Saxenda 101: The First GLP-1 Agonist in Obesity Treatment | Dr. Dan | Obesity Expert

Saxenda Spotlight: Why This GLP-1 Medication Deserves Your Attention
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Saxenda. You’ve likely heard me talk about it before. I often mention it in the same breath as Ozempic, Wegovy, and Mounjaro. However, I never talked about Saxenda all on its own.
Saxenda was the first GLP-1 receptor agonist that gained approval for Obesity treatment and essentially spearheaded the way for everyone else. Save the first for last?
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Watch my previous videos about how to fight obesity and about the best medicine for weight loss:
▪️ Food Noise: • Food Noise Explained: ...
▪️ Watch This Before Taking Mounjaro: • Watch This Before Taki...
▪️ From Ozempic to Mounjaro: • How to Switch from Oze...
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: • Muscle Loss with Ozemp...
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: • Managing Nausea from O...
▪️ Ozempic: Stomach Paralysis Update: • Ozempic: Stomach Paral...
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: • How to Switch from Oze...
▪️ Ozempic Paralyzed My Stomach: • Ozempic Paralyzed My S...
▪️ How to Inject Mounjaro: step-by-step tutorial: • How to Inject Mounjaro...
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Disclaimer of Medical Liability. HEALTHCARE EVOLUTION INC. DOES NOT PROVIDE MEDICAL ADVICE. The content of this material is for general informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Reliance on any information provided here is solely at your own risk. Individual medical needs are very different; you should not assume that the information in this document concerning certain courses of treatment or outcomes will apply to you. Rather, you should evaluate your medical condition and make treatment decisions based upon consultation with your physician.
#saxenda #obesity #weightloss

[@theofficialdrdan]

Thanks for watching! Download my FREE 7-Day Best Weight Journal: eepurl.com/gdB2qn

[@francinejones2524]

I’ve just started it and I’m super excited about it. My doctor said all his patients are quite successful on it with no SERIOUS side effects thus far! I’m a healthy eater and trying to exercise, I’ve made a whole lifestyle change, but just need this to boost things along in fat loss. I’m hoping to just need it for 6-12mths to reach my goal.

[@tangomike6712]

ive spent 4 weeks getting to 3.0 maintenance dose for Saxenda, currently down 9.5% BW from initial Dr consult, fantastic product - it has changed my relationship with food and alcohol, highly recommended.

[@theofficialdrdan]

Amazing!

[@liahk1000]

9.5% bw in 4 weeks??

[@tangomike6712]

​@@liahk1000 Yes, that's correct. I weighed 147 kg at my doctor's office. Alongside other health choices, like quitting alcohol, walking my dog for an hour four times a week, and investing $400 a month on Saxenda injections, I was determined to make the most of it. After four weeks, I dropped to 133 kg. Following six months (three months on Saxenda and three months on Ozempic), I haven't reached my goal of 100 kg yet, but I'm well on my way, weighing in at 111 kg this week. I'm also training for a half-marathon in July.

[@angexiety4815]

​@@tangomike6712 I think it's not just the medication that's helping you but also your change in lifestyle and the fact that you're a lot more active now. Congrats! I just started and am on 95kg, I hope I can get down to 60kg.

[@tracyjohnson9173]

@@tangomike6712Congratulations! Well done

[@kingwoescourt]

Thank you for your video Dr. Dan, I started my saxenda injections today so really appreciate the video

[@lee5267]

I have just started with this medication today I live in new Zealand and I paid 500 for 3 months supply I’m so excited to see what it can do for me x

[@courtney_lee]

I am NZ based too! I've only been able to find a month's supply for around $500, can i ask where you got your 3month supply? Thank you so much :)

[@KhawajahKhawajah-uh4vc]

Lee5267 share with me results your age

[@Sigmash1]

What happened can you give an update

[@newenglandsillynannies]

in NZ too, any updates? I just got it today

[@malama29]

I am in NZ and was wondering where you got yours from? also whats your verdict on saxenda so far

[@tonybalz2726]

I started on it at the end of May 2023. I have not suffered any side effects except when I eat a large meal, then it gave me gas and upset stomach (which is what it is supposed to do). In two months I have lost 18 lbs. It defiantly curves my appetite and stops me from binge eating, a major problem with my weight. I don't have an exercise program or changed any of my eating habits, I'm a picky eater, other than eating less during my meals.

