The Personal Fat Threshold: Disease striking at any Weight [Study 249, 250]

[@Physionic]

No amendments, currently. Follow up video releases on Wednesday.

[@joshlocher71]

I like David sinclair

[@baconinvader]

made it before the amendments, I'm so proud of myself

[@ellie698]

A friend of mine had chronic pancreatitis for months. Essentially his pancreas has pretty much destroyed itself so now he has to have all of the things that his pancreas used to produce, on prescription - digestive enzymes - and is type 3 diabetic (or was it type 1b?) having to inject insulin when he eats. Can you do a video about what causes pancreatitis? He reckons his thyroid gland is the problem? Or something. 🤷🏻‍♀️ Thanks.

[@davidmeloche3563]

In my 20's horribly depressed, and self medicating my pain from a transport accident taking a leg and permanently messing up the other, I drank myself into type 2 by 30. Yoyo dieting, bouncing by 25-40 lbs in a swing either up or down, year after year in 3 month cycles didn't help at all. You know what overwhelms the liver? 8-12 drinks a night, 4-6 nights a week, and just eating protein shakes all day, and then McDonald's breakfast at 5AM. Man...I did enough damage, I'm amazed I've made it to 39.

[@Physionic]

Glad you’re on the other side :)

[@joshlocher71]

@@Physionic hi have you heard about David sinclair's chemical cocktail

[@carlosgaspar8447]

Al Howie took up running to quit his smoking addiction but soon became addicted to running. became well known as an ultramarathoner and often running hundreds of miles in between events, and famous for his beer hydration methods. in the end he succumbed to diabetes and passed away at 70.

[@jmc8076]

Hard won good for you. We all end up learning this world is a tough go at times. We’re all just flawed humans doing our best no matter label/status etc. Don’t tell some influencers or gurus LOL. From dark humour ER dept/EM friends: Living to 80 gives us 4000 wks (didn’t verify this Nic.) Sounds a lot but is it? Also: never say can’t get worse or all quiet now. 😂 Best of luck.

[@jamescalifornia2964]

Fortunately, our bodies are always in " recovery " mode . 👍

[@abudhabi9850]

Hey man, ur content is gold. Love ur humor. It really helps me in deciding how to live my life health(ier)

[@Physionic]

I’m thrilled to hear it :)

[@donwinston]

This is the first time I've seen/heard/read a technical summary of the mechanisms that cause insulin resistance. For me fat "gums up" your cells has been my understanding which is good enough for the most part but it is cool to know someone really has figured this out.

[@salleone6387]

I listened to a lecture by Dr. Nicola Guess, and she said something that kind of pairs with this video. In my non clinical summary, diabetes has 2 ways of disabling the proper management of glucose, one by the liver, which doesn't turn off glucogenesis and one by the muscles, which become resistant to accepting BG. And that they really are 2 very different mechanisms that must be treated individually.

[@dough5186]

Excellent video! Professor Roy Taylor is a true hero for his pioneering research on T2D. The Personal Fat Threshold theory proved to be 100% accurate for me personally. I will literally test at pre-diabetic fasting glucose levels days after crossing above my PFT, and then my fasting glucose will subsequently drop by 12 or more points just days after crossing under it, as excess liver fat is cleared out. Because I'm a TOFI (thin outside, fat inside), it will be a lifetime struggle for me to avoid even modest weight gain, as I will become prediabetic even at a "thin-looking" BMI of 21.5.

[@JWB671]

Do some weight training get some muscle on you it sucks up glucose just to exist.

[@Ryan_DeWitt]

We always talk about people carrying too much fat. What we talk about much less is people carrying too little muscle. Undermuscled.

[@Physionic]

Covering soon

[@jacobdebernardi4385]

Dr Gabrielle Lyon wants to know your location

[@dokhanh1094]

Just about time I have to write an essay about Insulin resistance in obesity. This helps a lot, many thanks Hope you will cover other substrates like leptin, adiponectin, resistin in next video

[@condoriris6286]

What an amazing video this is, i always wondered how some very lean people get type 2 diabetes , this video explains it.

[@kellicardaras2805]

Nope, not in grad school. Just a fan from the medical field. Thanks for your great content.

[@Shibestrike]

I got fatty liver from corticosteroids chronically elevating my glucose. I got type 2 from it with a 60% saturation. A year later, my liver is clear and thankfully no damage. Keto, fiber, berries, NAC, taurine, choline, vitamin E, exercise. I can still get elevated to prediabetic levels on a normal diet. Still working to get my LDL and weight down before I know what’s what. Also wondering if a long fast might “reset” things. Super interested in your next video.

