The Surprising Science Of Uric Acid | Dr David Perlmutter Series Ep 1

In this video Dr Perlmutter introduces uric acid, where it comes from and its impact on our metabolism and overall health
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Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author.
His books have been published in 32 languages and include the bestseller Grain Brain. His newly published book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases.
He is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Dr Perlmutter's website
www.drperlmutter.com/
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#UricAcid #DrPerlmutter #DropAcid

[@ModernHealthspan]

Renue By Science 10% : tinyurl.com/4yrf4tv3 DoNotAge 10% discount code MODERNHEALTHSPAN tinyurl.com/ycyn9vhn ProHealth 10% discount Code MODERN : prohealth.pxf.io/c/3176409/1541296/17976 NOVOS Core & NOVOS Boost $5 off with code MODERNnow5 novoslabs.com/?ref=3957 Bulletproof 15% off with coupon code: HEALTHSPAN15: tinyurl.com/4npjk5vp Use SUBMHS when buying subscriptions for a continued discount of renewal orders. ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan

[@kutrabilada8865]

On another interview a couple of weeks ago, Dr. P suggested taking Quercetin. I have been suffering from gout lately. I already follow a low carb diet, along with tart cherry extract, celery seed extract and after adding Quercetin just for 2 weeks I have noticed a huge change. I no longer get those dreaded swellings of my toes or ankle. I also have less aches and pains in my joints.

[@ModernHealthspan]

Hi Kutrabilada, thanks for sharing. I am glad that it is working for you and reducing your gout. It is so good to hear stories like yours on the channel!

[@pinkiepinkster8395]

Gout is caused by the sialic acid in meat. Go vegan.

[@kutrabilada8865]

@@pinkiepinkster8395 Tried it, didn't work.

[@kathyreese4052]

@@pinkiepinkster8395 that has been debunked.

[@robinlillian9471]

@@pinkiepinkster8395 You vegans will tell any lie to push your agenda. That's enough reason for me never to go vegan.

[@keng7758]

I love your channel Richard! These relatively short vids are so much better than the 1-2 hour sessions that some authors require.

[@rachelwren-vipond6029]

good stuff, we are still learning about our basic nutrient needs. Much work to be explored. Dr Permutter is one of those pioneers, I look forward to more revelations

[@darkhorseman8263]

Usually, I'm 5 years ahead of everyone in longevity research. I even knew we were getting stuck into a cycle where our bodies were preparing for 'hibernation' via an evolutionarily conserved mechanism that causes us to pack on fat. Yes, what we evolved from hibernated like Bears. I just had no idea the exogenous signalling molecule involved; Uric Acid. Thank you. You provided something novel and new to me. This is not something that happens often. P.S High Frucose Corn Syrup also smashes the 5 pentose phosphate pathways, causing a surge in advanced glycation end products. It also destroys nutrient sensing in regard to Phosphate/Calcium Balance in the blood, which leads to a whole range of disorders.(hardening arteries, certain forms of arthritis, mitochondrial dysfunction, etc) This is why Ca-AKG is so useful. It restores nutrient sensing and Calcium/Phosphate Balance in the blood stream, correcting secondary hyperparathyroidism, which is driven by said nutrient sensing dysfunction.

[@darkhorseman8263]

P.S the Amino Acid Leucine regulates insulin production in the body, but only when it teams up with Phosphate, or Acetyl-Phosphate, another important exogenous signalling molecule like Uric Acid. When your body loses the ability to sense phosphorus level in the blood, it stops teaming up with Leucine. Maybe you can now see the cascading failures that are the result of High Fructose Corn Syrup.

[@kronk358]

Wow! Such humility! Impressive.

[@bernadettebecher5668]

Thank you for interviewing Dr Perlmutter. I was wandering about the connection to the gout tablet colchizine in response to covid early treatment as per the FLCCC protocol. The connection now seems clear. Thank you again.

[@bitteroldman2714]

I increased my vitamin C intake and have not had any further problems with gout.

[@rayyu8538]

Another brilliant guest, Richard! I'm reading his book. Good to watch your interview to get more insights, thank you!

[@ModernHealthspan]

Hi Ray, thanks!

