The Problem with America’s Lab Mice and Why it Should Matter to You

[@kaleiohulee6693]

why lab mice matter. 18 min later... ...well that was more disturbing than I was expecting.

[@ricksanchezC0137]

Man don’t believe this bs, I wish joe would fact check this, would take 5 min to explain why its bs

[@theonlyrobot]

@@ricksanchezC0137 You got 5 minutes? If so, we'd love to hear you lay it out.

[@ricksanchezC0137]

Robert Newby it’s hard typing complex subjects in comment (a white board is useful) but here goes nothing. 1) the target of the therapeutics they are talking about are often a protein that is expressed by an exon far far away from the telomeres. For example, let’s say a gene expresses a protein and a drug targets that protein, let’s say as an example it’s an enzyme that the drug increases function of and thus prevents hypertension. This increases life span but has zero to do with the telomeres length and telomerase function. Hope that makes sense 2. Genome of mice and humans (both at genetic and epigenetic levels) are VERY different. That basically means we have some genes that are the same, some genes that do the same but work differently and some genes that only humans or mice have. You could use this fact to say mice are not an ideal model and thus some therapeutics don’t translate to humans (but keep in mind we have to start somewhere and you can’t start with humans). If you make that point you’d be right. This is why many therapeutics (that I also work on) use what is called a humanized mouse model when possible. Google it it is really cool and clever. I’d be happy to explain different versions of it (and discuss the limitations of it) but I’m sure someone on KZbin has done already it better than I can here Am I explaining it clearly or not making any sense?

[@ricksanchezC0137]

Phronesis Atheious lol

[@mariusludwig3971]

@@ricksanchezC0137 Well this all makes sense, but in my opinion it does not contradict what was mentioned in the podcast. There was no talk about the influence of drugs on telomeres or genes. If I understood correctly, the general effect on the individual cell was discussed. When a new compound is tested, it could be potentially harmful to the cell, regardless of which protein it targets (perhaps by a different mode of action than was hoped for. Especially when it comes to new drugs this is difficult to predict). So if the substance damages the cell, the telomeres could make sure that this damage is "repaired" in the mice tested and the damage would not appear in the study. Therefore, the risk of falsified results could be very high. This could lead to the active substance being approved for further testing and the harmful effect remaining undiscovered until then. On the second point, it could be argued that (if we leave aside clinical trials for drugs) many investigations and studies in a number of areas only focus on mice. It is doubtful whether the same high standard is always used there. Even if the humanized mouse model is used, it should be checked in several studies whether there is a risk of errors as a result of the special telomeres. So whether or not Bret Weinstein's theory and the possible consequences are correct or not, should be checked for the sake of care. If the theory proves to be correct, in the best case a pile of studies would have to be thrown into the trash can and in the worst case human lives would be endangered (for example in human tests after the tests on mice). The arugmentation is convincing enough to wish for a scientific examination of it. A translator was used, so don't pay too much attention to the bad English.

[@wrAIth-AI]

That's the longest I've heard Joe go without talking.

[@JUKINGDUCKS]

11 minutes or so

[@WaddIes]

i was thinking the same thing, at one point i was wondering if he was even in the room

[@Drunkyboi]

Honestly I want a Brett Weinstein Podcast

[@AtomkeySinclair]

The dialogue was persistently remarkable.

[@hellfun1337]

you should hear the Edward Snowden podcast.

[@jameshudson169]

"It is difficult to get a man to understand something, when his salary depends on his not understanding it." - George Orwell * - Upton Sinclair

[@michaelblaes9847]

Nailed it. This is exactly the problem.

[@jameshudson169]

@@michaelblaes9847 come to understand it was uptain sinclair who said that. not george orwell. to be fair it sounds more orwellian than ...... than sinclairian. not even sure if sinclair HAS a sound.

[@michaelblaes9847]

@@jameshudson169 cool. Some quotes are true enough that many have made them.

[@mikealche3357]

exactly why we got NaziTrump because his RussiaNazi salary wouldn't allow him to make american any better what so ever. Not to mention he was paid to withhold Ukrainian aid. The aid being currently provided for helping to stop Nazi WW3

[@quitequiet5281]

@@jameshudson169 it’s awesome that you came back to correct yourself in the quote! : )

[@nathanielhoward1498]

Interviews like this is why JRE is valued by so many.

[@MaddRezz]

so we can be horribly misinformed??

[@COLIEMAC]

@@MaddRezz found the pharma plant everyone !!!

[@bigrobwazhere6268]

@@MaddRezz which big brother pharmaceutical company do you work for?

[@the_endgame]

@@bigrobwazhere6268 Do you ask the same questions about Weinstein? Who do you think is paying him now? Critical thinking is not one dimensional.

[@ThomasTheFapEngine]

@@the_endgame Cancer

[@justinwilson1526]

Out of everything that came out of this podcast I am surprised at the lack of attention given to this part by viewers/commentators. If what Bret is insinuating is remotely correct, we're in some serious danger. Not to mention the benefit of fixing such a problem and uncovering other problems that may already exist that we are ignoring.

[@raul0ca]

The moment science became a business with conferences and professional organizations and politics it was done being science

[@alexpetrovich85]

The implication is that humans are essentially beta testing these drugs; which our system has tacitly given the green light. Reminds me of that quote from the Chernobyl miniseries: "Every lie we tell incurs a debt to the truth. Sooner or later, the debt is paid".

[@thedevilsadvocate3710]

This video gave me a theory. What if the experimentation on mice is actually just a smokescreen. What if the drug companies uses mice experiments to easily pass tests so they can bring it to market and actually test it on humans instead of bringing to market an actual and tested drug? BOOOOOOOOOM!

[@caitthecat]

@@thedevilsadvocate3710 You just realized that? They'll also fuck with data they get from human studies. They'll release the data that makes it look good and keep secret the data that looks bad. It's how Purdue was able to sell oxycontin as non-addictive, even though they knew very well how addictive it is.

[@ricksanchezC0137]

Don’t worry what he is saying is not correct and he is not presenting a balanced view on the topic

[@DescartesRenegade]

Im a research engineer and was testing the performance of an innovative solution. The experiments yielded some benchmark shattering results. A week later, I discovered a malfunctioning part of the tester that caused inaccurate sensing. Needless to say, my heart sank to my stomach as my years of hard work were a failure. I begrudgingly broke it to my superiors. This is probably what these scientists are thinking, that his discovery will cause a massive rescission of published papers and works. These scientists are more concerned with their reputation than actual science.

[@mikethomas4423]

That is science in a nutshell. Evidence is disregarded and ignored if it does not fit with pre established theories. (Look at how Copernicus or Galileo were treated by their contempories aswell as their superiors) or for a more modern day example take a look at how Dr Mary Schweitzers discoveries were treated... I was taught that to be scientific fact something must be theorised, tested under controlled conditions , witnessed/recorded and repeated. However, This process of the scientific method absolutely infuriates scientists , fundamental theories such as the evolution of species and the big bang, can not be witnessed, tested or repeated thus, rendering them hypotheses only.. Science can tell us many things and can disprove some of the claims of religion, however science is not always accurate and it is a cliquey field where majority opinion holds more weight than controversial evidence. Mathematics is the only way of revealing true fact. Numbers don't lie . Apply maths to any theory and if the numbers tally up the theory is sound . If the numbers become incomprehensible then the theory must be discarded . Science has taught me to believe in God .but mathematics has confirmed gods existence to me

[@bradley478]

This is what I despise about science is covering up facts and studies because it will destroy someone's legacy or ego. Which is why I stopped at a bachelor's in Engineering after noticing how researches were convinced their work is right when it wasnt

[@EricSepulveda]

But perhaps his findings are an oversight, not unlike the results from the malfunctioning tester you'd mentioned. Does the entire scientific community really care more about their writings staying valid than acknowledging the truth? If so, then how pathetic.

