Synthesis of eicosanoids (prostaglandins, thromboxane, leukotrienes)

[@Hwo123]

FIRST! We miss you! Come back!!

[@Biomeducated]

Indeed, finally a new video! I didn't put AK Lectures on #1 in my Top 10 Biomedical channels video for nothing. You're the best AK!

[@damaster7276]

Literally the most in depth and best Channel in terms of explaining/understanding

[@AKLECTURES]

Thank you! Glad you think so :)

[@mmmmmmmmmmm111]

Just a small correction on 1:15, linoleic acid is an omega 6 fatty acid but it's not a 6 carbon fatty acid, it's 18 carbons.

[@anisfarhad1506]

I cant believe you have a whole video on this exact topic! i was so lazy to learn it from my book with all the crazy steps, you simplified it brilliantly

[@jonathanstartin3748]

Just saw this posted and I'm so STOKED YOU ARE BACK

[@binterabnawaz9421]

Same here

[@AKLECTURES]

Thanks! glad to be back! :)

[@jamessoto5723]

You helped me during undergrad and now you're helping me in medical school. Thank you GOAT.

[@kabikabi9028]

We miss you, thank you for your time.

[@yarashhab]

i literally have my biochem final in 6 hours and i was struggling with the arachidonic acid.... thank god i have his post notifications on

[@AKLECTURES]

Talk about good timing! Good luck on your exam, let me know how it went!

[@verrucktjunge7391]

where r u from

[@verrucktjunge7391]

do u study in med shcool

[@jacquesdalias5939]

Thank you for this video. You wonderfully summarized the proStaglandin-leukotriene cascade in one page which makes it much more easier to understand. REALLY HELPFUL!!

[@Lina-srkajol]

CANT THANK UUU ENOUGH, im a 1st year med student, and i couldnt understand what this is all about, u made it way clearer

[@JoshuaKevinPerry]

Welcome Home, we missed you.

[@AKLECTURES]

:) Thanks Joshua!

[@ekitochin6059]

Thank you and welcome back！You are my best teacher! 欢迎回来，谢谢你做的一切！

[@motivationtostrive1216]

thank you for helping me in my preclinical medicine, and now in clinical medicine, you're the best💕 God bless

[@MxLiKiE]

He’s back! I dont need to learn this but now i want to

[@AKLECTURES]

:)

[@manarabdelaziz6302]

He is back ❤❤

[@797brm]

Glad you’re back

[@ramchandrasuthar2848]

GOOD MORNING SIR LIFE SCIENCE TIGER HAS BEEN ARRIVED AFTER SOOOOOO LONG TIME WELCOME SIR

[@lubnajan9108]

Didn’t know will be seeing your video posted two years before in my medical school. Loved it. You just explained it so beautifully ✌🏼

[@dankgamer2004]

The legend is back

[@mathilda_dada]

Thank you. Your explanation is so comprehensive and wholesome

[@salikmanan5681]

COX 1 produces pgf2alpha and TXA2 COX 2 produces PGI2 and PGE2 . According to lippon

[@medical12262]

U saved my life tnx I have watched every single videos but this one was the only one who really helped 😊👏🙏

[@nikkyuong6793]

Ommmmmmgggggg... welcome back. You don’t know how much my class miss your lecture :) Okie study time now

[@hazarbuyukakpnar1356]

Omg you're still active! We've missed you so much.

[@priyadharshaniyappan2196]

Happy to see you back😀😀😍

[@miranmuslem]

Thank you for making me a good doctor! I appreciate you a lot...

[@77mayanksingh45]

Welcome back sir!!!!!!! I can't believe it❕❕❕❕❕❕

[@kibanaru221]

Well, not even done with gen chem 2 and I’m scared already but glad I have you 😭

[@AKLECTURES]

Take it one step at a time, this stuff is great! You'll love it :)

[@camilojoseacevedo8525]

Excellent as always!

