The 3 Things Bryan Johnson is Missing From His $2 Million Dollar Longevity Routine: PhD Explains

What’s the 80/20 of Bryan Johnson’s longevity routine? What can we learn with it that we can use to improve our lives without losing all our time and money in the process?
Bryan Johnson is an entrepreneur who sold his company Braintree Venmo to PayPal for $800 million in 2013, and now identifies as the world’s most measured human, and his goal is to use his Project Blueprint, a longevity project on which he spends $2 million a year, to bring longevity strategies to the common person for the benefit of all humanity.
As a PhD in Nutritional Sciences with over 20 years of research, including the vetting of hundreds of biomarkers, these are the three key types of data I believe he’s missing, what I think we can discard from his plan, what can be improved, and what you can learn from this to apply in your own journey toward a longer and healthier life on a budget of much less than $2 million a year.
Here is the written version of this analysis, with live links and references:
chrismasterjohnphd.substack.c...
For my protocol to uncover your unique super-unlock using ranked and sorted genetics, functional markers of nutritional status, and markers of idiosyncratic bottlenecks in energy metabolism, see How I Found My Health “Super Unlock” After 20 Years of Research and 20,000 Genes Tested:
chrismasterjohnphd.substack.c...
00:00 Intro
00:05 Who is Bryan Johnson?
00:56 Johnson Goes to Great Lengths to Bring Longevity Strategies to the Common Man
02:29 What's the 80/20?
03:54 3 Things He's Missing
04:36 Reversible Infertility
06:25 Decreased Sensitivity to Thyroid Hormone
08:02 Calorie Restriction Effect on Lifespan Depends on Genetics
11:02 The 80/20 of Body Composition and Longevity
14:16 Reasons for Genetic Effect on Calorie Restriction
17:39 Hacking the Tests
20:27 Is Johnson’s Energy Metabolism Optimized?
25:42 Missing Ingredient: Functional Markers of Nutritional Status
28:28 Erroneous Interpretation of Nutritional Tests
29:52 Missing Ingredient: Ranked and Sorted Genetics
31:00 The Bottom Line

[@0626love]

this is now quite clear, Bryan should hire you for $2 million a year

[@Always-xl9db]

He should definitely be on his support team!

[@chrismasterjohn]

We'll see!

[@HelloWorld-bc9fe]

I disagree. This video is largely pseudoscience. Making massive leaps based on genome sequencing and data in rodents is not science, it’s reading tea leaves. Seems like OCD behavior to me.

[@0626love]

@@HelloWorld-bc9fe I partly agree 🤫🤫 but only partly

[@Boyhowdy875]

@@HelloWorld-bc9fe I disagree with you. Maybe you have a problem with other people being intelligent and successful. What is it like to be so bitter and small?

[@RiverReeves23]

Thanks for doing the legwork on this Chris. You're a really important part of the nutrition community and your input on longevity research I think is really needed.

[@christinamilioni6325]

One of your greatest videos!! Always looking forward to your new content!

[@chrismasterjohn]

Thanks! I get very good inspiration and advice these days.

[@user-uq4wp6ux3b]

Love your attention to detail Chris, truly impressive 👏👏

[@chrismasterjohn]

Thanks!

[@Coolguyallthetime2k]

He really doesn’t look like the longevity thing is working. He looks fried and dried out which is not the epitome of youth.. Chris MJohn looks much younger overall tbh (barring the age discrepancy between them)..

[@lukeclaydon6670]

The data says otherwise get rid of your opinion and look at the data Bryan has. It’s working

[@Coolguyallthetime2k]

@@lukeclaydon6670 data means nothing when your physique and physical appearance looks aged. I mean have you seen his before and after pics?

[@Sean-ot5xo]

@@lukeclaydon6670 maybe Bryan's anon "american psycho" account LOL

[@enalo6261]

He looks terrible, I think he works-out too much, too much cortisol in the body,hormone that ages you.

[@shellderp]

@@lukeclaydon6670he took a bunch of tests and is optimizing for them. That has nothing to do with health. You can tell he is not healthy by his appearance

[@55mblindy]

Keep Up the GREAT WORK🎉

[@chrismasterjohn]

Yessir!

[@annebellamy]

Amazing video

[@billsemenoff]

Always sending us down rabbit holes😂, but always interesting and well worth it!

[@chrismasterjohn]

Enjoy the trip!

[@KasKade7]

Since most people are nutrient deficient because of poor food choices and soil degradation. Doing CR just adds to that problem. Bryan with his food choices and pills might be okay now. Problem is he started very late, age 40+. Also he had more then a decade of depression and very high stress. His upbringing was also very bad in terms of food choices. You simply can't just reverse all that damage in a few years of healthy living in my opinion. Actually, it's probably impossible to reverse certain damage like his hearing loss from gun shots with diet and lifestyle.

