Arachidonic Acid Pathway- The most Comprehensive Explanation - COX-1, COX-2, LOX,Prostaglandin, LTNs

[@MedicosisPerfectionalis]

👨‍🏫 💊 Cardiac Pharmacology Lectures: www.medicosisperfectionalis.com/ 💊🦠 Antibiotics Lectures: www.medicosisperfectionalis.com/

[@joshdudeguy2830]

Me *comes to video knowing absolutely NOTHING about the arichidonic acid pathway* MP *makes 18 minute video full of freaking magic* Me *leaves at end of video feeling like a subject matter expert* I know this is a 4 year old video but still. You do incredibly important work here, man! Thank you!

[@MedicosisPerfectionalis]

Thank you!

[@Mandh223]

Whoever you are, you’re just absolutely an amazing teacher! God bless you

[@MedicosisPerfectionalis]

😊😊😊

[@MedicosisPerfectionalis]

Please consider sharing my videos with others...Thanks in advance!

[@samuelwaithira]

A comedy pharmacology class, you have made my day, in autocoids am now good.

[@something93565]

@@MedicosisPerfectionalis always do!!! your dry sense of humor makes it all even better! made in egypt vibes ;) love it.

[@moonprincess1992]

My professor didn't even attempt to teach this, just gave us a chart to memorize. So thank you for explaining everything so well!!

[@MedicosisPerfectionalis]

You’re very welcome 😊 Good luck 🍀 Let me know if you have any questions!

[@yes7855]

Same here hahah. And these vids are great! :)

[@yui870]

yeah my doctors too .. never told me diz (in my campus there's no proffesor, just doctors until doctorate degree)

[@mariamlatif5095]

Share kardein chart

[@tauqeerahmadsafi8522]

You are lucky to have a professor 😅

[@Deepayan00]

I am rewriting an article on "arachidonic acid, inflammation and mental health" and needed to know the whole mechanism. This video gave me a head start to decode the overly densed wiki article on arachidonic acid and saved my mental health. :D

[@mariansmith9685]

Where can I read your findings? I'm really excited to see your work!

[@mossaybo]

15:21 to 16:10 was the best explanation of the pharmacology behind Aspirin , since it's invention !

[@MedicosisPerfectionalis]

Thanks, dear!

[@mossaybo]

@@MedicosisPerfectionalis I'm the one who should thank you , I'd love to know , when you're learning about a new subject , how do you approach it ? .. reading different textbooks , sticking with one book , reading research papers about it ? because you have an amazing big picture and you make smart connections between things , I'd appreciate it if you'd teach us how to fish

[@nfa861]

thank you sir you are essential to humanity and deserve a nobel prize 🏆

[@miradl]

This truly made my night! Who knows learning the AA pathway (that I've been dying to defy since medschool) can be fun?! 7 years later and this made sense

[@MedicosisPerfectionalis]

I appreciate you!

[@MrNakedWizard]

Thank you, banging my head against a wall to learn this and your style of repetition and humour was wonderful and refreshing, thank you again

[@MedicosisPerfectionalis]

My pleasure 😇 I am so glad you liked my video. Can you please help me by sharing?

[@josetrujillo738]

Lol

[@fionacole7811]

Thank you so much❤❤ i have a biochem exam tomorrow on this and you just about saved my life (gpa)

[@Guidus125]

where has this channel been my whole life

[@MedicosisPerfectionalis]

Hiding in a haystack 😊😊

[@ameerahal-sadi9596]

Love love love your teaching style!! You're making immuno more doable!

[@MedicosisPerfectionalis]

Thanks 🙏

[@abcgames4454]

The most doubt clearing video I have ever seen. A must for every medical student. Love from India! 🇮🇳👩‍⚕️

[@MedicosisPerfectionalis]

Thank you so much 😊

[@snehasha6891]

This is HANDS DOWN THE BEST video on arachidonic acid pathway

[@MedicosisPerfectionalis]

💊 Pharmacology Playlist: kzbin.info/aero/PLYcLrRDaR8_d5RzuEJprW-NWXTK22ByVC&si=MGlX4_a2LlLOo6Ed

[@FlowRXOXOXO]

Love the sense of humor with the teachings!

