Rise of the Superbug - Antibiotic-Resistant Bacteria: Dr. Karl Klose at TEDxSanAntonio

Please note: Due to a power outage at the event, there is a gap in the middle section of this talk. We do not have capture of that section of the talk, but wanted to make as much of Dr. Klose's talk available as possible.
As founder and director of the South Texas Center for Emerging Infectious Diseases, with 19 infectious disease laboratories, Dr. Klose's research focuses on understanding bacterial pathogenesis in order to develop effective vaccines and therapeutics.
For more information on Klose: bio.utsa.edu/faculty-staff/dr....
Overview: The Superbug does exist. Dr. Klose offers profiles of bacteria and their sinister ways of evolving into antibiotic-resistant menaces. A cleverly designed slideshow accompanies Dr. Klose. 'No more meat treated with antibiotics' might be your take-away mantra.
About TEDx, x = independently organized event
In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized (subject to certain rules and regulations).
Video Opener by Rod Guajardo foursandyfeet.com. Music: MUSICXXX Kevin MacLeod (incompetech.com) Licensed under Creative Commons Attribution 3.0.
Help us caption and translate this video on Amara.org: www.amara.org/en/v/BWQo/

[@Robertghty]

This was my microbiology teacher at UTSA! I miss this guy, his lectures were always so engaging and insightful. I wish he would teach med micro at my school now :)

[@craigmorgan4338]

This shouldn't be funny but this guy is hilarious I know they say a lot of people won't take something seriously if it's light hearted but I think it makes people listen more! Great presentation!

[@gobeklitepe8177]

Outstanding presentation. Comedy and simplistic descriptions. This is the mark of an excellent teacher. Highly complex data brought down to a kindergardener's level. Not everybody can do that. Again OUTSTANDING.

[@Holy_hand-grenade]

Gobekli tepe it was more like 11th grade level brought down to an infantile level, but I guess you’re easily impressed.

[@mokodomi]

Holy_Hand_Grenade-of-Antioch// The easier it is to understand, the better the teacher is. It’s better to have it at an infantine level where everyone can understand the material instead of a college level where no one understands it.

[@kuhmpashun]

Such an incredibly important talk, arguably one of the most important... It's really a shame they had technical difficulties....

[@dr.joanhousley480]

I was shocked at the end. Up until the end Dr Klose's talk provided support/evidence of overuse of antibiotics and at the end he said we need to make more antibiotics, just stronger and faster.....hmmmm....

[@kennethfaulds5250]

I agree. I think what he failed to mention was that the game of leapfrog will soon be over and pan-drug resistant bacteria will carry us seamlessly into the post-antibiotic era. Another sobering thought.

[@abhinav4change]

hi

[@lynn8875]

H'mm is right Dr. Joan Housley--it's almost as if his presentation is paid for by Big Pharma. The problem lies with Inappropriately prescribing "killer Broad-Spectrum Abx" like Fluoroquinolones --- the standard now in all health care delivery systems that follow Pharma's influence--Bonuses! Also done quickly with out proper Culture and Sensitivity to find the lowest level of Safe Antibiotic effective to kill the pathogen. Usually there are several cheap choices available. FQ were never intended to be utilized randomly as first line of defense, quite the opposite in fact. After 20-30 years of not using older ABX, the new bacterial strains will not have genetic resistance imo. The blame lies with Pharma, AMA education models lacking in old fashioned intellect, and doctors taking the quick easy way perhaps because of Insurance Companies influence to keep lab bills down.

[@austinmitchell2544]

THIS! THIS! THIS! This talk was pointless and in my humble opinion, he shouldn't have had the stage to blunder such an important topic.

[@saesangshrestha1008]

First I would like to say that the presentation was outstanding and thank you for explaining such a vague topic so simply and beautifully. To begin with, Antibiotic resistance has been called one of the world's most pressing public health problems. It can cause illnesses that were once easily treatable with antibiotics to become dangerous infections, prolonging suffering for children and adults. Antibiotic resistance is the ability of bacteria to resist the effects of an antibiotic. It occurs when bacteria change in a way that reduces the effectiveness of drugs, chemicals, or other agents designed to cure or prevent infections. The bacteria survive and continue to multiply, causing more harm. I also appreciated the point that every time a person takes antibiotics, sensitive bacteria (bacteria that antibiotics can still attack) are killed, but resistant bacteria are left to grow and multiply. This is how repeated use of antibiotics can increase the number of drug-resistant bacteria. Antibiotic-resistant bacteria can spread to family members, schoolmates, and co-workers, and may threaten your community. I totally agree with Dr. Klose that the bacteria are amazing organisms that have a variety of strategies to cause disease and antibiotics are the one to fight bacteria. The FDA should encourage the researcher and pharmacist to develop new antibiotics and new classes of antibiotics and other antimicrobials. Yet bacteria can rapidly convert to become antibiotic resistant, they are in the constant presence of antibiotics, such as in hospitals. If the fight against bacterial infections is viewed as a war against an ever-changing foe, the best strategy is to constantly develop new "weapons". It would be great if the researcher discovers new antibiotics. In addition, people should use the existing antibiotics carefully. As Dr. Klose mentioned, with new antibiotics we can maintain the upper hand against the rise of superbugs.

