The MDMA Lectures - Part 2 - What is a Proper Dose?

DanceSafe founder, Emanuel Sferios, discusses the complexities of dosing with MDMA. The CYP-2D6 liver enzyme is the primary enzyme that breaks down MDMA, as well as many other medications. A person's genetic profile for this enzyme may determine how strongly they react to a specific dose of the drug.

[@RektalFoerster]

150 is pure bliss, doctor

[@TrueSkoolMusic]

been supporting Dancesafe since 98' .. . on all our record labels

[@airaozolina7555]

Gratitudes! Love and light!

[@Annie-hw7fo]

This is so true. SWIM had 3 experiences in an integrative session at 125 with boosters because usually they are a fast metabolizer. However experiences were terrifying except The first 30 mins which were lovely. SWIM had the genetic test and IS intermediate. Normal 1 allele but no activity on 4….I wonder if the alleles make any difference independently. SSRIs mess SWIM up. SWIM will be trying 60 on next experience. Or maybe 80. Thank you for this. It’s good to hear.

[@RhetoricalMuse]

120 for me. 100% MDMA but with natural impurities. 120 + 60 top up after 2 hours = a good 4-5 hours, with a gentle come down until 6-7 hours.

[@kgpp2293]

that enzyme talk explains alot.got a test done and I'm a slow cyp2d6 metabolizer and I take 100mg with noopept and I'm a write off. don't need any more. very informative

[@pokeman3804]

KENAN PAVLOVIC what frecuency of use would u recommend

[@LuciferDSatan-vn8gl]

80mg per dose of the purest one can find seems to work wonders. Perfection imo. Me and my S/O start with 80mg of pure and re-dose with 80 every 2-3 hours until we feel otherwise. All depends on how we feel and how long we go. And we're old school. 40 and 36 years old and started in 2000. Always have been sensitive to the real deal, never have built a tolerance. 5-HTP 1-2x daily for 5-7 days and 30-45 days minimum abstinence following a single (one night) session of 8-16 hours. That formula keeps us happy, having one hell of a night/morning, healthy and with minimal depression the next 7-14 days. I'm: Male/36-YO/6 ft even/180 lbs. Her: Female/40-YO/5 ft even/130lbs and we have the exact same tolerance...a low one at that. We have kids that weren't born when we first dropped and they can take this stuff like it's water, LOL! No TY! The old school pressed pills were a bit much 90% of the time in one whole dose as it was back then. I'm sure the 15-20% meth cut helped that a bit, LMAO. Our family member takes 120mg to start and re-doses with 100 as he sees fit. His tolerance is higher.. But if he waits the same time e do, 80-100mg works just fine for him too. But these "450mg", "220mg", etc. are crazy ass numbers. THE ONLY instance where those insanely high numbers make sense is when people are heavy and/or tall. Have a friend that needs 200mg in one shot or it's not worth it. Heavyset. About 5'6'', 250-300Lbs. He'll do a gram in one 8-16 session easy. ********** Short, small, skinny, fast metabolism? Don't be stupid. Take 80mg and see how you feel in a minimum of 1-2 hours. Short, heavy, slow metabolism? Start off with 120-140mg and follow the aforementioned. There can be custom formulas/dosages created using this information, as long as your product is unadulterated, free of as much impurity as impossible and measured with accuracy/proper tools. Start smaller and go slower until it hits you and you find your groove. Be safe.... ....and kiss the sky.

[@trevdogbunkers1048]

Lucifer D. Satan I used to take not a lot but I just took 250 not feeling and I ate have no tolerance and don't it in the past

[@RicardoMontania]

Thanks so much for sharing!

[@LuciferDSatan-vn8gl]

@@trevdogbunkers1048 Sorry this is late, but if you ingested 250mg of legit, unadulterated MDMA, you'd be ER bound or floored out for like 3-4 hours, unable to do much except grunt and make noises tbh.

[@LuciferDSatan-vn8gl]

@@RicardoMontania NP! Hope it can help some people!

