Nucleotide excision repair

[@sheidogirl]

This is nucleotide excision repair in prokaryotes it is slightly different in eukaryotes. Just thought I would mention that incase people didn't realize and thought it was for in humans. Great video, all your videos are very helpful and effective.

[@mindofmine6581]

I like the way,how he suddenly remembered & explained the difference between 'nick' & 'gap' !!Have to show your videos to those undedicated professors to their job.Huge respect & hats off!!

[@zunairahbatool7573]

🥺oh!

[@purpleghost]

I'm a microbiology master degree student and this man is my savior during finals

[@shomusbiologyofficial]

You're welcome

[@sanjidaritu8961]

Sir, you are a life saviour!day after tomorrow I have my molecular biology final and I'm depending on your videos.The way you delivery your lectures, it really helps me!thank you!!

[@shomusbiologyofficial]

Glad to hear that you are getting benefit from the videos. Please subscribe and share

[@tablameghnad838]

@@shomusbiologyofficial if you please see the doubts that i have posted , i shall be grateful to you

[@titlighosh8313]

I have already check your previous videos and all of them are too much helpful to me. I always get a clear concept after watching your videos. So it's my request please don't stop making videos about biology. Thanks a lot .

[@shomusbiologyofficial]

Sure. I will continue

[@carmenartiles8114]

You are always so helpful, and with no need of great effects or tecnologies. Simplicity is key and you know how to teach.

[@mohsenakhavan3500]

I can not find a word to tell you thank you. You are a very talent man. Please continue your efforts to teach me and other people all around the world. Thank you again. God help you in your path. There is a very nice explanation about Nucleotide Excision Repair with nice clarification about the role of DNA Polymerase and Ligase in this process.

[@shomusbiologyofficial]

Thank you so much for appreciating my efforts. Glad to hear that you're getting benefit from my lectures

[@shkokurda2098]

There's some correction: 1-UVR aba. Dimer scanning the DNA for injury. 2-when finds, a portions release and b remains in the site of thiamine thiamine dimer, i. e injury. 3- UVRc come and combine with b to make 2 cuts few nucleotides away from the site of injury. 4- UVR d is a helicase Enzyme removes the cut portion. 5-DNA POL3 complete a correct strand. 6-ligase fixes it. Thats all. 😀

[@sampritydattaroy8610]

i think it is UvrA that makes a complex with UvrB and scans and binds to the lesion site. though thanks for the explanation

[@doriscastillo2232]

Superb explanation. Thanks a million. All the way from Republic of Ireland Filipino

[@shomusbiologyofficial]

Thank you so much for appreciating my efforts

[@adonay835]

you are genius men. i can't believe i got this helpful video for free!!!!

[@quratjaan5165]

Again here sir 🙋‍♀️ And again Crystal clear understanding !

[@quratjaan5165]

I have an exam tomorrow and this video lecture is really amazing.

[@shomusbiologyofficial]

Thank you so much for appreciating my efforts

[@mdphdloading5235]

I really enjoy your videos. Just 2 points. This is Global Genome NER in prokaryotes, not eukaryotes. Also, UvrA first recognizes the damage then UvrB verifies the damage. Everything else is spot on!

[@nuranbaabbad8828]

i wish you could explain Double Strand Break Repair

[@emmasyahira985]

thank you so much..you help me a lot in understanding molecular biology topic. i can say that you like my youtube lecturer.,

[@kshiprapandey2541]

Thank you so much sir... it's always less no matter how much I thank you..! But you always save me..! thank you so much sir.🤗

[@Xplorewith_ann]

I jst love all ur video's sir. U make things easy to understand BT jst for nt getting other people confused its the AB complex formed fist which scan the DNA and binds to it then after UvrC is loaded

[@anamshahzadi8853]

Thank you so much sir i really want to thank you because i attempted this question in my msc exams successfully just because of you your way of giving concept to yout viewers is simply owsum 👍👍👍

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@anamshahzadi8853]

@@shomusbiologyofficial lots of best wishes from Pakistan sir plz never give up this effort in future also we always need you

[@shobhasurbhaiyya3759]

Lot of thank... Your diagrammatic representation easy for understand and also clear the basic things....well done good job.. keep it up

[@shomusbiologyofficial]

Thank you

[@dilminirathnayake9728]

the lessons are very clear and easy to understand.thank you sir

[@shomusbiologyofficial]

You're welcome

[@lameaahmed1580]

He explains everything that related to my subjects..Iam Medicine student

[@ashoknarayandubey3896]

Thanks for keeping it free!

