the 2022 study also says low dose Resveretrol can induce autophagy of senescent macrophages as well as promote cell viability and proliferation. These appear to be opposite effects. The effect on senescent macrophages is contrary to the point you are making. Can you comment on this please?

[@paulkabrna345]

Very good analysis Rimon - thank you Where do you think this leaves us with taking Resveratrol together with NMN. Perhaps going too low may partly negate the perceived benefits of NMN. (Currently I choose to take 500mg of NMN with 256mg of Resveratrol per day being 70 years old :) )

[@WellnessMessiah]

Hi Paul, even though they may have slight synergetic effect (res makes sirt1 move faster, NMN feeds ALL sirtuins not just one), I wouldn't change the dose when combining them. If anything, I will take more fuel (NMN), not more acceleration (RES)

[@heimihenderson4543]

I’m confused now. I’m 56 and currently take 1g resveratrol and 1g NMN each day. Is this too much?

[@tomson11]

When you say high dose or low dose do you mean the overall intake over a long period of time or does the singular dose matter as well? In other words, if I take 200mg once a week do I still reap the same benefits as taking 50mg every other day?

[@WellnessMessiah]

I tomson, no. not the same benefits. I get into cycling deeply on episode 3 (e.g. taking a few times a week)

[@robertferguson7800]

I have been taking a teaspoon every morning Can’t say I feel any different But I am now confused on taking it at all I have been taking it for about 1 year but can’t say my health has improved I do have osteoarthritis/ rheumatoid arthritis Hurt in the joints and have had both knees and a shoulder replaced My other shoulder and hip are going on me Both give me constant pain LOVE SOME ADVICE THANKA

[@ivanschouten9382]

Can you explain the synergy Leucine with Resveratro and NMN.Also can you find out how much synergy or how less you need of Resveratro and NMN when combined with Leucine (and how much Leucine to take for ideal synergy)

[@WellnessMessiah]

Hi Ivan I'm posting a response i gave to similar question that you asked: If this is the study (leucine + 100mg resveratrol), from 2012, from a quick look, they took a small group of mice, not humans (10 each group). They were obese (not like our healthy community), and gave resveratrol for 6 weeks. It tells so little about longevity, and it's only a short-term mechanistic study on obese mice of specific strain that may only measure short-term effect. similar to my muscle growth experiment. ncbi.nlm.nih.gov/pmc/articles/PMC3506499 "At the end of the treatment period (6 weeks) all animals were humanely euthanized" I couldn't find the human study send it to me. Leucine itself is anti-longevity but helps with recovery from intense exercise or muscle growth. I've used it to grow 8 pounds of muscles in 4 weeks (Check the intro video in my channel). I took about 3 grams a day. 1.1 grams... not that high. By the way, it's the first time in my life I had a spurt of white hair, proving the point. I find it difficult to believe that leucine can have a longevity effect when combined with another supplement, but I'm open to it. The only interaction I can imagine between Res. and Leu is that Res may counteract the aging effect of leucine. Send me the study if you find it.

[@ivanschouten9382]

@@WellnessMessiah Professor Michael Zemel has studied it. But one source is no source. So hoped to find more support for this idea.

[@ivanschouten9382]

kzbin.info/www/bejne/fKvPaXlqjLaZitU

[@waynewells2862]

Your ananolgy of a Republic as representation for our cellular collective is good, however what may be keeping the cells cooperating to the goals of the human or animal may have more to do with the state of bio-electric fields that surround all our cells. I would urge everyone to review the work of Prof. Michael Levin of Tufts University. It would be fascinating to see the effects or rather the relationship of various supplements on cellular bio-electric fields.

[@nick711ful]

Take that, don't take that. Take the other, don't take the other. Take less, take more. It makes sense. It doesn't make sense. Do yourselves a favour and save your hard earned money. Enjoy your life and do what makes you happy. A short, happy life is much better than a long, miserable one.

[@nanohatakamachi1066]

You don't say? One can only bet living a long happy life. Life is risky. I bet.

[@jefftezos]

Do you have any videos that cover Apegenin?