[@Danuxsy]

You are right but also wrong, you can begin a healthy lifestyle in your 40s and 50s and still have major health benefits in a relatively short period of time.

[@paulsansonetti7410]

He could completely reverse the hearing pathology by successfully decalcifying his body You have no actual data ,you are just using a default pessimistic bias plus some form of generic scientific heuristic/Kentucky windage Your opinion is at best useless,and likely worse than that

[@marvin2678]

@@Danuxsy yes but can trdo it

[@logical_lb3059]

it's all possible. cells are just chemistry, once we figure it all out it's all reversible. hope he figures it out

[@naughtyUphillboy]

Not few years, maybe over next decade, good enough if maintains same health for say next 100 years.

[@richierich291266]

A fascinating vid which, in the politest possible manner, arguably drives something of a coach and horses through Bryan Johnson's protocol. It'll be interesting to see whether and how Bryan publicly responds to Chris's very interesting comments.

[@xp1296]

I agree - Chris goes to another level of detail which I'm sure Bryan will try to absorb, especially as Chris is so concise in his analysis. His style is so engaging as it is thorough, too hard for anyone to dismiss

[@chrismasterjohn]

Wow thanks!@@xp1296

[@chrismasterjohn]

Yes I hope he responds! Likely will have his team review first.

[@MsElaine122]

Fantastic review of BJ!! tnx I learned alot. I'll keep eating 130gr of meat protein and other protocls to keep urea/uric acid in young range. tnx

[@chrismasterjohn]

I'm eating over 200 grams of protein right now.

[@lukeclaydon6670]

Great 👍

[@chrismasterjohn]

Thanks!

[@dianalivingconsciously9013]

He's missing Sun, meat, animal fat, fish and cow butter.

[@isaactrevino7821]

Chris, what are your thoughts on regular intermittent fasting in the evening to optimize Deep stage sleep and HRV ? This seems like a caloric restriction also but it's more about the timing of calorie consumption than overall calories. I personally notice much higher HRV and deep stage sleep (according to Oura and my polar H10 strap for HRV) this is the only type of calorie restriction that seems to benefit me for my metrics like HRV , sleeping HR ECT ..

[@Always-xl9db]

You are making so much sense, thank you for that analysis! I wonder if fasting (not extreme, between 36-72 hours) is also genetically beneficial meaning only for some individuals

[@bp51082]

After trying all sorts of intermittent fasting and longer-term fasting protocols, this is what I organically landed on. Feels easy, and visibly and palpably rejuvenates me. Also interestingly, I have tracked over time that left my own devices I naturally overeat by 15 to 20%. I suspect this may be true of many people, and a big part of the overweight crisis besides less movement etc is that historically, we may have simply not had food 15%-ish of the time on average

[@chrismasterjohn]

Yes I think it is much the same as I described for caloric restriction.

[@greywolf850]

@at fasting doesn’t work for me at all… I’m a high metabolism guy and my body seems to require frequent meals… my skin gets drier as I fast so there is no one size fits all program

[@Always-xl9db]

Yeah probably not for lean, metabolically healthy people apart from innate genetics…

[@susie4045]

If only I had $8000 to unlock my longevity.🥺

[@sarahcolak9673]

I admire his diligence, self discipline and ambition. Still, he looks like a fit 50 year old.

[@user-yl7kl7sl1g]

Subbed. Great Content. I'd love to see you do a deep dive on extended fasting for longevity. Cycling extended fasting, to me a laymon, seems like it would give lots of anti-aging benefits, while giving the body time to restock the tissues with extra materials and get back to baseline during the feeding window. Vitamine C for example stored in the skin by making the layers of the skin thicker, which can later be catabolized for use by the immune system during extended fasting. It's one of the reasons I never shower, because the micro-biome on the skin breaks down the materials which get re-absormed by the skin, leading to thicker skin which can later be catabolized during fasting for the immune system and other repair functions. The literature I've read leads me to believe the optimum fasting length for humans is about one month.

[@simonwiltshire7089]

Honesty is the main thing that is missing.

[@williamdixon7401]

Would love to see this guy do a video on Hashimoto’s. He seems to dive really deep in his videos.

[@chrismasterjohn]

Search "hashimoto's" on my channel or with my name.

[@rocpile2773]

@@chrismasterjohnI’d love to see a video on Graves’ disease! There’s so much less information on graves out there and it’s arguably more severe.

[@isaactrevino7821]

You are extremely knowledgeable at what you do. I'm fascinated with this "Bottleneck" and my hanging Fruit I can do to optimize. I feel like my body doesn't like caloric restrictions, just neutral . I'm about 9-11 percent bf and ultra endurance athlete/Calisthenics athlete . At 45. I am prone to sleep issues when I'm imbalanced , anything I do wrong affects my sleep. .. How can I go about finding my bottleneck?

