The Randle Cycle: How Your Body Chooses Between Glucose and Fat with Dr. Ben Bikman

[@dromlakhani]

I am an Endocrinologist and this is brilliant!

[@johnshellenbach4600]

You must have a very big brain! Endocrinology is baffling to me.

[@johntatman9168]

I envy your students having you as their professor. I can not imagin anyone who could make complex topics more easily understood. You do this in a very informative way as well as entertaining. I typically need both oral and visual aids to learn however I find I have no need for visual diagrams when your teaching. I so hope you never stop these videos!!

[@bettiemccachren2776]

I am an RN and love your teaching. Keep up your great teaching.

Yes exactly! 👍

[@suprememasteroftheuniverse]

Stop simping. You clearly still need diagrams. This professor is lazy and you're getting almost no real knowledge. Ridiculous the fact he doesn't spend 5 minutes to make some slides or even type the names of the hormones, enzymes and so on, but still shill for supplements and fake salts industry or just straight ask for money.

[@Meyep1]

31:33 As a layman I found this understandable and really enlightening. Love your book!!!

[@tammiebrown8317]

I agree! I’m a dietitian and love listening to him speak/teach!

[@balabani]

I am an electronic communications systems engineer and I am amazed at the clarity by which Dr. Bikman explains the Randall Cycle and the function of insulin in different types of cells like brain, liver, muscle and fat. My hat is off to you Dr. Bikman.

[@SFDestiny]

Interesting. For me there are too many parenthetical comments. I agree the material is well-organized and clearly described; still, I grow impatient as he interjects. "Just the facts, ma'am," would suit me better. 🤷 (Also, it's not Tony Randall--it's Philip Randle. 😁)

[@zorinaganpaul1598]

FINALLY!! Thank you Dr Bikman for this deep dive. The Randall cycle has been invoked so often by influencers with little knowledge that it left my head spinning. I have clarity now ❤

[@jasoncdebussy]

No you don't "have clarity" now. Ben doesn't fully understand this topic kzbin.info/www/bejne/gqLPemiGos94g68si=cFGLeHOlFaps9Iby

[@christophernieves1215]

He’s wrong read my post above…

[@petejandrell4512]

I listen to these lectures as I do my morning exercising and find that the 8th or 9th listen is probably where I start getting a fuller picture and the info starts to 'stick'. Well worth the effort and thanks Dr. Bikman.

[@MichaelTyner-z9e]

as a physician who tries to explain metabolism to many patients, this was a great description of a complex problem.

[@jobrown8146]

The trouble may be having the time to explain it. At least you have the knowledge, which is seems that most doctors do not.

[@azgirl5265]

I wish I could find a Dr. who could explain it. II’m not sure mine even understand it. Well, they may, but would rather rx a pill.

[@carldulaney6570]

​@azgirl5265 the driver to all that is income. Their time is limited and their expenses are high.

[@jasoncdebussy]

Except that Ben doesn't really understand it kzbin.info/www/bejne/gqLPemiGos94g68si=cFGLeHOlFaps9Iby

[@michaelpadula2943]

@@jasoncdebussy Good luck following Bart. I am friends with a lot of high end scientists and they say Ben is correct.

[@rajeevarora190]

Dr. Bikman is a rare gem of a teacher! He explained the Randle Cycle and more in this class very simply and clearly! Wish I was part of his class.

[@jasoncdebussy]

Except that he doesn't actually understand it kzbin.info/www/bejne/gqLPemiGos94g68si=cFGLeHOlFaps9Iby

[@frodemansika5487]

I have followed Dr Bikman for some months now, and my daily work as an heartfailure nurse, has given me an incredible help to understand the metabolic problems many of my patients are suffering from. Keep up the good work Dr Bikeman. This knowlegde that you present is very importen and will probaly change the way traditional health system are thinking and working.

[@kristaG73]

I have read dozens of books on this topic, subscribe to multiple channels and have favorite website searches. I always go to Dr Bikman to wrap it up in a way that seals it in my head. Great, great teacher and helper of humanity.