[@michaeldalton8374]

“It’s been taken care of...” Yes. With a broom and a rug. Nothing to see here.

[@melansaloon]

Plague of Corruption by Dr. Judy Mikovits

[@dennispena4178]

Agreed. Until the pile under the rug becomes so big that enough people cannot avoid tripping over it and break their face from falling...

[@chris-cy5ed]

Yep crazy like wtf ...Look at Florida right now radioactive water being poured everywhere in Tampa here in my home towns where I'm from and along the i4 corridor unbelievable fucking unbelievable people being evacuated

[@craighicksartwork]

This is one of the most important JRE clips I've ever heard.

[@EuroG100]

As someone with a degree in biology I completely agree with you. I didn't think of this, it's insane.

[@timothymartin5538]

How does this syndrome not reflect to a justification of skepticism surrounding environmental consensus though, consensus is not a virtue in science, it is a demonstrable inhibitor. continued research with explored skepticism is the theoretical strength of science, so we have this potential issue with lab mice, why can that not be reflected in climatological research. why can Joe believe this and not the validity of skepticism within environmental policy, it smacks of dogma and an insular view that Joe usually is so keen to escape from. I know a bit of a change from the subject but I hope I've conveyed my point.

[@austinlittke5580]

@@timothymartin5538 u used too many big words and crap, made it hard/unpleasant to follow what u were saying. Try toning it down

[@timexplorer9708]

@@EuroG100 Insane that people think this is important?

[@hdcdtv]

Timothy Martin ELI5

[@harrisjarman3166]

2 years later and I'm just seeing this. That speaks a lot to what he was saying about their being no proper response to this problem when presented to the proper authorities. Holy crap this is scary!

[@jed-henrywitkowski6470]

I'm seeing this for the first time as well.

[@jacobcummings7768]

mice are early models because they are relatively cheap but non-human primates are more representative of how a human would respond to treatment, which are required for new drugs

[@ko7305]

Warchild, refugee and legal immigrant here. kina virus released to fk up the elections...millions dead, billion+ with heart/organ issues...evil know no bounds, 100% intentionally released...just to get one man out of office, one man they could not buy/control. I have seen what communism will do to stay in or get in power. Anything! Chinese killed 30+ million of their own for power less than a century ago. It was a crazy conspiracy theory that FBI smoked Kennedy and now we know it is true. It was a conspiracy theory that kina virus was manmade but now we know it is true. MSM/Big Tech working overtime to censor/ban. This was intentionally released to fk up US election and for the Chinese to get protesters of Hong Kong streets because if Hong Kong goes so do commies in China. Win-win for commies and US dems....millions dead, billion+ with heart/organ issues. Godless people will always create hell.

[@57z]

It's because he was effectively canceled by the powers that be/scientific narrative because he was an early advocate of the lab leak theory edit: too early of an advocate

[@jayblaze8609]

Same

[@Fencepost55]

What a well spoken teacher. I absolutely love learning from people like this who can thoroughly explain things I know hardly anything about in a way that I can put two and two together and see what they’re saying

[@smcha4]

Yep that's a very good indicator of a truly intelligent person.

[@dragospahontu]

Yup

[@dragospahontu]

His take on covid escaping the lab is incredible

[@darlantro]

Bret is a good story teller, but he has only ever been patient enough for the theoretical, just constantly spinning out ideas in all directions. We use cell cultures and outbred mice since the 1980s for discovery phase medical research, then it transfers to non-human primates for tolerance and toxicology (sometimes to dogs if they are a closer analogous species for the medical issue), then to phase I human trials for safety and dose eacalation, and then phase II for safety+effectiveness then to phase III for large scale safety+effectiveness. We never just take initial inbred mouse result into humans. Most of what Bret says is bullshit stories cherry picking the 0.01% of ideas he spun out that someone else independently proved was correct as of he is a rouge genius who predicts the future if only the world would listen. The rest are actual fabrications that are untrue but stir the pot in ways that upset the establishment, which is now what he lives for as a bitter old man that non-scientists are now listening to via the internet.

[@BuddyLee23]

Good storyteller, but his soft, constant voice was kinda lulling me to sleep. Not content issue, but a means of delivery issue.

[@leeham6230]

Get an American lab mouse on.

[@timrowbottom1244]

Lee Ham he’s had one few times - Brendan Schaub

[@Blakhawk1703]

Jamie, look that up

[@darkcoeficient]

"Have you ever done DMT?" "DMT, THCL, PCP, Shrooms, viagra and snorted some cosmetics. Narf"

[@leeham6230]

@@darkcoeficient hahaha

[@jakep1979]

Those lab mices turned gay!!!

[@chris51330]

It’s called cognitive bias - people in that field have dedicated their whole career to that way of testing and are scared to admit they have wasted their whole life testing something that’s flawed by definition. Just gotta convince them with hard facts and studies so they can no longer deny it. It’s a sad fact about so much that human beings deal with and it holds back our progression as a species.

[@millerabayomi]

Same problem happens in religion......smh

[@robertlarrypoor1465]

Yes sir

[@malta7406]

Why is this particular thread filled with so many people who make sense? This is the sanest I’ve ever seen a YT comment section.

[@Zoroasterisk]

"Convictions are a greater enemy of truth than lies" - Nietzsche

[@chris-cy5ed]

Yea let's you know how evil our world is for profit....We gotta fuckin change this immediately this is why big government is not good..

[@jno4159]

Joe is about to have nightmares over being “feeble and inefficient” for the next couple weeks

[@hiderz]

And then accelerate his TRT use

[@starmorpheus]

Might shoot some more stem cells into his ass

[@mjbears34]

You don’t?

[@codysmith5260]

Underrated comment

[@whitestguyuknow]

Until he orders a vitamin IV drip to be done while floating in his sensory deprivation tank and then he's revitalized

[@davidasher22]

It’s a shame that Bret gets zero credit for such an amazing discovery but continues to be remember for what those assholes at Evergreen put him through..

[@rawprawn8198]

I agree, David. But on a level, isn't it fantastic that so many of us around the world (I'm from Downunder) have come to know him and follow his presentations on all sorts of issues every week? Without Evergreen, I might never have 'discovered' Bret. So glad I did. And his wife. And his brother!

[@chrisnewell2107]

🤣🤣🤣🤣

[@ricksanchezC0137]

Seriously he is not being honest here or he doesn’t understand microbiology too well or he just wants attention

[@Mirristal]

Rick Sanchez C-137 what are you talking about? He’s not even talking about microbiology. Pro tip: if you don’t know anything about biology then don’t talk about it

[@justinp4659]

M telomeres fall under microbiology.

[@EuroG100]

As someone who did an undergrad degree in this area I cannot believe I didn't think of this. This is truly terrifying, oh my god...

[@WillofStone08]

Hits like a truck doesn't it. Biology and the things we learn from it are truly amazing though.

