The Last Of Us Explained | The Origin of the Cordyceps Fungal Brain Infection | Immunity and Outcome

The infected in the last of us are terrifying seeing as this type of disease already exists in the animal kingdom. But what exactly am I talking about? Lets take a look at The Last of Us universe and get a quick refresher on whats happening and how the Cordyceps Brain Infection may have jumped to humanity.
Thanks for watching Roanoke Gaming and I hope you enjoy The Last Of Us Explained | The Origins of the Cordyceps Fugal Brain Infection | Immunity and Outcome
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[@ryujigames2509]

The fact that you are not average "wikipedia youtuber" but actually scientist yourself - makes watching you so enjoyable!

[@rccollin7699]

It definitely spikes my interest of doing this type of research as well.

[@McJaggi]

Agreed

[@Ilovepoopin]

Not to shit on him, but he's in the same boat as: Sci Show (and all their sister channels), Kyle Hill, and more channels of similar nature. I.e, not actively working in the field but educated in the field. He's your average KZbin Explainer.... "Film/Comics Explained", "Mythology Exlpained", and more and more. It's a troupe on youtube that people goto school, don't get a job in the field, and then turn it their knowledge into a youtube channel. Unless I've misses something saying Roanoke has graduated and got a job in his field of study.

[@adeancousland2404]

@@Ilovepoopin He has said that he used to actually work in government labs. I think he mentioned it during his contagion virus breakdown.

[@thezambambo2184]

@@Ilovepoopin If I remember correctly, he's a virologist?

[@nonethewieser]

"soon after, the distribution of masked breathing apparatuses would become quite normal." Clearly this statement hasn't aged well...

[@user-uv5ld3cx5t]

Surgical masks or even just facial protection is not that hard and we see how well it went

[@TheArkTheArkTheArk]

“CORDYCEPS IS JUST A GOVERNMENT HOAX!” “You...you literally have a mushroom starting to sprout on your scalp.” “GAS MASKS ARE FOR PUSSIES!”

[@KingSouja35]

@@TheArkTheArkTheArk the sad part is SOMEBODY would be that ignorant to the whole thing.

[@sweetlouieward86]

My exact thought as soon as he finished that sentence...

[@glenngriffon8032]

Well it's mostly because we had an incompetent leader in the US who made wearing masks a political issue so all the people in his cult took itr as a political move, not a health move. Because they follow the prez blindly without question they figure if he's not wearing one, they don't need to wear one. Combine that with the fact that the baby in charge disassembled the pandemic task force that was put in place cause he thought "well what do we have you for? We haven't had a pandemic. You're not doing anything so you're fired." which is just.... it's like the bear patrol in the simpsons only backwards. So you have a virulent disease spreading across the world and people who deny it exists cause "president said so", people refusing to wear masks, people refusing to quarantine, refusing to social distance and many people who just stopped doing the precautions because they tired of it. I have literally heard people saying that they weren't going to keep up with all the precautions beccause they were tired of hearing about the virus and tired of wearing a mask and tired of "living in fear". They were sick of caring so they stopped caring because it was too inconvenient to just keep the quarantine going.

[@R3DD1]

2020: “You're treading on some mighty thin ice here.”

[@SPGHTTFRT]

“Soon after, the distribution of masked breathing apparatuses would become quite normal” 😂😨

[@ricoweapon1694]

@@SPGHTTFRT I was gonna put that on here as well 😂 the irony of that statement

[@gallo_knocks5308]

2020: hold my beer

[@Lionrisesproductions]

Lmaooo. Yeahh still waiting on these masks. Oh and 🧻. But I did enjoy the video 😝😅

[@frostycold1689]

If your reading this it’s 2020 and we’re under attack from a virus the world over run for your lives hide in nature

[@RoanokeGaming]

A Mushroom walks into a bar. The Bartender says "Sorry, we don't serve mushrooms here." The mushroom responds "Why Not? I'm a Fun-guy!" This has been my ted talk. Thanks for coming Thank you for watching! I hope you enjoyed this biology heavy video! Looking forward to covering the infection process and how it works its way into the brains of individuals! If you enjoyed it please leave a like as, I am super cereal, it gets the video out there much better. And If you are new, why not sub if you enjoyed it! if you hated it...well..I suppose leave a comment because I need those sweet sweet interaction points!