[@musicmakkataei9705]

The best video I found on this topic

[@Biomeducated]

What a coincidence! I recently helped correct the Pharmacology exams of 3rd year Pharmact students with my Professor. One of the questions was: "Why are prostaglandinE2 analogs often prescribed concomitantly with NSAIDS if patients are to use them rather long-term?" The answer is in the video of course ;)

[@AKLECTURES]

Thats great! Hopefully not too many mistakes were made. Good job on your channel btw, keep it up! Its great to see graduates who are passionate in their field becoming active on KZbin! :)

[@Biomeducated]

@@AKLECTURES Wow, this means so much coming from you! Thanks a thousand! And if I could have only 50% of your passion I would already go further. You made almost 2000 videos, dude, you're an icon! (and a lifesaver for many!). You should become a professor!

[@yourstrulychaos947]

I'm becoming good at biochemistry,Thanks to you🥺

[@sanchezjimenezisai4718]

Yes!! You're back, greetings from Mexico 🇲🇽😁😁

[@AKLECTURES]

Thank you!

[@hajerhaider6655]

Welcome back I Miss your lectures Greeting from china 🇨🇳

[@AKLECTURES]

Thank you! :)

[@vantien7219]

i think it don't has youtobe in china????🤔🤔🤔🤔

[@hajerhaider6655]

mac hoang yea but there is proxy

[@matthewshields7281]

Whoo welcome back!

[@abedgamer7773]

This helped me A TON .... idk how to thank you

[@ozfandukgaming6703]

The link of your videos is placed in official portal of the medical university. I got acquainted with your channel using these links .😊

[@MahmoudMohy82]

Best lecturer, welcome back -Egypt

[@elaphmadallahsh7811]

Do you know You are amazing..thank you from Iraq.. شكرا لك 🌹

[@zavionw.8052]

Welcome back, AK! Great videos by the way :)

[@AKLECTURES]

Thank you!

[@TheToxicMegacolon]

A random GOAT just popped up into my feed. Nice

[@nutzeeer]

Cool to see new uploads. I am just watching all of biochemistry. Cant wait to hear all the newly discovered things!

[@princeetok1018]

Great lecture. You make complicated topics appear simple

[@lynnemaverick1865]

Boss, linoleic acid is an 18 carbon unsaturated fatty acid. You said 6. Please 🙏 I'm learning a lot from this channel.

[@Hematite-Heart]

He still exist! Thanks for my amazing biochem grade!

[@habibullah7117]

Thank you sir for coming back ❤️❤️❤️👍👍

[@AKLECTURES]

:)

[@ThomasAlexanderMD]

Beautifully explained

[@pixiepower8052]

Also great lecture as a lay person I have a better understanding of what this is now 😊

[@Medicose2282]

May Allah bless you..doing extra Ordinary job👍🏻

[@mr-wc3xq]

Dr Andrey you're the best ❤

[@funtolearn459]

Sir please made more videos on heart related conditions. I am fan of your videos.

[@manarabdelaziz6302]

We miss you 😍😍😍

[@EarlAndGrey]

Just to note; Linoleic acid is an 18C fatty acid with 2 double bonds, not a 6C FA as said at 1:16

[@slavavassiliev3531]

I was about typing just exact the same thing but then had the great idea of scrolling through the comments firs ;-)

[@Larsa836]

Thanks for your efforts but I had noticed that you didn’t mention the prostacyclin in cox2 ?

[@kohinurkazal6788]

Doesn’t TXA2 belong to COX1? Kinda confused

[@MoonLight-sw6pc]

Welcome back its really nice to see you again , how have u been?

[@AKLECTURES]

Thanks! I've been great but a little busy :) hope all is well on your end too!

[@ravinaa315]

You're back :)

[@takashikun5446]

After a long time Have great journey ahead

[@arkveth6921]

A small correction, linoleic acid is actually 18 carbon fatty acid, I guess Andrew wanted to say that it is Omega-6

[@abdulbakiidriss806]

Welcome back doctor

[@MarkIron]

Great video 🌟 One question, isn’t EPA and dihomo gamma linolenic acid are used too? Not exclusively AA in these pathways?

[@urvimehta9717]

Hello, thank you for an informative video, loved it. I had a question. In 4:15 you mentioned that PGI2 inhibits platelet activation and formation. Should it not be the opposite? As NSAIDs like Aspirin reduce platelet function.