[@RitaTheCuteFox]

@@LuciferDSatan-vn8gl i weigh about 45kg/100lbs and im short and i took 360mg of pure MDMA on my first time. Felt like i was dying for about 10 minutes but then that quickly went away and i just felt good. I did feel a lot better tho when i took about 180mg today. But there was still a wiggle room for more (my pulse and everything was still normal) so i think a full 240mg pill is the perfect dosage for me. Atleast in terms of getting the most high possible without well dying or feeling negative health consequences like i h ad a pulse of 160 when i took the 360mg. And i felt iike i had extreme fever for a couple minutes with red spots coming up all over my body: Was pretty scary but it was just my body overreacting to the high dose i'm assuming or its attempt to get it out of me. But if you really wanna get high i would recommended like 150-200mg but 250mg will definitely not ER bound you..

[@non-ofyo-business3399]

I took approximately 4 points and boi I was rolling! But I also could not stop tightening my body like straightening my legs or whatever. But other that that it was a good trip and once I started my come down I was most at peace but it didn’t last long.

[@darylpage50]

I been experimenting with doses, usually take it once every 3 months if that. I’m like 210lbs the last time I took 350mg split over 2 doses, I think the 2nd one I took was 100mg. I don’t even remember taking the 2nd cap. I was rolling like a mutha but with that being said, I can’t remember the experience much and I felt like death for 2 weeks. Usually I’ve only ever had an afterglow or very mild comedown whereby I’m tired. I’ve learned my lesson, won’t be happening again, ever! I reckon somewhere at the 200mg mark for me is the maximum

[@SinergiaAlUnisono]

great info, thanks

[@connorodonnell6485]

I’m on mdma I have take 3 livky fingers also it’s my first time, and Im experiencing feeling so very happy and also extreme focus I just played pool and 7 balled 3 people in 3 different games in a row

[@NicoGee1]

Da heck Livky fingers?

[@a-aron2276]

Oh, I apparently have a ridiculous metabolism, I'm up about 250-300mg. I'm rolling but I'm not off my face on that much either. Now that's not all at once but I normally do it in two doses for a night. I also am not a regular user I've done it 6-7 times over 8 years roughly once a year. Didn't realise till this how high a dose I've been taking, I thought it was normal to take that much.

[@KobusOtto]

Me too.

[@huntersanderson2803]

Stay around 125 mg.... me rolling 1g, kinda late fam

[@huntersanderson2803]

@@cosmic_love_5 yeah but I only did md 1 or 2 times during that year and dont plan on doing it again

[@justdicer]

​@@huntersanderson2803 2 years later still alive ig 😂

[@HadesSaP]

Heey?

[@psyche8688]

It is very interesting how different the effects of 5-60mg and ~100 mg is. Around 30 mg (m) you can have medical effects, with low side effects. Around 125 mg (m) you have defenetly side effects. Although the quality of the drugs have huge aftermath on research and information. (Around 200 mg, which is pretty toxic i think, you can have the benefit of personality chanches.)

[@aluandjalal1324]

I take 250 every time and it’s brutally amazing and I weigh about 143lb

[@RitaTheCuteFox]

@@aluandjalal1324 same but i weigh 100lb

[@RedFlagCoalition]

30mg put me on my ass for 6 hrs yesterday 😂. 10mg - 25mg will do lol

[@kitunlapotun]

what's up with low dose why it says that 20-50mg not good or not working?​@@RedFlagCoalition

[@waterofbabylon9169]

good prof

[@timespaceperspective701]

ty, i might be getting some again and i really want to take a smaller dose , although it feels great taking the regular dose, im not sure it has to be so intense, maybe a half dose or even a third dose sounds good, it'll still feel really good i think , but the comedown will be better, also safer

[@trevdogbunkers1048]

Time+space=perspective be careful seratonin never rebuilds

[@triple_gem_shining]

Whens the full movie coming

[@kaszapnagypeter]

I roll just once a year,but when I take it. I just can't stop. I easily take 600 mg during the night and the sex is amazing!

