The Edge of Medicine and Ageing - David Sinclair

[@bernadettebecher5668]

Thank you kindly- Magic information

[@rabbitpunch1422]

We live in an extraordinary time.

[@increasemaximumlifespan2502]

I know right! do you take any life extension therapies rn by chance?

[@MyLongevityExperiment]

@@increasemaximumlifespan2502 I just started.

[@farshm.7400]

Dr. Sinclair is my hero. I regret that EVERYONE is not funding this research and contributing to it with their brainpower. But no, we must remain distracted with fleeting pleasures and superstition.

[@vickybiagini8623]

It's been over 7 yrs and no breakthrough. Hes full of it, and has aged.

[@farshm.7400]

@@vickybiagini8623 There have been major breakthroughs, this, for one: www.biorxiv.org/content/10.1101/2021.06.26.449305v1?BioViva&EMAIL_CAMPAIGN_2020_02_18_05_38_COPY_02&. And these researchers would break through more quickly if people and governments stopped their distractions and rallied to this cause.

[@vickybiagini8623]

@@farshm.7400 , I know of Bioviva from yrs ago. I also know the 1 million dollars most cant afford. Also, Celebrities are aging badly, so theres no breakthrough. If these people are aging with all their money, then theres nothing yet that works.

[@farshm.7400]

@@vickybiagini8623 "Nothing yet;" there would be a cure if more people contributed their resources and brainpower to this research.

[@vickybiagini8623]

@@farshm.7400 , I just watched a recent video where David said drugs are right around the corner. Same speech as seven yrs ago. It seems like stuff is being developed. I'm pushing 50 in three years, and boy the years went fast.

[@schalazeal07]

We're soo close..

[@increasemaximumlifespan2502]

I know right! Schalazeal, do you take any life extension therapies by chance?

[@MyLongevityExperiment]

NMN, NAD+ and Resveratrol is now commercially available.

[@eyewitness8145]

two years have past since this video issued, where is the anti-aging molecule pill supposed to cost a few cents only? How long we have to wait? old people can't wait

[@muresandani]

NMN is on the market. There are several companies selling it. NR, a very similar molecule to NMN is also widely available. It costs a bit more, still. About 2$ a day. But the kind of drug David is talking about will take a while to get to the market mostly because of regulation. It takes, on average, 10 years and 1.3 BILLION dollars to get a new drug approved. You can thank your government for that :)

[@GeorgGerdon]

Is there a Link for a public available paper about this research?

[@Monica3918]

There are some publications by D. Sinclair on genetics.med.harvard.edu/sinclair/ (Check under "Publications". You'll find some free articles). The webpage was updated in June 2016. Not brand new, but 10 years newer than this video!

[@OllieKubrick1]

How can anything be 10 years newer than a video from 2017, that would make it 2027. Given that it is only 2018, that seems unlikely. Or have I misunderstood something about your comment?

[@tonytwosweaters]

I wonder if they are aslo looking at anmals like bowhead whales, sharks, kangaroos or many reptiles that live to extreme ages or have indeterminate growth

[@quantumchang4410]

My grandma took metformin for many decades but she still developed leukemia in the end that ended her life.

[@Viertelfranzose]

That your Grandma get this leukemia...dont surprise me ,in general,Metformin is really bad for the Mitochondrials Function in Body..even with the "good" Sites of Metformin..but the Cancer proomting site is too much bad Side and if you dont beleave it...ask Dr.Mercola

[@ildisiri]

no its just his grandma probably was over 85 that's why, metformin is strangely good for anyone actually.

[@increasemaximumlifespan2502]

Yea, life extension pills don't completely prevent disease, they just make it a lot less likely that you will succumb to disease. They'll have stronger pills soon. do you take any life extension therapies rn by chance?