[@davethe-bear9923]

--Diacylglycerol, ceramides (And other intermediaries) / phosphorylation of IRS and Akt interrupting insulin signaling ,,,blowing my mind. Thank you for helping me understand the biochemistry. This INDUBITABLY helps my pursuit to more fully optimize the reversal of my former diabetic self. ,,,looking fwd to being an Insider. NERD ON!!!

[@edjack5on]

I've always been concerned regarding diabetes as my father is diabetic type 2. Despite normal weight, living and eating healthily, exercising daily, and not smoking or drinking, my A1C levels are always on the edge, which I could never explain. What one could do in this case if it can be liver related?

[@rodrigomachado5291]

I love this channel’s in-depth explanations, it’s like dr. Sten Ekberg on steroids.

[@mikeroll9868]

Thanks so much for this video. It helping me get to the bottom of my insulin resistance and CVD. I saw an interview with Roy Taylor about his research. You clarified it nicely.

[@wmichaelh29]

I just send things like this I come across that seem interesting. "In one study, people with diabetes were given guar gum 4 times per day for 6 weeks. It found that guar gum led to a significant decrease in blood sugar and a 20% drop in LDL (bad) cholesterol (8Trusted Source)." From Healthline.

[@donwinston]

Healthline is not the best place in the world to get good information about health. They are not terrible but WebMD is better. I've seen Healthline spew nonsense about Ketogenic diets and fluffy anti carb notions that are misleading.

[@leewoodrough242]

This might be out of your wheelhouse but I would like to know what leads to fungal nails and what nutrition or supplementation can avoid the development if fungal nails with age. Thanks to youtube I have unlocked this new phobia.

[@workout1520]

At my heaviest 390lbs and twice my healthy muscle to fat ratio, my A1C was still borderline. Life still sucked as a an obese person but my Doctors couldn't believe it

[@jaycarver4886]

Blood sugar can stay in an acceptable range because insulin is keeping it in check. To be at that weight you'd probably be pumping out lots of insulin - insulin drives fat storage. Have you ever had a Fasting Insulin Test? I've heard it called the most important test your doctor doesn’t order. Insulin resistance can be detected many years before you end up with a type 2 diagnosis. Check out the work of Dr. Joseph R. Kraft for more information.

[@Mario-forall]

Being able to get superobese is like a super power. Asians can't, which may be why they develop diabetes at 25-30 BMI

[@workout1520]

@@Mario-forall I come from a long line of Feast/Famine, Russian, Austrian, Eastern Euro genetics. During my Fat loss phase, I've been doing 1200 calories per day and avg. 160 grams of protein per day. I've been able to reanimate/reactivate all my muscle from my prior natural bodybuilding career.

[@Dan-dg9pi]

This video was overwhelming.

[@Physionic]

How so?

[@Dan-dg9pi]

@@Physionic I was pretending to be a pancreas.

[@saganspirit]

@@Physionic I think he was joking "overwhelmed".....

[@Physionic]

Ooooh! Haha! I was waiting for feedback. Completely went over my head.

[@paulruano1903]

Good video. How to verify if has been able to considerably improved the risks? What tests etc.

[@kurthanson7522]

don’t judge a book by its love handles 🤣

[@csabakarai4497]

Just read a study, that states that the diagnostic criteria for NAFL, which is now 5.66% fat content, should be lowered to 1.85% because above that, insulin resistance may occur.

[@paulman1970]

Great new video, but I'm still waiting for you to clear the air about whether resveratrol "negates the benefits of exercise", whatever that means exactly.... I've been taking it for about 8 years, along with the other stuff that David Sinclair touts, and will be rather upset if I find out that I've been shooting myself in the foot. I exercise almost every day too, either tennis, swimming, or walking...

[@real_sensible]

Resveratrol, if you watch Brad Stanfield, has been shown to negatively affect health. David Sinclair was wrong about Resveratrol. So many people trusted his Harvard credentials and tenure. It was terrible science on his part, and was rightfully debunked. Look on the bright side: You exercised all these years and are in better health for it. That goes much futher than “Resveratrol”. Try Bryan Johnsons Anti-Aging diet if you’re interested in longevity.

[@farhat5325]

So how do you reverse the faty liver

[@levprotter1231]

I got severe metabolic issues after being drafted into the military, eating ungodly amounts of omega six and sugar, and my liver was fried. Was still relatively underweight.

