Mismatch repair

[@alliswell8259]

You are messanger of God for us. Thanku for all your lecture s from the core of my heart.. Always stay happy in your life

[@shomusbiologyofficial]

Thank you so much for appreciating my efforts

[@anisaishaq-balogun9982]

9years after, still very relevant. Thanks for saving us during examinations 😅 and explaining so simply ❤

[@shomusbiologyofficial]

All the best for future

[@pluviophile6063]

Bruhh I’ll cry…so grateful to Almighty that I flounder your channel😭❤️

[@shomusbiologyofficial]

All the best

[@Bahar1370]

you are a gift to future doctors of this world thanks for making us better

[@pavizz4075]

Sir iam from kerala.. Ur lectures are superb.... Explanation is..perfect

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@didimoseprimal3509]

Yo malayali

[@fatemaalihabib8237]

you are a great teacher, you make every purpose for every process so clear and comprehensive. Make more videos like these, its great help.

[@prarthubidkar1135]

Great thanks Sir.... I watches only u r videos..... Bcaz it is too simple and in detailed..... Thnx a lot .no lectures as like u

[@shomusbiologyofficial]

You're welcome. Glad to hear that you are getting benefit from the videos

[@111656hila]

you are an angel in our bad time :) thank you!

[@shynakaushal853]

You are doing a great work sir...Lots of respect and gratitude for you 💓

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@salmasiddiq7521]

Thanks a lot😊😊😊😊😊. As student I hv watched lots of ur videos especially they helped for my seminars and exam

[@shomusbiologyofficial]

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[@rayanbhattacharya5549]

shomu da ... puro aguuun porale tohh ... bhai bhai bhai bhai bhai

[@tshakma3903]

You are saviour, appreciate your hardwork. Your lectures are really helpful. Thanks alot dude

[@shomusbiologyofficial]

Thank you for appreciating my efforts

[@laddugopal8137]

As it is your video is outstanding. This video is uploaded very early but still it's working is fresh and Waooooo👨‍🏫👌👍

[@shomusbiologyofficial]

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[@anaherrera4805]

I Love the way you explain everything! Thank you for your help You are blessed

[@karabeebaishya2060]

Sir , I am very happy by getting your videos. U are just amazing..my concepts are clear after listening your videos.thank you very much sir.🙏🙏🙏🙏🙏

[@shomusbiologyofficial]

Glad to hear that you're getting benefit from my lectures

[@gasperkosmac7672]

If it wasn't for you I'd be in a very bad situation. Thanks a lot I wish you all the best.

[@absksa8184]

I love your video man .. keep sharing your knowledge please .. many thanks and love from Bristol-UK, Abdul

[@meghasvibe6497]

I hv exam period.. ur videos r helping me lot.. . 😍

[@shomusbiologyofficial]

You're welcome

[@pakhisingh6378]

Sir you are doing a grt job keep it up its very helpful

[@mobenkane2075]

Excellent,I also watched the base mismatch repair and nucleotide excision repair videos ,,, great illustrations...

[@peachlife5118]

I lost my notes on this topic.. thank you soooo much for the work you do!!!

[@surakshajkumar5771]

all ur videos are soooo helpfull ... i lov listening to ur teaching.... u really nw how to teach... and in nucleotide excision repair u havent mentioned about uvr A forming complex with uvr B .... other than that evrthngs just too gud... thankyou !!

[@shomusbiologyofficial]

+suraksha jkumar thank you. Glad you liked my lectures

[@tulasibiswal2666]

Just love your explanation and after watch ur lecture it is easy to understand thank you

[@shomusbiologyofficial]

You're welcome

[@abusayeem1482]

Splendid brother💙💙

[@shomusbiologyofficial]

Thank you

[@mariashahid8871]

You are just superb.. No words

[@shomusbiologyofficial]

Thank you

[@doctorvimalkatarmal4704]

thanks somu bro.. it's easy and helpful... u are intelligent

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@doctorvimalkatarmal4704]

@@shomusbiologyofficial.. ☺☺ keep sharing knowledge... god bless u bro☺

[@grethelmeza4803]

thank you so much ! Gracias !! your video helped me a lot ! thank you all the way from mexico !!