[@shomusbiologyofficial]

You're welcome

[@vishwapatel6350]

your knowledge and your explanations both are best just keep it up and make more videos releated to genetics plz

[@maramahmed3992]

You are a life saver 😭😭

[@tablameghnad838]

And you said that the UvrB and UvrC dimer scans the distortions due to leision . But once i read that UvrA and UvrB scans the DNA for leisions . Then which actually does the scan??

[@tablameghnad838]

Is UvrB a endonuclease too?? Once i read that UvrB cuts at the 3' end of the leison and UvrC at the 5' end .

[@sudipakar2996]

I need a teacher like u💙

[@yagneshthakkar2060]

Uvr A dimer formation is not shown which is crucial. I disagree with video data. refer Friedburg book DNA Repair and Mutagenisis

[@sudiptajana1854]

Yes..at first UvrAB Complex should be formed.. it's A part help to recognize that faulty nucleotide...is it right??(Pathfinder publication..)

[@Bahar1370]

you are a magnificent help to this world please please keep of this awesome work. karma

[@ainanana4397]

in first step, either Uvr AB complex is formed or UvrBC??? according to my info it is Uvr AB complex formation..Regardless, i like ur videos overall. .. sir ur videos really help me in my studies... i am a microbiology student 😊☺thanks

[@stevedasari8923]

True Uvr AB form a dimer and as soon as it is loaded onto the lesion Uvr A disassociates and then UvrC dimer binds to Uvr B.

[@twinklepatel4589]

True ...

[@shivanigaur1711]

thank you sir...your almost all videos are very helpful.😊

[@shomusbiologyofficial]

You're welcome

[@skarpengland]

Awesome videos you have, Shomu! Thanks a million

[@SahilSharma-cu5km]

Thanks a lot sir your videos help me for preparing for exam

[@shomusbiologyofficial]

You're welcome

[@glamourofrealworldbysecret2599]

Thanks Shomu ❤️🥺

[@shomusbiologyofficial]

You're welcome

[@ritikgoyal7682]

Sir can u plz tell why UvrB is used here bcz the separation to the lesion region is made only the Uvrc ... Why we don't only used Uvrc for the process instead of the UvrB/c complex??

[@ashleysaxena]

Hey 2uvrA and 2uvrB is responsible for scanning d dna lession.actually uvr A does d scanning part and it leaves thn uvrc comes and forms a complex with uvrB cz c is responsible for cleaving.

[@kalyanlohar476]

Thank you Sir... Excellent lecture Sir 🙂🙂👍👌🤗💞💕

[@shomusbiologyofficial]

Glad it helped

[@sejalsoniya4767]

U r so good...thank u for clearing the topic .. Nd please make video on recombination repair 🙏

[@enviousproduction]

Is there any video where you described the RecBCD model in Prokaryotes ; very much needed ; pls help

[@jollytoppo8849]

Sir, how does an abnormal base determines it needs mismatch or an excision repair?

[@vedantsingh5574]

You describe the process in very good manner but how does this effect overall body and but kind of mutation it caused. Please give some brief idea about it. Example xeroderma pigmanotosum is caused due which failed repair mechanism.

[@aichahamdan5903]

you are so helpful !! THANK YOU

[@shomusbiologyofficial]

+Aicha Hamdan you're welcome

[@ruoidaalrahman9444]

You are genius 👍🏻

[@shomusbiologyofficial]

Thank you. Glad you liked my lectures

[@thirteenpinoy]

UVrB enzymes is exonuclease or endonuclease?

[@SeemaRani-ji2ee]

Brilliant Explaination😊finaallly 😌i got it🤟

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from

[@letslearntogether.4336]

You save me sirrrr❤ thankyouuu💞

[@shomusbiologyofficial]

You're welcome. Glad to hear that you're getting benefit from my lectures

[@nancysamir2505]

يكسبك دنيا واخره يا رب ❤️🌹

[@lonelygamerzwala4131]

Sir uvrB first bind to uvrA right ?

[@sahillangde947]

Why DNA polymerase can not ligate the DNA nicks by phospodiester bond but can make phosphodiester bond between daughter nucleotides?

[@harismagsi304]

Thanks a lot shomus je.. my topic cleard

[@shomusbiologyofficial]

+Haris Magsi glad to know that

[@ramizd.2811]

sir there is an UVrAB complext instead of UVrBC trimer complex as i read it from book......can u tell me whatactually that is?

[@meghasvibe6497]

U teach very well..

[@shomusbiologyofficial]

Thank you

[@DL551997]

you've been great help! thank you very much

[@ujwalshrestha6710]

cyclobutane pyrimidine dimer process is same?? please tell

[@apurvadhole5262]

Ur awesome....ur vdo's r really helping me...

