Structural Activity Relationship (SAR) of Barbiturates

Activity and duration of action of barbiturates is highly related to the groups at 5th position in barbiturates. Interestingly the total number of carbons, nature of chain, branching and presence of unsaturation all these factors at 5th position greatly influence lipophilicity of the drug thereby affect the duration.
#barbiturates
#phenobarbital
#barbiturateacid

[@01shadmanalshakib71]

Sir,your videos of SAR of drugs is very informative❤️. Plz make more videos based on medicinal chemistry(synthesis),stereo chemistry, biopharmaceutics.

[@egpat]

Definitely, Soon I will upload more videos on these topics. Thank you.

[@sandhiyasaravanan9968]

VERY VERY CLEAN EXPLANATION WHICH MADE MEDICINAL CHEMISTRY VERYEASY😊

[@rengi17dk11]

Sir your explanation is the best!

[@prof.drjaafarhjmdzain6032]

Its very educational and make it easy to learn

[@hanasilewnet2320]

Thank you very much

[@gopinathnarayanan9069]

super explanation.

[@anotherone4669]

Very helpful and informative

[@sonalipatil5008]

Thanks a lot

[@pundikrishna2136]

Good presentation sir p krishna

[@tashoi876]

EXCELLENT VIDEO!!!!

[@egpat]

Thank you very much!

[@user-dt2wu9zo9r]

my question is if we have alkyl on position 1 the activity decrease or increase?? please answer me

[@hanasilewnet2320]

N alkylation increase anticonvulsant activity and large alkyl have sedative hypnotic effect and only one of N can be substituted

[@user-dt2wu9zo9r]

@@hanasilewnet2320 thank you very much 🌼🌼🌼

[@TheBeresford7]

Barbiturates are an awesome example of what the power of simple carbon chains can do for a molecule , the ring / ketones are obviously the functional parts but without those elaborate carbon chains the molecule is useless

[@ceepeeverma7130]

nice

[@praveenkumar-jd1zl]

Nice explanation ,sir pls make video about anthelmintic

[@egpat]

Sure.

[@notebook4978]

Amazing sir

[@egpat]

Thanks and welcome

[@prisinha]

5:05 factors contributing to duration of action for Barbiturates

[@ImtiazAsim]

Make more videos on SAR of drugs.

[@egpat]

Sure, Keep watching.

[@sayanikundu8854]

Sir plz make a video on sar of Bzd

[@egpat]

Already uploaded earlier. You can find here. Thank you. kzbin.info/www/bejne/oZeznaGtj6xqmJo

[@prisinha]

3:44 Risks of Monosubstituted

[@Saleemsan]

Needs synthetic methodology

[@newworld.com88]

How u told 3-4 carbons sir

[@newworld.com88]

Any one Reply pls

[@VnoSelva]

Same doubt

[@jatinjadav1097]

@@newworld.com88 I think Unsaturation of Carbon Atoms formation of pi bond that makes electrons less available..

[@abhirathod9778]

Sir 5 position on methyl grup not ethyl

[@martinatravnikova7959]

0:17 virtual-chat-girls.online