[@micksilva7374]

Do you analyze movies like zombies, aliens etc.?

[@smileyzuro]

That joke, there is an exit over there

[@theimmortalsuperbeing549]

THE MORDER VS THE TORMENTOR.

[@RoanokeGaming]

@@micksilva7374 Not yet, but I do plan to make that leap later this year!

[@RoanokeGaming]

@@smileyzuro ;)

[@nobody9400]

Fun Fact: if you do a certain pattern during the prologue when playing as Sarah during the TV scene you can see a Cordyceps infected ant

[@jaysteezz7333]

How do you do it?

[@burtmacklin1880]

@@jaysteezz7333 kzbin.info/www/bejne/sH-9YaqeqL2EerM

[@elizabethpotts8495]

Leave Sarah's room don't go into Joel's room go down stares when you reach the bottom of the stairs save and close the game restart then go to Joel's room

[@thekittykatmack]

As a neurology student I really appreciate your commentary as it isn’t just lore but a real breakdown of how this could actually occur with backup by biology

[@RoanokeGaming]

Good luck with neurology and that's high praise! Glad you enjoyed :)

[@NordicJarl27]

So the closes we can get to a glimpse of real life post apocalyptic "zombie" scenario is last of us? I'm terrified yet somewhat excited. Last of us can actually become reality with certain points.

[@fabioooh]

@@NordicJarl27 no ,he actually explains "how to" for a lot more movies ,like watch the WWZ reaction ,I dont exactly remember but he explains how it could be possible I think

[@Pyrolysis2142]

"The mass distribution of breathing apparatuses would take place" meanwhile in 2020 we can't keep up with hospital demand for a coronavirus with factories working overtime.

[@MrMrblazer1234]

I was hoping someone else from the future would notice that too... oops

[@hottea9546]

I literally thought that. Like we’re seeing how this is actually not that far off because people want to go to the beach.

[@smgeezus7186]

@@hottea9546 Goddammit that burns, because the truth hurts!

[@exotikz7905]

It’s different it cost more and takes more recourses to make a ventilated but a breathing apparatus is just a gas mask where there’s an abundance

[@rolland890]

@@exotikz7905 we had a shortage of face masks let alone gas masks bro...

[@m.s.e.advanced2842]

It's not the cordyceps that's making me like this video

[@RoanokeGaming]

;) Thanks my guy

[@m.s.e.advanced2842]

@@RoanokeGaming no problem

[@plasmaxl8626]

That's what an infected would say

[@plasmaxl8626]

@Savage Jesus that's not ok

[@JustinY.]

Damn fungi always ruining the fun

[@GokkeGor]

Here before you reach 20000 likes on that comment

[@jeffersonpan6936]

This comment is gonna get 1 million likes despite being so shit

[@RoanokeGaming]

But they are fun!

[@consultativemind1206]

@@RoanokeGaming this comment marks a milestone on your channel.

[@ChokingOnRazors]

WHY ARE YOU HERE?

[@jimmilliano]

These are even more disturbing than the necromorphs, because they COULD be real.

[@RoanokeGaming]

Agreed!

[@cypher2194]

Yeah. Clickers give me the creeps... Uughhg

[@normaaliihminen722]

Real perhaps.. but not so human race ending disease like Roanoke explained :,) which is good imo.

[@jimmilliano]

Normaali Ihminen yeah of course, but it's still creepy

[@xxvaltielxx1789]

The Universe is most likely infinite, there could be ANYTHING out there, we're límited to our imagination of course, presuming that we know how the Universe works just because we barely left our puny planet in our insignificant corner on the Milky Way is a mistake.

[@BP-fx3qc]

With everything going on right now, this game has been on my mind lately.

[@Josephlunar824]

B P honestly me too this is the closer thing that could happen to us

[@lilsammich8252]

I wonder if ppl that sell prepper gear are looking at their stockpile differently now.

[@BP-fx3qc]

@@lilsammich8252 probably not, most people will choose money over everything else.

[@tokyocrystal]

I just finished watching part 1 and 2....and trust me....its tripping me the fuck out right now.

[@BP-fx3qc]

@@tokyocrystal who bought the 2nd game so far?