[@subhajitmondal8287]

Thank you so much sir ❤️

[@shomusbiologyofficial]

You're welcome

[@manishakilledar1832]

Explained very well

[@wesleybilly8097]

Not sure why I watched this but you are smart.

[@shomusbiologyofficial]

Thank you

[@MelomaniacEarth]

absolute help

[@bmbijayanee8399]

Dhanyavad

[@shomusbiologyofficial]

You're welcome

[@dibyasattwakarmakar]

Thank You , Sir

[@shomusbiologyofficial]

You're welcome

[@doriscastillo2232]

All the way from Republic of Ireland Filipino

[@bhavanathakare6034]

You are a real saviour before the exams🫂 Thanks alot sir

[@shomusbiologyofficial]

You're welcome. Glad you like it

[@roscawilliam301]

nice and awesome video... keep it up

[@kashishkamra4667]

u r the great 👏👏

[@sunandachanda8212]

Sir, I just want to about photoreactivation process

[@poojadubey8540]

Sir please explain the double strand base repair. Its a humble request to you.please sir

[@shomusbiologyofficial]

Homologous recombination is already there

[@soumikroy3313]

Wrong! UvrA forms dimer with UvrB dimer by ATP at the first step🤔

[@ebtihalahmed2289]

You are amazing dude!

[@dewakapoudel]

Thank you

[@shomusbiologyofficial]

You're welcome

[@jagatlalpoddar6201]

Thank you sir It was amazing

[@shomusbiologyofficial]

You're welcome

[@anandsingh4071]

why not dna polymerase 3 filles the gap...y always dna polymerase1...?

[@الرميصاءالرميصاء]

شرح ممتاز ❤❤❤

[@onaizasumreen1165]

Sir I have confusion in this lecture.. bcz my teacher talk about UvrA protein also but you didn't

[@nishavijayasarathi101]

Very useful video

[@shomusbiologyofficial]

You're welcome

[@harinis662]

clear explanation .thank you

[@rajkumar-tj6oo]

dont we need uvrA here because i studied somewhere that the detection process is done by uvrA

[@bushrasayeed8336]

+raj kumar yes the uvr A and uvr B form a complex and slides along dna to detect a dimer or any other major disruption. on encountering a dimer in this case . uvrA dissociates and then uvrC loads

[@ainanana4397]

Bushra Sayeed yes... u r right 👍

[@mulwelimushiana8388]

Yes this is true

[@Xplorewith_ann]

@@bushrasayeed8336 yeah this correct

[@shaswatichakraborty3631]

Yes uvr a and b scan it

[@sweetypanchal6918]

really u r so much helpful sir

[@shomusbiologyofficial]

+sweety panchal thank you. Glad you liked my lectures

[@addisalemtesfaye4592]

You understood the central dogma better than the ones identified it

[@shomusbiologyofficial]

You're welcome

[@cook.king0844]

Thanks sir ❤

[@shomusbiologyofficial]

You're welcome

[@learnquran28]

At the beginning it's uvrA and uvrB .

[@janardhan476]

Thank you sir

[@shomusbiologyofficial]

You're welcome

[@kerenmaruvka3934]

Thank you!!!

[@sukanyasudhakar1437]

thanku sir👏

[@shomusbiologyofficial]

You're welcome

[@khutejat-ul-kubrak5830]

thank u very much sir

[@shomusbiologyofficial]

You're welcome

[@sedeftalan6865]

i think in this video u should talk about exinuclease isnt it ?

[@oliverk349]

you are awesome!!!!! best way to learn genetics :)

[@shomusbiologyofficial]

+Oliver K great. Glad it helped

[@rainajana5709]

thankyou so much.

[@Gstring115]

dude you are awesome

[@sonalimohanty3717]

Very useful sir ...thanks a lot ...but there is confusion between UvrAB or UvrBC complex

[@mdalihossen3231]

Outstanding

[@shomusbiologyofficial]

Thank you

[@manjaridatta9997]

uvaA is not mentioned here, it is wrong

[@syedaaisha3858]

great sir

[@monikak1572]

Great

[@shomusbiologyofficial]

You're welcome

[@hafizdanish472]

very helpfull ☆

[@mehjabeenhaque1154]

Oh God!You are soooo goood..🥰

[@shomusbiologyofficial]

Thank you

[@ragavendiranushasri9310]

excellent

[@lameaahmed1580]

Is he a doctor?

[@vocalistguy9850]

He's a microbiologist!

[@rashheadX1496]

UvrA is the dna binding protein that exists as a heterodimer uvrA2B2

[@moumi5892]

Where is uvr A

[@sumonamondal2913]

Tnx sir

[@shomusbiologyofficial]

You're welcome