[@shomusbiologyofficial]

+Grethel Meza thank you. Glad you liked my lectures and

[@laxminamishra7126]

Thank you so much for making mutation easy❤️

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@shimafanimoghaddam7886]

Thanks a lot from Norway! This is so helpful.

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@cadendias3323]

I believe this is the mechanism used in prokaryotes not eukaryotes. Eukaryotic cells are theorised to use nicks made in the newly synthesised strands for this recognition to occur

[@shatakshisingh4709]

It’s DNA polymerase III that fills the gap(acc. to Watson). Other than that your video is a life saver 😁😁

[@shomusbiologyofficial]

You're welcome

[@boazomido2373]

Hello you are doing a great job, your videos are so helpful, however, I think polymerase III will be recruited, not polymerase I at 14.50 in the repair process. Kindly clarify

[@chx99]

Thanks so much. Your explanations are so clear! :D

[@shomusbiologyofficial]

You're welcome

[@miraclevibration5844]

Thanks a lot ....bro!! your so helpful and even your making biology more favorite

[@prativadevi2892]

Thank you sir.your vedios helps up in our bed time

[@apurvadhole5262]

thank u sooo much for giving us this knowledge.....it will definitely help me in my upcoming exams....:-)

[@1DangerRose]

i don't why every word you say make sense to all the words in my chapter that i was trying ages ago to understand 😀

[@shomusbiologyofficial]

+Undeadkitty c'v thank you for watching

[@majdmohamad30]

Man that was reeeally awesome ❤ it helped me a lot, thank you very much

[@aniruddhg.r]

Thank you so much sir for the explanation!! But, the part where you say helicase or UvrD cleaves the DNA is bit wrong I think. Helicase is required to open the 2 stands of DNA and it is accompanied by exonuclease 1 to cleave the oligonucleotide.

[@anands272]

Excellent explanation ❤

[@shomusbiologyofficial]

Thank you

[@dasjohn1813]

Excellent explanation sir.

[@shomusbiologyofficial]

You're welcome

[@shivleengill4976]

Appreciate your work and efforts tx man

[@quratjaan5165]

Crystal clear understanding .

[@shomusbiologyofficial]

You're welcome

[@anjalibhusari2831]

Thank you for your videos...they are very helpful

[@biswajitpeyada7320]

Outstanding daada ❤️❤️

[@shomusbiologyofficial]

Thank you

[@farishtanezomuddin2856]

this is a very helpful video. Thank you !

[@thokchomnaochaa9039]

Sir... U have explained very nicely...but i have one doubt.which dna pol will come....dna pol I or dna pol III?

[@krishanumahindar652]

Very good lecture sir..thank you..

[@shomusbiologyofficial]

You're welcome

[@jichupang5659]

This video is amazing but I I have a question. For the step that the segment that contains the mismatch is cleaved out, is the UvrD helicase doing the job, or is there another exonuclease presented in the process? Thank you!

[@lewiswalker5554]

Yes, uvrD removes the incised region of DNA containing the lesion by breaking hydrogen bonds between the parent and daughter strands, so an exonuclease is not required. (Although the excised DNA may later be degraded by a ubiquitous exonuclease that is not specific to the mismatch repair pathway)

[@farsana3555]

Video is superb but more time is utilised for explanation

[@phanitej3122]

thank u very much for ur lecture... bt plz explain about the basic difference between methyl mismstch repair and base exision repair.... only mutS mutL and mutH r participating in methyl mismatch repair unlike in base exision repair... dats it??? plz explain....

[@akanshanarayan5900]

This is so helpful. Thank you so much :)

[@shomusbiologyofficial]

+akansha narayan you're welcome

[@inspirationtalk7429]

Iam owe to sir a lot..🙏🙏literally appritiable..

[@shomusbiologyofficial]

Glad to hear that you're getting benefit from my lectures

[@ayeshairfan2695]

Very nice explanation thank you

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@MrVicinator]

Thanks, you really really helped me a lot!

[@alejarojasgo]

Very helpful, but I have found that MutH binds at hemimethylated sites along the daughter DNA and that at the end works Pol III not Pol I

[@kalyanlohar476]

Thank you Sir ....Thank you.. 👌👌💞👍🤗🙂

[@shomusbiologyofficial]

You're welcome

[@nithins3875]

This is awesome 🥰🥰🥰

[@shomusbiologyofficial]

You're welcome

[@ritubhura7448]

Sir,,why not DNA pol.lll is used here ,, instead of DNA pol l

[@rajlaxmiprasad7087]

Helpful sir thank you.