[@elanawills2364]

“The mass distribution of breathing apparatus would take place” LOL 2020 would beg to differ

[@coreywallace2052]

“Breathing apparatus would be mandatory along with Quarantine” *Laughs in 2020*

[@bisclipscorp4859]

Try 2022

[@Zenflyn]

@@bisclipscorp4859it’s almost 2023 and that virus is gone

[@LikeAGentlemanPlease]

When he pushed the spores out the mushroom thingy I got itchy as hell! Edit: That spider 🕷 made in itchy too

[@qrow7215]

I also felt rather itchy when I saw clicker and bloaters in the game and when seeing the images from this video so I decided to find out why. Based on some quick research I did that itchiness is a sensation known as formication. (Not to be confused with fornication lol.) There are too many underlying causes to it so I could never pinpoint an exact cause for any specific person but given the circumstances of this video and the game my guess is that wee see these really creepy things happening to insects and humans alike and unconsciously think that it could happen to us a our peripheral nerf start or essentially overreact when they feel an itch as the brain thinks it's something that could potentially cause the body harm

[@Trustworthy_McLegitimate]

... itchy... tasty...

[@Reyma777]

The Cordyceps fungus in The Last of Us to me at least sounds like a bioweapon gone wrong.

[@ultramanJR]

Fun fact: some fans consider both The Last of Us and Metro 2033 to be in the same universe.

[@Frostwolf_103]

@@ultramanJR Or there are enough people left in the world who have read Metro 2033 in their timeline as fiction. And since the game starts at the same year.

[@ultramanJR]

@@Frostwolf_103 Some fans theorized that Russia was behind the cordyceps infection since the fungus can't simply just jump from insect to humans without some help. For Metro fans, there's a location known as D6 which is revealed to be a bioweapons facility. It is believed that the fungus was engineered and tested here before being deployed to the USA. The backstory of Metro says that prior to the nuclear bombings Russia was at war with USA and it's allies and this fungus was made to drastically reduce USA manpower and resources. To avoid immediate retaliation as well as to make time to prepare the Metro should it happened the fungus was deployed from South America either by Russia or their allies there. The plan worked and it took a while before USA realized what is going on and proceeded to fire every available nuclear missile they can at Russia, which at this point had been moving civilians underground and key government functions elsewhere.

[@festenzurius7454]

The first time I played The Last of Us ( of 8 total play throughs) I've misunderstood the Fireflies completley. I thought they were responsible for the cordyceps attack, not for the explosions, and I thought they developed spores, not spores developing them selves

[@johngungaming749]

Umbrella, huh?

[@christophershrimplin1849]

DUDE, my parasitology fiend has just been teased I NEED MORE!!!!! So so good I miss my bio lectures from University an your channel is my fix 🤣🤣🤣🤣🤣.

[@RoanokeGaming]

ayyyyyy well then excellent! you might enjoy the regenerador episode from RE4 then! parasites for DAAAAYYYSSS

[@LordStankNuts]

I miss my dad

[@GlenfinnanForge]

11:50 the distribution of breathing devices. Meanwhile in 2020 there's no masks for healthcare workers.

[@freezer-monkey]

There actually was an event that happened a few years ago where coffee and chocolate crops infected with the fungus were then consumed by large amounts of people, injecting them. The infected individuals were documented as as acting more aggressively towards other people.

[@ParamoreFAV3]

You’re dead ass?

[@BelleSkelle]

Such a fascinating an awesome game. I love your breakdowns of stuff. You rock man!

[@RoanokeGaming]

Glad you enjoyed it man!

[@dude-jk2hn]

Exactly my thoughts

[@TheMoonShepard]

The morphology videos will be great

[@RoanokeGaming]

I am certainly looking forward to them!

[@g21sgu70]

Agree

[@adambullock6999]

That's it I'm holding my breath for the rest of my life

[@miablaine7571]

Mom: ''Games are useless, you get dumber playing them'' The Last of Us: ''I'm 'bout to end this woman's whole career''

[@Danielplays993]

😂😂😂

[@baronvon57]

*I just wanted some bread, now I've got a fungus growing out of my head :(*

[@RoanokeGaming]

Tragic stuff!

[@thedoruk6324]

The Biology Messiah Roanoke has Spoken ! Ants are always the unluckiest Bastards.