[@theofficialdrdan]

I would definitely look at how you can move your body more!

[@KhawajahKhawajah-uh4vc]

What's the result of saxanda any progress I am thinking to try it for weight loss

[@alisons1552]

I was on Ozempic and switched to Saxenda. I’m finding it more effective. And the side effects are much better than Ozempic. I was so sick on Ozempic. I haven’t vomited on this once in 3 months.

[@aquarianlove1787]

Have you lost weight on Saxenda. I'm having the same problem with shortages in my area.

[@Followthechariot]

I got esophagitis from Ozempic and didn't lose one pound after a month.

[@Aki-wq6xh]

Interesting to read!! I have done 2 Ozempic now and did my first Saxenda just five mins ago. Hope I find the same ;)

[@francinejones2524]

I’ve never vomitted on Saxenda. I’m quite excited about that because of what I hear about other meds similar 🤣

[@angiwarner3872]

I’ve not lost anything and I’m on week 3 dose 1.8 this week. Calorie deficit, Lots of proteins. Walking 1 mile daily. No side effects and not a single lb lost.

[@embemw]

I believe you need to see how it works when you reach the full dose. I have had a similar experience perience but it increased as got nearer to full dose. Hope it works for you.

[@angiwarner3872]

@@embemwthank you for the advice and I will do just that. All the best.

[@mupaaa9747]

Hey how is it going for you ? I was on Saxenda for 2 months and I didn't lose no weight

[@angiwarner3872]

@@mupaaa9747actually, once I got to 3.0…I started dropping. So as of July 9 to date (Oct 8) I’m down 25lbs.

[@pearlsandwisdom8863]

Thank you for this video, I just quit my diet using saxenda, if I had seen your video earlier I may have been better equipped to continue.

[@theofficialdrdan]

Can always start working on things today!

[@Newheartofpeace]

Hey Dr. Dan, i really appreciate your videos on weight loss medicine such as Saxenda and the like! Might i be so bold as to ask if Saxenda or any of the other weight loss medications such as Ozempic, Wegovy and Mounjaro can be taken if a person has a Type 1 or Type 2 diabetes and if not, do you have any alternative suggestions? Thank you for your time and effort!

[@merolychamberland1777]

I lost 50lbs on my own but I’m having defficulty for the past year. I want to try it and see. I work out and change my habits

[@theofficialdrdan]

Have you started yet? Good luck! 💙

[@NueRama]

I'm on my 12th day on Saxenda but still the lowest dose of 0,6mg, mainly because I barely have any urge to eat. I eat 2 times a day tops and I am afraid to increase the dose since I don't want to starve myself. I already lost 3,5 kg in those 12 days (technicaly 13 because I experimented with the application time) which seems a bit too fast. Is it ok to stretch the dosage titration above 2 weeks? It is obviously working for me and I don't want to starve myself.

[@Carolina_girl86]

How soon after you started Saxenda did your appetite change?

[@NueRama]

@@Carolina_girl86 Very good question. I swear it happened within 2 hours after first dose. My mom was sceptical since she thought it was too fast but actually it mimics a hormone so it really gets into your system fast. I switched to 1,2 mg after one more week when I felt the nausea feeling stopped and I got more appetite and also kept it a bit longer. 1,2 mg didn't make me nauseous and I don't remember if I got to 1,8 mg before I stopped for 8 weeks because I went on a trip to equatorial southeast Asia where I know I don't eat much anyway and I was afraid of getting some digestive issues from food which would make it a bit problematic on Saxenda (slowed processing of food) so I finished 2nd pen there and stopped. I managed to maintain my lost weight there and started again from 0,6mg after coming back. It went without issues this time and I switched to higher doses fast, I am now at 1,8mg for around 2 weeks now and I feel low profile nausea all the time. Also I think I will have to stop eating bread since it gives me heartburn. Even in small amounts. While I'm approaching the dose change a bit loosely based on how I feel and essentially to avoid not eating and loosing too much weight fast it is better to consult it with a professional. I'm going to do so on my next appointment soon.