[@ihcr100]

Hello, 36 male, just experiencing what I believe to be my second definable mild gout episode. Thank you for putting this interview and playlist together. Really eases my mind about being able to keep this under control with lifestyle changes and mindfulness. I'll be starting back in on the coffee in the morning and I'm munching on some dried tart cherries right now.

[@gprivat812_my_selection6]

Thx to Dr. Perlmutter for these clear and precise words on this issue i.e. Uric Acid

[@ModernHealthspan]

Hi thanks!

[@lorasolomon5112]

Love watching the video, lots of valuable info...love your channel...!

[@peterwroberts4379]

Thank you excellent work thanks

[@encounterwithlife6099]

*Thank you for this great information! I whish everybody a good day =)*

[@ronm6585]

Thanks Richard.

[@vimalneha]

I want to learn from and support the channel, so subscribed it!

[@zer0nix]

>we have uric acid levels 4 to 5x higher than in other animals But we also live 4 to 5x longer than other animals, and some animals with even higher uric acid levels, like sharks, can live even longer. The ties between high uric acid levels and inflammation, high blood sugar and vascular dementia are far more compelling.

[@susanc.2482]

My dad has gout and affects his overall wellbeing a lot. It's good to send the message out on High uric acid can be very harmful to our overall health", thank you Richard & Dr. Perlmutter!

[@pinkiepinkster8395]

You can cure gout by going vegan. Meat contains sialic acid which causes cancer.

[@dukington101]

@@pinkiepinkster8395 Plenty of vegan foods cause flare ups of gout and increases in uric acid

[@paradiseview]

many doctors like ken berry considered this bs.

[@kimberleeteeter6338]

I saw Dr. Perlmutter talking about Moringa. Been growing 10 years in Jacksonville. I am working woth guy that has developed a press to extract fresh leaves so was using from my trees. Makes concentrated juice and is ounce daily. This stuff amazing and even had friend having bad nausea with chemo and it helped her. Prevents treats covid and may be why I never had even when directly exposed without mask. I am Holistic nurse, cardiac too for years in health coaching and heart failure support. But a guy came to buy trees from me because he felt better from powder and capsules. He started on juice when we told him about it as giving away until actual sale starts. The freezes through off from getting fresh leaves now. But he had severe Gout, entire leg hurt. Working a lot land developement, etc. and could barely walk at end of day. After 6 weeks His Gout totally gone and leg pain. Moringa is highest anti inflammatory you can take, so we knew that would have helped. But the guy has not had labs yet for Uric Acid levels, and Moringa reduces Uric Acid. Waiting to see if it was anti inflammatory and Uric acid levels came down. Moringa hels me woth teas, powder and capsules which I make but doing the concentrate has totally controlled my chronic pain, fibro, back injury like 0. Anyway wanted to let you know about the gout. We have a couple people this happened with. Also reversed or controlled diabetes type 2.

[@tomjones2348]

I'll well into the book now, beginning the LUV protocol next.

[@maletero9888]

Do sucralose and aspartame mimic the pureen effect despite not raising the glucose levels and raise the uric acid level?

[@annhalbower1452]

It should be clarified ( and should have been done by Dr. Perlmutter) that credit for many of the studies on fructose, uric acid, salt, and biologic reasons for why humans have used fructose and uric acid for survival were done by Dr. Rick Johnson (presently at University of Colorado). He has books written for the lay public that explain these studies: "the fat switch" and "nature wants us to be fat" .

[@suzatlarge]

In his book "Drop Acid" about uric acid, Dr Perlmutter cites Dr. Johnson's work. Also, Dr. Perlmutter wrote the foreword to the 2021 Kindle updated edition of "Nature Wants Us to be Fat.'

[@paradiseview]

@@suzatlarge fat means overweight or following a fat diet like keto.

[@sylvielebrun8364]

I googled what to eat to avoid gout and it literally said" lots of fruits and jams to increase vitamin C" This in a January 2022 article. Wish your good information was available to the general public

[@michellemybelle9591]

The gout medication commercial in America says take this even if your gout gets worse!

[@michaelberman3648]

I have heard from Dr Cycae that he claimed that most of the purine source comes from the catabolic breakdown of our own cells rather than outside sources of purines from cellular breakdown products. He claims that the purines from foods are in most part not transported into the systemic circulation or portal system from the small intestines anywhere as much as the purines that come from our own DNA & RNA catabolism when our cells get replaced! Do you agree with these statements? If not, then why not please? Thank you!