[@RoanokeGaming]

first to form, first to get screwed over haha

[@thedoruk6324]

@@RoanokeGaming Evolution failed ! At least that species. Vampire Ants are cool

[@nekonekomikan]

I was curious of how we fell at the very beginning, as I noticed the 1st stage of infection isn't all that fast or quiet. More of a stumbling, moaning figure like that cop we find early game. Always confused me as to why the military fell at all, as they could've squatted in a base, pick off the worse quick infected, and then just cleaned up with lures and street sweepers squads. Also with how the power just cut off as it did and nobody could do a thing about it for yeeeears.

[@MayorOreo]

Watching this during the Corona Virus Outbreak: "Nah the last of us us realistic to what would happen" You know Buget cuts to masks People protesting that they should be allowed to not wear a mask And complaining thats they can't go outside because "its just like rabies" "i aint scared of some fungus"

[@androrobuiques9497]

I found the liberal

[@nobodyspecial4676]

Look at your profile pic you child

[@MayorOreo]

@@nobodyspecial4676 Thanks I put it there when I was 10 and I still like it

[@grimreaper8521]

@@androrobuiques9497 And I found the ignorant gagglefuck who just has to get politics involved.

[@androrobuiques9497]

@@grimreaper8521 hey look I found another

[@seanhenrylouis6630]

2020: Life imitates art.

[@matthewwynn3025]

It sure does, go watch contagion if you haven't seen it already.

[@starsilverinfinity]

Fungi are a fun topic! Always knew it was cordycepts, but your explanations always always refreshing!

[@RoanokeGaming]

Glad you enjoyed it my guy! and I had fun making this as well!

[@starsilverinfinity]

Roanoke Gaming Ye! Also wanted to add on your description for how they work for ants - when it makes the ants hide under a leaf, this leaf is also usually high above a party the ants normally use to travel 2 and from the hive!

[@g21sgu70]

@@starsilverinfinity Yup!

[@amanibob1416]

"In reality..." Oh, you sweet summer child.

[@tokyocrystal]

😅😅😅🤭

[@loki3275]

I love dnd's version of this. I'm actually running a campaign where Yuan-ti use the fungus creatures and spore servants to create an army, its gonna be fun when the players find it, lol.

[@RoanokeGaming]

ayyy well good luck man! give em hell haha

[@Dragonlover554]

Man oh man, I would be loving every moment of the morphology of the Cordycep-Festered "Things" and how in hell it formed. Fungal infections are underrated (or at least to me they are) and zombies forming from fungi is a pretty original concept, especially one based from a real parasitic type. Keep rocking that quality, Roanoke!

[@UngiftedWatcher]

I've never clicked on a video so fast to watch. Honestly you're awesome Roanoke.

[@RoanokeGaming]

Hope you enjoy it bro! and thank you for the compliment!

[@chunky539]

Before Covid i never thought this collapse was realistic, now im terrified at how inept governments are and how utterly stupid people are.

[@fulcrum2951]

I blame roanoke for experimenting on the cordyceps fungus and creating this situation

[@RoanokeGaming]

;) I would hopefully be alive long enough at this stage to be working actively against it! haha

[@gira4664]

A someone with an autoimmune problem I’ve learned to fear my own body

[@justsomeguywithoutalife230]

2020: I hope it don’t get that worst... 2021: this look like a picnic

[@SolidMemeMan]

Seeing the notification for these videos gets me so damn excited. Never a video I dont enjoy from you Roanoke.

[@RoanokeGaming]

That is pretty great to hear! Glad you enjoy them that much!

[@electronicmayonnaise5692]

Every single video is awesome

[@theimmortalsuperbeing549]

Hell yes this is awesome I love these kinds off videos talking about Zombie Crazy outbreaks in other worlds how they started what are they so fourth and so on. I have been on a binge with FilmscomicsExplained The Trixi Virus from The Crazies both movies is very interesting. Thank for these videos dude respect.

[@RoanokeGaming]

Bruh he makes such good videos, Love em, Glad I could add to the pile of zombies! haha

[@theimmortalsuperbeing549]

@@RoanokeGaming And he says a Fungus Human infection creature is not so far fetched yikes.

[@laROSEetLOLIVIER]

12:03 so Canada, Russia, Greenland,Finland and Antarctica are safe spots Well lucky me I’m a Canadian so I’m didily dadily safe from those spores

[@mewhen3395]

Ukraine also, since it has mostly cold environments as well.

