Stanley Falkow (Stanford University) Part 2: Helicobacter pylori and Gastric Cancer

www.ibiology.org/microbiology...
Lecture Overview
Ninety percent of the cells humans carry are microbes. Only a few of the bacteria we encounter are pathogenic and can cause disease. Pathogens possess the inherent ability to cross anatomic barriers or breach other host defenses that limit the microbes that make up our normal flora. A significant part of human evolution has gone into developing ways to thwart microbial intrusion. In turn, microbes have come up with clever ways to avoid and circumvent host defenses but human - microbe interactions is still a "Work in Progress." When we study pathogens we learn as much about ourselves as we do about them.
Helicobacter pylori lives in the human stomach. It causes gastritis, ulcer disease and even gastric cancer. Some H. pylori can inject a protein, CagA, into gastric epithelial cells. CagA interacts with the tight junctions that bind cells together and with signaling molecules affecting motility and proliferation. CagA is associated with ulcer disease and cancer but we don't understand how it works to favor malignancy. Not long ago in history most humans carried H. pylori ; the incidence of carriage and gastric cancer is dropping but there is evidence that this microbe also had a protective effect on human health.

[@RaminBaharzadeh]

Got to love KZbin! Your doctor won't spend more than a minute explaining anything! Just take these pills for two weeks and call us when the problem comes back again!

[@evelynreyes9342]

I agree they didn't even tell me i had to call and find out what the antibiotics were for

[@homea2z454]

They are anxious to reveal their knowledge to mass , not to a patient was victim?

[@nashondussinm.1536]

This is what we call the complete lecture. Thank you Professor🙏

[@MAmeer-fr2hp]

This video really open my mind on how I understand the microbiology. Thank you!

[@abigailo3512]

This is such a great informative video. Thank you.

[@sweetbutterfly5]

thank you so much for this information helped a lot in understanding my dissertation! he is a good lecturer.

[@amam9015]

Beautiful lecture. Thank you so much

[@ritalun7373]

Excellent work! Thank you.

[@kangyadi9633]

Thank you very much this information help me to understand relationship of H Pylori with gastric cancer...

[@pete3442]

Awesome lecture. watch till end

[@Muhozi251]

Thank you professor. This lecture is very interesting👏

[@julianmora7074]

Very good explanation, but how do we treat it now that we might have it?

[@RichRich1955]

I just finished the meds for it. I'm not confident the 'infection' will be eradicated.

[@thehomeplatespecial597]

Could h.pylori be indicted for autoimmune diseases. But protection against other similar diseases like MS? Why some and not others?

[@johnrowinski9]

Wonderful presentation Thks

[@thehomeplatespecial597]

Does it show up in ANA blood test? I showed very low elevated ANA .

[@inzmammahmood1527]

Maim I have hpylory positive, doc told me to do ct scain contras for abdominal. I have allergy with fish ,I told him he gave me deltacrotf(5 mg) 30 pills 10 pills 4 hours gap before ctscain. Should I do that . Main I was hospitalised in 2013 and I was done ct scan test to at that time after 2 or 3 days of scain I got allergy reaction and doctor gave me some injection so got normal after that , should I take that ct scan now or not please give me suggestions please, I have always with vomiting maleficent.

[@sharroon7574]

This was fascinating, well done.

[@thehomeplatespecial597]

Can one get it from donated blood from a blood bank?

[@annettegenis2781]

thank you Prof

[@thehomeplatespecial597]

How many strains are identified?

[@jdmcarandmotorcycle]

Thank you

[@thehomeplatespecial597]

Can it transmit from animal to human?

[@Ryan-yi6su]

Anyone have good results using betaine hydrochloric acid with pepsin? Or Royal rife, hudla Clark, Bob Beck, Tesla ? Protocols

[@VitaminJ7734]

Yes! I had H. Pylori that caused Hypochloridia. Betaine HCL significantly reduces night time pain and pain that occurs 1-2 hours after eating.