[@racheljones3297]

​@Itsjust-me With me it was Day 1 🎉

[@aightm8]

​@@racheljones3297placebo effect then

[@beautifuldfb]

I've just finished my 4 injection of Wegovy, but there is a nationwide shortage and i can't get the next few doses. They are looking to switch me to Saxenda so I don’t have a laps in time between when Wegovy is back in stock. What is the equivalent dose of saxenda to the 1.7mg, month 4 of Wegovy? Which is the dose that is not on backorder.

[@tessahenry4442]

I do high intensity workouts, weight lifting 4 days a week. Average 500-600 calories/workout. My hormones were causing rapid gain, after going into surgical menopause. Anyway I was 205 at 5 foot 9, no matter what I did. High BC risk and insulin resistance. On rybelsus for 6 months, 3 months of Ozempic. Now will be on saxenda. Now at maintenance weight maybe 10 more. I’m at 180 but a fair amount of muscle. I hope saxenda works. I’ve been on low doses of the others. Now as maintenance

[@Ms_Lilith011]

I have problems with my thyroid blocking my metabolism can I use Saxenda?

[@reganwolf4405]

Qeustion can i mircodosing on saxenda like on ozempic?

[@SusanGrace224]

I was on again and off again trying to loose 20 pounds. I never lost that much but I did loose some. The side effect that I had was it made me lazy. I didn’t want to get up as early as I did and wasn’t motivated to work out like I usually do. It did make me more social. I’m not one to strike up a convo with a random stranger at the check out line or respond to a stranger ( as long as they didn’t look like a creeper). This medication made me more of an open person. So for theses reasons I took a break. Oh and as soon as I injected Instantly had a euphoric feeling which I think would be an issue for someone with an addiction problem. So yeah I’ll stick to paying attention to what I consume for now and get more work outs in.

[@suefoulkes2755]

Hi Dr. Dan! I have a question for you. I have been on Saxenda for one month now, and I am wondering if I should keep taking my blood pressure medicine now?

[@theofficialdrdan]

Thats a question for your doctor.

[@francinejones2524]

What a question??!!!!😱 Of course you should keep taking it until your doc tells you not to😱 I’ve been on it for 4 months and still am on my BP meds. I would never stop unless my doc said so.

[@Moriabrosh]

I’m almost 6 weeks in saxenda and already I lost 8 kg, is that too fast?

[@priscillapresslee7686]

it's my week 3 , started 1.8 dosage just today and i lost 3.5 kg so far

[@CHBK]

That's encouraging . . . I'm considering Sexenda since it's the only GLP-1 my insurance covers

[@istarhabeen]

It's good

[@zaitoonzara8936]

Wow nice plz confirm what kind dite u use with this saxenda

[@priscillapresslee7686]

@@zaitoonzara8936 Saxenda does not allow you to eat/ enjoy food. 2 bites of anything and you will feel so full... soups , salads, light food only is allowed , anything greasy, fried or heavy will make you puke

[@Carolina_girl86]

Should you store the sandexa pen in the fridge after you use it?

[@tonifoster1835]

Yes

[@miamoon8907]

Originally on Ozempic but due to world wide shortages had to change to Saxenda. In one month on Ozempic I lost 7.5kg. I've been on Saxenda for three weeks now, starting again with dosages 0.6 now up to 1.8 but only lost 0.5kg. I don't have any side effects like in Ozempic (mainly nausea). I'll keep taking Saxenda as losing any weight is better than nothing at all. Maybe my weight loss will increase as I get into higher dosage. 🙅‍♀

[@theofficialdrdan]

Enjoy the process and focus on it. Focusing on an outcome, especially one you can't control, will only lead you down the same path you've been before.

[@lizw2853]

Can one stay on a maintenance dose after reaching a healthy weight? I mean for ever.

[@theofficialdrdan]

Yes!

[@shaunphillips6160]

Saxenda is the right drug for me becuase it only costs me 7.30 a month from the VA 😂😂😂

[@redheadneon0282]

I live in Virginia also what pharmacy are you using? I think I have to change my pharmacy I tried at Walmart but it's not working.

[@cspeaches]

@@redheadneon0282I think he means the Veterans Administration (VA).