[@harj5338]

Perhaps due to resveratrol low bio-availability, Dr Sinclairs protocol of 1 gram / day could actually be a low dose?

[@Chaotic313]

Are you suggesting the studies indicate that an older adult, I'll be sixty in about a week, would be better off taking the larger dose of resveratrol? You mentioned you would reconsider your dose when you reached fifty. I have been pulsing 1 gram every other day for about six months. And thank you so much for your amazing videos!!!💗

[@antonystringfellow5152]

Resveratrol is not the best senolytic. On the contrary, as explained in this video (39:20), a higher dose (such as the one you're taking) will actually increase the number of senolytic cells. Not good! By far, the most effective senolytic known is Rapamycin. However this is not easy to obtain and is extremely expensive. The most effective natural senolytic known is Grape Seed Extract. Not as well studied as the polyphenols mentioned in the video though, so maybe too early to be sure it's as safe. Next up are Quercetin and Fisetin. Though they're about neck and neck in terms of efficacy, there's reason to belive that Fisetin may be the safest of the two. As also mentioned in this video (44:40), an acute regimen (hit and run) seems to be the most effective. This involves taking a large dose, repeating this after 24 hours, then after 2 months. This could then be repeated over a longer time scale, maybe once per year, for example. The Mayo Clinic are currently running this trial on healthy humans, though it could be years before they publish the results (hoping it'll be sooner).

[@udenss]

​@@antonystringfellow5152 but what about cancer prevention in 60+ group? High dose may be more beneficial, right?

[@branjay3588]

​@@antonystringfellow5152 so in your opinion, high dose for cancer but terrible for senolytics? What credentials do you have or what studies do you have to prove this? Don't think I am attacking you. Thank you for your input

[@WellnessMessiah]

Hi not personalized/medical advice.- I think resveratrol has a place in cancer prevention when taking let's say one day a month in high doses or three dose every 2-3 months. Cancer risk really increases after age 60. The rest of time - low dose only.

[@wilsont1010]

What is the purpose of taking this?

[@BryanDalleStelleOfficial]

Hey Rimon, are you taking NAC as well? If so, how much?

[@WellnessMessiah]

No I don't, but it's a solid supplement for glutathione production.

[@create-a-state]

I have some 170mg resveratrol capsules. Do you think these will be OK for me to take twice a week? Noticed this was close to the 200-500mg medium dosage

[@WellnessMessiah]

Hi Tim in my opinion a bit risky, I would open an pour half into my sauce (personally, I also put in half a glass of red wine, not more than half). The timing matters too, see that in tomorrow's episode

[@create-a-state]

@Wellness Messiah with Rimon That's great, thanks for taking the time to reply Rimon 👍

[@Leo-wo4rx]

The amount you take for resveratrol, is that resveratrol or trans resveratrol? Because I have seen 500mg resveratrol which provides 120mg trans resveratrol. So which one should I consider, the 500mg or the 120mg trans for dosage?

[@marilouentrolizo3533]

I watch Dr DC video,he is taking 1000mg😊

Not clear if it is good to take low dosage, or is better to prevent cancer at high dosage??

[@WellnessMessiah]

Hi Pedro, tomorrow video (episode 3) go the end where I do an analysis of high dose vs low dose.

[@irenadurakic-edwards9577]

So how much resveratrol dhould fake person age 56?Should i be kklling my all cells with high dose resveratrol just because my cancer risk is higher or ..?

[@FortuneCookieLies]

The fail rate of cells after dying to another state that ages is substiantial When you look at cells with a 99.9% effective rating at maturity, you take 10 cell spreads and that is 95%^10 power and you get a less than 60% survival rating. Low doses likely lengthen the cell transformation through cell repair delaying the future fail rate because it will signal to repair the cells instead of destroying them and adding an exponent to the fail rate. This is also likely why high doses cause problems and a lower lifespan. The cells basically have a high reproduction rate due to a large enough signal to die and so the cell turnover rate is what causes the lower lifespan in it due to how the signal works in the cell.

[@WellnessMessiah]

I agree with you. You're very smart.

[@swim610]

Is there a difference between trans reseverstrol vs regular?