[@herbert9197]

@whesley hynes so I guess you've never killed a spider.Or is it only you who get to decide what gets to live or die.

[@donkey6906]

@whesley hynes if you have ever taken a bite of any meat or dairy your a torturer yourself by those standards

[@garymontes1901]

That your test models are going to provide horribly erroneous results is indeed truly horrifying.

[@ko7305]

Warchild, refugee and legal immigrant here. kina virus released to fk up the elections...millions dead, billion+ with heart/organ issues...evil know no bounds, 100% intentionally released...just to get one man out of office, one man they could not buy/control. I have seen what communism will do to stay in or get in power. Anything! Chinese killed 30+ million of their own for power less than a century ago. It was a crazy conspiracy theory that FBI smoked Kennedy and now we know it is true. It was a conspiracy theory that kina virus was manmade but now we know it is true. MSM/Big Tech working overtime to censor/ban. This was intentionally released to fk up US election and for the Chinese to get protesters of Hong Kong streets because if Hong Kong goes so do commies in China. Win-win for commies and US dems....millions dead, billion+ with heart/organ issues. Godless people will always create hell.

[@MisterZee92]

What a seriously well spoken individual. His ability to explain his field without making it overly convoluted shows you he really knows what he's talking about.

[@jimmythegreekable]

So true eh. He's an incredibly effective communicator

[@lukeblackford1677]

Yeah, I don’t understand either, he must be really smart.

[@nastybastardatlive]

It really shows he is a good teacher too. Some people don't have that ability, no matter how brilliant they may be.

[@elslick]

Amen, a master of a trait or skill can describe it to almost anyone of any education level because they know and understand the info well enough to make analogies and other things to help other understand

[@bobbailey4954]

Yes yes, how long he’s been waiting to be heard must have been agonizing!

[@Resjek]

SO WHAT YOURE SAYING IS WE NEED TO PROTECT THIS MAN'S LIFE HUH.

[@thrashSJ]

I honestly fear for his life now, glad he got this secret out to the public. Gotta protect Bret at all costs!!

[@freethinkingamerican80]

No doubt!

[@Timeforachange85]

✊🏻

[@hustleup3840]

He needs security

[@bajanworldstar5636]

His brother Eric Weinstien met jeffery epstien and has been speaking out against him for 15 years

[@SuperDragon890]

I’m high and I forgot it was a joe Rogan podcast he didn’t interrupt at all unlike any other

[@malta7406]

I wish I was high but I have to wait like 3 days to get my MMJ card

[@michaelmoore8680]

@John Marston Because you're too much not high enough. I got so high I saw your your face in his profile pic, and my dog in your pic, and the P and M just keep blinking back and forth like quantum dots, separated by different universes. "WOW.... I'm going to town....." -Dewey Cox-

[@iansmashtv]

This might legitimately be the longest jre clip without Joe’s voice

[@pootthatbak2578]

Great, your high, so, your saying your basically useless as a person?

[@sharlayboots2678]

I’m high and thought the exact same thing 😂

[@TeganRhodes]

What he's talking about about halfway through reminds me of the canary in the coal mine, like the actual usage of canaries. A tour guide through a coal mine told us a story about a miner who decided to use a chicken rather than a canary since the chicken was cheaper. He didn't show for lunch, and was found dead next to his workspace...the chicken still pecking the ground perfectly alive and healthy. Turns out chicken lungs can withstand much more toxic air than ours or the canaries.

[@justintime753]

Good to know. Probably not best to reinvent the wheel with a cube lol

[@dennispena4178]

That's scary. I guess it foes under the category of the importance to "Use the right tool for the job"

[@katyungodly]

Plot twist: the chicken murdered him

[@SueMyChin]

Why were we using canaries in the first place? The same reason we're using mice, of course. We know it works. For the most part he's overstating the importance of this..

[@obito8950]

Canaries hold onto air differently than humans. I think it goes left breathes in, right breathes out, right breathes in, left breathes out. They go down faster giving humans some time.

[@ranjan_v]

Thanks Joe for providing platform for topics like this

[@aidenfletcher6503]

Dr Judy mikovits has said the very same

[@to8449]

WOW

[@chris-cy5ed]

Yea if he would lettem talk instead of interrupt them right when they are about to fuckin finish

[@DeanfromBrockton]

Thank you, joe!

[@GFG2gifted]

He doesn't read comments.

[@TROOPERfarcry]

I cannot remember which study it was, but the punchline was essentially this: "The *control* group of lab mice *_also_* got cancer." That matters, because if the control-group is also getting cancer, then how accurate was the test? How many other tests got screwed? If the lab-rats are never allowed to go to a natural death of "old age", how often were they getting cancer anyway? I remember being very disheartened by the study -- appalled, actually, At that point, i decided that "has-been-shown-to-cause-cancer-in-lab-mice" wouldn't be much more than a guide. Whereas "has-been-shown-to-cause-cancer-in-HUMANS" would be a much more relevant study.

[@possible1111]

Imagine having the opportunity to take a class with this man and instead choosing to spend the semester throwing a temper tantrum.

[@Mumbamumba]

I feel offended! Where is the nearest safe space?

[@ethanvoelker2158]

Mumba Mumba lmaoo

[@whiskeycompany13]

@Mumba Mumba Dead meme circa 2016

[@ThisNewHandleSystemSucks]

@@whiskeycompany13 Imagine gatekeeping humor with an arbitrary expiration date

[@vyse102]

@@ThisNewHandleSystemSucks I regret only being able to like your response once. Hate those folks.

[@pooyafitness]

My mom went to the doctor for knee pain 10 years ago. The doctor gave her some meds. Each year the gave her more meds. Now she is on 100 different high dose meds and has at least 10 painful amd debilitating diseases. My brother developed a knee pain last year. I didn't let him go to the doctor and taught him massage and functional workouts. Now he's 100 percent healed. Now go figure it out for yourself.

[@shawntailor5485]

No money in healed patients .

[@markot563]

@@shawntailor5485 💯

[@devonadler5835]

Joe Rogan is such a great interviewer! Knows when to lead questions, but more importantly knows how to let his guest explain in-depth without feeling the need to talk. That’s why JRE is so phenomenal

[@ko7305]

Warchild, refugee and legal immigrant here. kina virus released to fk up the elections...millions dead, billion+ with heart/organ issues...evil know no bounds, 100% intentionally released...just to get one man out of office, one man they could not buy/control. I have seen what communism will do to stay in or get in power. Anything! Chinese killed 30+ million of their own for power less than a century ago. It was a crazy conspiracy theory that FBI smoked Kennedy and now we know it is true. It was a conspiracy theory that kina virus was manmade but now we know it is true. MSM/Big Tech working overtime to censor/ban. This was intentionally released to fk up US election and for the Chinese to get protesters of Hong Kong streets because if Hong Kong goes so do commies in China. Win-win for commies and US dems....millions dead, billion+ with heart/organ issues. Godless people will always create hell.