[@ethpling165]

That one guy Well, we see that there are infected people in the Rocky Mountains and in New England, both of which have a lot of snow (in the Rockies the infected are actually in the snow) so perhaps the fungus mutated or adapted to survive in cold climates?

[@AlphaQHard]

Sir Knight Ukraine has pretty much the same climate as the US. Im from Poland so we live in pretty much the same climate, and Poland doesnt have harsher winters than lets say the USA. Most of russia isnt even that cold, its a common misconception

[@amayobidjo]

So this video was 1 year ago and now it's being recommended due to Covid19

[@tokyocrystal]

Right!!!😯😯😯

[@TheOutsider69]

I think there are a few things you're missing in terms of the cordyceps' survivability. There were simians at the University of Easter Colorado, infected ones. I live in Colorado and the climate is pretty varied, enough that anything that evolved here might develop a resistance to both cold and hot, seeing as the temperature can widely vary here, even by the day. And as genes are plastic to the environment, it stands to reason. Not only that but it's practically right in the center of the US, meaning it has every direction in which to spread. In terms of _how_ it can spread, there was an article in the newspaper from the CDC about crops contaminated with "mold." It seems that the cordyceps can spread not just via spore or blood/bite but also through ingestion. If they can infect crops I have a feeling spores can even taint sources of water as well. Not only this but the fungus makes its hosts extremely hostile, which is one of its primary ways of spreading. I don't know, just a few little details that might close the gap between the fiction and reality of it all lol. The reality still remains that, in the modern era, something like this would have a hard time spreading like it does in TLOU. I've played enough Plague Inc. to know...

[@KittysInu]

2019: the spores would warrant suspicious and the widespread distribution of breathing apparatuses would become the norm 2020: we cant get enough cloth masks for doctors.

[@thedoruk6324]

Roanoke, please gave us your explaination of Black *Pathogen* from Alien/Prometheus ! It would be so awesome to watch !

[@RoanokeGaming]

might be able to do that down the road!

[@thedoruk6324]

@@RoanokeGaming Awesome !

[@MasterPodi]

Oh hell yeah

[@Willyam2797]

"The distribution of mask and breathing apparatus will become normal" You guessed wrong nate

[@arturbalakhnin9770]

Waited for this so long The Last of us part 2 hype

[@RoanokeGaming]

Yaaaasss

[@YaoiStick]

My skin got all itchy seeing that "zombie" ant.

[@xtthew]

This is amazingly well done! You've gained a follower today.

[@RoanokeGaming]

Thanks bro! glad you enjoyed it! :)

[@lm9858]

I replayed this recently and I realized... The Zombies talk. Sneaking around them and listening, in the mix of gasps, groans, and cries, there are also mixed in words. I wish I was just hearing things, but no.... The levels of unsettling hearing the infected shaking in a corners going 'Whhhyyyy?', 'Where... are.. you?', 'H...elp me', 'Stop'.

[@logger22]

It’s actually interesting to see a zombie type that isn’t just a reanimated corpse, but rather it corrupts the mind and eventually evolves

[@Legionfox1]

The fact that, in The Last Of Us 2, there were tons of infected in the blizzards and deep snow completely unhindered by the cold makes it clear that the developer has a poor understanding of fungi at best.

[@lobsterbark]

@I have no mouth And i must scream The last of us 2 isn't canon?

[@raydynnn]

@I have no mouth And i must scream it's not?

[@gplgs4640]

Or maybe it was a creative liberty taken for the sake of fun gameplay? That’s a possibility too

[@elitemook4234]

Neil took spores out of the HBO show adaptatin because he dosn't understand how they work. He thinks mouth tendrils are more realistic.

[@ferr0gan]

Reading this during the Covid-19 pandemic. Shit we were so unprepared

[@kaejuka6249]

11:53 "the distribution of breathing apparatuses would become quite normal" Well given how Many people refuse to wear masks for covid, how many would wear it for the cordycepts outbreak?

[@1bossofbosses]

I knew it was more real with the Cordyceps but im glad you let me know we worked on something to help with organ transplants. The scary thing about this is that it can be real but glad not to that extent. As long as we don't run into no Flood Parasites or Deadspace Necromorphs we will thrive for a while. Love watching you break down biology on these type of things. My thought on this though i keep thinking what if this fungus can evolve into a much quicker fungus with more deadlier spores?? Would we be able to handle something like that with out massive quarantines or would nukes begin to fall?