[@Canada2760]

Great Video.

[@ramchandrasuthar2848]

Great analysis of BIOCHEMISTRY

[@AKLECTURES]

Thanks!

[@patiencechepkorir5596]

Your lectures are awesome

[@genuine_meteen9169]

Sir..I Really Like your Lectures.. Well Explained in Detail of what Is Just Needed...thank U So Much👍👍

[@haileynathan1644]

Thank you!!

[@zaroonhaider9813]

Sirrrrr youu are just amazing🥰🥰you deserve even more subscribers🤩🤩🤩

[@alikufi7948]

amazing lecture

[@mudassarnadeem1778]

Ah ..isnt it like this ... Thromboxane A2 is made from COX 1 and PGI2 and PGE2 is made from COX 2 ..thats written in Lippincot ...and in the video its opposite... its confusing me ...do correct me if im wrong.

[@lynasalhi8766]

i'm confused too

[@AsadAli-rh3ew]

Replying late but did u get the answer??☹️

[@amermalik5885]

he explained it very well

[@vmanafroman1]

The Leukotrienes have 4 double bonds making them LTA4, LTB4, LTC4, and LTD4 (not LTA2, LTB2, LTC2, and LTD2)

[@vikas_kumar_sahu1965]

Missed you so much...it's so good to see u😍😍

[@pratikumar2602]

We miss u sir 😊😊😊 Sir 😊 Pls make the video on why AIDS can't be cure till now 😊

[@blueberry11051]

Great guy. Wonderful explanation. Thank you very much.

[@amnaalasha1552]

Very interesting exploitation 👍

[@Medicalbox1]

The minister of biochemistry ❤️

[@ΌλγαΜπαλκουράνη]

So good videos, thank you! Could you make a 5-Lipoxygenase specific one?

[@poojak9421]

Wow this is the best explanation that I ever heard.. gonna subscribe your channel

[@aditimukherjee6789]

u make learning interesting

[@bismaikram6390]

Sir i want to know , isnt it opposite Cox 1 produces txa2 while cox2 produces pgI2?

[@lihanou]

wow he's back

[@andrewboss2018]

Love the vid. I think you are saying "eiconasoids" as opposed to "eicosanoids"

[@marium1583]

Your videos help me understand and grasp concepts , can't thank you enough 🙌🏻

[@Hassan-tn2pk]

My Chemistry Crush >>>

[@rickshawley7683]

So what is the best and safest way to block excess prostaglandin d2 production.

[@taeyang]

Just dropping by to drop a comment/thumbs up/contribute a view.

[@AKLECTURES]

Appreciate it!

[@kashkushmedlecs]

8:13 (correction) we block Cox 1 not 2 because u already said it cox 2 in 8:05

[@habibhassan7770]

NSIAD block both Cox1&2

[@maryamtembo9057]

What a legend

[@mrsboogybren2657]

Thank you for the explanation. I really appreciate it. 😊

[@muhammadmaazmasood8472]

You have wronged COX-1 and COX 2. Pg I2 and PG E2 are synthesized by COX-2 PATHWAY not COX 1 PATHWAY. similarly PG A2 is synthesized by COX 1 PATHWAY. Cited from LIPPINCOTT BIOCHEMISTRY BY DENSIE R FERRIER WOLTERS KLUWER

[@zaheralsakka]

Welcome back

[@sarikavishwakarma2235]

Sir your hand writing is too much good and your teaching is very attractive thank you sir 🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🌹🍓🍓🍓🍓🍓🍓🍓🍓🍓🍓🍓👍👍👍👍💖

[@329santoshsapkota3]

just love.. thank u n thank u sooo much..plz upload more n more..

[@atahanersoy5168]

hypertrophy canavarı olmuşsun andre

[@sadeddeaded1091]

Welcome back

[@nadahussam5849]

Just subscribed. You're great!! 💜

[@supboy666]

and i think its ltdA4 C4 D4 and E4

[@amrelnhal9943]

So freaking awesome!!

[@dilminbandaranayake4757]

isnt COX1 responsible for TXA2 and COX2 for PGI2?? think it has gotten switched