[@Mario-forall]

Oh, so it is mostly due to liver fat and pancreas damage? I had understood that blood sugar started to rise once Adipocytes themselves became insulin resistant.

[@daysoftheboo]

I was wondering how is it that skinny thin people can get diabetes because you mostly hear of overweight people developing diabetes but when thin people get diabetes what are the foods or diets they were most likely eating to cause it?

[@Bucephalus84]

Lack of weight training and poor muscle mass

[@mikeroll9868]

Muscle loss as stated , but most likely overindulgence in high fructose corn syrup. I.e. sodas, fruit juice, corn chips. As fructose is mainly metabolized by the liver. Too much of these leads to fatty liver. Also alcohol. Undoubtedly too much sweets, candy and sugar. All of these are highly addictive for most people. Add other high glycemic foods like potatoes bread and rice.. in moderation maybe not a problem, but in excess a problem.

[@Icarianbrother]

My theory is that an age-related loss of fast-twitch muscle fibers that stored and used glucose, precedes and leads to an over-storage of fat in the liver.

[@oolala53]

Even in young people who exercise? But it would make sense in many cases, since muscle loss is associated with aging, and especially in many modern societies where there is no functional reason for people to stress their muscles.

[@sw6118]

I think you’re onto something, but the picture is more complex. It probably has a lot to do with where your body stores fat, legs/arms vs. midsection, back vs front. The more you store it in the front midsection the more likely it’s storing in the liver. He’s saying it’s about the subcutaneous, again that’s part of the picture.

[@Shibestrike]

Idk man I got it and I’m jacked otherwise

[@jonthomas9708]

To my uneducated mind your theory makes sense. It could also be an aggravating factor if not the sole cause - I like this curiosity. I would like to see independent science institutes able and willing to test such theories. Is hypothesis a better word? idk

[@Icarianbrother]

Thank you! @@sw6118

[@pierrejeanes]

Great content 👍

[@JacquesTreehorn]

Thanks for the studies. I just started Mounjoro in Abu Dhabi. 5.0 is hard to find. On the 2.5 for the first month.

[@donaldhenderson1870]

Awesome video!!!!

[@andrewrivera4029]

It makes sense, as we get older we can no longer handle copious amounts of carbs and get fat. Reducing fat is extremely difficult in the presence of carbs any carb, I’m 58 and have experiencing it now although I’m not a type 2 diabetic I do believe my insulin resistance seems persistent no matter how much I cut my carbs to the point that I’m carnivore now and am finally able to lose that last 30 lb of subcutaneous fat. The crazy thing is I’m not seeing it on the scale, I’m simply getting more lean while building more muscle!

[@sawa1067]

yes you can get nafld from overcomsumption of carbohydrates. 💯

[@Shibestrike]

Overconsumption period. Carbs are not the enemy.

[@DASLAKILL]

The only organ that can process and use fructose is the liver and its daily limit is roughly 20 grams. Once its over the threshold its turned into fat and stored in the liver. Too much fruit, high fructose corn syrup, sugar which is half fructose and all carbs cause the liver to become fat. Whats more important than caloric restriction is restriction of all sugar and carbs. Dr. Ekberg on youtube has tons of long format videos that break this down.

[@mikafoxx2717]

I pretty much agree here. A lot of people's problems are from general overconsumption, liver damage from excessive sugar(fructose) intake and alcohol, also medications. They're more effective than just fat for causing metabolic dysregulation. Liver fat is usually the first priority to get burned, so those that eat little despite alcohol or sugar don't usually have much liver fat. I think weight lifting and general exercise helps greatly with helping burn up glycogen so that our food can be processed and immediately have somewhere to go other than fat cells, plus it's good for you in a variety of other ways. I limit carbs and found out I'm celiac, but I won't deny that even a lot of, say French, are healthy despite having bread, cheese, and some wine fairly often, they just likely walk more and eat less, notably also less sugar.

[@Physionic]

All good points

[@jaycarver4886]

If only people would get up from the table and take a 20 minute walk after eating. It helps immensely in preventing blood sugar spikes. Also, with the advent of highly processed (engineered) addictive foods eating seems to have become recreational. Bored??? Gobble down a big tasty bag of chips and quart of ice cream! No problem if you just had dinner. 😂

[@mikafoxx2717]

@@jaycarver4886 Yeah, I agree. Snacks are also just emotional eating IMO. I don't think 95% of people actually know what actually being hungry feels like. If I wake up at 4, it usually takes until 10 before I actually get hungry, and if I eat them, it's about 7-8pm that I get hungry again, but that's too near when I sleep and it impacts sleep quality so I eat more at 4-5pm. Sometimes I have a bite of lunch for breakfast at 6 if I'm at all sore from working out and might benefit from protein earlier.