[@g21sgu70]

I would like to Witness the infection of the Necromorph..

[@douglastakle8242]

Virgo I'm just waiting til we become sustainable on mars, then we're good

[@adamwarner1548]

Virgo we would be screwed if necromorphs showed up

[@g21sgu70]

@@adamwarner1548 definitely.

[@Prank3dd]

If the immunity for Ellie hasnt already been explained and i just so happened to miss it i think i figured out why shes immune. Showing in the first scenes of the game that the infection has been around for 20~ years and Ellie is 14, this would mean she was born into the infection allowing her immune system to be understanding this infection since birth she may have built a permanent immunity to it and therefore unable to be killed by infection. If this has already been explained then I feel dumb but if not hopefully this will bring some understanding as to why Ellie is immune.

[@freezerounds]

The immunity was implied to be a mutation in the fungus itself, not her.

[@Prank3dd]

@@freezerounds Ah i see thanks for telling me that!

[@ryanjonathanmartin3933]

If that's the case then she and all the other survivors should have already been infected long before. The game itself contradicts your hypothesis. The Cordyceps fungus in the game only spreads through spores or bites from an infected animal. The spores should be able to get airborne since most fungal spores are less dense than air molecules, but for some reason you can only get infected when you go into a room with a high concentration of spores. Makes no sense. So are the spores more dense than air? Then we have to get to the way "immune" is being described in the game. It's total bs. Ellie is said to be immune but her blood samples have a high concentration of Cordyceps spores (as observed by that stupid doctor Jerry Anderson). That's just pure nonsense. If she actually was immune her tissue should have almost none of the pathogen inside and should instead have a significant concentration of antibodies if she has recently recovered. The immune system would have destroyed almost all of it. If she has a high concentration of the pathogen but isn't exhibiting symptoms, then she's just a carrier and she should be able to spread the fungus by biting others. But somehow she isn't? What pure nonsense. I called Anderson stupid because his idea of using the infected part of Ellie's brain to make a vaccine is completely unnecessary. If Ellie's blood already has a high concentration of Cordyceps spores then why not just use her blood samples to make a vaccine? Why go through the trouble of a fatal brain surgery which will take at least two hours and kill the patient, preventing Anderson from using her for further tests? I'm not shitting on The Last of Us because it is definitely some of the best 21st century literature I've seen, but please understand that the game devs have to take some creative liberties to make the story exciting. None of this zombie genre literature will ever stay faithful to biology because it simply doesn't make an exciting literary work. However this franchise is the most faithful to biology out of all the zombie genre literature.

[@emilielovesbooks1613]

The tv-show shows that her mother was bittel right before she gave borth to Ellie. I think it was implied that a small amount of the infected reached Ellie before the cord was cut.

[@JacksawJack]

Cool, I've been hoping one of the breakdown and analyze channels would do this one. So basically, the only way this would have gotta to the point it did in the game was if every health organization in the world rolled a 1 on their competency checks.

[@puppetface4210]

Not fedra they walled off big cities in the early game 20 years after initial infection

[@HydroPlush]

THANK YOU!! YOU FULFILLED MY REQUEST ❤

[@RoanokeGaming]

hope you enjoyed it bro!

[@Cumflavoredredbull]

"Your body ain't having that playa"

[@eyeln9ne696]

Just discovered your channel, and I've got to admit..... You've made extremely high quality content. Mixing games/movies with a scientific breakdown is right up my alley. You've got my subscription, so keep kicking ass my friend!

[@cloverdog85]

It’s safe up here in Canada. We just had a April blizzard lol

[@Scorpion2oo9]

I literally forgot he was explaining the game and not just real life until he said “fireflies” I was just nodding in agreement at a “hypothetical” pandemic situation that is currently playing out exactly like that

[@bingbangbong497]

Always knew it was codycepts but this was really good roan. Top notch

[@RoanokeGaming]

Thanks man! I felt like I may have rambled a bit because I was excited to talk about fungal diseases but its good to hear the explanation still came out clear enough haha

[@bingbangbong497]

@@RoanokeGaming Not ramble at all mate, really good explanation. I've always wondered if it could happen and now I'm kinda sad that it's impossible 😂😂

[@skavenlord8304]

@@bingbangbong497 it is possible if humans are dumb (spoiler :they are). the scale of the event would be tuned down a lot but most tropical regions would be overrun especially area with high population density and low medical presence. (but even then use the plague inc survival strategy and go to Greenland)

[@chrismechell1947]

Just another idea, maybe a video of how Ellie may have developed her immumity/Resistance to the fungi and how that would happen IRL? Also super excited about this series, The Last of Us is definitely in my top 3 games.