[@wjankowske]

I think it may make even more sense to focus on lowering one's ESR than CRP. Lowering either or both makes sense but I believe that Sed Rate is more of a longer term measure than CRP which can rise and fall more rapidly by the day or even hour. What say you?

[@chrismasterjohn]

Fasting CRP doesn't fluctuate that much if you aren't sick. Regardless, why is ESR a better index of the specific inflammatory effect of excess adipose tissue?

[@TL....]

Chris, what is your opinion on Buckminsterfullerene (C60 fullerene)

[@campersruincod6134]

Chris, what’s your skincare routine?

[@peterazlac1739]

The experiment on caloric restriction and lifespan was done unintentionally during the famine in Sweden of 1868 to 1869. During this time a retrospective study has looked at longevity of the ancestors of two villages in Northern Sweden one of which starved and the other did not. From detailed church records It found that the male children who were eight at this time lived to be centenarians whereas those of the well fed village did not and this has carried through into subsequent generations of their progeny.

[@nicholaswright6694]

I have a double Heterozygous MTHFR mutation, and fast COMT activity. Would it be smarter to supplement Methylfolate over Folinic Acid to correct my deficency? Thanks Chris

[@ThanksHero]

Hey Chris. I have a dumb question for you. On food labels, say eggs or liver, when it says a product has X amount of choline; is that actual choline or is it phosphatidylcholine? They seem to be used interchangeably. From what I could find phosphatidylcholine is only 13% choline by weight so this confuses dosing quite a bit.

[@chrismasterjohn]

No, they never are. If something says it has x amount of "choline" this refers to the mass of choline, always.

[@MClass2011]

Hi Chris, I'm having issues getting into my account. I purchased the vitamins and minerals 101 book pre-order, and ultimate cheat sheet. When I try to log in to see the vitamins and minerals online course, it says my account is not found. Where can I reach out for support with this?

[@lukeclaydon6670]

I’m a healthy fanatic and I love Bryan and you Chris

[@chrismasterjohn]

Thanks!

[@TL....]

is creatine nitrate the best type of creatine to take? in terms of crossing the blood-brain barrier, no bloat or minimal bloat, no hair-loss, etc ?

[@jskweres2]

How are your markers better?

[@hyperTorless]

There's a whole video at the top of this page you might want to watch it.

[@NickMarshallMusic]

Sunlight?

[@keemoify]

He probably takes vitamin d3 in high doses instead of trying to get it trough the sun. Because the sun will age the skin in the long run.

[@masonryjoe]

I just found your vieos and notice no new content, where are you ?

[@DinoAli1999]

I love the orthodox icon. Which Saint? God bless you brother I subscribed! Keep growing as Orthodox Christian ☦️☦️☦️ Jesus be with you ☝🏽

[@chrismasterjohn]

Porphyrios of Kavsokalyvia.

[@DinoAli1999]

@@chrismasterjohn Thank you brother ☦️

[@lalouloune6156]

Hi Chris, I hope you are doing well. I am here as doctor Peat mentioned you in a podcast. I have a problem, I am quite healthy, I tend to wake up very early in the morning like 4h30/5h30 the latest. I would love to be able to sleep at least 8 hours above all during the weekend. Can you please advise or help? Thanks in advance.

[@kennyprice5017]

Topical tretinoin is retinolic acid Therefore there should be no need for conversion. I was confused about that point?

[@chrismasterjohn]

If he was converting vitamin A normally he wouldn't need it.

[@user-br3sw4tm2c]

hello, hopefully i will get a answer.. ho much niacin for lipids? i know that i need to take glycine with the niacin. but ho much niacin to get best results on lipid but not to destroy the liver ?

[@stanleyyu2079]

Please do a web search on this paper, "New Perspectives on the Use of Niacin in the Treatment of Lipid Disorders" published in 2014. Figure 1 has the dosing info. Table 2 has the recommendations on how to reduce flushing.

[@sincity5268]

Mr. masterjohn is there anyway i can get in contact with you? Ive been tweeting you for a while regarding mysterious seizures in a relative of mine with no response and im not sure if youve seen any of my tweets, i am desperate and need help !

[@anovosedlik]

If i'm being honest, bryan johnson doesn't really look that young. But I guess his goal is more just to live long.

[@greywolf850]

Dude you’re a smart guy … nice/rats data is sorta pointless as it doesn’t really take into account hormones which is the primary driver of aging and anti aging Great video

[@Donutell]

Hello I wake up at night after just 3 or 4 hours of sleep. I work out all the time, do not drink Alkohol or smoke, eat healthy...Do you know what can cause this? Thanks!