[@Shibestrike]

I don’t buy that fructose is bad for your liver. Quite the opposite. Overconsumption of fat is what causes fructose to look like the bad guy. Basically, neither carbs nor fat are bad, but together in excess absolutely they’re both bad.

[@mikeroll9868]

You sum it up really well. I started some of what you said above to one commenter, but you really nailed it.

[@azdhan]

Many thanks for sharing. From what I have read and understand certain ethnic groups such as South Asians, which I am one of have a lower personal fat threshold making them more prone/predisposed to accumulating fat more viscerally around their liver and pancreas vs subcutaneously. The exact mechanism of why those griups may be more predisposed has not been established while theories and speculation abound. Also, I have seen it cited, although I am not sure how valid that some research suggests that fasting can help regenerate dying or near death pancreatic beta cells responsible for insulin

[@littlevoice_11]

I wonder if personal fat threshold changes if someone is severely underweight due to illness. There is some research showing that after long term weight loss below a healthy bmi, the loss of muscle mass means weight restoration often leads to a higher percentage of fat and an abnormal distribution of weight on the body. What are your thoughts? Worth a deep dive review?

[@saliksayyar9793]

Roy Taylor has published on this

[@Physionic]

It’s his study I’m reviewing here

[@joerockhead7246]

thank you

[@earlcollier4119]

And artifical sugars makes your body a lot more sensitive to real, natural sugars. Which leads to this, and more. Always eat more natural foods and products, less artifical or artificially based/infused foods.

[@lewynld]

I may be missing something, but this does not seem to add up. If excess lipids inhibit insulin production in the pancreas, how does the liver become insulin insensitive due to high levels of said hormone? It would seem that lower levels of insulin would increase blood sugar independent of what is happening in the liver. I always thought that the pancreas produced increasing amounts of insulin in response to too much fat and sugar, not less. Please explain.

[@tempcadoganenright]

What is the story with AKG , is it the new anti aging supplement?

[@seranonable]

I have a request for a video... there's a LOT of conflicting information about soy, breast cancer risks, gyno, etc. You're the only one who seems to do exhaustive diligence when it comes to available research. is soy a risk? does it blunt testosterone levels? and if it does, are there other alternatives on the plant-based side? asking as someone who is aspiring to be an Orthodox Christian, and they have a LOT of non-meat fast days... like half the year.

[@helmutkrusemann9194]

hello, sorry offtopic but I know here are a lot of smart people especially the host himself. can someone explain to me please why butter raises cholesterol, especially LDL more than coconut oil even butter has way less saturated fat? what specific types of saturated fats have the most impact on LDL? Which saturated fats (for example myristic acid, palmitic acid etc.) raise LDL cholesterol the most? Thank you very much

[@studentaccount4354]

Butter is purely high fat cholesterol. Cholesterol is animal made saturated fat. 😊 Coconut fat is saturated plant fat. Both types raise cholesterol levels. LDL is a number of fat cells in blood calculated by lab. Labs differ in how they calculate the low density lipoproteins.

[@mikafoxx2717]

I wouldn't worry hugely over the LDL numbers, it can change a lot and often just depending on what we eat. Even fasting raises LDL from fat metabolism. I've heard it told that it's essentially blood vessel inflammation that the cholesterol goes to to repair, which causes scar tissue called plaque. Reducing the inflammation source like smoking, high blood pressure, and certain food reduces that. Lowering cholesterol does work for smokers or such because it prevents the scarring, but better yet stop damaging the walls. One can get plaque buildup with very little LDL still. Some like actual familiar hypercholesterolemia is significant because their liver can't reclaim LDL particles so they have to be removed in the blood vessels, but if your body can recycle these LDL, then you should be fine. Fat metabolism raises the speed of LDL reuse as well, I believe. LP(a) does correlate much better with damage, I think it's oxidized LDL where the receptor for liver removal is damaged. But whatever damages LDL can usually damage blood vessels on their own. Do your best to limit inflammation, basically.