[@MedicosisPerfectionalis]

Thank you!

[@sharonkende4774]

Thank you so much. I am a nutrition student but hearing how meds work made the information so much more retainable. the difference between teaching vs teaching and the student learning is timing and ways to engage (showing connections between things and even adding humor). It makes all the difference.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@dh1147]

Holy moly, I “learned” this in nutritional biochemistry and in pathophysiology and after watching your video, I finally get it!!!! Thank you, subbed and saved! Thank you you are amazing!

[@MedicosisPerfectionalis]

I really appreciate you!

[@laibasheikh137]

This was explained 10x better than it was at my university. Thank you so much!

[@alibuknan193]

Thank you so much, you got me laughing while watching this and learn :)

[@MedicosisPerfectionalis]

Always laugh 😆 😂

[@partomeraji3084]

every single time I cry with happiness... Medicosis you are a gift from God

[@MedicosisPerfectionalis]

Thank you so much ☺️

[@colbertoise]

I wish there was a way to like and subscribe 1000x times srsly u have the BEST Hematology lectures eveeeeer thank you so much and GOD bless you

[@MedicosisPerfectionalis]

Thank you so much 😊 God bless you too!

[@mehdiazaz7669]

the best professor I've ever seen, good job !

[@MedicosisPerfectionalis]

Thank you 🙏

[@akaakram1347]

I am starting to lern with love&fun our medical lectures than i just find this masterpiece..thank god and may the god bless you 🫀

[@MedicosisPerfectionalis]

God bless you too!

[@dge.]

Came across your video while studying for Pharmacology. I am so glad I did! Not only did you make it so simple, but I was laughing throughout the video, too! Ps I'm surprised at how low the view count for this is. Honestly this is better than Khan Academy. It uses a white background and u managed to inject bouts of humor (which I think is so hard to do for topics like these) I hope you continue on making videos, my good sir! You have made a medical student's week 😊 I wish all of my lecturers were like you.... SUBBED!

[@MedicosisPerfectionalis]

Thanks a ton! I am honored...You’re such a kind person. Can you please help me by sharing my videos with your friends?

[@dge.]

Do you have any videos on anticonvulsants? 😄 also, I've sent this video to a ton of my classmates! They loved it!!!

[@chiahead52]

You speak my language MP! Acronyms and association helps better memory retention. Thank you

[@MedicosisPerfectionalis]

My pleasure!

[@BitseatGetaneh]

aren't you the best??? wow!!!! YOU MADE ME UNDERTSTAND THIS IN AN EASY AND DIGESTABLE WAYYY! Love how you repeat it as well to make us remember

[@eduardocarvalho7810]

I don't generelly make comments, but this lecture was AMAZING. Very clear and engaging explanation, congrats and THANK YOU!

[@MedicosisPerfectionalis]

Thank you 😊

[@KazokuMugiwara]

Thanks for the video. It went more in depth than my dental pharmacology textbook and helps me picture this action.

[@MedicosisPerfectionalis]

Awesome 👏 Thank you so much 😊 Can you please help me by sharing?

[@ieorj4080]

This is the BEST video I have seen on this topic. Thank you kind sir.

[@MedicosisPerfectionalis]

Thank you so much 😊

[@LisaClarkmedicalillustrator]

I couldn't love your teaching style more! Fantastic.

[@MedicosisPerfectionalis]

Thank you 😊

[@lorena6020]

Who are you? You are too good! I have to study for my periodontology exam but this is way better! Thank you!

[@MedicosisPerfectionalis]

My pleasure!

[@shubhampatil4496]

I never understood this in my second prof ..And the fear of this topic stayed with me for too long.Thankyou for such simple easy explanations

[@CeliaHH1]

Thank you so much! Many greetings from Germany!

[@MedicosisPerfectionalis]

My pleasure 😇

[@charlemagnebaguio3734]

Been sharing this golden content to my friends! Thank you for this and thank you for being a great teacher.

[@MedicosisPerfectionalis]

My pleasure 😇 Thank you so much 😊

[@aboodmoghraby4647]

When a young guy beats our professors Great respect for you bro🌺

[@MedicosisPerfectionalis]

Thank you ☺️

[@tyrhere]

My life would have been smooth af in freshman year if these existed, DANG. So glad I stumbled upon this

[@MedicosisPerfectionalis]

My pleasure 😇 Can you please help me by sharing?