[@Yt1925jn]

Can diamine oxide supplementation be dangerous as it can disrupt histamine functioning in the brain? I’m suffering from chronic nasal congestion

[@Mijn3023]

Would endogenous diamine oxidase work against seasonal allergies and allergic rhinitis?

[@LD-yq7cl]

how will you increase that? copper? dao in supplement form, maybe...

[@katherinegreen-we1ec]

Did you mention his thyroid problem?

[@inittiela4934]

Do anyone have issue with excess acetylocholine production which is respoding(those suplements reduced this excess production) to creatine/betaine suplemention so its obvious that it is connected tigthly to methylation itself. I suspect that there must be an issue with 1 of 2 enzymes in choline conversion to betaine and i seen that Choline Dehydrogenase is dependent on vitamin b2 but we dont have any studies that checked it. There is one study that could support that hipothesis but they were focused mainly on mthfr, im talking about study that showed huge reduction of homocystine in people with mthfr polimorfism suplementing 3mg of riboflavin, but its really suspicious that drop was so huge because of upregulation of 1 enzyme. We need to take in account fact that people in this study had some activity of this enzyme at the start of suplementation so even boosting activity by 50% shouldnt lead to 40% reduction of homocysteine so maybe b2 actually upregulated both of those enzymes which are mthfr and choline dehydrogenase. In the end im just curious if someone with same problem as me tried 3mg of ryboflavin or even more to check that?

[@orion9k]

my body temp is 96.8 Fahrenheit

[@nephilimninjaofnibiru2907]

Clone Vampirism hasn't been explored properly.

[@chrismasterjohn]

So much research to do.

[@nephilimninjaofnibiru2907]

Lol Merry Christmas Thanks for your work.

[@aamsergie]

I've never seen a person so crazy about being an 18 year old again....

[@Ella-qo1ec]

Great presentation Chris, though I'm stuck. I'm mid 60's and things are sliding south with my physiology despite the supplementation I've been blindly, extensively and expensively, following. To target metabolism more precisely I was considering getting a full DNA test through Nebula Genomics, which Dr George Church has some involvement with, yet you say that no testing company is giving the right breakdown of health biometrics regards their test? So I'd be blowing a 1000$ on a test and not get that information even with Nebula's self-proclaimed comprehensive test, breakdown and feedback?

[@bp51082]

Sounds like you might be well served to directly employ Chris or someone like Chris and do individual consultation and customization. Good luck! I appreciate the fact that you are taking ownership of your health outcomes

[@chrismasterjohn]

BioOpt Health uses whole genome raw data so getting it (for way less than $1K would not be for nothing).

[@Ella-qo1ec]

@@bp51082 Thanx for support, yeah, i gotta do something, can't take cash with ya when you shuffle off this mortal coil, and going to the amount of funerals of my contemporaries that I have rather sharpens one's resolve.

[@Ella-qo1ec]

@@chrismasterjohn Thanx for reply Chris, not heard of BioOpt, I'll definitely look into them before giving my bank balance a shellacking.

[@jeanmichel2642]

the major issue I think is that an experiment on only 1 person is absolutely useless to conclude on the whole population. with the fact that this experiment is an accumulation of several ones at the same time with possibly a cocktail effect. so at the end if something works or doesn't works nobody will be able to discriminate the key factors.

[@MichaelAndretti55]

The fact that he's a vegan negates his entire mission

[@lauroandrea3241]

Ah yes Bryan Johnson, the 40 year-old man who looks 50. Chuando Tan is a 60 year old guy who looks 25.

[@bobbobson4030]

I think the CR argument is a lot simpler than that. Your "ad-libitum" calories is totally arbitrary and differs between species and individuals. It depends on your appetite and is in no way a reflection of the correct number of calories for you. CR is subracting a percentage from this, so even if the ideal bodyweight was the same for all people (people are all the same height?) the CR would be be different to achive the same calories. Then for the weight you can have a totally different body composition. The CR concept falls flat on its face. Just try and have as much lean mass and as little fat mass as possible.

[@chrismasterjohn]

That goal is not supported by the data. The data on longevity say you want to be in the second quartile of fat mass and the upper half of lean mass. Neither of those are extreme.

[@bobbobson4030]

@@chrismasterjohn I think this is an artifact of the fact that there is virtually no one in the standard sedentary population that is in the highest quartile for lean mass and lowest for fat mass at the same time. Therefore having one quality will imply sacrificing the other. PS. If you could link the actual study that would be great

[@gerdin2]

What he is truly missing is the other half of longevity practices, the old school ones

[@motishabbat5292]

How can someone work with you?

[@Eddie-3466]

It would be more cost-effective and convenient to adopt the diet followed by the inhabitants of the Blue Zone in Costa Rica, where people consistently live to be over 100 years old.