[@deckofcards87]

Next week we hear Bret Weinstein "jumped out a 10 story window"

[@juliansuse1]

"Brett Weinstein: Suicide by 2 bullets in the back of his head"

[@iller3]

I doubt he is directly in danger, rather it's way more likely that any potential Whistle Blowers will be disappeared instead the moment they do anything that would offer Proof to these concerns. Without a trail of doctored whitepapers and corroborating Data he's just a harmless Lone conspiracy Theorist

[@vex6559]

...shooting himself 12 times in the head on the way down, landing conveniently on a bed of spikes, getting pushed into a junkyard, where he was then sodomized by Jeffery Epstein's reanimated finger, before being launched by a dysfunctional magnetic crane straight into Hillary Clinton's inbox...where he was promptly deleted. Coroner Ruling - Suicide

[@sheslikeheroin93]

@@vex6559 coroner ruling: coronavirus

[@gustavo-gs6jy]

Mac Matheson it already has. Look into the police officers that investigated into Anthony Weiner’s laptop case:. 6 of the 9 ended up being a “suicide.” What’s on his laptop is so wicked, the actual police officers who were following the case died suddenly.

[@MCsCreations]

Now imagine where else there are "mistakes" like that...

[@dominik13579]

welcome to earth. we learn as we do. this guy sounds like he's some sort of martyr smh

[@matinator2267]

Everywhere unfortunately.

[@matinator2267]

@@dominik13579 It would be a different if something was actually being done, which it doesn't seem is occurring. People will always tend to cover their ass (mistakes) when told they are wrong instead of correcting it.

[@bofasofa9399]

@@matinator2267 "always"???? not even close to true.

[@v1c5an6]

Current world events...

[@Ofmyownvolition]

This is one of the biggest news breaks in modern American health science history but KZbin’s algorithm wants to recommend kids flipping water bottles to me.

[@Ofmyownvolition]

@Viper vibe you seem uneducate in rite inglish

[@IveGotAHondaFifty]

The algorithm only shows you what you want to see, you need to watch better videos

[@Ofmyownvolition]

@@IveGotAHondaFifty do not be coy or stupid. don’t act like KZbin has never recommended “how to properly solder hydroelectric turbine motherboards together” just cuz it wanted to see sumthing real quick…

[@IveGotAHondaFifty]

@@Ofmyownvolition no, they dont. If you get a blank account and just search up puppy videos you will only be reccomended puppy videos

[@Ofmyownvolition]

@@IveGotAHondaFifty like this comment if KZbins algorithm has thrown you a curveball before since this bozo thinks he wrote KZbin’s software…

[@ChuckyLarms]

Sounds like Bret tripped over the monster’s tail, went to tell others about his discovery but only to have the park ranger tell him it was just a tree branch

[@wolfsden6479]

Best explanation

[@HoeYouGay]

But the question is, was the park ranger lying to not scare people away and make a profit? 🤔

[@CephalicMiasma4]

Complete delusion. He published this hypothesis 18 years ago. It received a little attention but overall had little impact and offers little actionable suggestions. It is still available online, for all to see. No one is hiding it. Bret is a failed scientist trying to stay relevant.

[@REMEMBERFINCH]

@@HoeYouGay The park ranger was one of the many heads of the monster.

[@spenck7740]

@@CephalicMiasma4 yeah because your an expert on the subject and can give us all an answer... NOT. Sick of people like you either shutting down ideas or promoting them with little to none evidence to support your claims. You used opinions in place of facts, but opinions don't mean jack in an argument won with FACTS. So many people argue things like you and truly believe they are right, its almost like YOU are delusional buddy

[@NaturalHypertrophy]

Lab mice are all going to develop myostatin deficiencies, escape into the sewers and start their very own bodybuilding club down there

[@andpeoplesayineedalife6418]

When you picking up your test 110 and clen off me chap?

[@KorDawg91]

Natural Hypertrophy I wish I could like this comment 500 more times lol

[@Miguelangelfilms94]

You're everywhere lmfao

[@pdot8659]

Will they be led by a turtle?

[@janeblogs324]

Wait this isn't an elk DMT joke

[@MrEmorales1213]

America: we can’t handle too much more! Bret: have you heard about the problem with lab mice? America: 😐

[@jimJim-]

I think this happens world wide

[@malta7406]

The Fermented Sailor wait is this sarcastic or for real? I can’t tell... if it is serious, then you should probably reconsider your values, because all you’re doing is wasting space in a backwater KZbin comments section. If you wanna evangelize, then just go out on the street with a soap box and yell real loud, because you’ll honestly do better that way. And, if you’re too scared to leave your comfy computer chair, then stop telling people they need to join the military and become an “alpha”. And if everything I’ve said is true, then I’m ashamed to share a continent with you, and the same basic genome; being human brings me shame when I know there are people like you out there.

[@ashwiniegosai9381]

Dead azz

[@erwinlopez8368]

@Dreymon Green lol wtf Jesus did not love war or pride get ur facts straight... Certain Bible characters sure did but Jesus himself did not,, dont mix the whole Bible with Jesus' teachings...

[@michaelriddick7116]

I laughed at this harder then I should have! 🤣😂🤣😂

[@deschantier9844]

If his premise is accepted THEY would then have to accept that this invalidates all previous studies using these tests subjects

[@johnygimo]

Being optimisitic and hopeful here would be they are now working on new medicine to replace those that are tested on the right mice instead of going back and correcting everything. But thats being highlg optimistic

[@bobthompson4319]

That's an extremely important point and extremely good point

[@iller3]

especially the studies on whether its safe to give young teens synthetic estrogen Hormone treatments

[@kentp.2309]

Most importantly, from a corporate standpoint, if this is acknowledged as truth, then liabilities skyrocket and lawsuits abound. It's denied vehemently because of this. They *might* at some point solve the issue quietly and pretend nothing ever changed, if they're smart enough.

[@burpostockings]

Does this mean we can bring back the Argument is Invalid meme?

[@Viper8828]

Pinky: "What are we going to do today?" Brain: "Same thing we do every day Pinky, fool the humans into thinking their medicine is safe! Muahahah"

[@mattd5240]

Honestly that would be the most evil thing brain could do.

[@nmarbletoe8210]

@@mattd5240 except get cancelled

[@ecastillo9804]