[@jasoncdebussy]

It is clear that Ben doesn't fully understand this topic kzbin.info/www/bejne/gqLPemiGos94g68si=cFGLeHOlFaps9Iby

[@CynCopeland-TheAnswerIsMeat]

Most of the references to the Randall Cycle I've heard 'bandied about' really push hard on the logic of 'don't mix your carbs and fat' (or you'll get fat) - if I've understood this lecture and the topic properly, it's really just about appreciating that if you load up on pasta with heavy cream, the fat in that meal will not be a) necessary for fuel or b) be able to burn it until such time as the glucose is used up, insulin has dropped and the body demands energy and uses fat. For folks who eat three 'mixed' meals per day (plus snacks), their body won't likely be needing fat for fuel, ever. Obviously, eating this way will contribute to the issues we see with regards insulin resistence, diabetes, obesity (that fat needs to go somewhere!). A very informative lecture Dr. B!!! ❤

[@MrBlaxjax]

I believe the main issue with fat/carb food is palatablility. So if you are given boiled potatoes you will consume fewer calories than the same potatoes served as French fries. They are much easier to consume cooked in fat. Chocolate cake or cheesecake are other examples. Mixing sugar flour and fat is hyper palatable and often the basis of ultra processed food. Loads of other examples. Who can resist good ice cream? Not me! So the body has mechanisms to cope with either sugars or lipids but it’s our appetite that can’t cope with this type of irresistible food! Personally I just try not to bring it into the house.

[@CynCopeland-TheAnswerIsMeat]

@@MrBlaxjax Chris and Xand van Tullekin (twin docs) did some personal experiments on palatability and essentially it's exactly as you say -- there seriously is nothing better tasting than a bit of fat/sugar. If our bodies WANT us fat, because they think we're going to go into the winter food wilderness, they can be quite persuasive. What is the phrase -- we're living in a Human 2.0 world encased in a Human 1.0 body.

[@CrumbleLives]

@@MrBlaxjaxthat’s so true. In cooking fat is the primary conductor of flavour - spices, herbs are fat soluble.

[@iswearallthetime]

​@MrBlaxjax bro nobody is cooking fries in fat.....any fastfood chain or restaurant or street vendor is cooking them in oils.

[@psxtuneservice]

​@@MrBlaxjaxyes and no. I eat relative low carb and do lot of sport. For a while I was complete keto. I only eat what I cook myself. I cant eat a normal ice-cream. It is way too sweet and the fat taste cheap. A long time I want to make my own with little to no sugar maybe some sweet fruits, creme from the milk and maybe some whey protein. Fat yes but not too many carbs.

[@YourTechOnLine]

As an elder ,deeply interested in the metabolic reality of humans, your information is spot on in my opinion. Your willingness to share your passion with mostly normal and less informed individuals, is a blessing to all who will hear, hopefully understand, and integrate into their lives to become healthier individuals. Thank you.

[@sherrioliver5083]

Best teacher EVER!!!!!!❤

[@retiredbitjuggler3471]

I am a layman and have been missing a few links to allow me understand the underlying mechanisms that influence hunger and insulin resistance. I have been trying to find the answer for the past 2.5 years and stumbled on this lecture which just switched a light on. It is so easy to understand, so why is it you are the only one I have found that distilled this into such a simple construct? Thank you for that! I switched to an OMAD lifestyle 2.5 years ago with miraculous results, but have been perplexed by not knowing why I feel little to no hunger daily, or during my periodic 3 or 4 day fasts (with the same near zero level of hunger). People around me simply believe that I’ve lost my mind because I couldn’t explain how that is possible. The answer was right in front of me - my daily mission is to suppress the production of insulin. I don’t measure my keytone levels (my interest is peaked, so I may start), but I suspect I probably maintain a fairly good level. I think I may have the missing link that might allow me to cast a light on my non-believers. 😊😊😊 Thanks again!

[@gribbler1695]

Any time there is excess energy substrates (digested food) in the blood stream, if there is both carb and free fatty acid, then the Randle cycle will be activated to whatever degree. Don't mix fats with carbs, since carbs shut down lipolysis leading to fat storage.

[@PaulaAlinsangan]

Do you know that you have a 77-yr old student in your class? Yes, you have, and that's me. And I do learn a lot from your lectures - Randle cycle, lectins and of course insulin. Thank you very much Dr. Bikman.

[@DavidHickenbottom]

I love being a lifelong learner. I hope your health is improving. I'm living my best life at 62. Just started on a Carnivore diet feeling great. Thankfully I'm mostly healthy up to this point.

[@PaulaAlinsangan]

@@DavidHickenbottom mostly healthy too at this point. Wishing you more success in your health journey.

