The Metabolism Of Estrogen- Part II The Good, Bad, and Ugly Types

Dr. Jawad discusses the metabolism of estrogen via many video's.
The liver is the primary site of estrogen metabolism through phase I oxidation reactions, which are mainly catalyzed by CYP1A2 and CYP3A4, and phase II conjugation reactions mediated by EST. It is thought that damage to the liver impairs its capacity to metabolize and inactivate estrogens, resulting in increased estrogen levels in the circulation.
This is known as phase I of estrogen metabolism. The 2-hydroxyl metabolite pathway is considered the best, as it creates a weak metabolite. The other two pathways, the 4-hydroxyl and 16-hydroxyl metabolite pathway, produce more potent estrogenic metabolites. The 4-hydroxyl metabolite in particular, is associated with a higher risk of breast and endometrial cancer. Phase II of estrogen metabolism involves turning the estrogens into water-soluble compounds that can easily be excreted in the urine or gut. It’s important that both Phase I and II are supported when addressing hormone metabolism.
View Part I:
• The Metabolism Of Estr...
Part III:
• The Metabolism Of Estr...
Part IV:
• The Metabolism Of Estr...
Part V:
• Metabolism of Estrogen...
Part VI:
• Metabolism Of Estrogen...
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Dr. Jinaan Jawad
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DR. JINAAN JAWAD
D.C., DACNB, FACFN, FIAMA, CFMP
Dr. Jawad is a board certified chiropractic neurologist and acupuncturist. He also is a diplomat for the American Chiropractic Neurology Board, Fellow of the American College of Functional Neurology as well as Fellow of the International Academy of Medical Acupuncture. He is a Certified Functional Medicine Practitioner.
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[@minnyjay4332]

Hi Doctor Jawad. Do you recommend any supplements/foods for reducing the Estrogen 4 & 16. And any supplements/foods in specific to increase the Estrogen 2?

[@thejdocrealminute4648]

chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=https%3A%2F%2Fwww.uwhealth.org%2Ffiles%2Fuwhealth%2Fdocs%2Fpdf%2FIM_Vol2_No1.pdf&chunk=true Hopefully -- this attachment helps. There is not ONE specific thing to do. Diet, exercise, and clearing out the liver pathway --- is your motivation

[@minnyjay4332]

@@thejdocrealminute4648 thanks for explaining. It sounds so simple but putting it to practice will take some rewiring of habits. Thanks for sharing the link. I tried copying and pasting but it's not working. What is the name of the extension if i may ask?

[@thejdocrealminute4648]

@@minnyjay4332 You can try sharing it from the links in the description.