originally posted by "nunya busniss" Brain: Through meticulous analysis of history I will find a way to make the people worship me. By studying the conquerors of days gone by, I'll discover the mistakes that made them go awry. Pinky: So that you can make the same mistakes if you just try. Brain: By studying the past so carefully, I won't repeat the same mistakes of history. Pinky: You'll never make another mistake, you see, 'cause you'll fall asleep from reading all that history. Brain: Pay attention Pinky! When Cleopatra reigned as Queen, With Roman leaders she was often seen. But when she had no ruling friend, She found a poison snake to bite her in the end. Pinky: A bite down there I really wouldn't recommend. Brain: I won't need world alliances, When I'm commanding everyone's appliances. Pinky: Oh no Brain, that would really smart, To be bitten on the bottom by a Cuisinart. Brain: Hannibal, our book confirms, Tried conquering Italy with pachyderms. Just why he failed, nobody tells, But he never could get past the Roman sentinels. Pinky: And he couldn't find his weapons in the peanut shells. Brain: An elephant is not required, If I can use the media to be admired. Pinky: The TV viewers you'll delight, Unless the network puts your show on Sunday night. Brain: Attila was a mighty Hun, He ransacked Asia Minor just for fun. But when he got to Europe's banks, He was routed by an army of heroic Franks. Pinky: I like mine with sauerkraut and mustard, thanks. Brain: Why pillage like a criminal, When I can send out messages subliminal. Pinky: Please send a message to that Hun, To see if he can pillage me a hot dog bun. [whack] Zort! Brain: Caligula was no boy scout, He did things that we can't even talk about. The Romans knew he'd lost his head, When he filled a vacant Senate seat with Mr. Ed. Pinky: What's wrong with being friendly with a thoroughbred? Brain: Why rule like such a reprobate, When I can put the world in a hypnotic state? Pinky: When everybody's in a trance, You can make the people do a chicken dance. Brain: Pinky, if you don't stop this foolishness, I shall have to hurt you. Pinky: 'kay. Brain: In France, Napoleon Buonaparte, Thought beating Austria was very smart. But when he took on England too, He was beaten up by Wellington at Waterloo. Pinky: And now he's just a pastry filled with creamy goo. Brain: Why conquer with depravity, I'll win the world by undermining gravity. Pinky: And even if your plan falls through, Maybe they will name a pastry after you. [squirt] Waahahaha! Brain: From Ghengis Khan to Charlemagne, From Alexander down to Tamburlaine. I find a ruler's tragic flaw, And gain a little wisdom out of each faux pas. Pinky: Don't forget the former Governor of Arkansas. Brain: That concludes my little rhyme, I hope this lesson wasn't just a waste of time. Pinky: Well Brain, I've learned that one thing's true, Every one of them has failed, and so have you. Brain: Thank you for your vote of confidence. Now come, we must prepare for tomorrow night. Pinky: Why, what are we going to do tomorrow night? (Gasp) Sing a song about all the world's cheeses? Brain: No, Pinky, we shall try to take over the world -- Through meticulous analysis of history.

[@zazarays]

Narf!

[@heyzeuscreestow9394]

Let me sign up, let's save them mice lol

[@camjo6397]

Hello, biologist here. Most serious drugs, biologics, and medical devices are required by the FDA to undergo a series of tests in different animals, starting with mice, ending with monkeys and eventually humans. Though Weinstein has a point in the mouse model’s flaw, most safety tests at the mouse level are just to ensure death does not immediately occur. As with any drug, even some that do cause tissue damage in humans, there is always a risk/benefit assessment. Are there drugs that may cause heart damage over years but prevent someone from dying tomorrow. Probably. So the FDA approves it, and you get a nice warning sticker on the side. Just my 2 cents. Of course, the Joe Rogan podcast is known to be somewhat sensationalist to draw excitement around previously discussed issues, and while again Weinstein has a point, the world and science are unfortunately not as clear cut as he tries to make them sound.

[@ericmoorehead3933]

Thank goodness I'm not the only one. Mice are not the end all be all.... they're a cheap, quickly reproducing, starting point before testing on more expensive and harder to care for animals.

[@robertlarrypoor1465]

Mice are the most widely used in science, its a huge problem that needs to be fixed and addressed.

[@nandolance91]

@@robertlarrypoor1465 There are currently studies into creating human tissue for use in testing drugs. They've already done this on a small scale with heart tissue so this lab mice thing I don't see as too huge of a problem.

[@colinn1898]

Thank you for your comment. If anyone finds a clip of Weinstein responding to this contention please share!

[@Tyraenel]

I don't completely agree , I think there is also problem in quantity. These drugs doesn't kill every human , but maybe 1 of 1000/10 000/100 000 cases. You can test drugs on 1000 mice , but you can't test it on 1000 monkeys. So there is a valid argument for Weinstein point, if the mice are genetically modified to be resistant to these drugs , you can change the ratio from 1 of 1000 to 1 of 1 000 000 or more . That means you can get very bad results ,which you can or can't catch later - example if you will test it on 10 monkeys later , it is statistically not very probable to catch it. There are only few mammals that you can use for drug testing in large quantities ( e.g rabbits ) but as far I know mice are the most common. Also the fact alone that FDA approves it , doesn't mean it is not a huge problem. Again as far I know FDA approved lots of things by mistake or despite error in the drugs , of course it is very long and hard process but if you model contains part where results can be altered by the test itself, mistakes happen.

[@logan.1390]

To summarise this video: - There are some substantial differences between wild mice and lab mice, lab mice have been altered for testing somewhere along the lines. Either accidentally or purposely. - We are using altered lab mice to test drugs before they are deemed safe for humans. - These altered lab mice are more resistant to certain toxins whereas those same toxins could have a detrimental effect on us humans. - This eludes that the current procedure of testing pharmaceutical drugs is completely flawed. And all drugs that have been dubbed safe via testing on altered lab mice are in fact, not safe at all and the effects long term on humans are unknown and could be extremely detrimental to our health and lives. Causing us serious harm and or death. - The papers and evidence of this apparent scientific mistake (which would effect the health and well-being of millions if not billions of people around the world) are not being put in the spotlight. - Media and news outlets all around the world should be reporting on this paper, which points to a completely flawed system in the testing of pharmaceuticals. One of the biggest industries in the world; the pharmaceutical industry, worth trillions of dollars has potentially got it all wrong which could have major consequences causing serious health problems and or death for millions of people. Yet nothing is being reported or aired by any major news or media outlets, quite strange isn’t it? In conclusion: - pharmaceuticals are not accurately tested. - Pharmaceuticals are potentially very dangerous for humans. - It’s probably not safe to take pharmaceuticals. - Proof of all of this is being covered up.

[@cooper5431]

🐐

[@gammaphoenix5893]

That's why there are something called clinical trials.

[@charlawilliams8697]

@@gammaphoenix5893 You completely missed the whole point.

[@gammaphoenix5893]

@@charlawilliams8697 No you missed my point.

[@hew195050]

Add vaccines to those bullet points.

[@AnN-py2em]

The real problem is he was trying to tell ‘drug companies’ they are wrong, and may be liable for damage.

[@jeffdillenbeck1278]

They wouldn't be liable for damages. It wouldn't stand up under legal scrutiny as being "willful".

[@Top_Weeb]

@@jeffdillenbeck1278 Possibly. But there is a looooooot of money on the line.

[@stankei535]

Problem is that the government has signed papers that protect pharmaceutical companies from all liabilities. There is a documentary on this.

[@drewtraveil239]

@@stankei535 what’s the documentary?

[@FuburLuck]

No, the problem is his 'discovery' is a basic fact that people doing genetics and molecular biology have understood for decades. It's shocking to him because he's not a geneticist. This has nothing to do with Pharma companies. University research labs all around the world are filled with people who understand the issue and work with and around it. There are LOTS of different strains of lab mice. They have different genetics, and can react very differently to different drugs. It's extremely well known. It's why we select certain ones for testing different things. Google Jackson Labs Mice Strains. They, as just 1 supplier, have a huge catalog of different strains with different genetics. He got ignored the way someone telling a mathematician that 2+2=4 would get ignored.

[@erichurley6149]

This has been the most interesting dialogue I've listened to in awhile

[@Seannyskillz]

been waiting for a solid science guest for a while

[@GS-kj6ur]

Listen to his brothers podcast

[@colvillebrown6912]

Keep waiting, because that wasn’t it

[@Red-pv7kx]

Vince Valdez biology somehow isn’t science?

[@evangonroff596]

"I was a graduate student studying bats in Michigan." Welcome to the Joe Rogan Experience

[@jonahgeorge7918]

I like it

[@joecobra48]

How curious

[@username4441]

next week "I am a weed smoking rapper, and retarded" Welcome to the Joe Rogan Experience

[@anthonyreynoso7275]

User Name that’s the Breakfast club

[@marcuspadilla65]

When you warn someone about something harmful, but it implicates $$$, then you’re just better off letting it evolve on its own

[@fakephoenixprince]

What a fucked up society we live in.