[@szghasem]

Talk about riding on the shoulders of giants. Thank you, Dr. Bikman, for this incredible ride. 😊

[@fronniebealer7808]

I wish I had known about your lectures and teaching style when I was still teaching. I could have helped my students so much more.

[@grochef]

Dr. Bikman, I agree with many others here. Deep dives are vitally important to really understand how things work. Your dives are sufficiently detailed to allow further digging, if needed. Please keep your metabolic SCUBA equipment at hand and continue diving!

[@mikeh7704]

This is energy metabolism gold. Content like this should be mandatory viewing at colleges and universities. I've been a type 1 diabetic for most of my life and started heading towards type 1.5 (becoming insulin resistant), needing to inject more insulin, and gaining more weight in my 30s. I decided to try Paleo and then Low Carb eating. I'm now back to the weight I was in my late teens/early 20s and remain on significantly lower insulin than before the diet change.

[@Trthsker24]

I totally understand now, why I didn't understand the Randall Cycle fully, until your brilliant explanation.Thanks.

[@sangitayadav223]

I have read many books, I listened to many KZbin videos by many of the worlds leading gurus and health experts but nothing came close to the hidden herbs by anette ray. I recommend everyone giving it a read.

[@kwestia9872]

The best explanation of Randall's cycle I have ever heard👏. I have finally understood it. Thank you so much🙏🤩

[@Maria-zv9up]

So good to get such a thorough explanation. Finally, I can start speculating how my loved ones hunger, eating a lot yet low energy is possible.

[@michaelsliwinski8044]

My 10 year old grandson has very recently been diagnosed as type 1 diabetic. Your lecture has been very interesting and informative. Thank you!

[@rickszczodrowski1412]

Absolutely fantasic! Thanks Dr Bikman, I have been through this stuff a few times over the past couple of years since I started my journey towards Carnivore/PHD//Low carb. This was the best delivery to someone that has listened to quite a few technical discussions and gone down many many rabbit holes trying to put it all together. This one video has stitched together some of the missing gaps and joined up a bunch of other topics for me. So a "win" by any standard. Best bits were the clear distinction between type-1 and type-2 diabetes. The explanation of how and what the brain needs and uses for energy (struggled a little on that one and had to listen a couple of times) Outstanding video. I am 63yr old, switched to carnivore focused diet in late 2021 and have never felt better. It does not fix everything, but it sure helps the body fix anything it can and as quickly as possible as soon as it stops spending all of its time and resources trying to fix the glucose overdose! Thanks again.

[@YELLOWFROGdesign]

Thank you for the lecture! I am learning so much about my T2D! I went from a 10.8 A1C to a 6.2! We are blessed to have teachers like you. G-d bless you!

[@danielcohen24]

Go carnivore and reverse it completely, I have and so has my mom who's been T2D for decades.

[@YELLOWFROGdesign]

@@danielcohen24 how crazy! I am Gus Cohen! hehehehe

[@YELLOWFROGdesign]

I am doing carnivore for over 18 months now

[@YELLOWFROGdesign]

@@danielcohen24 Where are you from?

[@danielcohen24]

@@YELLOWFROGdesign Good! keep it up and you'll get your A1C below 5.7, took my mom a long time as well doesn't help that she's not as strict as I wish she was.

[@JRBunch]

Thank you for this, as a former road cyclist the understanding of muscle tissue types, Krebs cycle and so on has led me here today. It looks like glucose intolerance has entered my life maybe my own doing. Just wanted to say your lectures are very informative and easy to understand.

[@stevePsutton]

For non-diabetics, the Randle Cycle, is Intermittent Fasting. Normally humans are hybrid fuel burners, glucose if present (high insulin), fat if not (low insulin). Understanding diabetes helps non-diabetics understand their metabolism & biology to manage their health. great video

[@BeefNEggs057]

80% of Americans are at least prediabetic. Don’t be compliant with the system to rob you of your health and wealth and inevitably your life. The primary food for humans is beef and eggs. Salt (plenty of it) and butter. Add some mct oil for ketone boosting. Nothing else is required. Electrolytes while adapting are needed but should be weaned off to allow the body to self regulate. At 50 I feel better than ever. No meds. No aches anymore. No pain. I was a mess. Mentally and physically.

[@BarbByArt]

VERY Well and succintly worded reply !! TYVM - summed up in a neat package!