[@euphoria3200]

i accidentally took 500mg 2 weeks ago i don’t know how i’m still here😂

[@SlowburnFoos]

Please share your story

[@victorenock]

😂😂

[@reselleo]

Dario Spirit No i meant i did 400mg and a gram of weed lol

[@ras_krystafari3333]

@Dario Spirit a gram is 1000mg......gonejuh to ganjaja

[@geu2367]

Lmao i slam Gs every weekend

[@casinoguap]

i do 120mg set a 59min timer and then redose at 60mg

[@kovir2555]

I know I am late but what advantages come with dosing this way?

[@kertbert1]

@@kovir2555 You don't end up in the hospital.

[@Martin-fk7yr]

I did 300mg and smoke on it at body waith 55kg . I would like to know if it is much?

[@joonajaakkola3865]

So is the 125mg dose measured with a substance of maximal / clinical potency? How does that translate to variants with higher impurity?

[@Mdmathemovie2016]

"Purity" has two meanings. The first, which most people understand, means there are no other drugs mixed into your MDMA, like meth, or bath salts, or fentanyl. The other meaning has to do with how much the chemist cleaned the final product. Depending on the precursors used and the method, there could be various left-over contaminants in the MDMA. They might not harm you but they slightly reduce the amount of MDMA per milligram in the final product. The "purest" MDMA should be pure white. The more brown or grey color it is, the less it has been washed and the more contaminants are in it. So, that said, any hydrochloric salt can only remain in solid form at a certain level or purity. Something like 85% (don't quote me on the exact number). That means the "purest" MDMA is about 85% "pure." The rest is the hydrochloric salt that keeps it as a solid crystal rather than liquifying. So this is the quality of MDMA that they use in the MAPS/FDA studies. What I would say is that even if you have 80% or 78% pure MDMA, you should still measure out approximately 125mg if it is your first time. The difference will be negligible. Hope this helps!

[@lukepatto4366]

I deffinetely have taken too much MDMA and have started to get a tolerance for 180-200mg. 300mg will be my new dosage soon but I often think any tolerance about 150mg is just worsening the side effects and losing the high effects.

[@MarVandeSande]

Take a good break, start over with a low dose

[@user-kn1qi5sf9w]

It's ABSOLUTELY increasing the side effects.

[@Mmcermes]

Take a break...after the first 2doses you're serotonin is depleted, if u continue to take Molly you'll feel only an amphetamine like stimulation and tons of exhaustion afterwards.

[@Rainer_ow]

@@Mmcermeswhat do you mean by after the first 2 doses? Do you mean the first two times you ever take MDMA or the first 2 does of the night? Sorry I’m pretty stoned

[@Mmcermes]

@@Rainer_ow 2 consecutive doses, 150-250mg each

[@burgeremperor4421]

Did a "gram slam" like week ago and it was minth af

[@nicmax444]

How much is a microdose?

[@michaelmccrossan7655]

50mg plus 1mg per kg of body weight

[@Kaiyats]

120mg first dose An hour later 60mg

[@randywatson5930]

330 and It was too much for me

[@neonaditi007]

Can someone use small dose of mdma everyday to keep up a positive mood?...just a question..can it be used as mood uplifting medication?

[@skyebarkus6733]

nooo please do not. in the long run it will strip your brain of endorphins and if you dose everyday it has potential to turn into meth in your body.

[@jimmybroussard7328]

i jusy took 6 points and now im starting to question if im gonna be ok bc i took it 5 minutes ago and my fi gets sre going so mutafkin fast i kinda feel scared

[@Mdmathemovie2016]

Please reply if you are okay. That is worrying.

[@alikrishosein3456]

I say 175mg good if its pure like I mean black and soft not pill form 125 mg if its xtc pills I take 2 at a time I wish I had pure that was the best

[@LuciferDSatan-vn8gl]

...black? Dude, that's not MDMA. If it is, it's highly toxic from impurity.

