The enzyme that could help 700 million people with chronic kidney disease

Scientists from the University of South Australia have identified an enzyme called NEDD4-2 which is critical to kidney health www.unisa.edu.au/Media-Centre...
Approximately 700 million people worldwide now live with chronic kidney disease (CKD), largely due to a huge spike in obesity and type 2 diabetes in recent decades. Low levels of NEDD4-2 exacerbate kidney damage, even in the absence of a high-salt diet and in people with low blood pressure. This critical finding could change the way that kidney disease is treated, explains UniSA researcher Dr Jantina Manning in this video. The long term goal is to develop a drug that can increase NEDD4-2 levels in people with CKD, helping to stem the 29 per cent increase in chronic kidney disease in the past 30 years.
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[@ralph1rodriguez]

klotho is the enzyme that reverses kidney disease. This enzyme is predominantly produced in the kidney and decreases as we age. It pretty much regulates everything that gets out of control in kidney disease. Klotho enzyme regulates the metabolism of calcium, potassium, phosphate, and glucose. klotho also has antioxidant properties and is involved in adipogenesis, angiogenesis, and insulin signaling. That is why things that increase klotho also help patients with kidney disease; examples are, exercise, probiotics, ACE inhibitors, vitamin D, cordyceps and more.

[@ariella4444]

Could you please provide us with more guidance and assistance about this enzyme??

[@dbeck82]

​@@ariella4444Comment if you hear anything back! 😊

[@sivathasanmayuran7828]

❤

[@ariella4444]

What about astragalus extract or corn silk?!!

[@deemh60]

Please lett me know a good cordyceps brand

[@charlessavoie2367]

Very light on specifics! Frustrating!

[@Ninurtha1]

diabetes(blood sugar) which causes Insulin resistance by the cells which raises Insulin levels in the blood causes kidney disease and failure over time . Completely reversable , stop all sugars, carbohydrates (Potatos.rice, pasteries,bread ,sodas,etc). Every six months do a Homa-IR blood test to see where insulin levels are and progress, its very inexpensive blood test $20 or so . IMO

[@monconcepcion2815]

I hope and pray that this research be given government support to hasten the development of the cure for us kidney patients. This would save so many lives, thanks for the initiative. I believe in your research.

[@rosalbadelriogarcia9598]

it's the lack of nutritious fatty meat and the order of the essential MACROS , carbohydrates are not essential. #ProteinleverageHyphothesis #metabolicHealthSummit

[@Insp.CountMortisWinshipKlaw]

Your kidneys are chronic because you are eating cooked foods specifically high protein meats and starches. Switch to a 100% raw fruit diet.

[@DazeOfBudtending]

Govt doesn’t care about people, unless they are getting boatloads of money in the end, then they are all about it.. govt is addicted to the deadly sin of greed unfortunately.. none of their actions have to do with the people coming first unfortunately

[@NicoSan805]

Sadly there's no money in curing especially here in the "good" U.S.A. where USD capitalism reign supreme.

[@joematties7557]

@@NicoSan805 I can assure you it has nothing to do with capitalism. Quite the opposite. If you need them to stay alive then they can control you. It's not like you'll cure kidney disease completely like it's leprosy or something. A pill to do these things would rake in billions of dollars to the capitalist that invested in it. They'd love for everyone to be on it. Unfortunately the pill is a science theory and they need people to believe it will cure them so they can get money. They need to convince enough people to pressure the government to fund them. Think of global warming. It's seldom about fixing anything.

[@scottg2155]

Its too bad that the music drowns out what she is saying Frustrating that I cant hear her

[@farshimelt]

It needs CC. Her accent is difficult to understand.

[@naruttaanime9471]

We still cannot understand the name of the gene?

[@naruttaanime9471]

Finally found it! NEDD4-2

[@Cosmo-Kramer]

@@naruttaanime9471 NEDD4-2 is not a gene, it's an enzyme.

[@marolynramirez9447]

​@@naruttaanime9471what is NEDD4-2, is it good for kineys

[@texaseaglejcl]

Pity this video has no CC for us hard of hearing!

[@48webber]

Do you think the big corps and gov are going to let the multi billion dollar dialysis industry stop??