[@RoanokeGaming]

Ouuuhh thats a great idea! I will work on that!

[@KevTheGalaxybender]

11:50 America has proven we're too dumb to do this.

[@LabMatt]

I never appeciated how much my macrophages do for me until Cells At Work came along

[@o.k.productions5202]

“The distribution of breathing masks” Hah! Pre Covid videos are funny.

[@feathero3]

You talking with such vast knowledge and a professional tone then suddenly switching at 5:12 made that line hilarious!

[@Alexm0321]

I think that the fungus could have taken a ride to most of the first world countries through the crops that are so widely used among the first world countries that being Cacau plants (cocoa) and coffee beans, this would immediately render most of the developed civilisation infected explaining why the out break happened so suddenly

[@buggyboy2849]

The fungus' name is actually Ophiocordyceps since the one that inspired the devs was Ophiocordyceps unilateralis , at that time it was known as Cordyceps but that changed.

[@RoanokeGaming]

thats pretty cop

[@jaimevalencia6271]

Hey man in the game when you play as Samantha right in the beginning you can go to the bathroom there is an article that says contaminated crops from fungus came from South America and or that cattle was contaminated as well if I remember correctly just hope you see my comment

[@RoanokeGaming]

Oh nice! Ill be replaying it so I will look at that!

[@camrenlopez5411]

I was thinking about coronavirus the whole time while watching this

[@FortniteClips_01]

So what I’m hearing is this could actually happen

[@the11382]

Well, things that kill you aren’t good at spreading. The person dies and the fungus dies with it. The most effective virus is the flu. More likely the fungus will become a parasite amongst the population.

[@victorgalindo8174]

Hmmmm **Becomes Biologist**

[@smokedurries3997]

Probably not since we use cordyceps for medicine n stuff and a human is much harder to manipulate. If cordyceps did become pathogenic to humans and that’s a big if, it wouldn’t cause the symptoms you see in the last of us. Cordyceps doesn’t cause aggression or cannibalism in insects so saying it would cause that behaviour to humans is purely fiction. This games depiction of cordyceps is really inaccurate

[@mysticalspace2596]

I love how the creator instead of using a excuse like it was made in a lab or a virus this guy used science that would make sense and got the idea to us fungus

[@brnclandonald]

Roanoke, this video makes me want to play "The Last of Us" more than before. My PC is pretty shit though, won't even run "Dying Light".

[@baker90338]

Get fallout new Vegas.

[@SpearM3064]

You can't play it on the PC anyway, unless you want to pay $20 a month for Sony's "PS Now" streaming service. TLOU is exclusive to the PS4.

[@Ky0ht33]

“The distribution of mass-breathing-apparatuses would become quite normal”. That speculation didn’t age well. 😂

[@matttaheri1979]

Who’s here during the new TLOU show? 👀

[@SkulkerMechanic1989]

I loved the “government would supply filter air breathing apparatus” Welcome to 2020 just wait for the infected lol

[@thedoruk6324]

1:40 - Fungust did Not Gave Consent ! Unsaaafee ! D:

[@RoanokeGaming]

REEEEEEEEEEEEEEEEEEEEEEEEEE

[@thedoruk6324]

@@RoanokeGaming Fungi Lives !

[@Journey_to_who_knows]

Grab her by the pileus

[@raviothethief8292]

The DORUK *big fungus*

[@UncleMikeDrop]

Yep. One such medicinal fungus derivative is called mycophenolic acid. It's the active ingredient in a common anti-rejection med. Other similar derivatives are also used to treat lupus.

[@sebas-pi8sz]

Me and the bois eating fungus mushrooms at 3 am

[@azzystyle94]

Nice to see that you have the credentials to backup what you state in the videos. Perfect mix of educational and entertainment

[@zero5496]

you also need to know chinese been eating those stuff for centuries as a form of medicine food, so most likely those things come close with us more than we could possibly know

[@noonswow7269]

This did not age well

[@Seedonator]

@@noonswow7269 brooooooooo

[@Woodlend]

Gald too see you come as far as you have brotha, been subbed since about 20k and have had notifications on since. Feel like your channel has become huge in a short amount of time, and I think it's just awesome you're getting the recognition you deserve. Srsly gud job m8

[@jonathanmitchell9821]

11:56 You mention in the real world we would have mass distribution of breathing apparatus and suspicion of the spores. I know this video was done before COVID. What you say different now?