[@snusemcgoose1001]

Joe's voice snapped me out of this guy's trance, you can just listen to him forever lmao 😅

[@abigailtrejo7027]

Snuse Mcgoose OMG right, I want him to create an asmr channel

[@nickr5494]

Any one else get that Biden ad? “I am coming directly to you for ask a quick favor” Is that really his best take? Scary.

[@rickrowld]

he's a person that stutters. seriously.

[@theflip650]

Yeah, no shit..

[@GarrysLP]

@@rickrowld Person with dementia stutters. Shocking...

[@intraterrestrial5035]

Geriatric world champ 2020

[@fromtheSon]

Soooooo cringey!! I can’t even laugh when I get the ad, he just creeps me out so much

[@mitchcompton5929]

Bret Weinstein is amazing in this, his explanation on this on this complex problem is very comprehensible. Well spoken

[@DraphEnjoyer]

"Everything's fine. Stop asking questions" -quotes seconds before things were not fine

[@PalashaGabarra]

@Nigel Lush It's better in some ways and inferior in other ways. Modern society isn't just better in every way all across the board.

[@ArmyNavyAcademy]

I studied Cell Biology at Johns Hopkins where Carol Greider works, I specially went their to study telomeres. I was shocked to learn the few telomeres researchers were either in the Aging labs or Cancer Center, this was 2008-2012 and I came to the same realization of this gentlemen here and was surprised the two sides were not chatting with each other. I tried to pitch my own independent research projects for years but nothing ever came of it.

[@holdemnfoldemman4407]

I hope that more labs communicate like they are doing with covid19 if thats even true nothing surprises me enymore.

[@Mstone03]

“It’s a general systemic failure...” yeah we’re good at those

[@richyvlewis]

Another nail in the coffin of big pharma

[@MarcoGarcia-lg5tl]

You are so naive

[@xDDufiosy]

Your going to need many many many more lifetimes to bring down big pharma. Especially since they are actively reducing the human life/health span.

[@mattymccolgan9453]

Flexner report... coffin buried and nobody cares

[@mrverklemmt7883]

This gentleman is a genious. Everytime a question comes on my mind, he answers it right after! Hence why Joe is so quiet 🤐🤔

[@chrisnewell2107]

Joe is speechless. He can't believe the BS he's listening to.

[@oddunb6190]

He’s not a genius at all. He’s not even talking about his field.

[@ameljasarevic5194]

@@chrisnewell2107 I am sure plenty of people called theory of relativity bs when Einstain was explaining it.

[@chrisnewell2107]

@@ameljasarevic5194 Yeah the Weinstein family are the new Einstein. Just stupid peer reviewed science getting In the way 🤔

[@zach6983]

@@chrisnewell2107 Einstein is literally in their name .... has to be true haha

[@jessejr.4929]

We need to spread this video! This is very important!!!

[@fookmiass3130]

This is huge. Glad i saw this. Another rabbit hole to dive in

[@smsandel]

Annual Pharma lobbying money in DC dwarfs that of all other industries’ combined. This alone answers many questions and clears up many uncertainties.

[@melansaloon]

Plague of Corruption by Dr. Judy Mikovits

[@MrCTruck]

It's incredible that even in academics truth is negotiable.

[@donaldtrumplover2254]

It’s all about the money

[@timothy2902]

It's not. Everything in academics is proved with evidence. Without evidence you're just lying to yourself. That's how your able to determine what is true and what is false. Sadly, people without an education believe anything people tell them and are not smart enough to look through the evident to determine the truth for themself.

[@donaldtrumplover2254]

Timothy so your telling me that there is no part of science kept hidden for the sake of money?

[@SirDavidAlvarez]

It deeply saddens me to think that we live in an era where mantaining profit for pharmaceutical companies is more important than giving way to new discoveries in the medical field. Good luck finding a cure for any particular disease and release it.

[@shawnesantana575]

Makes me wonder if ancient man had the ability to progress technology at a faster rate, but chose not to.

[@junebyrne4491]

I did not realize how rapacious bid pharma is.

[@ko7305]

Warchild, refugee and legal immigrant here. kina virus released to fk up the elections...millions dead, billion+ with heart/organ issues...evil know no bounds, 100% intentionally released...just to get one man out of office, one man they could not buy/control. I have seen what communism will do to stay in or get in power. Anything! Chinese killed 30+ million of their own for power less than a century ago. It was a crazy conspiracy theory that FBI smoked Kennedy and now we know it is true. It was a conspiracy theory that kina virus was manmade but now we know it is true. MSM/Big Tech working overtime to censor/ban. This was intentionally released to fk up US election and for the Chinese to get protesters of Hong Kong streets because if Hong Kong goes so do commies in China. Win-win for commies and US dems....millions dead, billion+ with heart/organ issues. Godless people will always create hell.

[@superjaguar30]

lmao. Maintaining profit? what are you even talking about? Like would you rather testing be done on humans? mice aren't a perfect model and never have. Wild mice would have more uncontrolled variables making research less reliable. And if you think people aren't constantly working to improve animals models you know little of the medical sciences world.

[@lenk172]

​@@superjaguar30No one smart thinks Brett is implying using wild mice would be better, use your brain. They'll use the animal models that make them the most money, not the ones that lead to actually helping people most effectively, Mr big pharma lapdog.

[@jctai100]

The Tyrell Corporation: " The candle that burns twice as bright burns half as long"

[@raul0ca]

Roy squeezes *jctai100* head in a rage

[@QubitVector]

She won't live you know....but then again who does?

[@jdoedoenet]

"I've seen things...you people wouldn't believe..."

[@dennispena4178]

Leon to Deckard "That's longer than you"

[@tarico4436]

I've written the screenplay for the sequel, not 2049. I need a reader. It's 347 pages, so you'll need to pack a lunch.

[@alabusn]

Now I know why my wife (who worked in a hospital) would be told by her doctor friends not to take any new medication until it has been used broadly for at least 10 years.

[@Joybuzzard]

Certain companies have important academic connections and use them to control narratives related to their products. Someone I know was a lab assistant in a lab studying diabetes treatments, they induced diabetes in rats and mice by mixing MSG into their food over a long period which caused them to eat much more and develop diabetes rather reliably. He then noticed the amount of MSG in many normal foods, particularly lower cost food marketed to low income people who were also known to be statistically more prone to diabetes, and he released a paper on it. He was shut out of grad school, no longer employable in any lab, and predictably nobody else wants to research links between MSG in food and rising rates of diabetes.

[@zeffery101]

I've always never liked taking medication. I usually just let my body fight a sickness naturally. Now I have an even bigger reason.

[@davidjenkins8449]

regardless of this fact there are a lot medicines that do work so i wouldn't write off medicine entirely

[@NosebIeed]

@@davidjenkins8449 he's not saying medicines don't work, he's saying it would be a good idea to avoid them when unnecessary because of undesirable effects that materialise in late life which are systematically missed by animal testing

[@dancarter255]

Me too i never even take painkillers

[@evanw2195]

Right, get off those mood pills they give everyone hate that shit nobody needs it

[@badeugenecops4741]

Good luck when that cancer shows up.