[@georgewaters6424]

Wow you just joined so many dots for me. Especially towards the end around your invocation of the rhyme of the ancient mariner. I can absolutely confirm that I was depressed before I was diagnosed. Then started to receive treatment and I all of a sudden started to get past my depression. It made no sense to anyone yet I knew it to be true, and no one wanted to confirm and even looked at me as if I was making it up!! Still fighting through, love this biochemistry btw. Very very helpful keep up the good work.

[@jobrown8146]

Same here, especially the ancient mariner; such a simple statement which made it so clear. The examples at the end helped the pieces to fall into place for me. And there was one point where I thought before he said it, yes, that's why there is brain fog and it clears once you become fat adapted.

[@meatdog]

I'm excited beyond belief about todays lecture. You are right, KZbinrs with absolutely no understanding of this spew these words out like they understand AND they do NOT. I hope they are listening and finally learning. Thank you.

[@jobrown8146]

It doesn't help when they use the wrong terms!

[@lindabirmingham603]

You might like Prof. Bart Kay's explanation too. He has some videos that explain it very simply and some that go deep in the physiology for the geeks.

[@meatdog]

@@lindabirmingham603 thanks. I will watch ut. I'm a highly educated scientist already in human physiology. I watch for thr latest information and any misinformation.

[@Kinkle_Z]

So for those who are insulin resistant and metabolically inflexible, even when glucose is low, they can't switch over to lipolysis and FFA burning for energy, so they just get hungrier and hungrier until they desperately eat carbs - yet they can never feel satiated; they're perpetually hungry and so that's how obesity develops. Wow. What a great lecture!

[@princesssweetpea9205]

Yes... I wish he would address this.... We need more helpful analysis and protocols to help with this situation,

[@ironmaidenfitness654]

@@princesssweetpea9205check out his chats on KZbin about how to reverse insulin resistance and his 2 books👏🏼

[@rjevans2728]

This is where volume eating and leveraging the stretch response of the stomach come into play

[@KellyRyan-r2l]

Thanks for this, Dr. Bikman. Your explanations are clear and concise. My mind automatically flows to the implications of what you are explaining. You are a great teacher.

[@DS-vu5yo]

This was exactly the level of detail that was needed to clear up several of my questions. Thank you. Much respect.

[@TomSmith-cv8hk]

That's how I understood it from yours and Bart's videos. I don't think Bart goes down the hormone path ? but he does say that glucose goes first to get it below toxic levels. Thanks for explaining how that happens.

[@MyMeatomorphosis]

Thank you Dr. Bickman! I'm in a KZbin Ketogenic study group and this tied in perfectly with our discussion last week. BTW, Rime of the Ancient Mariner is my favorite Iron Maiden song 🤘😎

[@tapiomakinen]

I love this hard core stuff. I've been watching Physionic channel, so I knew most of the funny words, and kind of understood about 87% of them. Keep it hard, doc.

[@dr.julia-heyakarcic8862]

I downloaded this video to listen to it multiple times, thank you Dr. Bikman.

[@bernadinecabanas331]

It’s very well explained….very passionate subject. I finally started to understand 😅. Thank you Docteur Bikman.🙏

[@zuleikadobson]

Dr Bikman, this presentation was especially educational for me - and, I suspect, for all who follow you. As for speed of delivery - would much rather have all your information and thoughts rather than a shorter and/or less detailed lecture/talk. If the biochem is going by too quickly, I just slow the Y/T video speed down to 0.75, and that does the trick. So, Dr, (God) Speed On!

[@meatdog]

@@zuleikadobson I agree. I much appreciate tge complicated biochemistry explanations, but I'm educated in this arena. You are very estate at not dumbing down the facts while addressing them in a manner you want everyone to understand.

[@johnsciandra-e9i]

Dr Ben. I am only five minutes into this video and have already learned at least 2 new phrases, after watching and studying metabolic centric KZbin videos for a year or two. After being steeped in information about the Mitochondria and the Krebs cycle, I have only now heard of the Randal cycle. Also you gave me my new identity as an amateur “Bio Chemistry nerd.” Subscribed and liked!

[@sharonsharing3313]

This is a great presentation. I watched it twice and started to understand more about how our metabolism chooses between glucose and fat burning and how it affects the brain. Thank you so much! I will start watching all your lectures, taking notes, and applying this knowledge to my daily diet.

[@dinavanwyk30]

My daughter study Medical Science and have alot of biochemstry classes. She share all her new knowlage with me. So thanx to her I can understand all this. Its awesome. 😅

[@adriansrfr]

Using both type 1 and 2 diabetes to explain the Randle cycle was super useful, thank you!