[@masskonmasskoff6188]

Acidently dropped 2 and a half import Dutch ectstacy peach ferraris the pills are roughly 220mg amazing tbh but yeah what a experience ahagah

[@noname94422]

I took 220 mg (a whole pill) once. After 20 minutes i just threw up before i could feel any effects😅

[@danieldutoit5847]

Only here so I know I won't die if I get a little generous

[@non-ofyo-business3399]

Daniel du Toit I highly don’t recommend going over a gram. I’m not saying 9 points is safe but I definitely feel after a gram is where overdoses happen. You just gotta know you’ll be able to handle it. But also remember this drug depletes your serotonin levels so as always lower amounts are always better and safer.

[@alejandrofabara9114]

What kind of symptons could we expect from the neurotoxicity due to really high doses?

[@Reliscian]

serotonin syndrome in acute or depression in cronic

[@huntersanderson2803]

Having recently taken 1g of mdma over the periode of 3 hours, the effects are WAY longer. I was high for almost 20h in totality, at the end i was very nauscious because my head was still spinning and i was trying to work. I was debating weither or not to go to the hospital but opted out as the high was finaly comming to an end (note that ive never had come down effects of sadness/depression after doing any drug, only physical fatigue) and i was finaly able to sleep and regain some energy. I always made sure to stay well hydrated, but not too much, and make sure to check up on myself on regular occasions to make sure my body tempature wasent going to high. After 6 hours i no longer felt like i was on 1g, but a solid .2, and that remainded for the following 14 hours until i had completly debuzzed, my pupils had finaly returned to normal, blood preasur was normal etc.

[@captaincrunch6113]

@@huntersanderson2803 yeah I learned my lesson after I did like .9 iin a night

[@Mmcermes]

Depression, memory problems, irritability and general anhedonia

[@Mmcermes]

@@huntersanderson2803 pupils normal after 14hr? No way 🤣

[@mrjamescurry]

400mg is standard for a 6 hr session for me

[@mrjamescurry]

@citrus notes i have been thinking that its time to wind down a bit to be honest.

[@davetheonton9849]

@citrus notes not being funny but I’ve done mdma for hours on end and end past six hours

[@hanskazan7403]

i dont feel shit from 100 mgs lol ive done alot of mdma in my years and tested it before taking i live in holland so i can send it to the lab for free and always had pure mdma and iam weighing 100 kgs and i normally go with 175 mgs and then 60-90 min after that i take 75 mgs and then after that i take nothing more for the rest of the night only smoking some weed. i have done alot more than that but that is my best dose with proper breaks between rolls, this way i dont have a comedown at all only a little sore jaw next day.

[@andriussinkunas9307]

How much mg is pure 0.6g? Cuz it was wow

[@educostanzo]

Technically 600mg. If you took that amount of pure substance in one dose, I believe it's very dangerous.

[@OGdrodro]

Well for a normal doce is about 0.15 but I do about 0.45 plus

[@ItsThatMilkshake]

150-200mg has me having a blissful time. Anything less is underwhelming. I dose 2-3 times per year.

[@turbonbc]

Depends on weight and diet/lifestyle mostly. 2x the bodyweight in kilograms to mg is a good rule of the thumb and some people with healthier lifestyles/diet recover in 1-2months to optimal levels were others can take 3-5months. All depends.

[@Mdmathemovie2016]

That feels very moderate and reasonable. It's true that under-dosing can produce almost a dysphoric effect. In the MAPS studies, they found that doses below 70mg actually made the PTSD worse in the subjects. It's like the MDMA increases anxiety if you don't dose large enough to get full serotonin release. If MDMA were a legal and regulated medicine, we could have more honest and public conversations about dosing.

[@turbonbc]

Well said, many people also mention about *The Magic* of the high is gone unless you take few months break this is what i was referring too above, to get the most out of the experience and a more profound one it is better to take longer breaks.