[@jameea8230]

It costs me $500pm in New Zealand

[@bobbiquigley7351]

Whoa! That's awesome ❤

[@elie9680]

😢In Greece it costs 300 euros

[@victoriacobham3775]

Hi Dr Dan ive had conflicting info about saxenda in fridge or just keep out at room temperature...i kept my out after first using pen ..but some say put in fridge after using..please till me correct answer ..and is my still ok to use while i was keeping out of fridge ones that are still not open i do keep in fridge. thanks Victoria...

[@theofficialdrdan]

If you are using a pen you can keep it outside of the fridge. However, after 30 days the drug 'expires' and must be discarded. I recommend keeping the pen you are using out of the fridge and store in dry, room temp environment out of direct sunlight. Taking it out of the fridge and using it immediately can cause it to sting as the solution is cold.

[@totpipsqueak]

Keep it in the fridge

[@currylynette]

Will it be effective if you take it every 3 days?

[@joannemartin44]

I'd like to know this also

[@theofficialdrdan]

Probably more side effects

[@currylynette]

@@theofficialdrdan What if you did not have side effects? And if taking it every 3 days would your appetite still be less?

[@rosenivanov7028]

Hi doctor, Im taking Escitalopram (antidepressant) in the morning and Quetiapine at night before bed, however when taking Quetiapine, i start thinking of sweets and eat, this really makes me struggle. My doctor offered me Saxenda, however im not sure if it will help against this Quetiapine and if it is actually ok to take it when taking psych meds.

[@theofficialdrdan]

They can for sure!

[@rosenivanov7028]

@@theofficialdrdan Whats your opinion, should Saxenda be taken before Quetiapine or after?

[@andreaholt8073]

Do you happen to know why bariatric patients were excluded in the clinical trial? Is there an issue taking Saxenda if a patient has had gastric sleeve?

[@theofficialdrdan]

Nope no issue with it. The reason for exclusion was an attempt to reduce co-founders - weightloss post sleeve may have lead to different results.

[@robertusga]

Gotta watch these co-founders, very confounding and huge conflict of interest!! Sorry doc, could not resist 😉 Love your work! Big fan.

[@BenSimone]

Do you need to take it for life? is it manageable to keep weight loss after stopping the madicine?

[@theofficialdrdan]

For 95% of people it's not possible to maintain

[@BenSimone]

@@theofficialdrdan really? so does that means that people should stay on it for life?

[@theofficialdrdan]

@@BenSimone Yup. Obesity is chronic and progressive disease requiring lifelong treatment/management.

[@Carolina_girl86]

I’m on day 2 of Saxenda. The first day which was yesterday, I had bad nausea when I woke up and went away after 3 hours but after that I didn’t want to eat anything. We had a holiday thanksgiving meal at work yesterday and I love to eat but I only took a bite or two out of everything and was done. I was thinking the sandexa was really working, but today I’ve eaten so much and am hungry. Idk if it’s working or not.

[@theofficialdrdan]

It's working. You just ate barely anything the previous days. Your body is making up for it.

[@Carolina_girl86]

@@theofficialdrdan no, it was just one day that I barely ate nothing which was yesterday, my first day on it.

[@theofficialdrdan]

@@Carolina_girl86 patience. You just started.

[@Carolina_girl86]

@@theofficialdrdan but ppl say it curbs your appetite for good right off.

[@NueRama]

Could you by any chance be before the beginning of your cycle? I have more appetite around that time. But since it has been only 2 days I would not freak out. 0,6mg is a very low dose. When you get to higher doses you would see the results. Also cravings happen sometimes. To me it is mostly pms related. :) and I actually like it because it can be a bit dull to not have the enjoyment of eating food sometimes on these meds.

[@TrionaDormer]

Has anyone found they have extra energy ??

[@francinejones2524]

Less energy atm

[@TrionaDormer]

@francinejones2524 sorry to hear that, hopefully it will pass

[@jasonmadello7345]

This is to you. Can you tell dr.mog who works in martinsburg,wv to get me put on 0.6mg of saxenda so that i dont have to hear a sound anymore. I hate it when i have to hear a sound. I hate it when i have to hear a sound.

[@jasonmadello7345]

I hate it when i have to hear a sound.

[@jasonmadello7345]

I hate it when i have to hear a sound.