[@johnvercellone1988]

There is no government Public Health Agency ( most specifically federal govt)that's majority priority is Public Health..Dr.is correct that USA life expectancy started to decline 4 years before 2020.. Another reality for ethical USA health professionals to contemplate is that 20 to 25 % of USA health medical cost has not an iota link to curing,to treating to relieving pain and suffering of American citizens been going on for 35 to 40 years. That's not a small amount of money ..Sammy and pols have been knowledgeable of this for at least last 25 years...Covid 19 has been called scamdemic may be very appropiate

[@abrahamnorthhampton3327]

Haha! When I saw your #dropacid hashtag, I was expecting something entirely different!

[@ModernHealthspan]

Hi Abraham, thanks for your comment. It is a good piece of marketing from Dr Perlmutter!

[@liyahtasliyah4794]

My blood pressure is 112/54 Cholesterol 263 Urid acid level 16.4 Blood sugar 127 158cm and 49 kg Now i became very concerned

[@pram9832]

Are you using allopurinol for uric acid?..

[@ModernHealthspan]

If you would like to support our channel, we’d love a coffee ☕…thank you! www.buymeacoffee.com/mhealthspan

[@KenOtwell]

"Buy me a coffee" because, hey, coffee helps clear out uric acid!

[@shaughtup7554]

Uric acid is also a powerful antioxidant itself used by the body in that capacity....for gout sufferers another treatment modality is inexpensive, over-the-counter low dose lithium orotate - this assists the body to dissolve existing crystals

[@michaelberman3648]

Doesn’t some oxidative stress in the body particularly in the mitochondria a good signal to have? I think we all must have some oxidative stress to tell our system not just how to handle it but is a part of healthy metabolism? How much really is too much since even normal exercise generates free radicals and some oxidative stress as well! How does one know that we have too much oxidative stress? I have been using liposomal glutathione to quench much of this I think but isn’t that a way to also over do the quenching of too many free radicals or general oxidative stress?? Can’t you go overboard towards both extremes of this spectrum?? Again, how does one know when we are on either extreme of this spectrum of oxidative stress????

[@mrigankadeshmukh2602]

Those who suffer from uric acid problems they should take half teaspoon of Baking soda mixed in 250 ml of cold water in the morning in empty stomach for 2months.This will reduce their uric acid level in blood.

[@StarNumbers]

I left the moment Pelmutter quoted WHO (6:06).

[@chinbabyogbonna1285]

God Bless you dr odija channel keep on the good work you have been doing and thanks also for curing me off this disease you are truly a God sent towards humanity I appreciate you sir dr odija!!!!

[@mgarde7748]

Confusing. It would seem most people in America anyway.. eat fruit, honey, some alcohol and purine sources.. why do some people get gout or have elevated uric acid and some don't?

[@MrBDezno]

OK. I'm more confused. Bart Kay claimed uric acid is a powerful antioxidant and unimportant - (That after I'd watched the Richard Johnson lecture "Nature Wants Us To Be Fat"). Should I be taking quercein to reduce uric acid levels?

[@preymanta6389]

I’ve had gout nine times my first bout was when I was 19…I heard that Black Currant drops remove the uric acid from the body…is this true?

[@IronKing79]

My gout problems began when I started taking allopurinol.

[@ScottSummerill]

I don't know. Where are the studies confirming his statements? I recently mentioned uric acid on Brad Stanfield's channel and he directly commented and pushed back saying there are no supporting studies. Brad made it sound like he's just selling a book. I went out and bought a uric acid tester and have started tracking my levels, which are on the high side, but where's the proof? I would love if Dr Perlmutter went on Brad's show and had to defend his views to a skeptic. It's one thing to go on a show and tell his story. It is another thing to defend that story.

[@abdelilahbenahmed4350]

A lot of studies has been done by Dr Rick Johnson about uric acid . Isn't Dr Brad Stanfield aware of that ?

