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1:02 The DIY manual for combating Prostate Cancer series
7:57 QR code for DIY Combat Manual for Beating Prostate Cancer Videos
9:07 The different types of Prostate Cancer - Local, Focal, Zonal, Diffuse
11:03 Metastatic Spread of Prostate Cancer
12:47 Clonal Model for Cancer Progression
13:52 Heterogeneous Model for Cancer Progression
15:01 Immunotherapy
16:24 Systemic Treatments 2024
17:50 Directed Therapies 2024
19:18 Regular and Comprehensive Follow Up is Key
21:42 Live Discussion - Fact or Fiction
23:58 Stage 4 Prostate Cancer = "Put your affairs in order?"
31:00 The higher the PSA the more aggressive the cancer
35:40 If my PSA has been undetectable or not moving for years is everything ok?
38:17 Should I ask for a second opinion?
43:23 When an insurance company says "no" is there anything I can do?
54:22 If you've had radiation treatment once can you have it again?
56:57 How many people receive spot radiation and later another spot radiation?
1:01:16 With radiation targeting spots is it better for spots close together or spread out?
1:02:32 With reoccurrence what about other treatments other than radiation?
1:05:56 Chemotherapy is rarely needed because of too many side effects? True of False?
1:10:35 How long are you on chemotherapy?
1:12:54 Does chemo therapy work against mutated cancer cells?
1:14:39 Is chemotherapy good for low and high volume disease?
1:20:08 In the era of PET imaging disease is being seen earlier
1:21:10 A lot of times the things you see in a scan aren't what needs to be worried about
1:21:40 Will Pluvicto get FDA approval for castrate sensitive prostate cancer?
1:25:54 Actinium-225 radioligand therapy possible approval in the next 3 years?
1:33:33 As you get older recovery becomes as important as the actual physical activity
1:34:20 Is Provenge the only approved immune therapy for castrate resistant prostate cancer?
1:35:47 Genetic testing may reveal enough mutations for good response to immune therapy
1:41:32 Melanoma, renal cell carcinoma, bladder cancer, have highest level of mutations
1:43:27 One liquid biopsy is better than no liquid biopsy?
1:47:58 Is PSMA PET/CT scan better than any other type of PET/CT scan?
1:50:30 10-20% of patients will have forms of disease that cannot be seen on PSMA PET scan
1:52:35 Top 5 slide topics
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Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.

[@robwells230]

Thank you Dr. Kwon I usually rage at some of these video, but this is truly amazing, informative, and inspiring; a perfect blending of expertise with compassion with plain language and common sense. . ...I am still enraged at the way that I was treated like a concentration camp inmate during my treatment at the CROSS CANCER INSTITUTE, having been dictated one treatment plan, coerced, deceived, intimidated and extorted into a six month shot of Eligard ADT CASTRATION which caused such insufferable quality of life destroying and life shortening side effects that I refused any further ADT, and when my 25 fractions of 68 Grey IMRT was completed, I was tossed to the curb and denied any followup care for horrific side effects. You are a shining example of what shared decision making patient centered care should look like.

[@hatemfarhat5489]

Amazing. I'm glad that we still have an honest straightforward human being. (Every one has different DNA) Following him since my diagnose 2020.

[@debrawalker2035]

I think the gift you are giving the viewers is the gift of hope. IMHO the patient/family hear the diagnosis of cancer they immediately shutdown and go back in time to archaic treatments with horrendous side effects and poor outcomes. It is a game changer to know that patients are living with cancer and advances are being made every day. It is now viable to string treatments across decades and giving patients quality and quantity of life....thank you

[@chaussmk]

I did chemo. 6 cycles of doxetaxel and it kicked my arse. I lost 60 pounds and had neuropathy in my feet and hands. The hair loss was a bonus, not having to shave! LOL. Maybe I was an outlier. On the upside it worked and I am now NED for 1 1/2 years! And yes it was worth it!!

[@martinsmith439]

What is Ned .?

[@chaussmk]

@@martinsmith439 No Evidence of Disease

[@maverickat4544]

Wow i learned a lot from this. So Im not safe just because my PSA is under 1....Time for that PSMA pet scan. Thanks Dr.Eugene Kwon😊

[@ovidididaho]

I have learned a so much about my disease from all of you at PCRI. Thank you very much.

[@franklinfiguera2826]

#PCRI , Dr Kwon, Moyad, Scholz thanks for helping me decide my treatment since 2022 after Gleason 9-10. RALP surgery, pet psma and Proton RT + ADT(6 mths now) and feel better everyday. Hoping everyone find their path to fight this common enemy with faith 🙏🏼and science 🧬 . Thanks again for your contribution. 🧪

[@ThePCRI]

Thank you for sharing, Franklin! We stand with you!

[@Terryhirst]

Thank you to PCRI and Dr. Kwon for the discussion. I came to Mayo last week to get a better understanding of my diagnosis and treatment options. Still working on the understanding part but videos like this really help so thank you.

[@stevenpeterson659]

I think Dr. Kwon does and incredible service to prostate cancer patients. I just wish more general oncologists would also be members of the audience.

[@dinkydo1576]

15 years and counting……..Thank you from Illinois.See ya soon.

[@BrentonFernandez]

Thank you Dr. Kwon. I have enjoyed following you for 6 years now since my diagnosis. Always very informative and easy to understand.

