Synthesis and Column Chromatography: Crash Course Organic Chemistry #25

Even though all living things have a lot in common, different organisms can have very different reactions to the same organic chemicals. That means it’s really important for organic chemists to be able to purify chemicals and separate the products we want from reactions, from the side products we don’t. In this episode of Crash Course Organic Chemistry, we’re heading into the lab to learn about one of the ways we can separate chemicals in a mixture: chromatography!
Episode Sources:
Mahdi, J. G. (2010). Medicinal potential of willow: A chemical perspective of aspirin discovery. Journal of Saudi Chemical Society, 14(3), 317-322.
Dempsey, D.A., Klessig, D.F. How does the multifaceted plant hormone salicylic acid combat disease in plants and are similar mechanisms utilized in humans?. BMC Biol 15, 23 (2017). doi.org/10.1186/s12915-017-03...
Still, W. C., Kahn, M., & Mitra, A. (1978). Rapid chromatographic technique for preparative separations with moderate resolution. The Journal of Organic Chemistry, 43(14), 2923-2925.
Pastre, J. C., & Duarte Correia, C. R. (2006). Efficient Heck arylations of cyclic and acyclic acrylate derivatives using arenediazonium tetrafluoroborates. A new synthesis of the antidepressant drug (±)-Paroxetine. Organic letters, 8(8), 1657-1660.
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
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[@ryanbd8354]

How long is this series planned to be? On behalf of all fellow chem students please don't end anytime soon!

[@madboycal7859]

Yes, what he said.

[@XanderGouws]

I believe 50 episodes. I never want it to end :(

[@howardbrandon11]

Probably 40-some episodes, like most of the rest of their courses. So that means we're currently about halfway through the series.

[@SW-bg3ht]

I totally agree!

[@SuperAndrewlove]

All in all it will be 50 episodes of organic chemistry goodness!

[@Frida2024]

Absolutely LOVED the experiment animations in this episode!! Brought back some of the more fun memories of ochem lab :D

[@beaono8997]

LOVED ! I seacherd for this video here a month ago and so glad you heard my prayers!

[@usagitsukino8766]

I love this teacher. Her explanation is so clear!

[@nisalo]

Doing TLC in lab and watching this video makes everything even more interesting

[@tricktrick4940]

Are you a professional 😃?? Tell me more about it plzzzzz

[@ATLrockforever]

Watching this just to see how much I remember from undergrad :’) it makes so much sense here but when I first learned about it I was 💯 p confused

[@psychologytricks5109]

Thanks for this and all your videos Really like 👍

[@chillsahoy2640]

Why did the chemist ask for a cuddle? Because they needed some TLC after doing The Literally Countless runs of TLC.

[@ShirinRose]

Accurate 😅

[@Tech.Library]

Great video

[@kocengineering769]

Great mam I wanted this thanks for your help in this subject coz I may not be able to get it this easily

[@trex0004]

WHOOOWWW YOU'RE INTO COLUMN CHROM NOW Congrats !!!

[@conspicuousgetawaycar8684]

Thank you.

[@3thomasH]

Reminds me of my days in the lab.

[@researchstudentacademy3512]

Nice video 👍

[@annarose932]

Could you do more videos on theatre and playwrights again please :)

[@gajanan7517]

Yes mam Gajanan Borude

[@houssan3953]

The thumbnail is Travis McElroy, right? :D thank you for the videos!

[@SuperAndrewlove]

Actually that's me, but thank you haha I'll happily take that comparisson! :D

[@bernfran1313]

Wow.

[@tricktrick4940]

I wish i get to do flash chromatography and collect the pure product 🌚🤩

[@jennifergreenberg9477]

I would really love to assign these to my students more, but the person talks too fast for my grade level. Please consider making a series for 5-6th grade!

[@zaynjulien5817]

i need hank green

[@brainstormingsharing1309]

👍👍👍👍👍

[@MatveiPB8]

Sería mejor si traduxen estos videos al Español

[@fredtrunce5931]

This video came out 7 hours too late. We did this in lab today. 😆

[@tricktrick4940]

So how was ur experience

[@IgmuHammerer]

It just occurred to me by watching this video that using this in a series, one could detect the order of the strokes a painter used to create a masterpiece by testing the graduations of each pigment as they mix in the water or paint solvent mixing with the next stroke of new paint.

[@tricktrick4940]

999 IQ

[@henryelicker2403]

I hate when the TA yells at you for eating the silica

[@asharali2177]

Hello I downloaded the app

[@aaravraju8094]

hi

[@1.4142]

oh no my grades

[@zacke6]

0:20 But im not Hugh tho...

[@BaneLoki]

Can we get Hamilton Morris cameo an episode?

[@randomhumanbeing591]

not first

[@Kairikey]

This episode is actually not that hard to understand, especially when I've watched some synthesis video on yt before like NileRed.

[@vaughnjohnson8767]

You are a man of culture

[@vongalaxygg4216]

The first 100 commenters/likers are the smartest and most dedicated fans. (im 11th btw)

[@nomnom112]

you sound like a real genius.

[@teamhaselmyer]

Chromo Tom's Assemble!

[@goat1462]

I'm first here.

[@eagpacheco]

First :)

[@mquale7438]

First comment

[@thecommunistdoggo1008]

I failed my exam yesterday you're a bit late with the upload

[@bryanmavis8771]

Better late than never. At least you can understand the failure now