[@catalinaarellano5221]

You probably would have to move to those places to get all full benefits, Sun exposure, environment will also make a difference.

[@xp1296]

I wonder if Costs Rica will be a "blue zone" for much longer as the aerial chemical spraying is now next level, one of the worst in the world

[@Eddie-3466]

@@xp1296 in the next 20 to 30 years their will be no more blue zone in Nicoya Peninsula Costa Rica.

[@chrismasterjohn]

How do you know it's their diet?

[@Eddie-3466]

@@chrismasterjohn You have this thing called the internet, it has you-tube google and chatGPT where you can get the information from. SMH.....

[@travv88]

Wasn't aware he stopped the TRT.

[@chrismasterjohn]

He described it on Twitter.

[@ew-zd1th]

Why did he stopped it?

[@travv88]

He started it because he was doing lower calories because of his thought that it this improves longevity. Lower calories lowers testosterone so he took TRT to offset that. I'm not sure exactly when but he decided to increase his calories and has now dropped the TRT. There are a number of reasons why he may have done that but for one taking hormones from external sources interrupts the ability of your body to produce them itself which is problematic long term. @@ew-zd1th

[@keemoify]

Why would anybody under the age of 60 go on trt? You can produce test well yourself up to that age with the right nutrition and training.

[@theatoke6181]

If you plan to live forever, becoming infertile is actually a good thing. Or we run out of space 😆

[@greywolf850]

As a vegan he’s missing real vitamin A and real omega 3s -- it’s why his skin look so pale and grayish -- also I don’t know if he has given out his T results but he looks like he’s has low T … also he should eat raw veggies

[@sooooooooDark]

the elephant in the room of his data certainly is lack of microbiome specification he seemingly does just look at SCFA (which supposedly were low according to something he once mentioned), which tends to be a marker of general gut dysbiosis but no one knows how the gut microbiome truely works, even those with multiple phds, no one

[@drednac]

There I one thing that I don't really get. How can you be constantly in the caloric deficit, you would be loosing weight until you die.

[@chrismasterjohn]

It's based on calculations, not on weight stability.

[@drednac]

@@chrismasterjohn Of course you calculate it but you caloric deficit means that your available energy input is less than the energy output. So that's how you loose weight. Body needs to get the energy from somewhere. Usually from fat but when it runs out of fat it will burn muscle and pretty much anything until you die. When you loose weight your energy requirements goes down so the absolute amount of calories is constantly changing if you are not getting enough energy, than there is a speed of metabolism which is slowing down, but either way to maintain a constant caloric deficit you are let's say -200 calories from your current maintenance calories to achieve energy balance .. you are still missing those 200 calories from your current needs so if you stay in that you will eventually die as you run out of ways to get extra energy from your stores. So maybe saying "calorie deficit" is misleading statement.

[@user-uq4wp6ux3b]

​@@drednac​ I totally get your point. If truly in a caloric deficit, one WILL initially lose weight by burning fat + lean tissue + with some fluid excretion, if there were no other dietary and lifestyle interventions introduced. Over time, however, if one remains in a calorie deficit, the body will begin to lower it's metabolic rate so that the body can survive on this reduced calorie intake, so you won't actually die BUT your health will suffer long term due to reduced availability of energy substrate necessary for essential system function. This is my understanding of it anyway

[@drednac]

@@user-uq4wp6ux3b Yes your metabolic rate will decrease but it cannot decrease up to zero .. it has limits. That's why you would die ..

[@user-uq4wp6ux3b]

@@drednac wrong, it depends on the MAGNITUDE of the calorie deficit. The formula, according to Dr Robert Lustig MD, is ~65% calories goes to basal MR, 10% for the thermic effect of food, and the remaining 25% of calories is for DAILY ACTIVITIES. So, if the calorie deficit is 200kcals, this represents a SMALL reduction in the amount of calories available for the 25% of calories set aside for everyday activities BUT there will still be a surplus of calories remaining for everyday activities, as a typical male uses approximately 2200 kcals per day and females around 1800 kcals. So, for a male, 25% of kcals for EVERYDAY ACTIVITIES is approximately 550kcals. A reduction of 200kcals per day means a loss of 36% of calories for everyday activities with NO CHANGE in the calories for BASE MR or the thermic effect of food. Does this make sense? If the calories deficit for this male was closer to 550kcals per day, then the situation is more dangerous as he would have almost no energy available for everyday activities (requiring 25% of calories) and would need to seriously slow down (but STILL would NOT DIE as there is sufficient calories available for his BASAL MR and thermic effect of food) This is a detailed example of how calories are used in the human body and no, a male on a 200kcal deficit will not die, but will need to slow down a little to conserve energy

[@robertdaymouse3784]

I am starting to think BJ had Chris eliminated.