[@leandradalais3859]

Are you ok?

[@jasonmadello7345]

@@leandradalais3859 Can you please stop asking me if im okay and tell dr.mog to adjust my zoloft medication to 200mg so that i can eat lessr and exercise more but with the zoloft increased it will help myself eat lesser and exercise more!

[@jasonmadello7345]

@@leandradalais3859 but with the zoloft increased to 200mg it will help myself eat lesser and exercise more. I wont be able to get out of the hospital until i can take the 200mg!

[@julihebert2903]

I can no longer get Saxenda in my area due to the shortage!! What can I do?

[@louofm1]

Im at.least.100 lbs over weight and have battled it for years. After bloodwork and a recent checkup, Dr agreeded.to write me a script almost a month ago, but been battling with my insurance company to cover either moujarno or zepbound, but keep getting turned down. Im not a.diabetic. then one of my coworkers suggested saxenda, telling me it helped her. Tried to get this medication instead but still running into issues with pre-authorizations. No way i can afford to get any of these without insurance.. Also,.there is a saxenda shortage. Im frustrated.that i cant even get started on any of these meds

[@theofficialdrdan]

Sorry to hear that friend! That is one of the ongoing battles with pharmacy benefit managers. They are the real problem.

[@MrsD-nx7ui]

The insurance company may approve it if you"re a pre-diabetic (test result numbers would show that), if you have high blood pressure or high cholesterol. Check with your doctor. You or your doctor will probably have to submit an appeal to the denial listing the previous one or more of the conditions mentioned above, then they MIGHT approve it. But it's worth a try. I look think it's faster if your Dr. Submit the appeal.

[@louofm1]

@@MrsD-nx7ui they did end up approving it with the condition that I lose a certain percentage over the next 6 months. This was likely due to high blood pressure. Took me about a month and a half to find it somewhere as the shortages were all over. Been on it now since the third week in April and down almost 20lbs. It does require that you still watch your portions, exercise,.and try to eat healthier. You do feel full quicker, so it's much easier to control portions. Not sure about long term but so far so good short term

[@davettawilson5611]

My doctor is currently trying to get me on saxenda. I was approved for wegovy but it has been out of stock since June 2023. I really need some help. Old arthur is setting in, I have a bakers cyst, ankles swollen, knees swollen. I'm truly worried about fluid developing around my heart and lungs. I'm not diabetic surprisingly with my weight, that's the only reason I'm not on ozempic. My A1c is good. I'm 48 years old and it's hard to lose weight. I'm praying something comes through for me soon.

[@MrsD-nx7ui]

If you have high blood pressure or cholesterol you might be able to get Saxenda approved. Check with your doctor about it.

[@AlphaGeekgirl]

I used Saxenda from Jan to Oct 2021, and stayed on 0.6 throughout (because I was nauseous from day 1 and was too scared to titrate up) I lost 22 kg (about 50lb for the 4.5% of the planet who refuse to go metric). I kept it off for just a year before gaining 60% back. I’m not sure whether Saxenda did anything other than act as a placebo (by guilting me not to be a such a guts after spending hundreds of dollars) I’m thinking of going back on it next month

[@PsychGirlRaven]

It clearly did something if you lost weight using it, and gained it back once you stopped. It you likely stopped all your other habits as well.

[@rosaelenasanchezdelossanto3245]

Hey did you use it everyday ?

[@feli-vx2xi]

My doctor just told me about saxenda. Im 4'10 at 244. Always struggling with my weight. I had never heard of saxenda till this week. Im just eaiting to do some imaging to make sure everything ok so i cam start this. Im kinda nervous but excited. Thank you fornthis info i look forward to trhing saxenda first.

[@ThankGod4Jesus]

Any update?

[@Margo14373]

Is this suitable for people with BMI

[@ThankGod4Jesus]

@@Margo14373 no

[@victoriacobham3775]

Thanks for the info Victoria Cobham

[@ladymuskoka1015]

I lost 10% and have been on Saxenda for at least 5 yrs. I went off in January 2022 til October 2022 and maintained but started to gain so went back on. Stayed the same . Now I'm wondering if I should try a Gen 3 med? Kinda bump me over this hump?