[@thehomeplatespecial597]

We're you prescribe antibiotics?

[@thehomeplatespecial597]

@@VitaminJ7734 so it raises the acid in stomach? I have some betaine hcl from Pure.

[@VitaminJ7734]

@@thehomeplatespecial597Yes. It lowers PH or raises acidic concentrations so digestion goes a lot smoother and pathogens are less likely to survive.

[@carlosdesousa2394]

Dr. Can i have a consultation, please?

[@shencaamago5619]

I have h pylori positive 😢😢😢 I don't know what herbal I drink

[@herlysarmiento9863]

I made it to end! Expecting a better movie ending... great info and all but! ...I find it hard to comprehend how this bright scientist refers to H. Pylori as if it was a “pet”! Considering that 1% of humans is a ton of people who will die because of this “pet”, perhaps we need to urgently remember why we study these bacterias, that is, Not for the fun of knowledge but to save lives of dads, moms, sons and daughters of someone. Let’s refocus! *snap!*

[@MBAM02]

He doesn’t have it himself that’s why.. more scientist should infect themselves to see how it feels 🤷🏽‍♂️

[@larryhayes1684]

.I.

[@Beniamin6665]

Right.. As I have it and the majority of Canadian doctors seem to stupid and so uneducated on the matter.... Like for fuck sakes will they get their shit together....

[@Boojerella]

@@Beniamin6665 let me know if you find a good Dr in 🇨🇦!! 😖

[@Beniamin6665]

@@Boojerella Not sure where you are but you need a gastroenterologist who has experience. Now you can immediately get ease by drinking coconut probiotics. It comes in a glass jar with a blue and white label. You can get it at any health food story. 25 bucks but will last you no longer than 7 days or less. I drink mine every 5 days and oh my LORD what a life saver.

[@aeridyne]

Great video. I don't buy the thought that it could be commensal however. I think the rise in gerd isn't because we got better at eradicating it but rather the rise in processed and crappy food, which is well known and ever more well studied to show increases in digestive issues. I tend to think h.pylori is simply an enemy we have never been able to eliminate, but should. There are a few very promising ways to do this via incredibly effective probiotics such as CECT 7736, but no one makes it available, and they have been working on a phage treatment for it which would be AMAZING and I would be first in line for.

[@thehomeplatespecial597]

I still wonder tho why h.pylori seems to be protective against MS.

[@Empressme222]

There are actually many ways to rid of it. I’ve using raw honey and black seed oil that I use every morning and it seems to be working

[@aeridyne]

@@Empressme222 I can't use black seed oil anymore unfortunately. Anything remotely hot or burny only makes me worse now as I already have a lot of damage.

[@Empressme222]

@@aeridyne have you tried eating something small first before taking the black seed oil, or do you take on a empty stomach?

[@omarez6896]

@@Empressme222 how do you know it is helping you?

[@ceelovely6812]

Is it safe to kiss geez and what he says about Fecal

[@shehnaaz5712]

I had an endoscopy last month and it showed hpylori positive . Yesterday had a stool test and it came back negative. Am very confused. I did not do the triple antibiotics, just using mastic gum and manuka honey and other natural remedies.. could the stool test be a false negative, should I retest to reconfirm if I have this aweful bacteria.

[@TeoGeo-dy3pc]

Biopsy is the best! Treat it

[@olga9539]

I got the hp infection as a consequence of gut dysbiosis and candida overgrowth.

[@Boojerella]

That’s me too…just the icing on the cake of an already messed up gut. So out of balance that everything else is running wild!

[@sharroon7574]

Wouldn't it just foster the environment but not give it to you though? I think the h. Pylori can set you up for dysbiosis too because your stomach acid is low. I think I'm in a similar situation so it's hard to know where to start.

