The Complexities of Treating Depression | Dr. David Linden & Dr. Andrew Huberman

Рет қаралды 25,111

Күн бұрын

Пікірлер: 81

@LonelyTreeSunset 2 ай бұрын

What's driving the inflammatory response? Food-like substances, high sugar, high LA, chronic stress, nutritional deficiencies, etc.

@rockroll7649 2 ай бұрын

I suffered major depression from 2013 to 2019. I went through venlaxaxine, amitripptyline, buproprion, mirtazipine, a couple other meds, and many therapy sessions. The only one that even helped slightly was venlafaxine. I weaned off venlafaxine 3 weeks after starting microdosing of psilocybin. It was a miracle.

@shakierputtur 2 ай бұрын

How are you now? Got completely healed?

@davidpenas4719 2 ай бұрын

hey how are you ? doing better know?

@Mark-pm1uy 2 ай бұрын

I want to do that too

@7fall 2 ай бұрын

SSRIs and SNRIs (like those you listed) must be avoided during use of the mushroom. It can cause serotonin syndrome by releasing way too much and it gets trapped. Use only after a few weeks once you stop SNRIs / SSRIs.

@CraZy291 2 ай бұрын

What would you say was/is the cause if your depression, if there even is one?

@ptoro5803 2 ай бұрын

As always, TY for comprehensive info empowering us to understand & direct our wellness!

@newday2637 2 ай бұрын

Great information, it’s refreshing to hear other avenues looked at when it comes to depression. All you see is big pharma ads for medications and ones to add when the first doesn’t work.

@nickgettins6606 2 ай бұрын

Training mind and body helped me get rid of my depression.Small steps add up.Relaxation so you can calm down when stressed.Train where your attention goes so things don't get in the way of being present in the moment.

@LonelyTreeSunset 2 ай бұрын

Diet and lifestyle are always overlooked.

@CraZy291 2 ай бұрын

Even if they are not the cause, they certainly help in alleviating the pain from depression.

@saadbintanvir 2 ай бұрын

Yes I agree

@swarden2 2 ай бұрын

In how many of us is it overwhelm that we cannot personally fix? SSRIs have been useless if not harmful. My comorbidity with ADD has been a grace at times, except when the dopamine totally runs out…

@sportsguy569 2 ай бұрын

solid hypothesis from Hubie - spot on!

@oksanakaido8437 2 ай бұрын

Mental health doesn't get addressed enough in people with MS, even though depression and anxiety is so incredibly prevalent in this population. It's like no one thinks "hey if there are inflammatory changes happening in the brain that affect physical and cognitive abilities, can't they also drive mental health dysfunction as well"? ☹️

@robinsierra1029 2 ай бұрын

Hello, it would be so helpful if you included information on how long Covid affects everything you're talking about and all your videos. Thank you

@christinathein951 Ай бұрын

Benadryl actually helped my brain fog/depression and I felt that was related to inflammation. Not sure if this could help anyone but 3 Benadryl at night allowed me to wake up clear headed in the morning which previously waking up foggy was a huge factor to my depression 🤷‍♀️💯 if anyone else tries this and it works for them let me know!!!

@millriverfarm 2 ай бұрын

Thank you 😊

@kimberlyasborno1250 2 ай бұрын

I have struggled with depression since my 20's. I guess im one of the lucky 30% that found an antidepressant, Citalaphram, that works ok. I have friends who are still struggling with the terrifying depths of despair from depression. So do i periodically. Im wondering if Dr. Lindon has ever experienced it? Sure doesnt seem like it to me. Btw Im 72 now. My meds keep my head "just above water," most of the time. Settled on Celexa/Citalaphram 20 years ago, never miss a day. Plus it doesn't make me feel dead emotioally like all the other ones did. Maybe you are making progress, but not a whole lot. Yet. Hopefully, the silicybin studies will make better headway in the future.

@xanderisawaken 2 ай бұрын

I've suffered depression 3months. now, i think it's better to got suffered .

@DansBasement 2 ай бұрын

How are people supposed to excercise when they have extreme fatigue, muscle tension, exhaustion from depression/anxiety?