[@MargieIslandArt]

So ,I have been looking for Mounjaro but haven’t found any for weeks . So what I’m understand that Saxenda is daily and Victoria daily .What I’m trying to say I take Mounjaro 12.5 once a week Will that be the same as taking Saxenda n Victoza daily . I been allergic to a lot of diabetes pills since I took the radiation .Trulicity gives me UTI alot but Mounjaro no side affect .

[@theofficialdrdan]

Saxenda and victoza are not as potent but work on similar paths.

[@moiramcfarland539]

Hi Dr Dan, saw your short on Tiktok and want to try Saxenda. Do you have any info regarding using it while breastfeeding? Im seeing info on Google saying to take caution with lactation, others saying low risk and others forbidding it altogether.

[@shaunphillips6160]

It says not to use it if you're planning in getting pregnant

[@LK-lz6lk]

​@@shaunphillips6160 Prob not trying to get pregnant if breastfeeding already lol. I personally would be leary of starting it postpartum even if suppose to be okay. Your body's just been thru a lot alrdy & time is needed to fully heal & recover. I imagine poss side effects could be greater than expected & "normally" experienced. (Not even mentioning the poss of passing it on to baby thru the milk.)

[@Followthechariot]

I would say no for sure if your breast feeding. Everything goes straight to the babies stomach.

[@johnlee-fg8ij]

I have been struggling with the side-effects of Saxenda for some time. Only able to get to 1.2 dose. Tried for 3 months. Giving up and going to look for another aid

[@istarhabeen]

I usually take a short walk after I inject myself and it has helped me. Also drink alot of water. Thosr double W will ease your side effects

[@roberta9293]

I’m paying 280€/month in Italy

[@liamnulty]

It cost £120 in Northern Ireland

[@josabenajean-pierre6069]

@@liamnultywish I could buy

[@eileencasey9891]

Me too in Ireland

[@Finxina]

Here in Australia it’s about $100 per pen, one pen lasts one week on the full dose.

[@BassBossLwYr]

​@eileencasey9891 Me too Ireland.

[@user-su6nt3en3n]

is there a study about saxenda and de/increase sexual hormones on male?

[@theofficialdrdan]

No specific study. There is evidence that indirectly via weight loss and managing blood sugar can indirectly increase testosterone and sexual function

[@manng7454]

I am considering to try saxenda. Can any of of give me advise？ i am afraid of the side effect which is not good to my body. Is it safe？ i am 164cm tall with 60kg. Wanna get rid of 8kg

[@mayazz]

im 166cm and 90kgs, my doctor advised me to use it and i am, im 3 months in and i already lost 10kgs. this medication helped me because of its side effects. I feel like i can’t digest everything, so they end up bothering me until i throw up. I keep feeling nauseous and end up throwing up before school everyday, i can’t eat everything because they might make me nauseous, and i keep feeling tired, sleepy, and i keep forgetting fast. it’s a good medication for me because i needed it buy at some point i have to stop it and from people’s experiences that once i stop it the weight come back the double, but my doctor and dietitian said not to worry if i stop it gradually with their help. Overall i suggest you ask your doctor before you try anything

[@inikainika1523]

Good tip is to have it before bed

[@jacqueline8665]

Thank you

[@manng7454]

Is it safe？ i am 164 tall and 60kg. Should i use saxenda？

[@tm01311976]

What is the standard dosage protocol for this? Is it daily? Weekley?

[@theofficialdrdan]

Daily

[@bushrabibi76]

3mg

[@bushrabibi76]

Daily

[@dianaeldaba3190]

Thanks for the video but 7-8% of weight loss in more than a year is not attractive at all!!

[@theofficialdrdan]

Why is everything about weight-loss?

[@Minetty]

Exactly! I am using it as i am feeling better, eat less and lost 13kg since October last year. Have energy and Feel great

[@2tees]

I believe I will be a good fit for your program. I want to shed some weight

[@anukadarika1170]

shoul i take out the balls everytime i inject?

[@zenaoconnor473]

WARNING!! Dont waste ur money on saxenda!!! ITS NO GOOD!

[@YmamaY-sv2xd]

Pourquoi

[@cloakster]

Derp.

[@BassBossLwYr]

It's worked for me 12kg in 4 months, that's 25 pounds for those who won't do metric.