[@shadysid5570]

Best education channel on KZbin

[@MedicosisPerfectionalis]

Thank you 🙏

[@alibaldiwala1604]

THIS IS A CRIMINALLY COOL EXPLANATION! Thank you so much!🤯❤

[@agyadmohd1395]

You are so freaking genius!!! Can’t say how much u make medicine interesting and logic 🥺🧡🧡

[@MedicosisPerfectionalis]

Thank you 🙏

[@SaraMicallef]

This textbook chapter traumatised me. Thanks for undoing the damage :)

[@MedicosisPerfectionalis]

Wow 🤩 Thank you 😊

[@NightWiitchh]

Absolutely loved the video!!! It was wonderful and not confusing at all. I am currently in Pharmacology and everything makes since now!!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@rimshaabdullah8373]

You proved that.. yes I am medicosis perfectionalis love your method of teaching you are best 💗

[@MedicosisPerfectionalis]

Thank you so much 😊

[@drtahirakhtar2485]

Thank you so much for this masterpiece, this is really helpful for medical students and I am sure no body will deny this fact, 💯

[@MedicosisPerfectionalis]

Thank you 🙏

[@swally1206]

I love the way you make life easier, that was incredible and so helpful, thank you so much.🤩😁🙏🏻 I wish you were my Doctor at Uni😅

[@MedicosisPerfectionalis]

Thank you so much 😊

[@j.sbhandari8813]

what an explanation, PERFECT MAN! thank you so much and God bless!

[@MedicosisPerfectionalis]

My pleasure 😇 God bless you too!

[@daingfirdaus7951]

The explanation is crazy yet understandable

[@shyamagrawal36]

First time ever I could understand the exact mechanism by this video.. Thanks

[@MedicosisPerfectionalis]

My pleasure!

[@sxvioux]

Wow I never knew Studying these mechanism will be a lot of fun, its so colourful and I love how u throw jokes sometimes. Keep up the amazing work. 💙💙🥺

[@MedicosisPerfectionalis]

Thank you so much 😊

[@parishaykhan8139]

We need more lectures on pharmacology plz upload ...waiting ...God bless you

[@MedicosisPerfectionalis]

Sure!

[@yanli3245]

one explanation i came across with aspirin is that platelets can not generate their own TXA2 so TXA2 is not replaced, whereas endothelial tissue can generate more PGI2 despite Aspirin inhibition, hence PGI2>TXA2 in the presence of LOW dose aspirin. HIGH dose aspirin will inhibit both.

[@farhinsiddeka8345]

This really is the most beautiful thorough explanation! Thank You!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@becky5950]

This made everything so crystal clear, thank you!

[@MedicosisPerfectionalis]

My pleasure!

[@mennanabil9680]

This looks like heaven thanx from Egypt

[@MedicosisPerfectionalis]

Thank you 😊

[@afsa2973]

Thank you for the wonderful lecture . Love from India 🇮🇳.

[@MedicosisPerfectionalis]

Thanks 🙏 Love you back!

[@lisameller1]

Thanks for making this easier to understand!

[@josephbanoub8392]

Excellent presentation and I am really impressed how you could simplify the science Thanks

[@MedicosisPerfectionalis]

My pleasure 😇

[@rizz1088]

The way you teach is similar with my biochemistry teacher in medschool. ❤

[@MedicosisPerfectionalis]

Great 👍

[@kharboze_asmr]

I love how easy it seems when u explain it. Tnx so much 🌹🙏

[@MedicosisPerfectionalis]

My pleasure 😇

[@radojemarkovic5290]

Man. This is masterpiece

[@MedicosisPerfectionalis]

I really appreciate you!

[@MedicosisPerfectionalis]

From the arachidonic acid pathway, can you mention some side effects of Acetyl-Salicylic Acid (ASA)?

[@ricardobaroni1714]

Bleeding, peptic ulcer (decreases production of mucus)

[@MedicosisPerfectionalis]

Good...and why does it decrease production of mucus?