[@shomusbiologyofficial]

You're welcome

[@beegaluanjali739]

Thanks a lot for your vedio it will help me a lots

[@hakandelilbasi2635]

U teach very well thank u:))

[@AsmaKhan-fh9on]

I think DNA polymerase III in prokaryotes and DNA€ in eukaryotes will work.

[@heerachoudhary2885]

Thank u so much sir U are great

[@shomusbiologyofficial]

You're welcome

[@M_5787]

Thankyou so much sir 😊🙏

[@shomusbiologyofficial]

You're welcome

[@aratisahoo6254]

Life saviour ❤️

[@shomusbiologyofficial]

Thank you

[@sutopasingha290]

can you please make a full video on axis formation in Drosophila it will be very helpful :)

[@sinthy8447]

Best video!!! But why every time and always having having having and having???🙄🙄🙄

[@shomusbiologyofficial]

Glad to hear that you're getting benefit from my lectures

[@junkmail8883]

Cheers man, very helpful

[@khadijabegum4333]

Sir can I get the materials

[@shaikhalarab8662]

You helped me alot freind

[@sanaashfaq1290]

DNApolymerase I or III in 2nd last step ?

[@tan4640]

Can this method repair dystrophin gene which causes DMD or BMD?

[@parvathalumadgula4976]

Mut L attach non methylated strand or methylated strand??

[@marlenagwardys9716]

Is this about E.Coli ?

[@Weirdaf_07]

Am here after 9 yrs.

[@shomusbiologyofficial]

You're welcome

[@pragyanpriyadarshini5856]

Me too 😁

[@dnadatadive]

this is for prkaryotes any thing for eukaryotes

[@dipanghosh9996]

what is the importance of dna replicatio.? pls tell me

[@bdffmonster....1735]

Tqsm sir❤

[@shomusbiologyofficial]

You're welcome

[@merikhatoon4707]

Make a video about epigenetic....

[@Anisa-kx3pt]

Can cell uses all the repair mechanism to repair the damage

[@shomusbiologyofficial]

Yes

[@toybajan85]

Really helpful

[@shomusbiologyofficial]

You're welcome

[@ramathanga268]

very much useful easily understandable thank you

[@arpitasahoo5698]

Thank u so much sir

[@shomusbiologyofficial]

You're welcome

[@Spriyajain43]

Worldwide liked vedieos

[@shomusbiologyofficial]

Thank you

[@rathprasenjit07]

Pol I or III??? will fill

[@CreatorNasir04]

hi sir can you please make a video on lac operon and trp operon translation if you can than it will be helpful to me

[@shomusbiologyofficial]

+Manas Roy it's already made. Please check.

[@54shamamairam38]

Very clear

[@shomusbiologyofficial]

You're welcome

[@shivam781]

Amazing amazing amazing

[@shomusbiologyofficial]

Thank you

[@amirulfaez8437]

well explained

[@jiayapcrysix7929]

Excellent !

[@carnage2k4]

No, it was horrible... I'm not kidding, complete nonsense video.

[@carnage2k4]

lol... wtf... this is like a convoluted mix of MDMR, BER and NER.... Deamination is mostly repaired by BER, MDMR does use the MUT complex, but UvrD (Uvr helicase) is from NER... used in excising something like a thymine dimer, UV damage... hence the "UVR" UV repair in the name, this mostly (as I'm sure there are exceptions) does not happen right after DNA replication, MDMR is to fix replication errors, hence why there is no methylation on the strands... Please, if you are watching this video, these are 3 different processes, this vid is very very mixed up.

[@mitrabinda1992]

But role of mutL is unknown written in pathfinder book

[@khutejat-ul-kubrak5830]

thank you sir

[@bibhubhusanchaki7642]

excellent...

[@Clarawinfred96]

nice job

[@frozenartss3770]

❤️❤️❤️❤️

[@shomusbiologyofficial]

Thank you

[@mulukentekle7181]

waw thanks a lot

[@bessbestmithra8268]

Thanq ..u r a saviour

[@shomusbiologyofficial]

You're welcome

[@babluhrangkhawl4699]

👍