Short-Term Plasticity & Binomial Synapse Explained (Paired-Pulse Facilitation & Depression) | Clip

Welcome to Science With Tal!
In this video, we will go over some concepts of short term plasticity (PPF & PPD) as well as the binomial model of the synapse.
This conversation on neurons in the CNS derives from important concepts that are described in two previous full discussions:
1- To watch the first part (Signal propagation in the Neuron), make sure to go to: • Signal Propagation In ...
2- To watch the second (The Neuromuscular Junction as the model of the chemical synapse) make sure to go to: • Neuromuscular Junction...
To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.
TIMESTAMPS
0:00 Introduction
0:16 Synaptic plasticity
2:27 Binomial model of synaptic release
9:47 Short term plasticity (PPF, PPD)
14:09 Conclusion & citations
RESOURCES
Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)
- Dale Purves: Neuroscience (6th edition)
- Eric Kandel: Principles of neural science (6th edition)
- Lodish: Molecular Cell Biology (9th edition)
- Niswender, Colleen M, and P Jeffrey Conn: Metabotropic glutamate Receptors: physiology, pharmacology, and disease
- Bünemann, M et al: Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
- Howlett, Allyn C et al: CB(1) cannabinoid receptors and their associated proteins
- Morris, R G: D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949
- Stent, G S: A physiological mechanism fo Hebb’s postulate of learning
To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.
CREDITS
Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower ( • lukrembo - sunflower (... )

[@davidklemetz2299]

Thank you!! Looking foreward to other videos on synaptic physiology such as dynamically primed synaptic vesicle states, tonic and phasic release, and loose and tight docked vesicles!:)

[@sciencewithtal]

Thank you, I'll keep those topics in mind!

[@otterb]

great explanation! pretty much on par with quality of my lectures, but appreciated the alternative perspective

[@sciencewithtal]

Thank you, glad it helped!

[@7egoss]

you are saving my whole college gradess, thank you so much and i hope you keep posting these science videos!

[@sciencewithtal]

Thank you for the support! Good luck with your studies!

[@music-only7]

Short term plasticity facilitation and depression ---- Broadly, short term plasticity can be classified as synaptic depression and facilitation. Depression refers to the progressive reduction of the postsynaptic response during repetitive presynaptic activity, while facilitation is an increase synaptic efficacy. The link between neuroplasticity and depression ---- The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. What is the difference between short term and long-term synaptic depression? Short-term depression and long-term plasticity together tune ... Synaptic efficacy is subjected to activity-dependent changes on short- and long time scales. While short-term changes decay over minutes, long-term modifications last from hours up to a lifetime and are thought to constitute the basis of learning and memory. What neurons are involved or causes in depression? Stress, which plays a role in depression, may be a key factor here, since experts believe stress can suppress the production of new neurons (nerve cells) in the hippocampus. Researchers are exploring possible links between sluggish production of new neurons in the hippocampus and low moods.