[@ricardobaroni1714]

@@MedicosisPerfectionalis Because ASA inhibits the COX pathway, consequentely inhibits the production of prostaglandins, wich are responsable for the production of mucus. Sorry for my english, I am still learning haha

[@MedicosisPerfectionalis]

You’re excellent 👍

[@osayamenogiugo3864]

Thank you! Thoroughly enjoyed learning.🙌🏾

[@MedicosisPerfectionalis]

My pleasure 😇

[@a_a_n_i]

Gosh your explanation was amazing!!! The way you made every single step funny was just cute and helped me memorize them easily, i'm preparing a presentation about arachidonic acid derivatives and was very worried where to find information cuz there isn't much to find, your video is the best, couldn't be better, thank you! 😭

[@MedicosisPerfectionalis]

My pleasure!

[@qusai1437]

I CANT THANK YOU ENOUGH !!!!!!

[@MedicosisPerfectionalis]

Thank you ☺️

[@YusraAli313]

I actually Love you, you are so entertaining it's not funny! haha Education on another level. Thank you doctor xxxxx

[@MedicosisPerfectionalis]

My pleasure 😇 Thank you so much for watching!

[@edthoreum7625]

4:35 5:40 7:20 platelets as H2O pump 13:48 aspirin

[@mylessimmons4037]

Hi medicosis, I have a question: do leukotrienes cause vasoconstriction of arterioles? which is the opposite effect of prostaglandins which cause vasodilation of arterioles? thanks

[@p.1127]

thanks for this great lecture, I have a question. What triggers PLA2 ? On inflammatory state, where all these pathway happen, in leukocyte or endothelium or any other structure?

[@wafaeltaief723]

Looooove this one it makes sence in an amazing way , may god bless you medicosis 🥰

[@MedicosisPerfectionalis]

Thank you so much 😊 God bless you too!

[@haseraaaopi3433]

i m about to sit for my Professional Exam in 5 days and this playlist makes my 5yrs in medsch into sense 🤧🤯

[@MedicosisPerfectionalis]

Good luck 🍀

[@masoomafatimah]

The best explanation! Bravo 👏🏻

[@MedicosisPerfectionalis]

Thank you!

[@elenamirova7990]

Thank you for the great explanation and the great content you put out regularly! Your videos are of great help when preparing for exams :D About the anti-platelet activity of aspirin, despite its inhibition on prostacyclin synthesis, I found this piece of information in Voet's Principles of Biochemistry: "Vascular endothelial cells are not so drastically affected, since, for the most part, they are far from the site where aspirin is absorbed, are exposed to lesser concentrations of aspirin and, in any case, can synthesize additional PGH2 synthase".

[@MedicosisPerfectionalis]

Excellent! Thank you so much 😊

[@nikolamarkovic4845]

i dont understand. how are endothelial cell far from aspirin ? endotleh covers all of blood vessels, so ist it all around the body?

[@erykahbrown9239]

Additionally, as I've now learned in my hematology course, since epithelial cells have nuclei they have the ability to regenerate cyclooxygenase whereas platelets, being only cell fragments have no nucleus and lack this ability

[@darwintuscano8625]

you are so genius! but I find it little bit confusing, because at the beginning of the series you said, platelets aren't cells. but he you said platelets are the only cells that contains thromboxane. but otherwise, your lecture is the best!

[@mohamedafifi955]

This is genius as always .. thanks doc. Bless you

[@MedicosisPerfectionalis]

Thanks bro, bless you too!

[@victorsinghayam297]

please upload the videos of Anti-inflammatory assay of plant extracts or natural products: i) Lipoxygenase Inhibition Assay ii) Cyclooxigenase Inhibition Assay

[@subeshsaurav8046]

You are simply EXCELLENT!!!

[@MedicosisPerfectionalis]

Thank you so much 😊 I appreciate it

[@SW-fk3rb]

You are funny!! Really enjoyed this, so delighted I found your channel.

[@MedicosisPerfectionalis]

Thank you 😊

[@keurinrin16]

Thank you for making medicine fun!🤗🤌

[@MedicosisPerfectionalis]

My pleasure 😇

[@keurinrin16]

It would be nice if we could have a pdf form of your notes hehehe because it is much understandable than reading books lol

[@MedicosisPerfectionalis]

I do actually...Here: www.medicosisperfectionalis.com/products/illustrated-notes-pdfs/

[@swngstr]

Wow. Great job. I like how you think. This works for me!