[@gooby8953]

"Quarantines would be activated, but soon after the distribution of masked breathing apparatuses would be quite normal" Huh, funny that

[@ChokingOnRazors]

fugal... isnt it fungal?

[@RoanokeGaming]

DID I FREAKING LEAVE OUT A LETTER

[@ChokingOnRazors]

Roanoke Gaming yeah

[@cypher2194]

@@RoanokeGaming well, time to unsub :P

[@fulcrum2951]

Literally unwatchable, disliked, unsubbed, deletes youtube from phone, shuts down internet

[@ashleyparks6952]

Sitting here mid 2020, during an actual global pandemic, refreshing my memory to start Last of Us 2.... Your outlook on how the world would handle a situation was... so hopeful.

[@Michaelvlog-yh3ru]

You nailed it man i love this game and i can't wait to play the new one

[@RoanokeGaming]

ayyyy thanks my dude! I am looking forward to part 2 as well, Joel has got alot of explaining to do to adult ellie haha

[@Badookum]

@@RoanokeGaming ouch, this aged poorly

[@fahadalourifi1849]

Lmao when he said “it won’t be as big” if it happened in real life... then I looked at the date... yeah that was before we found out how dumb are we in handling an outbreak lol

[@Cooke125]

Mad init, it’s been nearly 2 years since it started, and yet it’s getting out of control again

[@scared-skitto2781]

I love your videos

[@RoanokeGaming]

Glad you are enjoying them bro!

[@meatylenguini1585]

Nice video! I'm sorta new only subbing last year but I really would like to say thank you for putting out videos on biology (such is my absolute favorite subject)

[@RoanokeGaming]

absolutely man! I love making these things, glad others are enjoying them as well!

[@meatylenguini1585]

@@RoanokeGaming oh my god this ..this made my year. Just gonna say this ,you inspire me to become a biologist

[@whendarknessfalls6969]

'the distribution of mass breathing apparatus would be quite normal" From 2023, are you sure about that?🤣

[@RoanokeGaming]

well not now lol

[@whendarknessfalls6969]

@Roanoke Gaming idk how it was everywhere. But in Oklahoma, we had to buy those bs cloth masks or make our own for awhile. As filtered and N95 mask sold instantly. Soo I'm not feeling hopeful that the government would've supplied them with masks in-game universe either

[@jakethatcher_]

wild to watch this post COVID

[@dawsqhtdfx6736]

This is scary close to what is happening right now.

[@kylie6701]

2020: *WRITE THAT DOWN*

[@hithere5553]

Quite incredible that the infection is able to get such a foothold on the human body, usually a fungus infection targets damp areas like the lungs, groin, or athletes foot. But not only is it able to have large growths inside the body, it’s able to do it while the person is still alive and healthy. The fact it can survive a mammals immune system and act the same as it does in an insect makes this one of the hardiest things on the planet. All hail our fungus overlords.

[@f.palmero5010]

Slurp.

[@f.palmero5010]

Slerp

[@RoanokeGaming]

Slarp

[@cypher2194]

@@RoanokeGaming Slorp

[@GunlessSnake]

A possible counter to the cold-weather obstacle could be that the fungus uses the Human body itself as a sort of thermal regulator, raising the body's metabolism and burning fat to keep the fungus at an optimal temperature, or lowering activity and steering the body towards cool damp areas in extreme heat on the opposite end of the spectrum.

[@RoanokeGaming]

oh I am sure it uses the bodies natural heat while functional, but after death it would definitely have some issues surviving to produce spores

[@Lost_Dawn]

🐽FURST🐽

[@RoanokeGaming]

AYYYYYYYY! Nicely done!

[@Lost_Dawn]

😄🐽😄

[@parallax_review]

Thanks for the interesting video! Six weeks ago, I would even have shared your optimistic assessment regarding the distribution of respirators!

[@mrdgenerate]

Dude..... This is crazy. And youre oddly good at expaining for a gaming channel