[@metaphysicalArtist]

I hope to see you interview Bryan Johnson btw nice Orthodox Icons, who is the Saint? , ....you don't have Greek heritage do you?

[@chrismasterjohn]

That would be fun. Porphyrios. 1/8 Greek according to family tradition, more Italian according to 23andMe.

[@rolew7882]

Is that St Charbel behind you?🙏

[@chrismasterjohn]

Porphyrios.

[@drytropics]

Doesn't being slightly underweight give a longevity benefit till around 60, then it switches and being slightly overweight has longevity benefits if over 60? Possibly as they have more bodily reserves if they get ill. I would have thought being slightly overweight when under 60 is unlikely to be beneficial, considering the research on CRON diets. At 65 about half of humans develop sarcopenia, and resultant fraility and falls dramatically reduces lifespan. Caloric restriction works very well until you turn 60 but if continued can lead to sarcopenia, which then offsets any longevity benefits. Classing all humans as needing equivalent dietary and supplement regimes isn't taking into consideration the changes that happen in an aging human.

[@nathan500100]

didnt mention hyperbaric oxygen therapy

[@vince1229]

He is also taking dutaseride for hair loss. Risky?

[@chrismasterjohn]

Definitely some risks.

[@sincity5268]

Mr. Masterjohn sir please im begging if you see this please let me know if there’s a way we could communicate!

[@akbarshoed]

Breathing. He's not breathing purposefully

[@chrismasterjohn]

Interesting.

[@travisl9201]

Chris is trying to get in on that 2 millie

[@chrismasterjohn]

We'll see! Haha.

[@keemoify]

Not eating meat is the worst thing you can do in the long run.

[@PClark-tb5ww]

I admire Bryan’s determination. However where is the joy, the joy of eating, of living. We live to make mistakes and learn. To interact with others. We also get sick… and bounce stronger. We also live to love. As much as he thinks he’s going to live forever what is the purpose. What if he’s losing the time he’s given by trying to save it.

[@chrismasterjohn]

He gets all his joy from his workout, he says.

[@JohnnytNatural]

He's trying to sell a program as well, this is all part of the plan he thinks he's revolutionizing a new industry but chances are he's going the wrong direction

[@stx7389]

​@JohnnytNatural BS

[@michaelransom5841]

I seriously don't know how he's spending 2 mill a year.... testing costs??

[@edwardscott2510]

He has a team a chef n assistants

[@MrShitConnection]

Hey, Chris. Regarding your video on seed oils… you provided great knowledge, yet mechanistic evidence. Although fascinating, folks like Dr. Layne Norton, as well as the hench behind the channel “Nutrition Made Simple” have made videos compiling actual OUTCOME data regarding PUFA consumption, most of which flies in the face of what you claim. Could you update us on that? Perhaps address those videos?

[@erikahuxley]

Stop copy pasta this every new video. The two you mentioned are clowns, do you own homework.

[@MrShitConnection]

@@jlushefski I’ve gone through his archives. It’s mechanistic. The reason I ask Chris to address the outcome data presented by other credible sources (Layne Norton) is because I can only imagine someone with as much knowledge as Chris to be able to provide nuance.

[@chrismasterjohn]

It doesn't. And I do focus on outcome data.

[@chrismasterjohn]

False, I've covered all the long-term randomized controlled trials. @@MrShitConnection

[@MrShitConnection]

@@chrismasterjohn Yes, I even listened to one of your great Spotify podcast episodes on that, and paid attention to your criticism. However, Norton really brought a boatload more evidence to the table with his recent video. I would have to rewatch the video and list them down, if it ought to come to that. The main crux of my question is, do you have a nuanced explanation of why health markers improve on higher PUFA in those trials Dr. Norton mentions? Or have you perhaps already addressed this? If so, I’ll have to look further.

[@MrBlueBrains]

U gotta treat that froom a bit! Dang..lol. good stuff tho

[@rwh4114]

#4 - regular and intense exercise

[@chrismasterjohn]

He does that.

[@despertardacentelhadivina7952]

You're a genius, he should hire you instead..

[@loicdrloopang5671]

"No sunny vacation" seems the most crazy to me : not sure anyone can properly defend this being holistically healthy with any data ...

[@rigaleb]

Sun exposure is the most accessible anti-ageing practice.

[@alterego157]

@@rigaleb Vampires disagree. And they live for centuries or millennia.

[@travv88]

It's pretty simple. I've seen the skin of someone who has had lifelong sun exposure. Compare their arms to their thighs. Their thighs with little sun exposure looks literally 20-30 years younger. Another example is of a woman who wore sunscreen on her face but not her neck. Her face was much younger looking than her neck. While sun has health benefits, we need to be very careful about exposure if we care about aging.