[@MedicosisPerfectionalis]

Awesome 👏 Thanks 🙏 Can you please help me by sharing?

[@fazalwahid9950]

Excellent easy and clear vision 👌 Thanks dear you are doing a good job. Please keep it up

[@MedicosisPerfectionalis]

Thank you 🙏

[@radojemarkovic5290]

Man, I I'll post another same comment. This i s masterpiece. Now I understand corticosteroidss and aspirin use( never knew why would drug which inhibit inflammation inhibit trombs) .

[@MedicosisPerfectionalis]

Thank you 🙏

[@MrSaloha]

Please make neurology Medicine series like hemiplegia and para... Again you’re the best...

[@MedicosisPerfectionalis]

I appreciate it

[@احمدعبدالعزيزسلامه-ه4ك]

God bless you ,indeed I benefit alot from you Sir

[@MedicosisPerfectionalis]

Thank you!

[@tashreeqa_ek]

Absolute lifesaver

[@MedicosisPerfectionalis]

Thank you so much 😊 Would you please help me by sharing?

[@hhus691]

Excellent lecture. Is the whole pathway carried out in synovial mast cells?

[@nishaanbhagwandin9394]

Thank you ,your explanations are just awesome 👌

[@MedicosisPerfectionalis]

I am so glad!

[@ricardobaroni1714]

Hello from Brazil... this channel is amazing, please keep the good work!

[@MedicosisPerfectionalis]

Thanks, brother, for your encouragement 👍

[@ricardobaroni1714]

@@MedicosisPerfectionalis I am very grateful for this channel You really left the content fun and didactic.

[@garrett_jp]

Loved this, very helpful. Thank you!

[@MedicosisPerfectionalis]

So glad!

[@Djjdjdjdks123]

Hi if you do answer can you please tell me if there is a chance that taking Arachodinic acid can enhance muscle gain

[@lostSempaiWissame]

Your laugh always cracks me up .. thanks a bunch

[@MedicosisPerfectionalis]

You’re always welcome 🙏

[@fireblossom8544]

May I ask what triggers the release of AA from cell membrane? That what will activate PLA2?

[@ishaqureshi402]

I was emotional cuz I watched sth emotional just before starting this lecture. My tears still hadn't dried up when he talked about Aristotle's deduction followed by 'Buhahah' which cracked me up. Thank you. I am back.

[@MedicosisPerfectionalis]

You’re very welcome!

[@dianareyna8889]

You are right, best explanation!

[@MedicosisPerfectionalis]

Thank you so much 😊

[@mdam1543]

Me when I watch other educational vids: *nods* yeah okay. Thank you Me while i watch medicosis perfectionalis: *smiles* *chuckles* haha yeah. I understand better now✨ thank you 🥺💕

[@MedicosisPerfectionalis]

Haha 😂 You’re awesome 👏 Thank you so much for watching!

[@thathaw7769]

Indeed the best explanation! Thank you!

[@MedicosisPerfectionalis]

My pleasure 😇

[@JoseGutierrez-ny8co]

Brother, thanks for this explanation, I was distressed, but because I did not find videos that were in my language

[@MedicosisPerfectionalis]

Thank you so much for watching! I appreciate you!

[@parishaykhan8139]

Waiting for pharmacology lectur on antibiotucs and bacterial classification ...plzzzzzzzz....God bless you sir

[@MedicosisPerfectionalis]

Thanks a ton...Pharmacology is on my list...You can visit Patreon "my goals” to know when it's gonna be released...Thanks a ton!

[@sammay4063]

A very helpful and clear video

[@MedicosisPerfectionalis]

Thanks, a lot! Can you please help me by sharing?

[@hananemess8696]

You are my Savior ! Thank you ❤️

[@MedicosisPerfectionalis]

Happy to help!

[@pablogonzales1980]

Your videos are so on point, thank you so much once again

[@MedicosisPerfectionalis]

The pleasure is mine! Thanks 🙏 Can you please help me by sharing?