[@AmyBHollingsworth]

Excellent talk! I plan to use this in my biology class when speaking about antibiotic resistance. Thanks!

[@OvenBakedCookie]

Who the hell dislikes such an insightful video about a serious issue???

[@austinmitchell2544]

If you'd like to figure it out, read my most recent comment.

[@Anduaful]

Beautiful way to explain this difficult topic...thanks :)

[@selectivestudy4680]

Amazing outstanding description by Dr Karl..Difficult concept now for me looks easier one..

[@atteediferdinand1401]

amazing presentation. no word to add

[@ibrahimtwahirkilagwa653]

November 2022, I sure I won't. Forget this day.

[@carltercak4742]

Audience keep laughing. I can tell you one thing. I was sick on superbactetia. There was no laughing then.

[@maxrules2161]

Carl Tercak how did you get better?

[@cookiecat3625]

Carl Tercak how did you get better because I think I’m currently fighting these things

[@zahraali7905]

How did u got rid off it???

[@TheRichSolution]

Thanks for breaking this down so that I can understand this subject matter.

[@parsar4842]

Who’s watching this in 2019 after the super bug news?

[@alarmsquadnj]

parsa r here 2020

[@ThePoshboy1]

watching in 2020 because of a slightly related but entirely different pandemic.

[@sereenkhader7497]

thank you for this valuable and fantastic lesson !

[@emitoneb]

Awesome, Karl! I loved it!

[@ejetzer]

Good point. My test was quite shallow; I just pressed the button and checked to see if I could.

[@sierragreen]

I'm a little disappointed that the conclusion is that we need new and more powerful antibiotics. How do we address the problem of bacteria continuing to evolve to resist the antibiotics?

[@healthyhomesofnfl1391]

I believe the solution is to put replenish our environment with good bacteria, Enviro-Biotics.

[@pithikoulis]

There might never be a solution to that.. He talks about a methodology that has proved to worked for the last decades.

[@bobstroup4625]

The World Health Organization states that the greatest risk for zoonotic disease transmission occurs at the human-animal interface through direct or indirect human exposure to animals, their products (e.g. meat, milk, eggs...) and/or their environments.

[@ejetzer]

I agree with you; but I am watching it right now and fear I might be missing all the edits, ie I don't see them. Can you share at what points the talk has been (visibly) edited? Thanks :)

[@10snakeboy]

this is my uncle and i have gotten this lecture before. he can be a very funny dude but not when he is on business. He is a great guy tho ^_^

[@Holy_hand-grenade]

cool guy for an uncle!

[@dischargesummary8794]

I had acinetobacter,pseudomonas,enterococcus,clostridium difficile,Mesa,cadidosis all going on at once contracted in Thailand

[@apexxxx10]

Discharge Summary *I got MRSA Staphylococcus Epidermis during a TKR (Knee Operation) in Sweden. It was cured here in Thailand, at a government hospital in Bangkok*

[@JZAW11]

Our answer is Hemp Oil. That plant was given to us by nature. Should be used to treat any infection or possibly any disease. There is no such thing as "hemp oil resistance" lol

[@ejetzer]

I jsut made another test; after reloading the page, Thumbs down is still down, and shows on the counter. Maybe that part is jsut a bug in KZbin, or a glitch with your browser? I don't think it's possible to disable *only* Thumbs downs without disabling Thumbs ups.

[@austinmitchell2544]

I agree with his sentiment towards the idea that we need to help humanity. But, his ideal solution is to just keep developing antibiotics as if that can last forever, when data clearly points towards a total immunization within the next 30+ years. He is quite LITERALLY speaking on how the bugs with time are easily catching on to our "super drugs", yet clearly insists that we continue to follow the same path. We need to turn back to nature and find naturally powerful solutions. Check out Manuka Honey

[@Cap661]

How many people in America have an antibiotic-resistant condition? Not how many cases a year (2 million).

[@pietgodaard4610]

New antibiotics. Yes. Stop giving antibiotics for every little thing? For sure.

[@SSKuleDe]

Anybody watching this while doing school?

[@afijunkie562]

I'm with Ian. If there was a power outage wouldn't the light have gone out? It would seem as if there would almost be total darkness. And a brief intermission to restore power. But is was cut and picked up as if edited. I have seen power outage videos and this TED video was edited. For what reason I'm not sure. I wouldn't go as far as to say censored but this is very sketch.

[@braqxn]

Who else had to watch this in biology😳

[@tartantilia]

Anybody wanna work on a topical bacterialcide supplement using tannins, flavonoids, polyphenols, and pg with me?