[@alterego157]

@@travv88 True. You can see that on all older people. The parts of skin that were exposed to sun always look much older than the parts that are usually covered by clothes. .

[@rigaleb]

depends of the type of skin, depends with they have blue light toxicity or if they use sun glasses, if they've been on imune suppression, if they have had contact with any process that destroys their non visual photoreceptors, if they had sunrise infrared exposure that sets up the cascade of adaptation to the sun and so on... Nothing is linear with the human body.

[@alterego157]

Too vague. No actionable information.

[@szymonbaranowski8184]

we want other Bryan Johnson who eat human food - meat

[@healyourgutguy]

lol he is missing much more than 3 things!

[@Sean-ot5xo]

missing a soul, probably never had one lol

[@lukeclaydon6670]

Sorry expert. Think you can do better than Bryan then show us your data. Oh what’s that you can’t

[@SIIKAP1]

@@lukeclaydon6670vegan troll

[@LD-yq7cl]

ah the dude has/had 800 million of spare cash to go play 2 million a year...

[@birage9885]

Just think of the people whose life he could have saved or improved with his money.

[@SteveRichards27]

Yeah, that’s exactly what he’s doing by making his research public

[@birage9885]

@@SteveRichards27 The same research that people can get free other places, I stand by my comment. He isn't doing anything ground breaking, if even effective.

[@SteveRichards27]

@@birage9885 you are of course entitled to your opinion, but he’s published data that shows his results are way better than anyone else has achieved. He’s opened himself up to a lot of criticism and scorn when he had no need to, he could have just kept all of this private. He’s trying to help the world in his own way and yet people still seem to feel that he deserves to be criticised for it. I personally doubt that all of the work he’s done developing a techniques for measuring the effect of his protocol on all of the major organ systems at the same time is readily a available elsewhere, but prove me wrong and post the links, since you’ve already done the research to support your opinion

[@edwardscott2510]

​@@birage9885I learnt off him

[@travv88]

I sure hope you give your money away to random people. I think Bryan is doing a good thing and you're just being weird. @@birage9885

[@bengrey4856]

he blows millions and i just eat steak , filter water and sea salt - i dont age and strongest i ever been LOL

[@ballinshogunrk]

I’m so confused how your audio can be so thin sounding when you’re that close to a microphone. There is either something wrong with your editing workflow or that mic is terrible. I’ve heard cheapo $15 headset mics sound way better

[@Always-xl9db]

I agree. Audio is raspy and scratchy, this is really one major drawback of this channel ,content is so interesting but hard to listen to it.

[@edwardscott2510]

He's getting his cucumber sucked

[@hosoiarchives4858]

He isn’t even close

[@MC-op6gb]

Once someone gets whole genome testing are there any way to analyse your individual bottlenecks. Your videos have no guidance on this.

[@chrismasterjohn]

I specialize in that. Will talk about it more when we can accommodate more clients.

[@Always-xl9db]

Chris, I’ve joined the waitlist and can’t wait to become your client. When do you think it can happen, approximately?

[@JonWRowe]

I'm not sure if I can sit through all of this. But I seriously believe that Bryan's diet is WAY too plant based. I think it's all insanely supplemented vegan; and indeed, if you don't supplement a vegan diet it's unhealthy/downright dangerous. He'd be better off if he were keto-carnivore.

[@user-uq4wp6ux3b]

100%, he has sold out to current plant based dogma. He has no idea about the vastly superior bioavailability of animal and marine foods, as evidenced by his OTT 100+ daily supplements. Striving for ultra low body fat is just plain ignorant (as he found out when his testosterone levels tanked). I admire his conceptual mindset of improving his biochemistry to maintain long term health, but his nutritional strategy is more cyborg than human

[@chrismasterjohn]

It would be interesting to see him experiment with it but he says he is vegan because of preference rather than science.

[@juliuss.5797]

the funny thing about him is that he's aging just like any man in his age bracket, he wont live any longer

[@chrismasterjohn]

I suppose we will see who lives longest in decades.

[@erikahuxley]

I would argue he's not eating a nutritious diet.

[@audrey3042]

Interesting point. I’m really not sure how his team derived that specific plant based diet to eat every single day 🙃

[@SteveRichards27]

A myriad of tests provide evidence that he is eating healthy, what evidence do you have that disproves those tests?

[@user-uq4wp6ux3b]

@@SteveRichards27 human historical eating patterns, loaded with innate wisdom & experience over thousands of generations NEVER embraced an exclusively plant only diet, as it's loaded with a host of anti-nutrients/enzyme inhibitors, mineral binders etc..AND is devoid of numerous micronutrients found in non plant sources (which is partly why he has to supplement so heavily each day)

[@SteveRichards27]

@@user-uq4wp6ux3b that’s just a theory though, his data shows something different

[@chrismasterjohn]

I think it's nutritious in many ways but not totally optimal.

