The Connection Between Lean Mass Hyper-responders and Cardiovascular Risk | The Proof Clips EP

Are you curious about what happens when someone on a keto diet has high LDL cholesterol levels, yet seems to be in great shape? It's a phenomenon called "lean mass hyper-responder," and the health community is buzzing. Dr. Bill Cromwell and Dave Feldman dig into this intriguing topic in a clip from The Proof EP #311. They chat about:
• If these folks are more likely to develop heart disease
• How long you can have high LDL before it becomes a problem
• What you can do if you're a lean mass hyper-responder, like tweaking your diet or maybe taking medication
• Using fancy scans to keep an eye on your heart health
Stream the full episode on KZbin: • High LDL Cholesterol o...
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[@gro16]

I think it's a great idea to give us a 2, 10, 20 minutes partial of a previous video but it would lend more credibility to your truthfulness on all fronts if they are labeled not as NEW but PARTIAL of a full interview dated such and such. Thank you for your thorough questions, content and top notch scientists interviewed.

[@HeibesHealth]

The description on this video says it’s a clip and says what episode it’s from.

[@longevitycoach1573]

@@HeibesHealth well, I’m not sure this vegan is taking the supplements he should.

[@pedro.almeida]

Yes its a bit of a trick, because you can't really tell it's a clip without clicking on it. I also wasn't expecting this to be a clip, because it's in the main channel and not on The Proof Clips channel. Could have been a mistake, we'll know for sure if it happens again.

[@kazoz3520]

​@@pedro.almeida It's also in the video title, ie labelled at the end as a "The Proof Clip". But in this case where the title is long, it may be abbreviated by KZbin in the video feed, until the video is clicked on.

[@HeibesHealth]

@@pedro.almeida I’ve been following this channel since its inception on KZbin, and he posts clips frequently here.

[@barrycorney3665]

My HDL never quite hit 80 but TGL was down to 50, LDL was >400... I'm done with keto and have made the ultimate jump back to the flipside- ultra low fat high carb... and these carbs are clean starches- no bread just potatoes, rice etc and lean pork/fish/chicken. It suits my endurance cycling way better and now I can actually attack the climbs. Been monitoring my BG postprandially and not any concerns. I think the real dietary issues are the mixing of the fat and carbs into obesogenic chow and the activation of the Randle cycle. Sugar (starch) and even simple sugars are (to me) not "addictive"... mix in some fat (ie chocolate, donuts etc UPF's) and it's the dopamine switch turned on and can't stop.... at least on this diet there's no seed oils and any fats I do eat are saturated or naturally within the animal products, that's something from keto I will continue with for sure.

[@straightedgeveganbel2453]

That's awesome, I'm glad you were able to change your numbers before it was too late👏

[@mikafoxx2717]

You realize that it's the saturated (and trans) fat that causes the most short term insulin resistance? And also increases ldl. There's been no research showing bad things about seed oils until they get hydrogenated or overtly damaged like fast food fryers that might get changed once a WEEK. If you really worry about it, have olive oil instead. Type 1 diabetics are special in that they can directly measure exactly how many units of insulin they need for every gram of carbs they eat, and saturated and to a lower extent other fat increases the insulin needed.

[@barrycorney3665]

@@straightedgeveganbel2453 Yeah when all the "experts" (except the LMHR camp)reckon 280 is seriously high you start to get worried..I'm down today to 235- though my HDL is now 31 (that's not good...) and my TGL is 88 (that's ok)...I'll monitor in a month or so and see what's happening...

[@barrycorney3665]

@@mikafoxx2717 I'll probably make that switch to EVOO when the butter runs out in the fridge, thanks for that input!

[@KenWang2]

High LDL of more than 400 means your blood is pure grease by then

[@JesseStarks]

Great comment, contributes a lot, very educated and thoughtful with scrupulous scientific references. 5 stars.

[@KenWang2]

@@JesseStarks Common sense is not for the masses.

[@aboutsupplies]

What gets missed in these conversations is how the matrix gla protein plays a role. A healthy mgp prevents the calcium from going hard and attaching to the arterial walls. Damage is done to the mgp from the toxins released from visceral fat.

[@bobo-si3kw]

Iam more concerned about Triglycerides, no sugar or processed foods, fasting and being very active.

[@mikafoxx2717]

Triglycerides are just the second part of LDL that add up to ApoB.

[@billdublewhopper3064]

@@mikafoxx2717 lol. Atheromas are not made of triglycerides. They are made up of LDL cholesterol molecules

[@vince1229]

Dana White's triglycerides are 746.

[@DCGreenZone]

Are these statins safe.

[@peterwilson1038]

High LDL is not the cause of atherosclerosis . If it was you would also see plaque in the veins. The cause of atherosclerosis is the bodies responce to damage and inflammation to the arterial wall which only happens in certain High turbulence junctures of the high pressure artery not low pressure venins. So what causes the actual damage and in the first place? Chronically high insulin levels, high blood pressure, and overall poor metabolic health . The result of a diet that is inappropriate for our species. Specifically eating too many carbs too often. So LDL is not causal, but to the extent to which it may be contributing to atherosclerosis , it is only potentially problematic if it has become damaged in the form of glycation and oxidisation from excessive carbs and seed oils. We did not evolve healthy LDL so it can kill us.

[@StanDupp6371]

About 24 years ago David Letterman was 52, a tall slim guy he found out he had a total cholesterol of about 650 mg/dL and then had to get quintuple bypass surgery. Regis Philbin had 300 total cholesterol and had to get bypass surgery.

[@greggbambu411]

Your view on this is a cult. A small cadre of believers who continue to push this narrative. The deleterious effects of high ldl is not even debated anymore among serious people, only on-line.

[@kazoz3520]

​@@StanDupp6371 Yes. Similar with some of my family members (heart attacks in their 50's and early 60's, lean, fit, non smokers, non drinkers, no diabetes, etc). There seems to be a generational gap in knowledge, plenty not realising the peak in CVD in western countries occurred well before the dramatic rise in obesity & metabolic disorders that has occurred in the past few decades. And certainly well before the rise in seed oil consumption & ultra-processed foods in many countries.

[@petertownsend252]

​@StanDupp6371 This comment might mean something if David Letterman was following a long term ketogenic diet with a high HDL and low triglycerides (i.e., a LMHR phenotype). So what were David Letterman's HDL and triglyceride levels at the time of his bypass surgery? What was his diet? I am guessing you probably do not know?? Is that correct? As stated, the David Letterman anecdote is indicative of nothing with respect to the potentail CVD protection offered by the LMHR phenotype which by definition includes a high HDL and low triglycerides in conjuction with a low carb diet. The investigative topic of this video presupposes and requires the subject person of interest is in fact a LMHR phenotype following a long term ketogenic diet.

[@mikafoxx2717]

But what of the long term studies following individuals and showing that those that eat the least saturated and trans fats and have the lowest LDL end up living with less cardiovascular disease?