[@akperov2]

why was this messed with?

[@billbryan3654]

dr.Karl klose tells it like it is.

[@ridefree2153]

I'm lost, I understood that he said until 10mins in. Lol

[@ridefree2153]

I mean 5 mins in not 10

[@edwardbrito3332]

Alex Wiskin He was talking about bacteria and comparing them to people. I thought he did good. Bacteria can eat or absorb DNA from dead bacteria in "plasmids", bacteria get DNA inserted by viruses and there is a form of bacterial sex call "conjugation" he was explaining the 3 ways bacteria gain DNA and in this case antibiotic resistance and he used the exact name of the resistance. Check out some videos on that it's pretty cool once, you figure it out. The analogies make more sense after this explanation I hope.

[@ridefree2153]

Edward Brito thanks for explaining for me I got a bit lost after a few minutes in lol. I will check out other videos

[@ridefree2153]

Edward Brito thanks for explaining for me I got a bit lost after a few minutes in lol. I will check out other videos

[@luccatuffery8826]

Inkorect bots - Octopus

[@james6401]

Epigenetics: don't it make my brown eyes blue PS I became resistant to antibiotics when I suffered from tonsillitis as a child. Bouts escalated from one to three and four a year and I was due to have them removed age 12. But I had a cold on my first day in hospital so the doctor sent me home and rescheduled for 2 weeks later. I didn't want to go back to hospital so my grandmother suggested gargling with lukewarm salty water next time I got tonsillitis and I did. I never went back to have my tonsils out and now I'm 49, still have them and if I feel im getting a dose of tonsillitis I gargle with lukewarm salty water. This can happen once every two or three years. I haven't used antibiotics for that since I was 12.

[@lucionildo100]

ok solution???

[@jobjehovah2979]

Kind of choppy, but gives good exposure for the antibiotic epidemic.

[@capnmercury]

If antibiotics were originally adaptations developed by organisms as a defense mechanism against bacteria, perhaps the key to solving antibiotic resistance is exposing these types of organisms (fungus, etc.) to antibiotic resistant bacteria to try to provide the evolutionary pressure for them to develop an effective defense. Now evolution is a slow process but perhaps it can be helped along by carefully monitored selective breeding and genetic engineering of promising organism candidates.

[@MrDavidBFoster]

Bacteria live in very specific environments. Most can't even be cultured in a lab, much less forced to infect something they aren't adapted for. Even if what you suggest were feasible, causing bacteria to mutate to fit a new environment would also likely make them no longer a human pathogen, so there would be nothing to cure.

[@edwardbrito3332]

capnmercury Their called probiotics... yep antibiotics destroy them as alluded to above. Throw out the baby with the bath water sort of deal. Probiotics are that natural selective pressure you refer to... if were their environment and we die well not as smart as being in a human for 40 yrs by not killing them.

[@eschmutte86]

Actually, there are blue eyes under every set of brown eyes lol

[@muwongejosephjunior6131]

Prevention the best and maybe only way to go, invest more in environmental health. However, with evident effects of climate change, antibiotic resistance will only get worse.

[@RossYoungsOhioUSA]

Industrial Scale Microbiome Mining for anti-infectives and antivirals - building an arsenal using advanced direct access technologies.

[@jthono]

Thumbs down because you can tell they chopped the video down

[@wrs3004]

Did you read the caption?

[@michaelphallus1854]

Using cheap, shitty generic versions made in India doesn't help either. Cheap medicine brands are poor quality and often don't work as well as the branded stuff. Cost-cutting costs lives!

[@badger5079]

Generic medicines are the same as their branded equivalents. You are just buying into big pharma's myths. Brand name medicine are pharmaceutically the same as their branded equivalents.

[@jerkrichie]

Michael Phallus Do you have any clue how the medicines get expensive? You pay for the investment done on the research for the drug,to be fair with drug companies, it most times is a big amount. Then comes drugs like Panadol / Pain Relief which costs $5 a strip for the US made and 20cents a strip for the Indian made. Both are the very same Paracetamol tablets any research on which ended at least a century ago. Then how is the US(branded) one so expensive? coz they have added blood of a virgin Unicorn to make it high quality? Branded medicines brand themselves because they know there are idiots out there who thinks expensive=better. Cutting costs dont cost life, cutting costs for greed costs lives.. so does GMO, corp farming and mandatory vaccinations (google it if you dont know yet what it does to your kid).

[@desireme3019]

I feel like a zombie apocolipse could happen

[@ibrahimtwahirkilagwa653]

March 5th 2023

[@mythicalvoid]

I am forced to watch this for school. Anyone wanna play Minecraft like ya know if your also forced to watch this for a school assignment.

[@mythicalvoid]

(ONLINE School)

[@ejetzer]

That's right... Thumbs down seems to be working, though.

[@theimaginarygallery5935]

Fake news.

[@cocobeybanton6189]

This dude lie