@glock-17sniper57 2 ай бұрын

You start really small and slowly build over time 🙏

@andreicapi3535 2 ай бұрын

I got back into fitness a few months ago and have really struggled with the fatigue and muscle tension aspect of depression/anxiety, I initially started by giving my self a little boost with caffeine to help combat the fatigue and then I started following a workout plan that I worked on before I had a little hiatus from fitness. After my workout and hitting the sauna I would feel a lot better mentally, my head became quiet and I felt much happier, the sauna really helps with muscle tension as well, now I look forward to getting that same feeling after a workout as an escape from depression/anxiety, so no matter how shitty I feel during my day I still have at least one thing I can look forward too at the end of it. Also setting goals helped me a lot too, after achieving small goals I felt more and more motivated towards more difficult goals which also helped me in my consistency. It's always important to set goals for what you want to achieve. Start small and let your body adjust.

@jenmckee1302 2 ай бұрын

⁠my fatigue is so extreme just starting is not possible….it is such a vicious cycle

@DansBasement 11 күн бұрын

Same. The insomnia keeps me depleted.

@stacyyoung8422 2 ай бұрын

my physician told me by taking venalafaxine for 35 years , changes your entire makeup... wondering if this is why you cant get off them without severe phychosis?

@plockacherrys5765 2 ай бұрын

It does. Cox 2 inhibitiors for depression studies exists

@kwa_nguyen 9 күн бұрын

🎯 Key points for quick navigation: 00:00:14 *🤯 Depression is not uniformly treated by SSRIs; only one-third benefit significantly, suggesting it may encompass various biological disorders.* 00:01:07 *🧪 Inflammation is linked to depression, but anti-inflammatory treatments like ibuprofen do not significantly alleviate it.* 00:01:47 *🌿 Hepatitis C treatments increased depression, highlighting the link between inflammation and depression.* 00:02:14 *🤔 High depression rates in multiple sclerosis possibly relate more to inflammation than the psychological impact of disability.* 00:03:22 *🧠 There may be progress in understanding body-to-mind medicine, especially for depression unresponsive to SSRIs.* 00:04:30 *🍄 Psilocybin therapy shows significant promise in treating depression, with higher success rates than SSRIs.* 00:05:11 *🔗 Neuroplasticity might be central to treating depression, potentially linking neuroplastic mechanisms and inflammation.* 00:07:03 *🌐 Neuroplasticity could be key to alleviating various neuropsychiatric conditions, highlighting advances beyond synaptic plasticity.* 00:09:04 *⚙️ Microglial cells, involved in synaptic pruning and responsive to inflammation, could play a crucial role in depression mechanisms.* 00:10:25 *🏃‍♂️ Exercise is as effective as SSRIs in treating depression, benefiting brain function through biological pathways involving various brain cells and vasculature.* Made with HARPA AI

@rlucas7374 2 ай бұрын

All i learned here was scientists still have no idea what causes deppressuon much less how to treat it

@vaibhavsingh7734 2 ай бұрын

Please watch the 2 hr video, it covers the topic in details

@supermarkethobo9567 2 ай бұрын

I'm in the 1/3 where medication has no effect. I've tried 15 different ones and none have really moved the needle. Also did Ketamine therapy and Transcranial Magnetic Stimulation. I cook all my own food at home and lift and do cardio and sleep well and try to socialize and blah blah blah. Nothing works or helps. Been looking into euthanization lmao

@carlakenyon6073 2 ай бұрын

You sleep well with your depression?

@Mark-pm1uy 2 ай бұрын

You should try micro-dosing. I want to try it too once it becomes legal in WA state. Also, I was thinking about Ketamine therapy and TMS, how was it for you?

@CraZy291 2 ай бұрын

Have you tried therapy? I am reading a book called "A Liberated Mind: How to Pivot Toward What Matters" which covers the Acceptance and Commitment Therapy (ACT). I am only at the beginning but I feel like it is helping me quite a bit already.