[@robertferguson7800]

So how much should I at 72 should be taking

[@Arbarano]

Could a quartery high dose of reseveratrol during a few days help killing cancer cells?

[@sabrinaperry7744]

How much do you take if you have cancer

[@andreamazzaferro5168]

ok great - what s a low dose the n?

[@sabrinaperry7744]

What is the dose for cancer

[@markvoelker6620]

So resveratrol in high doses induces cells to kill themselves by activating the apoptosis program, by creating a signal that causes the cells to think they have been heavily damaged and therefore need to be killed and removed instead of repaired. Okay. But then, why would taking high doses of resveratrol (for example, 5 grams once each day for two consecutive days) preferentially cause cancer cells to commit suicide, compared to healthy cells committing suicide? Do cancer cells have a lower threshold for activating the apoptosis suicide program than non-cancerous cells? A few years ago I participated in a clinical trial designed to evaluate the efficacy of the senolytic combination of quercetin and dasatinib at preferentially killing senescent cells. The dose I took was 0.5g dasatinib + 5.0g quercetin, once. After three such dosing regimens, spaced 6 months apart, the osteoarthritis in my knees disappeared. Perhaps the optimal way to use resveratrol and other similar compounds, is to take low doses daily or every other day, and every once in a while, take a high dose prophylactically to clear out cancerous and/or senescent cells. Here I would say a low dose is about 250mg and a high dose is 5g.

[@williamx0]

So I’m eating 100grams of blueberries per day which equals 5mg of resveratrol daily. Should I still supplement with resveratrol cuz 5mg daily is too little if I want to target longevity?

[@WellnessMessiah]

In my opinion there is a bit larger benefit in slightly higher. Are you sure blueberries are 5% resveratrol? sounds high as most of it is water

[@williamx0]

@@WellnessMessiah Thanks a lot for your response. Sorry, I meant to communicate 1g of blueberries as having 0.005% of resveratrol. So 1gram of blueberries would give 5 milligrams. I also really appreciate that you bridged the controversy between Dr. David Sinclair and Dr Brad Standfield, that's very helpful to understand the nuanced differences

[@lionick8]

Good job, but I'm still not convinced. Why such a respected scientist like Sinclair is wrong about the dosage?

[@nickwit21]

After watching this several times, I cant help but wonder if the anti apoptopic nature of Low dose Resviristrol is actually a safety signal. Is there any data to suggest that it wouldn't increase overall cancer risk? The studies seem to suggest that you may actually encourage cancer cell growth if there is an underlying disorder

[@PatriciaMiranda-dg5pq]

I'm with u on this. Maybe this is why Dr. Sinclair keeps a high dose. Do we want to promote a cancer cell to grow? No!! It makes more sense to me to keep the high dose every other day.

[@YouTubeViewerHandle]

I’m around 6ft and 143 pounds. What dosage would you recommend at this size?

[@marklucas1898]

weight is important... you will fall in the small category of 50--60 mgs. Certainly not more than 80 mgs... have fun getting those doses.

[@YouTubeViewerHandle]

@@marklucas1898 I have 100mg capsules currently. I guess I’ll have to start cutting them in half…

[@YouTubeViewerHandle]

@@marklucas1898 Thanks for the info!

[@ttttia4734]

I love your videos! I'm 53 and 170lbs. I think it's time for me to try to kill some senescent cells. How much resveratrol do you think I should take. Also you mention taking something every quarter after you turn 50 - what were you meaning? Thank you for your work!

[@WellnessMessiah]

Hi if you noticed, senescent sense becomes an issue really after age 60. It may be too early to target them unless proven existence.

[@pavanlulla]

Ok so combine low with occasional high dose?

[@WellnessMessiah]

Hi Pevan depends on your age. I don't, I'm 36. I speak more about it in episode 3. when to use which dose

[@levinelson3508]

The question I have does low dose resveritrol help cancer grow by stopping the body’s inhibitory process?

[@marklucas1898]

Large doses to stop cancer... small doses not so much... more for longevity.

[@WellnessMessiah]

What Mark said. I speak more about it in episode 3. when to use which dose.

[@docflyer4001]

Can you please place references for your research studies you quote? No I idea who is publishing these studies by your video.

