Safety of PPIs: Fact and Fiction - Thomas Kovacs, MD | UCLA Digestive Diseases

[@mizmizappa]

Having experienced horrible side effects from ppis. I have decided to stop. The doc says that they are safe and have been in use since the eighties, but having worked in the health industry I am aware that some drugs that were deemed to be safe were withdrawn after being in use in excess of forty years. The amount of damage that can be done to the general health of the population is enormous. Minimum prescribing has got to be the best option. A lot of family physicians just go for the highest does right off the bat. More emphasis needs put on diet and exercise and relaxation techniques- this is where more prescribing is needed-. Everyone's body chemistry is different also drugs often interact with each other negatively and even interact with foodstuffs in off ways. As we age it takes the body longer to excrete drugs and toxins from the system. Be very careful about taking any kind of meds. Non chemical options are often the best.

[@drSJV]

Great information. Side effects from PPIs are immense. They should be prescribed with extreme caution and rather for a short period of time with the lowest possible dose

[@Vpopov81]

That was so good. Initially I hesitated to give 20-something minutes but I'm so glad I did as somebody who takes a PPI in a low dose every day I wanted to know the implications and this was very informative and very well presented thank you

[@smokesgtp]

Same here. It's a risk/reward scenario. You have to monitor your serum mineral and vitamin levels.

[@fotismals7253]

s

[@fnhc2023]

@@smokesgtp it’d be nice if when DOCTOR prescribed, they also told you what you NEED to supplement

[@smokesgtp]

@@fnhc2023 it would. They aren't generally aware because the vast majority function fine without them. I've been on one for decades and my endo was normal and my magnesium is normal. Go figure... I also take a low dose.

[@hunter-ct9ky]

The anxiety about ppis will do more damage than the ppis themselves. Not being able to eat or sleep also worse than ppi.

[@JuanMartinez-ie9et]

prove it.

[@MicahBuzanANIMATION]

Nope. PPI extremely dangerous longterm. They should be an absolute last resort and not handed out like candy by doctors.

[@LaughinLoneStar]

Drugs have side effects. Can you control your GERD with lifestyle changes? Good for you. For those of us who can't, we'll take our chances with a quality of life worth living.

[@MidsierramusingBlogspot]

How about this affect? PPIs create a low acid environment in the stomach and gut. How about their affect on the gut biome?

[@powerpuffnyc]

dematson effect

[@drSJV]

They decrease the variety of microflora

[@theresageiger584]

They killed me

[@kiwipics]

PPIs just make things worse ..... I've gone the opposite way, and everything is fine now I've increased my acid level.

[@konnichiwow3139]

What did you do? Im taking pantoprazole now

[@ckmckay7636]

@@konnichiwow3139 just got prescribed this

[@konnichiwow3139]

@@ckmckay7636 just take it as prescribed, but if you dont feel well then increase your stomach acid, take apple cider tablets or betaine hcl tablets.

[@kiwipics]

@@konnichiwow3139 ... I don't use PPIs now, and had the terrible Frankenstein operation that is the Fundoplication (NF) IN 2012. The long term useage has affected my health in so many ways, and the subsequent follow up surgery has ruined my once healthy self.

[@fnhc2023]

@@konnichiwow3139 why take the pill, if you’re going to add back acid!? Lol

[@MichaelSmith-hz1oz]

I have been taking omeprazole for 7 years now to manage GERD I am not b12 injection dependant

[@shiftyshamsk]

I was poisoned at a Chinese restaurant from undercooked chicken around 30 years ago. I've been on tablets all this time. I've pissed blood out of my backside, I couldn't sit on a toilet as the pain was so bad and sore my legs shook. I could eat only dry toast and water for 6 weeks. I had campylobacter followed by colitis followed by helicobacter pylori. Recent I've be diagnosed with asephigitus, duodenitis. I ended up with a doctor visiting then calling an ambulance. So I say take Nexium. It's expensive but you'll get over it with a decent diet and regular walking or cycling.

[@mballer]

This video is now beyond the "sell by" date, when he says there are no studies.