[@ItsThatMilkshake]

Very interesting. I am 6'4'' and 200lbs by the way, so I would assume that is why I tend to need a larger than 'nornal' dose. I have also dont seem to feel down/crappy the following days; I did feel like my mind and eyes were strained the following day after my first ever dose (which was 100mg + 100mg redose of high purity, tested MD from a trusted vendor on the darknet), but every roll since has had no ill effects the following days, in fact I got a sense of relaxation and joy the following days, thinking about how wonderful life is. I hope you guys can branch into LSD and Psilocybin (or someone else). LSD and Psilocybin had an even more positive post-experience effect on my life. 110ug in a national park during spring had me tearing up like a child on christmas, seeing the incredible visuals in nature. 3g of dried cubensis also had me in a very nature loving mindset. I dont litter anymore, I recycle, I went vegetarian and so much more.

[@ItsThatMilkshake]

Yeh I am 200lbs and 6'4'' so that is true :) peace

[@reselleo]

On my first time i had 400 and i took it in a capsule and i didnt feel anything an hour into taking it so i rolled a 1 gram joint, in the middle of rolling it the mdma all hit me and i smoked the joint anyways😂 it was a month ago and idk if im going to do mdma again

[@Mdmathemovie2016]

Why did you take so much? Just curious.

[@reselleo]

MDMA The Movie I think because everyone i knew was taking the same amount

[@reselleo]

Dario Spirit Yeah it was an eventful day/night 😂 I did it again a few days ago but i took wayyyy to much, i took a half gram maybe even more but i snorted it this time and it was weird i didnt even feel it like kicking in at one point i was sober then i realised i was rolling but when i ate it it hit me like a truck So i done too much and i had the worst come down and i had suicidal thoughts and was miserable and im still feeling that way. Just saying be very careful with this drug it can fuck up your brain i have friends who cant remember shit and have viduals when they are sober because of mdma

[@reselleo]

Dario Spirit Thanks, keep in mind im british so thats why lol, i wish i could share the videos i took becuase its the funniest shit in the world. I also chewed chewing gum so much or harsh it turned to a liquid and i was convinced my spit was acid idk how, im not doing mdma till a few years all my friends have stopped aswell. im about to do acid for my first time with a 140 ug tab I know people who have done 1.5 grams of mdma and omg i wouldnt ever wish that upon myself

[@RaceActionNL]

@@reselleo do the Wim Hof methode. It brings your emotions back after one session. It's free

[@politiciansthrowstones]

Less is more with real mda and mdma!

[@clairedebear2652]

I rolled for the first time a month ago and took 200 mg and I had no problems and enjoyed it. I’m gonna roll next weekend and I’m thinking of doing just 100 mg

[@karimjr28]

I strongly recommend you to space it out with at least a month or 2 between rolls.

[@clairedebear2652]

@@karimjr28 yeah I’m doing the 3 month rule from now on :)

[@Kaiyats]

@@clairedebear2652 Great just remember for about 3 weeks after your going to have cravings for it, you’re going to be thinking about doing it but after about 3 weeks you forget and move on from the experience it’s vital you don’t fall into the trap of taking it a lot because it will ruin the experience permanently as well as do damage to your brain.

[@sataniclife993]

2000mg on 2 nigth (in 2 days of week)

[@elchamaco15]

Personally, I'm a fan of about 500 lolz. Then ill take another later on 👊🤪

[@considercyanide5399]

should i feel scared i did 400mg first time?

[@Mdmathemovie2016]

You should feel lucky. 400mg is way too much. You survived it, but if you had one of a handful of preexisting health conditions that are contraindicated with MDMA, that dose could have killed you. A proper therapeutic dose is 75-125, with a booster half the original dose at the 2-3 hour mark. I'm curious, though. Why did you take so much? Did a friend tell you that's how much you are supposed to take? And how are you sure you took that much? What country do you live in also?