[@richardb8267]

That's the best tutorial I've seen in the topics of Randle cycle! Thank you!

[@livelearnandteach7402]

Great stuff. I'm only a bookkeeper by trade, but I love these videos. Thank you.

[@numbakrunch]

...and the first thing I see after your video finishes is an ad for the bold powerhouse of thirst-quenching flavors, Brisk! The comedy writes itself.

[@Garseraph]

Thanks, Ben, for yet another great video- I've followed your work in podcasts, lectures, & books since 2017 & always find more to learn. We are so lucky to have you!💖

[@programmer1356]

Delightful and inspiring. Thank you so much for putting this on KZbin.

[@vettesquared]

Well done! Despite the deep technical nature of the lecture, it was still easy to follow for a non-technical guy! Thanks for providing such rich information on why our bodies are what they eat! And even better, how to select a path to better health! I'll be watching more of these.

[@MrFefeleaga]

Incredible explanation. Thank you so much! This is exactly the kind of explanation I've been looking for and you make it so clear, even when you talk about such complex processes. I've watched quite a few videos from other people explaining things related to this already, they've been helpful, I admit it, but this is really great!

[@MFT069]

This is perfect timing. I had been pondering and researching the very subject of this video. Thanks for making my job just a little little bit easier.

[@mattmendez8517]

Super thanks Dr Ben for sharing your vast knowledge. We hope you won't get tired of doing this everytime.

[@dpc2858]

Thank you, Dr Bickman, for another outstanding lecture. Personally, I would love to hear deeper version as well. I was told I was insulin resistant in 2017 and have been studying the human metabolism since. Thanks

[@Pre613]

This is a great presentation. I understand more of why our metabolism chooses glucose vs fat burning and especially how it affects the brain.

[@jobrown8146]

Thank you. I'm glad I stuck it out and watched until the end because the examples really helped me to make more sense of what was said earlier in the video.

[@jobrown8146]

I think I will listen to this again. I'm sure it will make even more sense after the examples.

[@GetMeThere1]

Wow! This was really excellent. Thanks for putting this information out there.

[@weightlossmiddleage-johnjo7377]

What a fantastic and thorough explanation of the Randall Cycle and insulin's role. One of the best lines is that insulin is the conductor of the metabolic bus. It's hard to believe that you are offering this knowledge for free, and your explanations are so well thought out for laypeople (myself included). It seems that since type 2 diabetics may have difficulty using fat for fuel initially, exogenous ketones could play a role. Specifically, the ketones should help knock the "rust" off the metabolic switch and help the diabetics. MCT oil might do the trick? Just spitballing here. Thank you for all of your amazing videos.

[@brucemoose926]

Dr Bikman, I need your help in understanding the difference between berberine and metformin. Can you do a lecture on this?

[@MelzCarnivoreJourney]

One difference is that berberine is a supplement, and metformin is a pharmaceutical. Therefore, berberine is not regulated, and metformin is. Both can lower blood glucose, but both have unique side effects and can interfere with other medications. However, if you stop eating all carbohydrates entirely, you don't need to suppress gluconeogenisis via medications/supplements and blood glucose levels out naturally. Insulin resistance goes away. Leptin resistance goes away... That's what worked for me 3 years ago. In 60 days, my A1c went from 5.7 to 5.3. Also, my fatty liver went away.

[@adopt8165]

I think for each person, depending on how damaged their body is, that process of healing with no carbs diet, eating meat and animal fats only, will take longer for some to achieve success and reverse that insulin resistance.

[@rebopdeluxe9463]

Easy to listen to, makes everything understandable, the best 👌

[@justawordaway]

What a great explanation. The puzzle pieces are finally fitting together. Thank you.

[@HCW2855HCW]

Awesome explanation to clarify and solidify my understanding of the Randle cycle and the “working” of insulin in Type 1 and 2 diabetes. Thank you!

[@patvb3243]

Fascinating stuff, and SO well explained... Thanks Ben !!!

[@pamelacunningham8015]

Love you explaining the Randle Cycle flex of which fuels get burned. I would also love it if you consider in the future to give a lecture regarding this topic in what we can eat to maintain a healthy flexible metabolism keeping with the Randle Cycle topic. Thanks Do Fiberous foods help to maintain cycle of keytone fatty acids or work against it? Also do fermented foods such as sauerkraut keep you in the cycle of keytone fatty acid burning mode or glucose cycle? Or is Protein/Carnivore a major flexible key?