[@user-ii7xc1ry3x]

Idk if there are studies on this, but I assume research has to have been done at some point: could we get a video on RDA for micronutrients? How did they reach those recommended values, why do they always (afaik) seem to be based on a 2000 kcal diet, and should they be adjusted to people who consume much less/more than that or who exercise very often? As well as implications of going way over the RDA, since often supplements reach 200%, 1000% or even 10000%+ of the RDA for certain nutrients

[@jamescalifornia2964]

👍 Always interesting stuff on this channel - as the rapid subscription growth attests .

[@edition_8923]

They call us TOFIs: Thin Outside, Fat Inside. 😊 I don't think the liver is "overwhelmed" by just all carbs; some are definitely more dangerous than others. Excess added sugar(fructose) and glucose syrup are the worst. Alcohol of course is a famous one, but most importantly, seed oils! I just watch video after video about how these create inflation and fat storage in the liver. I even heard some doctors say that they're the number one cause of t2d! I'm not a scientist, I'm just sharing what I've learned.

[@pjaworek6793]

15% fat seems to be the lowest I can get and have ever been but I always looked emaciated even up to 19%fat. Want more fat here but I can't gain weight. Watching out for fat related info to do the opposite.

[@rodrigomachado5291]

Its probably a lack of lean mass that is causing the emaciated look.

[@raraavis7782]

That thumbnail though. Why do I feel, you don't have good news for us...😭

[@zombi3lif3]

I believe the most important question viewers should have, after watching this video is, what genes put mustaches on pancreatic cells

[@Physionic]

An area of intense research...

[@mikeroll9868]

Too funny. Thanks.

[@Ronlawhouston]

You see a lot of Asians that are thin diabetics. I guess genes are heavily involved. I kept hearing about beta cell dysfunction. I figured after 30 years of diabetes and many years of exogenous insulin, I would suffer from this. Fortunately, no. I have had proinsulin and fasting insulin tests run and apparently my pancreas is still going. I would like to see you deep dive into glucagon. It's the ugly step child in the diabetes story. Research shows that type 2's have bad insulin to glucagon ratios and often suffer from too much glucagon. Recent studies also show that the GLP drugs seem to lower blood sugar by helping restore glucagon balance. Few people talk about this.

[@jaym9846]

You are Clark Kent, aren't you?

[@dianetheone4059]

⭐⭐⭐⭐⭐

[@jmc8076]

Damn beta cells. Lol

[@SootyPhoenix]

OVER for beta cells :O

[@Gymwarrior12]

Anthony Chaffee, a carnivore MD said he lost 30lbs 3 weeks after dropping greens bcs oxalates kept him constantly inflammed so please don’t mess with broccoli. I see I have to clarify that I am being sarcastic.

[@Gymwarrior12]

@@stevet5549 I am being sarcastic. I don’t buy clown Chaffee’s fairy tale 😀

[@jamescalifornia2964]

​@@Gymwarrior12 - Bok choy - not spinach 👍

[@WildTaltos]

I wonder how much of a role sex hormones also play in said "personal fat threshold." I am in a unique position as a woman bodybuilder, and among that small circle, you often hear the anecdotal assertion that too much and prolonged exogeneous testosterone eventually makes women hella-insulin-resistant, up to developing full blown diabetes. The superficial implication I commonly see is that "testosterone is just not good for the female body," which of course doesn't make sense because women also produce testosterone naturally and in far higher amounts than estrogen. My own thinking has been that high testosterone in general - whether in and of itself or from some consequence of its metabolites of DHT and/or estrogen - eventually induces and advances degrees of insulin resistance in both sexes. That resistance loans itself to men's ability to hold on to weight - both as muscle mass or fat - much better than women, but it also results in the overall shittier skin and androgenic alopecia as they age (what with some tossing around the theory that "male pattern balding" is actually triggered by insulin resistance). I anyways have found that past a certain testosterone threshold, my features eventually start taking on that "masculine" - insulin-resistant - quality, and my metabolism goes to shit insofar as I start holding on to fat more easily, my energy starts to tank, my appetite goes out of control, and eventually I start losing more hair. I know from a research study I once participated in involving blood sugar when I happened to be taking the most excessive doses showed that I was pre-diabetic for sure, which has since reversed since dialling the testosterone way down.

[@raraavis7782]

Women with PCOS typically have unusually high testosterone levels and are also typically overweight and prone to developing diabetes type II early in life. As well as other health issues like heart disease, infertility, acne and unusual hair growth. It's quite interesting, that under optimized conditions, high testosterone in women can lead to a 'ripped' physique, whereas in someone with a normal lifestyle, it just completely wreaks havoc with their bodies.