[@considercyanide5399]

uuhm, i live in belgium (the part that speaks dutch), and i was planning on taking only half of it but when i took it i just swallowed the whole thing and my friend who has done it multiple times didn't tell me it was supposed to be that much, i kwew it was a high dosage but i just forgot it when i took it , and yeah i don't suffer from any disease or allergies,

[@AgentRafa]

Holy shit excuse my french... This is how I've been doing it: I buy 1 G and I split it in two equal parts (measuring with my eyesight only so it's not accurate), that means roughly 500mg each. I Put one part away for next time, I wait at least 6-7 weeks between taking it. So I have roughly 500mg and I split that up in two parts, measuring by eyesight, one part clearly bigger than the other roughly a 2/3 (of 500mg) and 1/3. I take the big one (2/3) let's say at 20:00 and I boost with the 1/3 anytime between 23:30-ish to 01:00-ish. Done it this way at least 6-7 times during the last year and into the first months of this year, and the MDMA came from the same stock, it was the same drug. Never had a problem with it. So taken into count that I measure by eyesight an evening dose for me could vary between 400-600mg. Any thoughts?

[@reselleo]

Consider Cyanide On my first time i did 350

[@kacpertomaszewski2771]

ive done 600mg in one go, wanted to test the waters and do a g, any thought?

[@RicardoMontania]

don't. just don't. not even for testing the waters bro, you can fuck yourself up so bad. that is abusing the substance, use it carefully. this is not like acid.

[@burningknuckle26]

A g in one go could probably kill you

[@revfunk8823]

Is microdosing safe?

[@hemphoeather5504]

Must be. Im trynnin it

[@psilopsychic]

@@hemphoeather5504it’s not lol

[@psilopsychic]

Nah

[@cadamham]

300-350

[@skavidlemley341]

You guys weigh your molly?

[@skavidlemley341]

I'm not a nut tho I weighed one time and it was 115 mg and lost of my lines are the same lol

[@lotenofficial]

I did 1.5 grams yesterday

[@nebula3089]

Lol

[@apochidafein]

Could u walk when it hit

[@apochidafein]

I did a gram and was paralyzed

[@triple_gem_shining]

That's just abuse

[@triple_gem_shining]

And dumb

[@Sam-bd9wz]

Taking 600mg tonight

[@kylegaskamp5666]

dam i take .4

[@TheBic4]

200mg is amazing fuck 100mg.

[@devondavis1316]

If you are first starting, no more than 150mg, from that point, don’t do anymore than 400mg

[@tallfungus]

I take like a g at a time…. Sometimes more. :/

[@tallfungus]

@Three fiddy added.

[@hemphoeather5504]

What if I just decide to just take molly as a regular part of my life

[@princelyclouds7980]

You will likely develop serotonin syndrome. Where your brain won't be able to produce the chemical that makes you happy naturally anymore.

[@princelyclouds7980]

Not worth it

[@Mmcermes]

On a daily basis I don't recommend it but once in a month why not

[@jessemays82]

This shit pisses me off . Just break it down and measure it by finger print . 2 points seem low af to me but idk just might be . I like to be smacked . Closed eyes visual and some more shit . If you gone do mdma might as well be on like a light switch

[@Cheximus]

Junkie.

[@High_Monk]

​@@CheximusBro you're watching the same video

[@candyyrmz]

how many points do you do

[@fideldisalvo]

well shit, i took 0.32 for my first time...

[@Mdmathemovie2016]

How was it? Did you have massive jaw clenching and eye wiggles? Was it too much? MDMA should produce a relaxed euphoria. Alert but calm. Also, did you test it first to know it was MDMA?

[@callumfuller7666]

Errr 2000mg never again

[@iridiumFalcon]

2grams beat that

[@johncrona5784]

Its not a contest. The only thing you might win is low serotonin the rest of your life, constant depression.

[@juanhertsensmarques9796]

@@johncrona5784 and your iq

[@93stang19]

How about zero mg and don't lose interest in your kids ?

[@nickcompton4772]

what

[@albertomartin4812]

???

[@dylanparr6880]

That's a bit of a stretch but ok

[@end-game2030]

That's crack, not mdma.

[@Shroom_toks-on-insta]

If you’re looking for where to get ecstasy from,

[@Shroom_toks-on-insta]

Look up👆