[@darlingwolf21]

You frequently reference 'low dose' and 'high dose' - does low dose constitute 500mg and less? High dose, above 500mg?

[@moiLawUk]

Really enjoy your videos.anything on spermidine and Apple cider vinegar? Liked and subscribed

[@WellnessMessiah]

Hi Moi, there is little research on spermidine so I don't take it until more data is available.

[@moiLawUk]

@@WellnessMessiah thank you, how about Apple cider vinegar ?

[@mieciuuu506]

So how better to take this Resveratrol every day or what? and what dose is best?

[@eyeswideopen7777]

Depends on your weight

[@mieciuuu506]

@@eyeswideopen7777 I weigh about 93 kg, how much and how should I take it?

[@eyeswideopen7777]

@@mieciuuu506 they sell 500-1000 mg doses typically in bottles. If you scrolled down comments in many videos, you'll find what ppl are experiencing. There's someone saying here who took 500 mg everyday until he found he was having blood in his stools. A few ppl will have bad reactions. I personally think 500mg to 1000 mg intake is lethal as daily doses. People want results fast esp the guys. To be really safe and to help your body acclimatise, there was a comment here that said 50-60 mg is recommended when taking it with other aminos for a better synergistic effect on an empty stomach early the morning. If you buy the capsules, you can open it up and release abit to be weighed on a little microdose scale device. Then keep the rest of the powder inside the remaining capsule and use it the next few days. Do what you think is the right amount. If you are sensitive to aminos or easily stimulated by a small intake, then 50-60mg is good if you mixing it with four other aminos

[@mieciuuu506]

@@eyeswideopen7777 Sinclair in his book supports this bandit and genocide Bill Gates and this shit worth the vaccine, for me Sinklair is suspect Man

[@maltetriermrch1757]

What is a low dose? I take 500mg a day. Is that too much? Should I take that every other day?

[@georgechristoforou991]

22:41 You say you would never take low dose resveratrol if you had an active tumor. But didn't the research state there was no inhibition of cancer cells not that it induced an increase in cancer?

[@WellnessMessiah]

a study I referred to with metformin. They actually showed (I didn't want to scare people off) that active tumor can help cancer survive but high dose kill it. Plus the 2008 study showed low dose rev with abundance of tumors (but a young body!), which fits in the big picture that low dose resveratrol helps cells survive and live longer. besides, if you have tumor, and low dose doesn't help for sure, why take it? there is no upside there.

[@laurentiurudeanu4102]

Interesting information, but hasn't this same topic on low/high resveratrol dose been covered in other videos in the past?

[@kenswanston820]

71 yrs 6'4" 220lbs with a CAC scan of +1000 and a GP who wants me on statins. Recently started daily taking K2/MK7 (300mcg) with D3 X3 (25mcg/1000IU) instead and NOW's Resveratrol (200mg) along with LOTS of other OTC supplements. I currently have no sign of cancer but Dad (not sure what type) and a brother (who had Large B-cell Non-Hodgkins lymphoma - survived!) had it. Should I take 1 gram sequentially (i.e. every day for a week once a month)...or? Not taking NMN, but should I? Any other health/longevity suggestions for a semi-active old fart would be MUCH appreciated! Thank you for the great info!

[@dianamayfield5615]

Tally Health, one of Sinclair's companies is offering a supplement with the following - CAK 1000 mg, Resveratrol 500 mg, Quercetin 500 mg, Fisetin 100 mg, and Spermidine 900 mcg... Note there is no NR or NMN...

[@stevec7777]

I had thyroid cancer 18 months ago. They took half my thyroid out and I'm on thyroxine. They say the cancer has now 'gone'. But it's leaving wondering if nmn and resveratrol (that I've bought since but haven't yet started) is right for me. Should I consider myself as someone without cancer, OR should I be careful that some small cancer might exist and these supplements may aid their growth. I want to get started but I'm unsure what's best. (My Dr's don't want to advise on anything like rtrol or nmn or similar.