[@brandillysmom]

please ….. Full speed ahead with this research! Thank you, thank you thank you✨

[@xairin33]

Excellent 👍 video my advice for you all. Reduce your meal rations to the minimum Heads up! 🚫 not saying do not eat at all, if you are a meat eater, reduce it, if you eat carbs, veggies and meat, same thing. Avoid foods with high potassium content, like bananas or, reduce it. Be careful with oscelate, just about all foods has it. Same thing with sodium That's why size portion management is important. I 🙏 pray Christ all the time, May he be with you regardless of your ☯️ religion

[@golflouis52]

Oxalate right

[@nevaehlumiere5418]

Xairin...Don’t make blanket statements. As someone with kidney problems from lupus… I have to take high amounts of potassium. I use that potassium-based salt on my food. Btw....Potassium is the chemical opposite of salt. Just sharing.

[@DeAnnaYah]

I’m stage 4 but my potassium is chronically low. (3) even though I eat lots of high potassium foods, it just keeps going down. My phosphate is normal. But my gfr is 19 😔

[@InsolentVillager]

Meanwhile, in the US, a woman reversed stage 3, and a man reversed stage 5 kidney failure. They both went carnivore with salt.

[@edoc431]

link?

[@deborahszafraniec4829]

Don't believe everything you see on the internet! I dug deeper and this simply isn't true!

[@aliefacmal]

I'm the type of person who doesn't like drinking a lot of water but that gradually took a toll on my kidneys especially now that I'm almost 50. Word of advice, take care of your kidneys and drink more water! Since we're talking about Kidneys, I've read online that Tongkat Ali can prevent kidney injury caused by excessive paracetamol consumption. Is this common knowledge or am I just not well-informed?

[@naruttaanime9471]

Gene screen test needed for: NEDD4-2. Please add screening via gene tests online.

[@barbaras3206]

Mmm had raw data read. Gonna check on that

[@dohc1067]

One characteristic of many of these so called health videos at least as it relates to the kidneys is that this ground breaking research seems to always be focused overseas. I am just saying from the videos that I have seen.

[@strangeTV1]

Yea because big pharma in America is only there to sell you clowns medication not cure your ailments

[@mrmikef1972]

I was thinking the same thing. It seems as if the system wants you to stay sick because it pays. 💰💰💰

[@randalldavidson7474]

US doctors don't want to cure anyone...they want that residual income...

[@concernedcitizen9466]

Nothing wrong with your eyesight.

[@ronselliers6951]

Wow! Good luck in your research.

[@agl1925]

High sugars are the culprit - cut the carbs eg via keto or paleo or carnivore way of eating. Sodium (from salt) is super necessary - DO NOT cut salt - body is well adapted at regulating salt (but has trouble when insufficient salt).

[@curiousbystander9193]

I agree about sugars, but complex carbs prepared correctly foster a healthy gut biome, ......such as making resistant starches ,which limit blood sugar spikes and encourage lower intestinal bioactivity.... this is the problem I suspect with this carnivore rage going on..... people are changing their biomes and getting relief because many carbs/grains are so polluted now...... you get my drift? If your teeth were like my dog's I might agree more with some things I read.

[@GraceDollesin]

True! We need salt. Our heart won’t function properly without salt.

[@marolynramirez9447]

I heard sea salt and Celtic salt are good for your body not table salt

[@farshimelt]

The information is interesting, but the background music is annoying. This isn't a melodrama, drop the music.

[@karppakamsubramanian1950]

True. And the doctor does not answer viewers questions on what is enzyme, where to get it or is it from food etc. Which is also annoying.

[@Ladytwosocks486]

@@karppakamsubramanian1950 Ask AI it will tell you.

[@tonyinfinity]

Time restrictive eating, fasting, and cutting out carbs/sugar. That's it, pretty simple. You're welcome.

[@lovejoylynn2]

No animal products, processed foods, oil or salt. Eat all whole foods, 80% veggies 20% legumes & grains. Nothing to lose & everything to gain.

[@Brad_Pittstop]

@@lovejoylynn2 Nope, a plant based diet isn't good. You'll lack all sorts of minerals and vitamins.

[@Boddah.]

​@@lovejoylynn2That's for if you want to damage your health.

[@caroline61804]

kefir fermented foods good gut microbes makes enzymes and vitamins

[@YankeeDoodle2]

@@Boddah. How can eating healthy damage your health

[@joelcrawley4542]

Would the copper peptide stem cell rejuvenation theory apply

[@AsiaGuy2025]

but doesn't say how to get it?