[@al-oh8fq]

@@sharroon7574 people talk 2 weeks of antibiotics help

[@joaquinzannchez3184]

Thank you Sir

[@vladm9384]

After one month of cabage juicing my ulcer of 12 years is gone. The pain in my intestines is gone. Farting all the time is gone. I can sleep at night.

[@shashikanthd4767]

I have this now!

[@vladm9384]

@@shashikanthd4767 Yes. I could not sleep because of the pain. Use organic cabagge if possible. I pray all that suffer from this will be healed. God bless you.

[@Boojerella]

Did you have H Pylori or just an ulcer?

[@shashikanthd4767]

@@Boojerella he is right i tried cabbage juice......its certainly working..... Just give it a try after all whats the Loss , its just cabbage Juice, you see this i am writing this comment after a month I really works!

[@hemantsinghrathore1577]

@@shashikanthd4767 how many times in a day you took and when ?

[@rorylennon]

Mastic gum appears to have no effect on my Pylori infection...

[@NaziaS]

Same:(

[@jayanair4424]

Is it safe to use prolonged antibiotics treatment as it will lead to wipeout of useful bacilli too and again poor digestion and thus the cycle of stomach issues continues.🙄

[@killamic2478]

Eat probiotic yogurt 3 hours after taking anyibiotics to keep your stomach feeling good and smooth

[@shehnaaz5712]

Add probiotics

[@MBAM02]

Can you go into the treatment options and how it kills the bacteria 🦠

[@adrianomeneses6683]

Yes am taking antibiotics

[@adrianomeneses6683]

Can look Amazon for the natural cure

[@immadisarojini2775]

Nice

[@shehnaaz5712]

I had an endoscopy last month and it showed hpylori positive . Yesterday had a stool test and it came back negative. Am very confused. I did not do the triple antibiotics, just using mastic gum and manuka honey and other natural remedies.. could the stool test be a false negative, should I retest to reconfirm if I have this aweful bacteria. Thanks

[@bellisima0917]

I would test again! From all the videos I’ve seen 200+ is a stubborn bacteria to rid of. At least 2-3 months consistently in the natural remedies

[@shehnaaz5712]

@@bellisima0917 thank you. I started the triple therapy with 2 antibiotics, plus my natural protocols, and alot of prayer and hope..

[@alexmutai7323]

@@shehnaaz5712 hi, how are you so far? Hope you’re doing great

[@tomdavid952]

i believe that biopsy more accurate than stool test.

[@selecttravelvacations7472]

I just had an endoscopy today. Dr told me that the Cadillac tool of diagnosis is endoscopy. They leave tell tale signs of damage behind and the mucous is more “friable” there. I’ve been in hospital twice this year, in July I was in the ICU over this due to all the vomiting that put me in serious trouble both times. It’s been going on for years, especially since 2014 for me and seems cyclic, like every 90-120 days. It’s bizarre. Anyway he told me the endoscopy is the right way to diagnosis it.

[@thehomeplatespecial597]

I need a Genetics test

[@fakerz5544]

I have this. How long until it kills Me?

[@MegaDjspike]

Won’t kill you if you eat healthy, the percentage of cancer is 3%. Eat healthy and you could control it.

[@NaziaS]

You’ll be ok don’t worry.

[@thehomeplatespecial597]

Is h.pylori dectected in blood tests? Does it change white blood cell counts to an fro? I have it and am being treated. WhAt percentage chance does it have to come back?

[@shashikanthd4767]

Yes it is detected in blood theirs a separate test for it, but usually doctors prefer a stool test or rut, as they are cost efficient+ accurate

[@stevenparent7886]

I think they take stool and breath test.

[@thehomeplatespecial597]

🧡

[@doctorakinclicks2650]

👍👍👍

[@starr8111]

18:00

[@Beniamin6665]

He is hard to watch and listen to as he has little enthusiasm and treats this like someone would washing dishes.

[@Oceanmachine27]

So don't watch it

[@Beniamin6665]

Better said would be respect your elders. I was looking for fast information.