[@TheSchematican]

This is fascinating and unsettling. I’ve always felt that I’d never take pharmaceuticals unless I had no other choice and this is just another reason to be very wary of the industry as a whole

[@DarthPlagueisTheStupid]

“It’s been taken care of”. AKA, you’ll be taken care of.

[@MrEe1010]

16:30" "The culture of Science has become so rotten..." that says everything!

[@AidenCassaroArt]

One of the most important conversations on the internet at the moment.

[@trevon4896]

I hope they don’t take him out for saying this.

[@tropictom5996]

Bret: 🤓 Joe: 🤔 Bret: 🐭 Joe: 😳 Me: 🤯

[@starmorpheus]

Lol

[@milkgxng]

This is a bad sign. You feel the need to simplify this small clip of an episode into emojis because it's the only way you can think about it with your tiny brain lol

[@domsooch]

Love Brett Weinstein, but I have a few sticks I can throw into the wheels of this argument. You are right, there are no good animal models, they all have issues. The loss of telomeres does not in itself prevent cell growth, instead, it might be better explained by the loss of actual genes at the ends, which would in turn lead to a loss of cell viability. Cell replication is more complicated than just telomeres, so even if you were right, it may not affirm your hypothesis. As for cancerigenic compounds, while most tests look for cancer, years after ingestion, newer tests (see TwinStrand, Seattle) let you see those mutagenesis rates almost in real time.

[@raysarlie7786]

Corruption knows no bounds. Power is the root of all evil.

[@mouwersor]

No, power shows what people would do if they had more capabilities.

[@acosta2493]

Money = power . The love/lust of money/power is the root of all evil .

[@melansaloon]

Plague of Corruption by Dr. Judy Mikovits

[@iraklitos20022003]

Not power. Human nature that craves for power, money and social status. The problem is us humans.

[@terrycrowley3904]

@@acosta2493 exactly, its the people that love the shit, abuse the shit, and will do whatever it takes to get it. certain people can handle being in a position of "power". The thing is in order to get to many high levels of power, you have to be corrupt and basically heartless.

[@tyder26]

Joe” I’ve never been this quiet” Rogan

[@stonerfreakvids]

Thanks for doing this show joe, we appreciate everything you do! A modern day Robin Hood of knowledge. And thank you all of joes guests! You guys are amazing

[@garymontes1901]

Joe is a national treasure that few people know about. 😕

[@ewan5542]

@@garymontes1901 he is the biggest podcast there is

[@firstnamelastname9215]

@@garymontes1901 7.08 million people are subscribed. I’m not even subscribed but know about him

[@ScottieBMan]

Joe Rogan: “l may have to stop pushing Alpha Brain so hard” 😂

[@willhopkins8839]

This is scary as hell. I hope we can get more people talking about this

[@samhilllll]

JRE I think it would behoove you to link his articles in the description so that it can be found by your audience! I am in medicine and I haven’t heard of it as I know how biased the medical community can be. Also it’s important to know that mice are not the last line and then human. It usually goes cell line, mice, pig, monkey, then human. So there’s a lot of testing on many different animals before human. Interesting though!

[@WhiteWolfos]

I've heard years ago that many lab rats used were also extremely prone to developing tumors though they still lived longer than outside rats due to safer environment conditions.

[@steves1015]

Depends on the strain. There are many strains of mice and other rodents that are used in labs. Some are well known for spontaneously developing certain kinds of tumours. Good scientists are aware of that and will factor that into their results. But many bad scientists have used tumour prone mice to "show" that something causes cancer when it likely doesn't.

[@peytonolson9195]

"For reasons that still elude me", doesn't elude me. Money, follow the 💰

[@jeffdillenbeck1278]

I'm sure he knows that but won't say it.

[@yursmith3056]

Or that he could get bodied

[@juwanharris1334]

Don't get suicided.

[@fakephoenixprince]

@@juwanharris1334 "suicide" by two shots to the back of the head.

[@g0ferboy]

I was thinking there was a way to use cancer cells to elongate life, and then the hypothesis went another way.

[@spartanrh83]

When people in the future study why Rogan was so successful, they need to study episodes like this. Rogan maybe asks like 2 real questions and makes maybe 10 comments in this whole segment. He let's people with something to say speak and explain their positions. It's truly revolutionary. Greatest concept since books.

[@NaturalHypertrophy]

10:35 Who would have thought that a human would react differently to a drug than a mice?

[@fishsmell2570]

Everybody?

[@ThomasTravis1990]

They use mice testing for our flu vaccines. Now think if a bad batch went out multiplied by hundreds of millions globally.

[@Irregulargremlin]

On drugs mainly effecting physiology it should be relatively similar as nice have all the same organs that we do only smaller

[@bans9183]

@@ThomasTravis1990 ... a bad batch huh

[@ThomasTravis1990]

@@bans9183 you get covid-19 positive results when you test people. They're testing you for white blood cells but if something attacks the walls to your heart that is the same positive that will come out, similar to cancer patients testing positive for cancer.

[@etxeberre1]

Awesome talk! It illustrates how progress, even in the most researched and controlled field can always have its faults. Nobody is too smart, you should always take a moment and check if what you do is right.

[@swgeek4310]

His brother spoke of this SAME THING on JRE in February right as COVID hit.

[@Earwaxfire909]

Had similar experiences. My most cited paper was on a trivial thing. Once recognized, I become a world's expert and was funded for obvious experiments in that area. But, when trying to take a small step in a new direction, nope, unless a well known in that field is on the grant. Science is no different than other endeavors.

[@Wolf21973]

Wow. That is interesting I use to work at a lab that bred these mice and rats. That's all we did was breed a specific type and then colleges and testing labs would order from us. We box them up and ship them out. I HATED it. It was messing with my health and causing me to break out on my face. I worked in the area that killed rats that were sick or had tumors...at least this is what they tell you. Yea the occasional one had a tumor or looked sickly but 99 percent of the thousands we killed were just overstock and some being babies that were days old or if they wanted to start a new breed but didn't have room they would get rid of another to replace it which was hundreds. We used Co2 to kill them and it was anything but humane. They would slowly die and some would even seem dead but then come back and you could hear them. I didn't even give the place a two week notice. I just quit. They would have people try to sneak in their like reporters and get hired just to spy on them too. It was crazy. Crap insurance and paid 9 dollars an hour.

[@florgonzalez1211]

Sad but it needs to be done maybe a better more humane less killing way but it does need doing

[@Mike-jx8ks]

Why kill them couldnt they just let them go free in the woods or wild.. i no im asking a fairy tale question but it just shows how money is way more valued them life all life... Sad...

[@uhhwhat8660]

​@@Mike-jx8ks release them and disrupt the entire ecosystem? These rats have not been exposed to nature for generations - they do not survive in nature and if they do then they endanger other aboriginal species

[@antonchilinski9729]

​@@Mike-jx8ks Extreme ecological damage, thats why you cant just let them go in the wild.

[@mythcurcheckit]

It's insane to me that you Google the most humane way to kill a rat and they say CO2. I am a rat breeder. And CO2 is definitely NOT the most humane way. Mise well choke them. It'll be faster and less stressful. My snakes do a better job. Science, opinion, sucks on this matter.