[@johnsneade2995]

They give me horrible anxiety

[@ghassenbohli4056]

Yep they do

[@corleone8385]

Has anyone experienced inverse psoriasis as a potential negative side effect of long-term PPI use? Also, is anyone familiar with the newer TIF procedure as an alternative to traditional fundiplication surgery?

[@jwayne75]

Yes jon, I just had the Tif procedure 3 weeks ago if you have Gerd and regurgitation it will work good for you if you have LPR with extra esophageal symptoms in your throat and back of your mouth it totally sucks. I have LPR and Tif made my symptoms ten times worse. People with gerd so bad it goes up into the throat need a 360wrap, like Nissen fundoplication or Linx. If your gerd is just in your chest then Tif might work well for you for it is only a 270 to 300-degree wrap.

[@jwayne75]

Listen to how crisp this man's voice is he obviously has never experienced gerd or any severe acid reflux. And in 2020 everybody knows ppis aren't good for you.

[@abigaila7341]

Yeah my health was ruined by PPIs and antacids.

[@gabenelson878]

How so?

[@PratibhaKaradbhajne]

How bro

[@ZaydDepaor]

Despite all this "dismissal of scare stories" if you are prescribed Lansaprazole (a common PPI), then check out the literature in the pack that gives about four levels of side effects (1 in 100, 1 in 1,000, 1 in 10,000 etc), a long list of them...all which coincide with the 'scare stories' and go beyond them too, so obviously pharma is aware of the side effects and has to report them as a disclaimer and as a warning. It may well be an effective drug and useful, but if it is doing something effective, then like most chemical treatments there are often significant costs to the system, as the biochemistry in its natural God given form is a highly complex but balanced and integrated form where the various bodily processes and organs, all have their own optimum biochemistry... It isn't as simple as saying "Well this will work as you have an acid excess and this gets rid of the acid" As that acid serves many purposes. Withdrawal symptoms are a problem and long term use might well be a problem on many levels for some or many people.

[@anthonydecarvalho652]

Excellent report

[@kennethlim210]

Ppi are given out like sweet in my country. Zenpro Omeprazole. Walk into a clinic, complaining lump in the throat feeling, 15 mins later, 3 months of ppi supply. To take 20 mg, twice a day....😢

[@alexneumann4623]

Holy cow Doc. Are you sure you don't have any affiliate disclosures you want to make? It sure sounds like PPI makers are in pocket. Remarkable how you can discuss conflicting studies on every potential drawback, and yet somehow seem to conclude that the studies suggesting minimal concern are the most noteworthy.

[@lobba123]

bullshit i took PPIs because i could not swim as heavy with throatache and cough but after taking PPIs i could not swim at all because i had zero strength, plus anybody told me i looked sick and older, after 2 months on esomepraole throatache was still there but it also made asma.lansoprazole worked a little 2 times a day max dose but after 2 months i had a TIA.end of story a gun pointed at your head is safer and they made me sick curing nothing.diet and d-limonene are working better than PPIS with zero side effects for me

[@reyhassan3111]

Dull not that informative and a refusal to call out the pharm for addicting the population without sufficient warnings.

[@ambermarchand7079]

I don't plan to be on my ppi a year. I have a hiatal hernia and I want surgery and then I can stop my ppi

[@gracegrace4116]

Thank you very much Doctor.

[@evanwilson9906]

Great information.

[@abbasessi]

One thing pepole or doctor dosnrt warn yoy is that ppis is actually are little bit addictable which are bad

[@Han-es8qu]

Dysbiosis, is the worst side effect of PPI.

[@petelester8279]

Are there any studies on how to stop PPIs? I have taken Nexium for over 10 years because of NSAIDs problems but I stopped NSAIDS long ago. I have lots of stomach discomfort within two days when I reduce or stop my PPI dosage. Also, I have read that there is a rebound effect experienced when stopping PPIs.

[@Jere616]

Don't know if this is too late to respond to. Hopefully, you've found an answer, but there are weaning-off methods that would help but cold-turkey is bad for rebound. Search on YT for this.