[@ModernHealthspan]

Hi Scott, thanks for the comment. I am sure this is not cut and dried. But here are my comments. Here are two of the studies that Dr. Perlmutter refers to in his book. onlinelibrary.wiley.com/doi/epdf/10.1002/art.24164 (“Serum Uric Acid Level as an Independent Risk Factor for All-Cause, Cardiovascular, and Ischemic Stroke Mortality: A Chinese Cohort Study,”). The conclusion of this study is that high UA is an independent risk factor for all cause mortality, www.sciencedirect.com/science/article/pii/S2090123217300346?via%3Dihub (Physiological functions and pathogenic potential of uric acid: A review), This review shows positive effects of UA but also says in its conclusion "The contribution of uric acid to development and progress of gout and metabolic syndrome appears to be well-established". There are more given in the book. These do not include the work of Dr Rick Johnson, mentioned by Abdelliah. One of the key messages from Dr. Perlmutter is also that fructose, especially in the form of HFCS etc. is not good and causes accumulation of fat. That in itself seems like a good message. There may well be studies showing that HFCS is not harmful, because there is a large industry behind it paying for them. In summary: There are definitely papers which link high UA to metabolic disease as Dr. Perlmutter has stated. You must decide whether they are sufficiently convincing for you.

[@entropy0917]

I wonder if Brad has read the book? (and taken the time to look at the supporting studies. ) ...

[@ScottSummerill]

Probably not. More and more Brad is striking me as a practitioner of traditional medicine, not functional medicine. For example, he’s still firmly planted in prescribing statins to mitigate high cholesterol rather than addressing the root cause, whatever that might be. That said, I appreciate his work.

[@entropy0917]

@@ScottSummerill Yes that has been my exact opinion recently as well.

[@littlevoice_11]

If avoiding foods with added sugar/fructose would Perlmutter still feel fructose in natural fruit should also be avoided? Would the same apply to fructose containing vegetables? Also, I wonder about the effects of time restricted eating and short fasts have on uric acid levels e.g. 16:8 or OMAD?

[@ModernHealthspan]

Hi Thanks for the question. We do get into fruit later on, and Dr. Perlmutter's view is it is good in moderation. Fruit comes with nutrients as well as fructose and the fiber helps to slow the absorption. He does caution against fruit juice though. We talk a little bit about fasting and in the book he does suggest a 16:8 split or even OMAD

[@superluci58]

Why complicate your life with plants? Just avoid all of them.

[@superluci58]

Why complicate your life with plants? Just avoid all of them.

[@3wolfsdown702]

​@@superluci58uric acid comes from meat as well😅

[@superluci58]

@@3wolfsdown702 no!

[@scottmiller2591]

Urea and similar nitrogen byproducts, ammonia, and cortisol are tightly intertwined.

[@hercules71185]

Almost. Keep learning. Cortisol is a hormone and levels are affected in ways yes.

[@VonKirda]

Sounds as if (intermittent) fasting is increasing uric acid ?

[@anamsohel2677]

Does perimenopause cause increase in uric acid levels?

[@faridabombaywala7151]

Menopause causes increase in uric acid estrogen helps in flushing out uric acid from body through urine

[@faridabombaywala7151]

Take herbs like ashwagandha,aloe vera, suranjan Shirin . Do you stay in india or Pakistan you will get these herbs easily here

[@maulajatt5655]

So the key question, how do we reduce uric acid?

[@lucyrodrigues7609]

reduce sugar intake

[@lucyrodrigues7609]

also, beer

[@elevatedemotions4548]

How to remove purine from foods?

[@faridabombaywala7151]

Take ashwagandha, aloe vera, suranjan Shirin,gokhshuru herbs

[@MrMilanoLau]

@@elevatedemotions4548 It is difficult to remove purine from foods. All you can do is avoid foods that contain a lot of purine. If you want to remove purine from your body, take quercetin, tart cherry extract, vitamin c, luteolin, celery seed or EGCG.

[@jamesalles139]

Fructose is the enemy

[@dr.zamzamparveen8559]

So confusing.. Some doc says to uptake the intake of fruits n veggies n to lower the intake of protein.. And u r saying fructose is the culprit.. So confusing..

[@terminispon590]

I eat fresh fruits every day, some researches show they are benefit for health, but fruits contains lots of fructose What's Dr Perlmutter or your opinion on fruit? Should we eat them for better health, or should we avoid them?

