The ABCs of Androgen Deprivation Therapy

(Visit: www.uctv.tv/) Dr. Eric Small, Professor of Medicine; Urology; and Chief, Department of Medicine/Division of Hematology/Oncology, UCSF. Recorded on 06/08/2019. Series: "Prostate Cancer Patient Conference" [Professional Medical Education] [Show ID: 34965]

[@stevemetts6206]

This is one of the best presentations on ADT Therapy I have seen. I better understand, what I am going through, what is causing my side affects. My doctor, hasn't taking the time to explain this whole process, and I've been on ADT for over a year

[@robwells230]

I seriously doubt that your doctor told you how little overall survival benefit results from ADT... ...or that there are very serious quality of life destroying, and life threatening effects, ..that there is a twenty percent chance in older men that their testosterone levels will NEVER RECOVER and that they will remain castrated for life. ......or that many men find the cruel and barbaric chemical castration treatment to be INSUFFERABLE and refuse to accept or continue this horrific treatment.. Please don't believe the BIG PHARMA SALES PROPAGANDA, and gather ALL THE FACTS, so you can carefully weigh benefit vs. risk , and only then can you give your FREE AND FULLY INFORMED CONSENT. Good luck with you journey. You are not alone

[@Doctor9599]

Thanks for everything Sir

[@rickrick5041]

Very good presentation

[@briangriffith2394]

Thank you so much doctor

[@williamtucker709]

Thank you doctor

[@rhyothemisprinceps1617]

Would fasting (or a fasting mimicking diet) during the intermittent ADT treatment period improve efficacy?

[@anilmehta6425]

ADT means (although effective) EDT energy ( whichever remained ) deprivation therapy

[@michaelyarmas4423]

Why cant Non-extensive metastatic disease be treated Intermittently? I am on Eligard+ Abiraterone my psa dropped to 0.018 I would like to try Intermittent therapy but I am being told no as in your slide at 18 min mark

[@rhyothemisprinceps1617]

So I came up with this brilliant theory after thinking to myself, now if I were a cancer gene in a tumor cell or cancer stem cell, how would I spread myself all over (explaining why sometimes treatment resistance just seems to explode). I would make myself into a transposable element and package myself into an exosome... I checked PubMed, and, yup, people are already working on 'my' theory: www.ncbi.nlm.nih.gov/pmc/articles/PMC3040683/ Perhaps a therapy based on blocking the ability of these exosomes to fuse with other cells would help stop the spread of drug resistance? (researchers are probably already on it)

[@peterh4446]

I thought testosterone converted to dihydrotestosterone, which the converted to estradiol, which is what actually nurtures the cancer cells. Correct?

[@dlindo8892]

That’s what I’ve always heard too. There’s no way in hell I would ever take these drugs!

[@jeffkelley5847]

The Huggins study only involved two men, one was already castrated. How can you still use this as your basis for treatment.

[@rredding]

As many times before, it struck me that there's a stricking resemblance between medicine and quackery... ("good" and "bad" cholesterol, the dangers of salt, prescribing antacids and probably chemo in general 😲)

[@dlindo8892]

Yeah, these doctors are a bunch of clowns!