[@stevenjordan6389]

What was the name of the enzymes?I did not hear the name of the enzymes.

[@jacqualinesummers2539]

Please just explain how to increase the enzyme if possible.

[@FlipMacz]

They never did🤷

[@beckiwildeman600]

@@FlipMacz Because that would take aware the money coming in to bring in a drug for in. Rather that Natural health they continue to in gorge the Medical system for sickness. All sickness starts in the stomach and moves to the brain.

[@eac-guy7272]

Why should they? They want your money. The more sick people the more money

[@joanneyoung1081]

There is a link to the s Australia university in the description box above for further info

[@joeplacetas1]

What's the encime

[@tiborzkarate1]

The music making this video unbearable to listen. Drop the music.

[@db2251]

OK how do we get the enzyme?

[@paulasusan63]

Where to buy this supplement?

[@kelliedougherty4041]

A lot of People with kidney disease end up with parathyroid issues, osteoporosis & heart disease. 😩

[@lovejoylynn2]

That’s true if they don’t radically change their lifestyle. And sometimes it still happens. But you can slow it down! It takes dedication & willingness to eat differently & chop lots of veggies.

[@kevinwellwrought2024]

That is true!

[@naruttaanime9471]

Does the kidney suffer after the parathyroid fails from all the chloride and fluoride in drinking water?

[@williamarmstrong8734]

Anyone have a link to buy supplement for nedd4-2 enzyme??

[@bryanwoodward1822]

It's a naturally occurring enzyme in the body. Can't buy it.

[@leblanc55337]

Any progress in on Ned for two?

[@mountainmedium111]

So, what is the Source of NED42? Is it in food?

[@daDiamondcode]

Yh i wish she told us more

[@jbsquare]

If there is nothing to apply now, I don’t need this information.

[@privateconfidential4775]

When is this coming to Toronto, Canada? My fathers dying Pls help him!

[@shashi14376]

Bilateral grade 1 renal parenchymal disease. I come to know this week. How to get cure ? I have been googling and no definitive answer from any where. I was hit with covid19 in 2020. Since then I am on low sodium and walking everyday 10 km. I am eating bowl food everyday. Food is okay for life. But treatment and cure I need.

[@cr-iv1el]

How are you doing?

[@Bewefau]

what is grade 1 mean ? You mean your at stage one kidney failure ? If so there are 5 stages just change your diet. No Soda no added phosphate

[@JudasTadeo77]

how to buy the enzyme

[@bryanwoodward1822]

It's a naturally occurring enzyme in the body. Can't buy it.

[@davejive989]

cant find them anywhere? any help please?

[@beckiwildeman600]

Research Nedd4-2 it may be Lysine but please do not take my word for it.

[@neptronix]

Wow, great news, interested in hearing further research :)

[@theninthfloorpodcast2501]

Powerful!

[@grahaology]

Where the testimoni of the patient

[@rickynaidoo2921]

Informative

[@Lynne76]

Im sorry but i cany hear you, please could you tell me what enzyme your talking about.

[@lakshmanakumar87]

What is the name of that enzyme ? She is saying in the video

[@bryanwoodward1822]

NEDD4-2

[@widyarafnita1349]

How to buy it? My husband in kidney deases stage 5

[@himanshujovi]

Has this been released to public ?

[@lvncsr6166]

WHAT IS THE ENZYMEM, PLEASE?

[@Akash11898]

Nedd4-2

[@beckiwildeman600]

@@Akash11898 Which may be connected to Lysine. But please research before taking my word for it.

[@ariella4444]

@@Akash11898How do you know? They haven’t said anything

[@bydoua714]

Where can i bought it

[@bryanwoodward1822]

It can't be bought.

[@NicoSan805]

Now what about Chronic ESRD.

[@Victoria-nh9sp]

That was pointless...how do u get it..where do u get it

[@beckiwildeman600]

They want to make a drug of it. I would research Nedd4-2 it may be related to Lysine. Please don't take my word for it but research.

[@JNieckarz]

I have a mutation of the NEDD4L (NEDD4-2) gene. I'm getting no help.

[@theninthfloorpodcast2501]

Sending prayers your way 🙏🏾

[@MsLisalotta]

How did you learn of this mutation as it doesn't turn up in regular blood work, as I understand it? I'm stage 4, no high blood pressure, no diabetes, I wonder too if I have this mutation of the NEDD4-2 gene as well. How wonderful for Australia to be on this at least. Hopefully we get more info...