[@ModernHealthspan]

Hi thanks for your question. Dr. Perlmutter covered fruits in the episode that we released yesterday. But essentially he says that fruit is OK in moderation, because of the added nutrients and fibre.

[@til2529]

As Dr. Stephen R Gundry is known for saying “give fruit the boot “.

[@vonwolly2]

What are the ideal levels of blood uric acid what's the number blood levels

[@ScottSummerill]

According to Perlmutter, below 7 is the traditional medicine target but he wants around or below 5.

[@littlevoice_11]

@@ScottSummerill is that mmol or mg?

[@abdelilahbenahmed4350]

@@littlevoice_11 for general health less than 55 mg is good. But less than 70 MG is good to prevent gout

[@ModernHealthspan]

Hi Thanks for the question. We do get into that a bit later, but his recommendation is 5.5 mg/dL. Standard normal level is less than 7 mg/dL.

[@pallarsen561]

If you investigate the research on this topic you will find a lot of papers with the complete opposite result.

[@paradiseview]

especially dr. ken berry.

[@MrMilanoLau]

Big pharmacies do not want you to know the truth. I am not saying which of them is right. I am now doing an experiment on my body. I follow advice from the two schools, one month for each. Then I will check the changes in the biomarkers in my body.

[@JudyBarrette]

I have been hearing about fructose being basically poison for humans for decades. Why is it still in our food?

[@cyndhar4841]

At approx 10min into this video, he says, "a hormone that affects the contraction of the gallbladder". What hormone is he referring to?

[@tessymartins2871]

HI,The hormone is Cholecystokinin CCK

[@anandkibe7554]

I have a Gout attack every time the season is changing. March-June-October

[@michaelberman3648]

What does too much fructose have to do with the body’s sense of possible famine is nearby??? That makes no sense to me!!! Can you please elaborate on that particular connection much better than you attempted to??

[@rejiequimiguing3739]

When winter is coming all summer fruits are near over ripe. Over ripe fruits have high fructose

[@Rainbowdancefactory]

Very simple👍

[@shannonkincaid8711]

My daughter has high uric acid caused by her PCOS.

[@nicolejamieson6693]

Just wondering if it could be the other way around?

[@hertfordable]

I don’t drink alcohol I don’t eat meat I don’t drink soda, the only carbs I eat are rice and potatoes . Yet my Uric acid levels are high constantly

[@scramblendan]

I think you answered your own question. It's just as important to consider what you ARE eating. Starches and carbs

[@hertfordable]

@@scramblendan maybe you are right I need to try keto I am actually unable to walk right now the pain is excruciating 😩

[@hasansvideoz4645]

rice and potatoes not good for gout, no sweet less carbs, no chicken,no lamb,no inside organ and processed meat. celery and papaya very helpful.

[@hasansvideoz4645]

@@hertfordable keto effect in time, first make uric acid more higher. I can't walk 2.5years and not believed can walk again. my all body full of uric acid, on my mouth bone too, can't open my mouth, use many voltaren for pain and steroids. never can sleep, all days only pain. i started thai herbs and my pain lost. my knee started to get smaller and relax. can stand up now and i believe in can walk in 2weeks. you can return your gout. never give up.

[@ayo9057]

All the sheep are worried about cholesterol when they would be better off tracking uric acid.

[@donna7338]

Interesting, but I question Dr. P's analysis when he refers to our "primate ancestors." Any doctor who believes in evolution I think of as a quack. Many readers who commented on his book 'Drop Acid' say his book talks in repetition about evolution. Science denounces evolution as a science. It is only a theory, with no scientific backing. Sorry, not sorry, that this critique isn't what you wanted to hear.

[@RUFFFHOUSE]

Primate ancestor? How ridiculous! you lost me right out of the gate genius .

[@AyeWitness]

Amazing how smart and stupid some can be at the exact same time. Nobody is perfect. I have issues. I make mistakes. But I know I’m not from apes 🦧 I also know the Earth ain’t a spinning ball.

[@ra3i.alalia]

Dr karl goldkamp refuses all this fructose story he said eat fish and that is it

[@AyeWitness]

Too much waffle 🧇 please get to your point.

[@chinbabyogbonna1285]

God Bless you dr odija channel keep on the good work you have been doing and thanks also for curing me off this disease you are truly a God sent towards humanity I appreciate you sir dr odija!!!!