[@stevec7777]

I'm 55 and otherwise feel very fit and healthy

[@WellnessMessiah]

Hi Steve, The medical situation you're in prevents me from directly giving advice (the laws where I live prevent that - believe me if I could I would). The recommendation at the end of episode 2 is for most healthy people, but people vary. I take 50 mg 3 times a week.

[@stevec7777]

Thanks for reply Rimon. Yes, tough to get a chat with anyone worthwhile so ironically, while rules are trying to protect me, the rules leave me guessing with no direction. Resveratrol I also read in studies is considered a goitrogen and thyroid disruptor so that gives further hesitancy. I can't see context to these statements with regard to what dosage and over what time line..... a lot of the writing is very lazy and misleading. I've given the nmn away for now (costly). I still have pterostilbene and berberine and tmg but haven't started any of those.... im just on more standard stuff as my lipids and hba1c were a little high (ala 600mg, tumeric, omega 3) and I've cut out sugar and reduced food quantity and calorie down... I don't drink (hardly) or smoke anyway and I train 5x p week..... becuz I'm fit my Dr's dismiss the prediabetes and lipids saying my profile doesn't give them anything to worry about.... I said "OK, I'm pleased you are not worried, but what about me? Should I be worried!!?!" Frustrating. Id travel and pay to see someone but I've read and seen so much recently that it's clear so many so called docs and pros are simply not good (and hence a danger).... any way, thank you again for writing, and best wishes for your wife's well being

[@farmerjohn6526]

Well, if less is best, maybe none is better.

[@theancientsancients1769]

This explains why I often get palpitations when I take at around 500 mg I tolerate 100mg the best

[@WellnessMessiah]

Interesting stuff, you're not thee first to say that!

[@theancientsancients1769]

@@WellnessMessiah High dose means not the best always . The first time I heard lower level of Resveratrol was around 2008. I think things like NMN people take too much too and other things unfortunately. I get similar palpitation effects above 500mg. NR at 300mg I tolerate much better. I always thought smaller doses in synergy work better for supplements and from blood test it was evident as some affected liver enzymes etc

[@WellnessMessiah]

@@theancientsancients1769 Palpitation suggests stress response from your body = your body doesn't like it. I would trust your body, it has some inside information with double meaning.

[@davidboyle1193]

I take 1 gram per day , is that to much

[@badhairballer23]

Next time be aware and please mention which of the studies have been in vivo and which in vitro, for it makes a big difference!!!! in the interpretation of the findings.

[@marktapley7571]

Cancer is caused by a deficiency of vitamin B17. Cancer cells are just regular cells that remain juvenile (indeterminate) and fail to mature into a specific (determinant) type. Cancer therefore is a metabolic disease and cannot be cured by chemotherapy, radiation or surgery except only ap. 4% of types (childhood leukemia). Animals and humans who consistently maintain adequate levels of B17 in the diet did not get any form of cancer. All forms of cancer involve the same process. Read G.Edward Griffin’s book “World Without Cancer."

[@flawlesscomplex]

I wonder if anyone here has experienced the side effect. I was taking resveratrol, then direaha happened, and then the doctor found blood in my stool. After many scans, they found nothing wrong but it was the supplment. My stool returned to normal after I stopped taking this supplement. After a few months, I thought I tried to retake a resveratrol supplement, and the same thing happened!

[@eyeswideopen7777]

1 gram dosage?

[@flawlesscomplex]

@@eyeswideopen7777 1000mg pure form from DoNotAge. Never again!

[@eyeswideopen7777]

@@flawlesscomplex that's way too much. It should be at most 200 mg. As a standard but it is recommended 50 mg as mentioned in a comment here.

[@flawlesscomplex]

@@eyeswideopen7777 I didn't know. I was just following the guideline from the DoNotAge packaging. Shouldn't they put a warning there!?

[@eyeswideopen7777]

@@flawlesscomplex I don't understand why they didn't put that in the label? Is resverstrol an amino? I understand any drugs intake prescribed are also based on weight as well as ivermectin too. It should apply to supplements too. Alot of standard dosage of nootropics are made at about 100 to 250 mg. I heard of guys in comments saying they take 1500 mg for example L theanine. That's way too much. It causes insomnia, gut issues or liver or kidney damage