[@mchapman2424]

I may not be packing a lot downstairs, but I have giant telomeres

[@masonparis7472]

Lmao

[@ryanagee5540]

#telomereslivesmatter

[@Kirealta]

Enjoy the cancer.

[@nuclearcatbaby1131]

I don’t see a lot of cancer in people with genes for longevity though.

[@alwaysdisputin9930]

@@nuclearcatbaby1131 People with genes for longevity have long telomeres. Cancer sufferers have long telomeres

[@TaylorMorgeson]

Sleep tight everyone 🥰

[@brownjatt21]

Smd b

[@intraterrestrial5035]

Can't now

[@aibhlinryan7857]

As a recent science grad, this is not the first time I’ve heard researchers talk about how the truth is covered up or brushed away behind closed doors.

[@LucidStew]

Doing cable installs I ran into 2 instances where there were issues of massive systemic interference, both of which were known by at least some line techs. Management ignored the problem presumably because it would have been hugely expensive to fix and/or because it would have exposed the fact that they ignored it.

[@Xyphra]

Cable tech here, same bro

[@victorthomas5402]

No Conspiracy here.Just keep it moving folks Just the Facts!😉

[@danielescobar7618]

Bret is an unbelievably cool guy. Media hit jobs like what was done to him proves there is a systematic eradication of educators that teach you to think vs teach you to memorize "correct" answers.

[@seabrook1976]

Isn’t this the premise behind “Pinky and the Brain”?

[@stephenbarone4053]

He’s glossing over the subject of drug trials. Trials work in 3s. After long, long investigations in the labs they look for 3 human subjects who fit very specific requirements who have no other options available ( meaning they are going to die). If there are any negative results - cardiac arrest, organ failure etc. not caused by the disease, but by the medication, it’s a no go. If there are no negative results then three more patients are found for the next round. These patients are very hard to come by. They must be healthy and yet have a terminal diagnosis (as explained to me by an oncologist). Yes, this is a simplification.

[@imeprezime4764]

That's what I was thinking. There is a tendency for the academics to oversimplify or gloss over things that people that actually develop these drugs think about.

[@pleaseyesmemore918]

@@imeprezime4764 Odakle ste vi?

[@imeprezime4764]

@@pleaseyesmemore918 Novi Sad xd

[@deepblueatticus]

But then how would you know the long term effects of the drugs? If the human trials are short (using people who are going to die already) then you wouldn’t really know the real consequences of the drug?

[@stephenbarone4053]

Deep Blue yeah, I am just spewing about cancer drugs and regurgitating what I was told. But from someone who knows his stuff. It’s just the way this guy was speaking that he would lead one to think they give drugs to mice then release them upon the populace. Also want to add that if the “new drug” is what they hope, it will prolong the patients life and therefore provide longer term effects.

[@EsotericGold_net]

🌹Jorge Araujo, former lead supervisor of Merck's vaccine division, along with several of his colleagues, decided not to vaccinate their children from birth because of bad science and corruption. 🌹

[@WorldsOkayestSorcerer]

The disinterest tells me that somebody, somewhere (and maybe several somebodies), stands to lose a bunch of money and power if people start digging into this.

[@yursmith3056]

100%

[@SPAMDAGGER22]

Even though I only understand every third word or so, I can't stop listening to this man.

[@alwaysdisputin9930]

it took me a while but what i understood was: Telomeres shorten whenever our cells divide. Short telomeres causes ageing. Telomerase elongates telomeres. People with cancer have long telomeres. Telomerase helps when we are young by preventing ageing. Telomerase hurts us when we are old by making u more prone to cancer. A thing that hurts us when we're old but helps when young = the missing pliomacy. The missing pliomacy explains why we age. A species that is boosted when young but hurt when old is more likely to survive & pass on it's genes. This is because the "hurt when old bit" might not happen because the world is dangerous. did i get something wrong?

[@haitikuwait360]

Fear of lawsuits makes people unreasonable

[@user-pc1gu6ur1g]

Give this man a Nobel prize!

[@sjsisjsjks]

He's a grifter.

[@user-pc1gu6ur1g]

@@sjsisjsjks you don't even know what a grift or a grifter is

[@matthewjohnson4583]

Dear Lord. This is one of the most eye opening things I've ever seen. I've always had my suspicions that pharmaceutical companies were doing something wrong but never expected it to be this obvious. Youd think that if you test your drugs on one species then youd atleast know if something was majorly wrong with that species

[@canileaveitblank1476]

The fact that a container in a bathroom is even called a “Medicine Cabinet” is INSANE! 🤯

[@JS44444]

Everyone in every organization is corrupt or corruptible. Thanks for affirming my lifelong assumption. 😅

[@katjaisaksen1382]

I hadn't heard this example before but it doesn't surprise me. This kind of wilful blindness is one of the main reasons I left my long term, well paid job as a lab animal technician at a good university to go further my own education. Any attempt to talk about laboratory animal science and good research practice with scientists was met with an attitude that made it very clear that our knowledge didn't mean anything because we didn't have PhDs. Well I'm handing in my thesis in a few weeks and I would still make the same arguments that a lot of the research those guys were doing used stressed out, sedentary, overweight animals who were probably terrible research models. And they would usually use one of a couple of inbred strains just because that's what everyone did.

[@natecw4164]

Been 6 years since I finished chemo. Hurry up on the cancer research already. I really don't know if I could take another 14 months of that crap.

[@sombojoe]

Sometimes Joe knows when to just be quiet, and Brett is fantastic especially when he is 100% in his wheelhouse!

[@presenceofthedanklord-_-3603]

I agree that mice are not the best model organisms. But even with what is said, 1)will it matter if we are using lab mice as the test subject and the control for the experiment ? 2)does the telomerase from mouse and humans follow same pathways? 3) is there significant difference in the life span of lab grown and wild mice? 4)isn't there 4 phases of clinical trial in human before selling the drugs? I don't know any answers , please answer if anyone knows

[@thomasreed2427]

The problem is that you cannot test the long-term effects of drugs on humans, because you cannot spend 30 years testing a single drug. So we test the long-term effects on animals that are similar enough to humans physiologically, but have much shorter lifespans, allowing us to see potential long-term damage much faster. If Bret is correct, researchers may have missed harmful long-term effects of drugs, because the effects didnt show up in mice trials due to mice being masters of cellular repair thanks to long telomeres and didnt show up in human trials due to them being way too short.

[@Ryuk-apples]

1) I think thats a good point, unless he means that the mice are so resistant that it doesnt affect them in the slightest which I believe cannot be true. They do multiple ascending doses, they establish the fatal dose which can sometimes be over 20x to 100x if not more than doses given to human (converted) 2) I don't know 3) Yes 4) there are 3 phases in clinical trials none of which study the long term effects. Phase4 can be called long term studies but generally they are done right after and a few years after release of the drug to patient population. Preclinical trials use mice for long term effects because they are the easiest to breed, they also do long term effect studies using rats but they are less common.

[@KGBookkeeping]

I will watch and like every episode with Bret! This is such a great educational course and source of biology and life!!!

[@alimosed2815]

It’s about 💰

[@timlewis9004]

All of it is. That's why I can no longer take any of it seriously. Fix the greed/power issue first.

[@DETSRC313]

Yup a health system that relies on profit A political system that relies on profit Very sad America succumbed to those to forms. Those should be the exceptions to capitalism. For the greater benefit for Americans and we keep letting it happen