[@carnivorehippie8071]

There is a theory espoused by some that asserts insulin "resistance" is not pathological, rather that this cross-inhibition becomes extreme due to chronic overdosing of exogenous glucose. The cell eventually (being replete with substrate) ceases to uptake despite increased insulin precisely for the purpose of preventing glycation of the interior of the cell. The body, presumably, is designed to sacrifice the red blood cells and those of the interior layer of the vascular tree because they are more easily replaced over muscle or organ tissue. The upshot being that "insulin resistance" is NOT a pathology, it is a normal response to glucose toxicity.

[@maalikserebryakov]

This isn’t some basement theory. Its quite mainstream. my doctor even explained this to me. Insulin resistance is indeed just a response to too much cell glucose. That’s why low carb diets are good ar reversing insulin resistance

[@maalikserebryakov]

you have a very lucid writing style by the way

[@raykinney9907]

Yes, very helpful! Very clearly stated, and put a lot of puzzle pieces more easily into place.

[@mundhirkhatib8293]

This has been incredible useful talk of all times .thank you again and appreciated .

[@RoyEltham]

I really appreciate the details you go into, while still keeping it understandable for most anyone. While I have been using a ketogenic diet and fasting to lose weight, this helps me understand why (which I always want to know), and to adjust things a little for perhaps more benefit. Thank you!

[@rickwardrop1877]

Thank you for tying the two together to explain why and how insulin and glucose affect mitochondrial function, and thus T2D.

[@thomasrobinson4401]

Thank you, Doctor. Great lecture 👌

[@kathya1956]

He’s not a doctor. He’s a PhD.

[@thomasrobinson4401]

@@kathya1956 I know?

[@meatster29]

Randall, the only dude with a cycle!

[@DavidKD2050]

I cycle from anywhere indoors, to the fridge. This cycle can be as regular as every five minutes. 😬

[@ianstuart5660]

😂😂

[@iloveseaglass]

😂😂

[@Mark-zu3sc]

Thank you! Just had a question regarding this subject yesterday.

[@joecaz]

Beautiful talk! Thank you for your service! Very clear explanation.

[@ferransuayVAL]

Very clear and instructive. Thanks a lot!

[@janedrouot5933]

Really helpful! Thank you for your excellent teaching.

[@superfit60s21]

BRILLIANT, Prof !!! You are a MASTER !! Thank You for your super informative lectures

[@C0nstellati0ns]

Great to hear you speak on the Randle Cycle!

[@turtledunkknucklebaby8089]

Please go on and have a discussion with Professor Bart Kay on this topic. It would be great to hear you two give your inputs together.

[@anthonytamaccio9092]

Your explanations of the complex are clear, logical and understandable. Thank you for sharing bits of your brain with us.

[@sergiopozo4062]

Loud and clear!! Thanks!! 💯

[@brianmarsh8828]

Dr Beckman I love listening to you and learning, and it will be so helpful if you would use the whiteboard or graphics to illustrate how all of this works together

[@its-me-dj]

Excellent lecture professor. Great explanations. I learned a lot from this lecture.

[@TorBoy9]

The biochem portion was over my head, but I learned a lot about the general topic. The last portion, about the liver not able to make ketones, and how ketone deficit affects the brain can lead to depression, Alzheimer's is quite fascinating. Metabolic flexibility, the easy switching of burning glucose and ketones, is critical for good health. Thank you.

[@lindabirmingham603]

Yes, if you eat a mixed diet. I like the way Professor Bart Kay explains it too. If the cell is full of either fat or glucose, the cell locks the door and won't let any more in until needed. Excess glucose allowed in the cell would be toxic as it glycates (coats and damages) the proteins in the cell. The excess glucose in the bloodstream glycates and damages the red blood cells and the lining of the blood vessels, especially where the blood pressure is higher - where the arteries bend and branch. This is where atherosclerotic plaques form. He stresses not to eat a mixed diet. Eat either carbs or fat. Animal fat contains the fat soluble vitamins A,D, and K and doesn't spike insulin. Our bodies don't need any carbs or fiber, we are just conditioned to believe we do... and they are tasty and often hard to moderate.

[@egg399.]