[@peterz53]

Footnote on one paper is 2014. But he's not saying anything new. NAD+ to NADH ratio is now known to decline with age and disrupt mitochondrial cross talk with the cell nucleus. Fasting and exercise will help. Supplements like nicotinamide riboside (much less expensive than the NMN Sinclair mentions) will also help. Search for BASIS NR. I wish these researchers would be more objective and highlight non-pill methods for resetting pathways to more youthful healthy levels

[@scottcosentino5239]

I am already taking Epitalon, metaphormin, NAD injections, along with good eating. So far my body is changing a little every month

[@highlightfactory85]

please take photos and document them online. we need people to document this stuff over the next 10-20 years.

[@richardnunziata3221]

How old is the talk...the cover sheet for Scientific American is from March of 2006. I hate it when site republish old material with out a reference to the original date of recording.

[@Monica3918]

I totally agree with you, Richard Nunziata! Old articles reposted! Try reading something a little newer (2015) in Spanish here: www.technologyreview.es/s/4722/pildoras-para-escapar-de-la-vejez (You can find it in English, too, since it was originally published by the MIT).

[@peterz53]

Footnote on one paper is 2014. But he's not saying anything new. NAD+ to NADH ratio is now known to decline with age and disrupt mitochondrial cross talk with the cell nucleus. Fasting and exercise will help. Supplements like nicotinamide riboside (much less expensive than the NMN Sinclair mentions) will also help. Search for BASIS NR

[@increasemaximumlifespan2502]

I know right! This is pretty recent though. do you take any life extension therapies rn by chance?

[@DormantIdeasNIQ]

so if we stay healthy by resetting the cell's clock, why would we still die!?

[@farshm.7400]

We wouldn't. And that is the elephant in the room in this topic, which is CRAZY EXCITING!

[@BreiiisBreiiis]

Accidents, suicides and homicides will still be a thing.

[@Beyond_Matter]

We are all designed by intelligence, and that is life. We can’t reverse the aging process, nor can we stopped it. Unless we found gene and modify it so that the next generation will live longer.

[@deanmindock5020]

David lately says they have found the location of where the original copy of the info needed to restore epigenome back to original copy thus erasing all the "noise" built up over the years.

[@dzuliettavilenski7652]

i am interesting to know what changes can post menopause women expiriance with taking NMN, if any?

[@James-jc4xn]

valentin65 nice :)

[@annastasijafey4585]

It made mice able to uave babies again

[@Elayman1]

He has said that his sister in law was going through perimenopause in her '40's and became fertile again on NMN. I do believe it after trying the supplement....

[@Elayman1]

Well I am taking sublingual NMN powder from Alive by Nature which is what has done it for me. I think it may be out of stock at the moment on Amazon but you can buy it from their site. alivebynature.com/nad-products-2/

[@jimphelps5163]

Deuterium in food and water determines longevity

[@DormantIdeasNIQ]

huhhh! why don't you elaborate on this silver bullet statement!? I shall chime in a reply, once you laid your egg... avoiding to taint your write-up. Thank ya veruh muchuh.

[@squamish4244]

Got my pill yet?

[@increasemaximumlifespan2502]

You are taking NMN?

[@user-vc5nq3kl4h]

This is a *horrifying* prospect. Tell Americans they can eat all they want and give them a pill to live longer. As if the world weren't suffering from lack of resources as it is.

[@micboiiii]

Drugs are bad mkay

[@Tanglaw777]

During those days people will seek death but will not find it; they will long to die, but death will elude them. Revelation 9:6. This fountain of youth is the missing piece of the puzzle in the above verse.

[@James-jc4xn]

Michele Geronimo Evangalisti yes that was my thought ... it's kind of like that verse was telling the future ... damn ... but what if it is all part of the plan?

[@Tanglaw777]

James Alexander Rocha Robleto * Declaring the end from the beginning, and from ancient times the things that are not yet done. -YHVH. You don't need to worry about that if you're in Christ because He will snatch you away to heaven before that woeful day comes.

[@tylermcnally9931]

These drugs don't prevent you from death. Enough trauma and the body will stop working.