[@johndiamond6931]

@@MsLisalotta I was told I don't have diabetes but I experience many symptoms of a diabetic.

[@mariechaekyung3]

Genetic testing

[@DihelsonMendonca]

​@@MsLisalottaHow did you get CKD without diabetes nor high blood pressure ? Did you intake much painkillers ?

[@vasetitoleafoa5583]

Which corporation is behind your research please?❤

[@robcheeley]

tried extensively to figure out what she is saying this enzyme is. can't hear it. why not actually allow us to know what you are saying???

[@brettlaw4346]

Seems logical that age and disease related mitochondrial activity would diminish production of new cells and functional proteins like NEDD4-2. Is CKD in its advanced stages, sufficiently bad enough to interfere withe exercise induced mitochondrial genesis effectively creating a doom loop where the most effective treatment option would likely be exogenous NEDD4-2?

[@jtgmail459]

Great work! Keep probing combined great sleuthing....

[@bingalabanza6290]

Is it a natural remedy or we need a doctors prescription? Where can we buy it here in CAlifornia, USA

[@Insp.CountMortisWinshipKlaw]

STOP EATING WHAT IS CAUSING THE PROBLEM, COOKED FOODS! Switch to a 100% raw fruit diet, humans natural food.

[@beckiwildeman600]

It may have a connection to Lysine. Please research and don't take my word for it.

[@farshimelt]

@@Insp.CountMortisWinshipKlaw Most fruit is high in potassium and that's not good for CKD. Please don't recommend things that you know nothing about.

[@ariella4444]

@@Insp.CountMortisWinshipKlawSo do we just have to eat raw vegetables and fruits?? That’s it??

[@ariella4444]

@@Insp.CountMortisWinshipKlawYes just stop eating all the essential and necessary nutrients that could keep us stay alive, and everything will be fine.

[@stanleychamallas2331]

What was the enzyme??

[@DevinBreshears]

nedd4-2 enzyme is what it’s called.

[@johnnovick1643]

When you say oscelate do you mean oxalate?

[@nonyabeezwax8693]

The wrong salts. Drink water, lemon added.

[@CGMB777]

All salts are far from equal. Study with pristine sea salt.

[@jasoncheshire6153]

Can you also tell us about the live forever enzyme???

[@kevinjolin6313]

The system will remain silent on what could cure people fast.

[@ralph1rodriguez]

klotho is the enzyme that reverses kidney disease. This enzyme is predominantly produced in the kidney and decreases as we age. It pretty much regulates everything that gets out of control in kidney disease. Klotho enzyme regulates the metabolism of calcium, potassium, phosphate, and glucose. klotho also has antioxidant properties and is involved in adipogenesis, angiogenesis, and insulin signaling. That is why things that increase klotho also help patients with kidney disease; examples are, exercise, probiotics, ACE inhibitors, vitamin D, cordyceps and more.

[@ariella4444]

@@ralph1rodriguezBut this enzyme is not on the market and not available to the patients. So what should the kidney disease patients do?

[@marolynramirez9447]

​@@ralph1rodriguez how else can I get the enzyme other than exercise because when I exercise I get fatigued really fast like in seconds

[@alfonsobond321]

Have you ever been on a trial o some protocol to know if common table salt (with iodo and fluoro) has the same negative impact as the completely natural salt without any process more than d'hydratation. It seems they are no the same thing when you say "salt" 🤔

[@irwanharzky6062]

High blood pressure plus high sodium and also high potassium may trigger

[@veasnaphai8]

What enzyme ? How we can get it ?

[@beckiwildeman600]

They do not what to tell anyone what enzyme. But research Nedd4-2 it may be Lysine. Please don't take my word for it research as they are confining(hiding) this very well.

[@43wagonwheel]

Well, I can guess this doesn't work either. We would be hearing a lot about this but we dont.

[@ludacannon6526]

Enzymes 2-4: Biology Flashcards enzymes. are proteins that act as biological catalysts. enzymes. speed up chemical reactions that take place in a cell. lowers. an enzyme does to

[@user-fv7xk5ht8x]

We're do we get these enzymes

[@vedscrazylife2623]

From where can we get this enzyme?