@@lindabirmingham603So how would you eat carbs for metabolic flexibility? Would you just have a small vegetable only meal once every few days if you are carnivore?

[@anyajohnson4471]

It is eating carbs that destroys the ability of the brain to switch fuels. I would not come away with the conclusion that metabolic flexibility is optimal.

[@hugoanderkivi]

​@@egg399.You wouldn't. Eating carbohydrates is what makes metabolism inflexible. If you do carnivore, then you become flexible metabolically, as your body will go into glucose-burning mode after a meal or very intense exercise, and then shifts back into fat burning.

[@egg399.]

@@hugoanderkivi Wow that’s great. Does carnivore fix CKD? Medics say protein stresses the kidneys.

[@hmlxur54]

Excellent lecture of the Randel Cycle, it is very clear to me after your presentation, thank you very much.

[@jasonanthonywilper]

Nice one Dr Bikman!

[@susieqmartin2746]

Can you go in to a deeper dive on fatty acid 17 and fatty acid 15 and how they affect the body? I am very curious to know about these two fatty acids between the brain and the body?

[@melissawitherspoon9094]

So many questions I had are better understood now! Thank you, Dr.!❤

[@johnwoodard8717]

Please correct anything I say that is wrong: First, during exercise, doesn't GLUT4 kind of happen without needing insulin? Like, even taking a very modest walk with elevated glucose dramatically reduces blood glucose; my wife has seen a modest 20 minute walk at a relaxed pace bring her down 50 points. Second, continuing with exercise, how does this square with the Inigo San Milan model of exercise output and what fuels get utilized? His model shows that at lower wattage outputs your body burns primarily fats, until FatMax, where the burning of glucose gets high enough to release lactate into the blood which inhibits fat burning and eventually eliminates it altogether, leaving you buring just glucose and lactate. Finally, what then does it mean when you're Type 2 Diabetic and the primary symptom was you LOSING weight instead of gaining? I lost about a pound per month for 18 months before I realized I was T2.

[@my-yt-inputs2580]

Thanks for explaining this one. I had been meaning to listen to the one down under explain it but I feel he might have it incorrect in some ways. I've listened to Dr Rob Cywes give an updated explanation and he felt it was somewhat misexplained in some cases as well.

[@kathya1956]

I guess Kay and Bickman don’t agree?

[@WARRIORofHARDCORE]

@@kathya1956 absolutely not, Bart also calls IR a construct and not bad inherently. Not agreeing or disagreeing

[@robhutch]

Brilliant. Now enlightened but will listen again and take notes - always was a bit of a swat 😂 thanks so much DR. B.

[@AnitaCorbett]

A beautiful explanation .. A complex issue made very clear …. Much thanks Your students are very lucky

[@mrmarcioconte]

This subject is extremely important, thanks for address it.

[@annakortukov2845]

Great job explaining! I have no ed to do with the complex matters discussed but was able to understand the basic mechanics behind importance of not eating glucose when trying to shed some body fat.👏👏👏

[@bme7491]

Excellent description. I had no problem following along. I am looking forward to more of these especially with regards to mitigating pre-diabetes and full blown Type 2.

[@motivo-academy]

On keto (2 years). This video helped shed light on why my ketone levels are lower range (c 0.5) recently (glucose is also low of course at 4.6). Heavy weight lifting recently too, are the mitochondria using up all the FFAs with not much left over to make ketones? Maybe there’s also less demand due to higher efficiency at using ketones? Would love to see a video on this!

[@soyboymotivation]

Try the Carnivore diet.

[@anifeek4341]

Sooooo interesting!! Thank you from the Netherlands!

[@Michael-pn2ye]

Thank You for the information love to listen to you and your content is always appreciated 😊✌️

[@robertlaslo8951]

Thank you; Ben for the lecture.

[@andreffrosa]

I would like to hear from you an explanation of "burning" ketones vs "burning" fat directly. Which cells do which and when.

[@greenfield1944]

Thankyou for explaining this. I'm an engineer so I don't know much about biology, but my wife is a T1 diabetic. Insulin resistance is cause of so many modern diseases.

[@maalikserebryakov]

Type 1 diabetes is not due to insulin resistance dummy

[@edharding8372]

Thank you Professor for this amazing insight.

[@ivanardila]

At last I was capable to understand how the use of one or another fuel is decided by the body. Thank you so much. I enyoed a lot this class. I subscribed to your channel, and want to follow your other videos. God bless you.