@CarolynMcHaney 2 ай бұрын

Fungal infections? Food sensitivities? Mercury poisoning? So much to test and eliminate-keep searching…

@michelep.7249 2 ай бұрын

I suffered every couple of months from depression from ages 7 to 30. Looking back on it I blame it on negative thinking. When I was close to the age of 30, I read the book Meditation for Dummies. I practiced mantra meditation and would spend 45 minutes, five days a week for 18 months repeating a positive mantra in my mind. While meditating anytime my mind wandered to something else I would bring my mind back to repeating the mantra. I would write out my negative thoughts and come up with a new positive mantra contradicting negative thoughts every week. My thinking actually became more positive and I became happier. Also the book Meditation for Dummies states that feelings are not evil. The book recommends feeling feelings like anger, jealousy and fear until they go away. I was so afraid to feel these feelings due to my Christian upbringing that it was a relief to feel these feelings without the guilt trip. The book emphasized that I can feel these feelings without acting on them. Having more positive thoughts due to mantra meditation and no longer condemning myself for my feelings helped me feel happier than I had ever felt before. For the past 20 years I have rarely felt depressed and when I did it wasn't as bad as it was before I found the book Meditation for Dummies and started implementing it's teachings in my life.

@kimberlyasborno1250 2 ай бұрын

Totally skeptical.

@noelalam9731 2 ай бұрын

i used epitalon, thymalin and oxytocin. it went away in a day

@saadbintanvir 2 ай бұрын

😂

@mysteradio 2 ай бұрын

heil yes. these are dawgs right here.

@ManjeetSingh-oz2fd 2 ай бұрын

Nice

@handyhacker11 2 ай бұрын

Everyone just looks at SSRIs and wonders why this 1 neuro transmitter doesn't work for everyone. Woah big shocker. There's different types of depression and mine will definitely be treated by either wellbutrin or better gut biome cause this is just straight brain stew and has nothing to do with my life because my life & i are awesome.

@nitinudaiwal2822 2 ай бұрын

What is depression?

@saadbintanvir 2 ай бұрын

I assume you are a teen . I also used to question like this in your age . I'm a 20 now 😎. I pray that you never go through depression 🤲

@godsblackpanther 2 ай бұрын

Good Question 😊😊😊The Opposite of Feeling Uplifted and Enthusiastic. A Feeling of lack of Choice that Leaves One Feeling a Chemical Reaction. An Imbalance of Chemical Harmony....a Feeling of Disharmony that Has an Overwhelm of Effort to Effect....A Lack of Wellbeing, Vitality and Enthusiasm for Life Changing Choice🕊️🕊️🕊️ Blessings 🕊️🕊️🕊️

@DewaldLouwChannel 2 ай бұрын

An extreme prolonged low mood and feeling of hopelessness.

@pocketfulofscribbles 2 ай бұрын

❤❤❤

@johnCjr4671 2 ай бұрын

Just a thought . Anything coming out of a lab that involves the in humane treatment of animals will be cursed with negative side effects just based on bad karma alone . God can’t reward torture !

@futures2247 2 ай бұрын

And a significant amount of people are harmed by these drugs but let's not mention that

@ProgressWithChristina 2 ай бұрын

Yes. Coming off antidepressants is a nightmare and not talked about enough. Flu like symptoms for weeks, not to mention intense suicidal ideations.

@futures2247 2 ай бұрын

@@ProgressWithChristina its much more serious - most people want to come off them because they are emotionally blunted, unable to feel. Others develop akathisia, others complete suicide, others lose the ability to feel anything in the genitals, and post SSRI sexual dysfunction can be permanent, other gain weight, others lose weight, some develop insomnia and the list goes on

@futures2247 2 ай бұрын

the term 'anti depressant' is a marketing term and there are is no such thing - they are drugs with a range of drug effects, but generally they suppress, numb, sedate, or stimulate/agitate the nervous system.

@ProgressWithChristina 2 ай бұрын

@@futures2247 they are horrible and I wish I would’ve known more about the side effects of coming off them. Dizziness and extreme fatigue is another one.