[@wambam1741]

You’ve talked for 20 minutes now and haven’t said much of anything except to use loaded words like Johnson’s doing “crazy” things, completing mischaracterizing or just completely making up things. For example, you of course begin with satiating the unoriginal, “and you won’t have to spend $2 million to do it.” It’s not even worth saying because no nobody else is going to spend $2 million upfront to research. But you’re implying you’ll get the same or better results. No you’ll just get different results. Another thing that is complete BS is, he didn’t inject himself with his sons blood. As a nutritionist, you should know the difference between blood and plasma. Actually, there was nothing wrong with find out what happened himself was. But he tries something and he discards it if it doesn’t work. You really just rehashing everything he’s already explained online, except for one crucial thing. You’re a nutritionist you’re supposed to know about all this optimal health stuff. So where is your diet plan?

[@tp6834]

Bryan Johnson looks younger and healthier than you.

[@chrismasterjohn]

Well we will get some quantitative data soon! I'm competing in his Rejuvenation Olympics :)

[@tp6834]

@@chrismasterjohn Eagerly anticipating the results.

[@zeev]

This is TOTAL nonsense. you are using data on caloric restriction to push a TOTALLY unproven and speculative thesis about 'everyone being unique'. it's nice to get good data and critical thinking you are providing , but you are pairing that with bunk. bunk is bunk.

[@emh8861]

He’s missing common sense 😭.

[@NeverFollowTheCrowd]

Get to the point lol

[@robmik83]

Calories is a false paradigm, it matters what you eat, not how much. So go carnivore + optimize vitamin D3 levels and you will look and feel way better than this Johnson guy.

[@alterego157]

" it matters what you eat, not how much" Both matter. Claiming otherwise is just ignorance.

[@robmik83]

@@alterego157 Yet within context. Such as eating only carbs is bad, eating too little only carbs is even worse. While eating meat is good and doing a fast here and there is even better.

[@tomnjudyorton732]

@@robmik83All plants have carbs, fats, and proteins. He eats lentils (protein), nuts and seeds (fats and proteins). Plant protein doesn’t cause cancer like meat and dairy (especially dairy). Blue Zones eat lower protein especially animal protein usually only a minimal amount a couple times a week. Also check out the China Study.

[@robmik83]

@@tomnjudyorton732 Take a look at carnivore results people report. The idea is that one eats ONLY animal fats / proteins.

[@tomnjudyorton732]

@@robmik83 no long term studies just antidotes for carnivore. Colon cancer, LDL, saturated fats are big concerns.China Study was 20 years most comprehensive nutrition study ever conducted. People love to hear good news about their bad habits when there are now long term studies.

[@kirill747]

why dont u read it with own words instead of reading from a document. everything loses point and sense when you read it with no meaning just as fast as possible. #boring #senseless #zombie

[@DuderofDudeness]

Ppl like Bryan are quite vile. He's rich as hell but chooses to spend loads of money on slightly slowing aging. He instead could have been investing in small businesses or volunteering in an underserved area or donating to small organizations. There's so many rich ppl that have had little adversity to forcibly humble them.

[@lukeclaydon6670]

It his life and his money he can do what he likes with both. You sound rather jealous

[@johan2380]

bro. use your brain for a sec, just once please. and really think. he's doing research that could and will help millions of people advance in longevity, anti-aging, and improving their lives. but yeah man, you are right, investing in a small business prob would be the best thing for him to do.

[@SteveRichards27]

He’s thinking big, how to make his money work to help billions, not with his exact protocol, but with his preventative health research, you are thinking small, both approaches are useful to the world

[@DuderofDudeness]

@@SteveRichards27 Preventative hcare goes against our economic system, which he luckily benefited from. He's hardly researching and testing things mostly for himself. How is his "research" going to help "billions" 😂?

[@DuderofDudeness]

@@johan2380 "Use your brain, just once" is something an adolescent would say. What "research" is he involved in? He's a lucky, rich bstrd.

[@loicdrloopang5671]

kzbin.info/www/bejne/rovNaYV9map7hsU The guy this video is about is 60 and actually impresses me much more than Bryan Jonhson in the way he looks, he seems not to worry too much about sun exposure and follow basics and simple principles that would make sense for quite a big portion of the population, he demonstrates in "live" the picking process of the low-hanging fruits available to most of us,,, He looks amazing, maybe he has a lucky genetic or what ,, but I quite sure following his simple principles has a strong effect.

[@nootri]

So the dude likely had a young mother, got some great mitochondria, is on a low seed oils low carb, barely any fruit diet. We can do better than him!