[@DebbieDebcor1]

I cut my 20 mg. protonix in half and took that for two weeks. Then I took a half every other day for a week. Then a half every two days for a week, then I stopped completely. During this time I drank Evamor alkaline water all during this process. At night I drank Gaviscon extra strength. No alcohol, carbonated beverages, coffee, tea, chocolate, spicy foods, tomatoes or tomato sauce. I am free of my PPI at this time. Feel better than I have for several years. Good luck!! Hope you can escape long term use of your PPI.

[@garetthewitt9976]

@@DebbieDebcor1 No alcohol or coffee or tomato sauce ever again??? Or just in moderation??

[@garetthewitt9976]

@@DebbieDebcor1 Also I have severe GERD and allergic Rhinitis which is a huge cause for heartburn. I have been on Ppis for ever 10 years and I am 37 now. I want to get off these pills but I work shifts which is also not good for heartburn.

[@DebbieDebcor1]

Garett Hewitt I have it every once in awhile. I had 2 drinks Sunday for the first time in about a month and a half and it triggered “the burn”. The alkaline water is easing it. Won’t drink again for awhile. Sorry you are having to deal with this problem so young. 😩

[@kiwipics]

My life has vastly improved since stopping PPIs after long term useage. Only the damage caused by them remains .... Many thanks to the UK Drs that prescribed the damned things in the first place, and many thanks to the UK gasro team and Surgeon that pushed for the Funoplication procedure that further wrecked my life ...... Thanks to PPIs and Frankenstein surgey my life has been hell.

[@papagronk]

John Taylor maybe you can try the linx surgery instead, supposedly that has less risk.

[@bdhjbazekduve]

Can you tell us what is the damage that remained after stopping?

[@theresageiger584]

Stop lying doctor

[@bertrandchandler]

had a lot of yeast infections on prevecid quite it problem solved

[@chiliray4515]

But how do you stop ppi quickly if you need to, as in the case of c. Diff.?

[@kiwipics]

Just stop them ....

[@mortonfamily8609]

TLDR: Nothing so far shows any real problems with PPI's and long term health issues.

[@IrisColeHayworth]

actually there are multiple side effects from long term use of PPI's. Do your research. Anemia, loss of calcium and the inability to absorb nutrients to name a quick few that my Father experienced.

[@cbisme6414]

@@IrisColeHayworth in Australia your Dr now has to phone in for authorisation to write a script after advising why it "must" be taken and it's for a shorter time, the script can't be filled by the Chemist without the Authority number and the dosage is lower, mine has been cut to half the quantity but as gastric and duodenum cancer run in my family it's a must. So much for the Gall Bladder not being a necessary organ, mine removed due to being septic not gall stones.

[@rubinieto1024]

very interesting presentation.

[@brendawalser5225]

WE obviously haven't been listened to our grandmothers!!! CHEW YOU FOOD!!! That's where digestion starts in the mouth. You chew your fod to a creme before swollowing it you shouldn't need ppis!!!

[@ciaomamabella]

brenda walser not all the way true. I’m taking them because I had a gallbladder removed a few years ago and I have a massive stomach acid imbalance. I’m taking them for a short period of time.

[@jaimeberkovich]

unfortunately that doesn't help when your stomach is herniating through your diaphragm

[@educationcentral_]

Dementia is a risk for the elderly, what a shock. What he's saying Is that people who take ppis are often times the type of folks who have other unhealthy habbits already and correlation doesn't necessarily mean causation

[@cbisme6414]

@Education Central maybe you could educate yourself on the effect of having a gall bladder removed and the liver continuously dripping bile into the stomach and the effect of that. The gall bladder removed in my case was due to a growth in the duct causing the gall bladder to be septic. It's uneducated remarks like yours which don't help.

[@educationcentral_]

You are absolutely right, I totally yield to your amazing wisdom ❤️ what would the world be without worderful comments like yours.

[@educationcentral_]

😂

[@MicahBuzanANIMATION]

Not all smokers get lung cancer. But smoking absolutely increases your chances of lung cancer. PPI's increases your risks of dementia (but that doesn't mean it causes it, as you point out). Your comment demonstrates a misunderstanding of correlation and causation in science.

[@aldoaldi2613]

Anyone here with atrophic gastritis?