[@dinudejesus8739]

Bananas+honey

[@BNN.official_indonesia]

Putih telur rebus

[@edithattreed4762]

If you’re acidic,you’re kidney will suffer as well,as we age 30 and over make very small amounts of bicarbonate,that’s the reason I learned to have bicarbonate and a bit of citrus mixed into the water to help me stay balanced with my ph

[@curiousbystander9193]

why the citrus? You are adding an acid to something that makes acids basic..... the chemistry of this confuses me.

[@Ladytwosocks486]

@@curiousbystander9193 Actually its' the reverse.

[@monicapalu2352]

🙏🙏🙏🙏😪

[@manuelosuna9184]

How soon before u find a reverse cure for kidney disease

[@elhavenopuormatro8027]

pharma will surely block this research

[@trueseeker262]

@@elhavenopuormatro8027 a patient cured is customer lost.

[@farshimelt]

If anyone knew the answer to that, there would be no kidney disease. At this point, the disease can be managed with diet. See a Kidney Nutritionist, they know much more than drs.

[@williamhoeweler8259]

Its what type of salt we use. 3 things harm the body salt sugar and oils. Sugar is just evil but we can change the type oils and salt

[@musicandfun7059]

Why kidney patient get altered ?

[@Susieq26754]

So a person is screwed no matter what they do.

[@peovbenjamin9006]

Well…. Well…….. well…………….. well, I think it is not easy just to cut out Carb/Sugar.

[@lindadurand247]

I did, no carbs or sugar for 2 months now, never felt better

[@victorloya1590]

I want to know how many chronic deseases have been cured 🤔

[@selinainsel6198]

Ned 42 ?

[@percyhawkins716]

Wish there was closed captions on this video. I can't make out the words with that accent.

[@golflouis52]

I think Nedd4-2 is the enzyme...

[@sujathak2488]

Reduce the bgm

[@vlad842]

to whom ever edited this video. the Australian accent is hard enough to understand with out the loud back ground music almost overpowering the audio. its a shame though, the content is interesting.

[@UniSouthAustralia]

Thank you for the feedback - we'll keep it in mind for future videos.

[@alexciocca4451]

Dawk lower intake of salt or eat the boloney

[@golflouis52]

Nedd4-2 enzyme, is that it?

[@jeromedenis4754]

klotho enzyme

[@irwanharzky6062]

What final product of these enzyme.. Or just speed up biologicaly reaction...thinks needed further research..

[@Bewefau]

Why not grow it in a lab per person who needs it than inject it back into the kidney ?

[@bharatbushan9658]

I am CKD patient IGA nephropathy stage 5. What should for survival

[@jsc5423]

Earlier this year I was diagnosed with stage 3 kidney disease and also I had kidney tumors for a while. Now I am healed. Jesus healed me and also by changing my diet. I am back to normal kidney function and all tumors gone.

[@user-wm9bw3jw2q]

​@@jsc5423 do you follow any diet? I'm stage 3 😢

[@jsc5423]

@@user-wm9bw3jw2q I eat mainly vegetables and have fish few times weekly. Also low carb but that is due to not wanting to put weight on. Best to eat healthy carbs and in moderation. I try to drink enough water too. Nuts and seeds in moderation.

[@sonikavasanth1873]

@@jsc5423how did you heal it can you provide the doctor number I need it for my mom

[@lakshmanakumar87]

What is your creatinine level? Be prepare yourself for dialysis !

[@crabbypaddy5549]

Could, not would.

[@DihelsonMendonca]

This video is completely useless. Information released partially is nothing. 😮😮😮

[@dleimkuehler]

Very bad video. If there is a needed enzyme how do you increase it?

[@beckiwildeman600]

they want to make a drug of it. Research this but it may be related to Lysine. (Nedd4-2_

[@jafojafo5412]

They have to make a pharmaceutical to sell so they won’t tell you how to do it naturally

[@sonikavasanth1873]

So are they still in a plan to make it or they are promising they will be releasing that drug in a certain period of time where can we get it and whom should we consult ?

[@kentporterfield3968]

If I did a video of any sort I would make sure that the viewers understood precisely the name and spelling of the enzyme instead of just slurring it about. Its almost as if it were a prank of some kind. No one can understand her pronunciation of the gene. Lost time I'll never get back... smh

[@hippopotamusanonymous1580]

Table salt not celtic

[@ardiyansyah7120]

Kaka saya ginjal nya sudah tidak berfungsi 😭

[@stilllearning7434]

i hear you !