[@robertrosanelli444]

Great to see Dr. Kwon again.

[@eddiegardner8232]

Going into my third year after diagnosis and treatment, now on TRT and feeling great, I think of you as my "Ace in the hole" if I ever get a recurrence. Thank you so much for your expertise, and for spreading it on these video presentations.

[@mulder2400]

Thank you for this useful information, been just diagnosed myself trying to cope with it all while dealing with pain.

[@mulder2400]

And out of nowhere stage 4 prostate cancer with the PSA numbers around 11000. Just received my 4th radiation treatment, hoping for an outcome that leaves me surviving with use of my legs again. I went from being able to walk to being just temporarily hopefully, paralyzed below the waist

[@koof1776]

​@@mulder2400 Spinal chord invasion?

[@nickband2072]

Wonderful information thank you so much for your time

[@tomswoverland]

Still going after over 3 years thanks to Dr Kwon and my wife for calling after I finished 44 radiation treatments and got me into Mayo. Believe me Dr Kwon will not give up on you.

[@taichitanaka6237]

Thanks a lot. It was really helpful to me.

[@pwaveqrs1]

I am surviving thanks to your guidance on PSMA-PET. I fought for one in 2020 after biochemical recurrence., found two iliac lymph nodes. Small. Added to Salvage scope + 18 Months Lupron (yuk) now T levels back to normal PSA still undetectable. Six months at a time. Carnivore diet since 2024. NO PAIN ANYWHERE. No prescriptions. Lifting weights and thriving. Thank you for giving the me the confidence to fire a few Urologists along the way.

[@Skwarek-wp8dc]

I hear everywhere not to eat red meat with prostate cancer ...?

[@pwaveqrs1]

@@Skwarek-wp8dc I heard that too. I was eating plant based for the last few years. Now after nothing but meat eggs salt and water for 5 months I am much stronger and ready for any treatment that comes next. I will never do Lupron again. The testosterone research is mixed and mostly pre-PSMA-PET scans.

[@edcooper4301]

PSMA scan done last week, positve. Awaiting decision from Kaiser on whether I get Pluvicto or not. 10 year stage 4 metastatic to every bone.

[@koof1776]

Dr. Kwon is a genius~

[@RhysRobinson8822]

Out-of-pocket costs for a PSMA PET-CT can be up to $10,000. Someone has to do something to get the cost down.

[@terriblepainter7675]

In Europe they are less than half of that.

[@kawaahangar4570]

God bless you guys, best doctors, best human, wish you all the highest success.

[@bobliening5783]

I apologize for my first comment, it was truly off topic. For a patient with diffuse Mets who show’s PSA undetectable for 2 years, only being on Xgeva (18 months), Xtandi, and Lupron, with no chemo, radiation, or surgery, is chemo a viable option or wait till the PSA rears it’s ugly head? I’m sure there are others in this boat who had a fairly high PSA to start (mine was 1,300) who’s oncologist and urologist have said to leave that as the “next bullet” if the PSA rises. I watch all the PCRA videos for one reason . . . very informative with little to no BS. Thank you.

[@johngrimkowski598]

I heard of a new oral drug just approved by the FDA. I'm interested what is the success rate and can it be used with other treatments?

[@stevenpeterson659]

What about monoclonal antibody linked radioligand therapy? And I received AC225 in 2018 in Heidelberg Germany.

[@cherylm2C6671]

Is there a lymphatic massage program for this? Where can I find classes? Thanks, any help would be a kindness.

[@nevillewood8194]

I had my prostate removed 20 years ago, but the PSA has since increased to 1.86. However, over the last two years I have had three PSMA PET scans that have shown nothing. Mark remarked that some with increasing PSA have had to turn from PSMA PET scans to alternatives before they could locate their cancer. I would be very interested in getting specific details.

[@ThePCRI]

Hello, we are not able to answer case questions on our comment section but we can help you through our Helpline who can speak with you either by phone or email. Here is the link to contact them: pcri.org/helpline

[@jaktao6044]

I like Dr. Kwon's style! Of course, a tad biased with the "standard of care" and typical AMA mentality, but his realistic view is good with relation to prostate cancer. However, he needs to branch out further with consideration of other modalities.

[@jstanbury61]

I am allergic to cremophor the carrier used for docetaxel.What other systemic therapies are available to me?

[@dino6161]

Hi, I’d appreciate a comment…. I was diagnosed 8 years ago, after a psa of 7, had a biopsy, Gleason of 5+2. I chose not to have treatments offered, which was removal of the prostate, and due to my physiology this wasn’t possible easily. I chose to take homeopathic , hopefully immune boosting substances. However my psa has risen slowly but somewhat steadily to now be 28. I did have scans two years ago that didn’t show any spread, but not had a pet scan. I don’t have any symptoms, maybe rise 3 times a night for urination, am 68.

[@jabster58]

Is it true that the American cancer society survival rate for prostate cancer is 98 percent for 10 years on local and regional prostate cancers.?

[@johnmchale8308]

Correct whether you have radiation surgery or do nothing

[@jabster58]

@@johnmchale8308 but then it says the reoccurrence rate is almost 40 percent within 5 years

[@johnmchale8308]

I was just talking about 10 years survival rate. If you have an aggressive cancer recent 8, 9 to 10 That’s a whole other discussion

[@jabster58]

@@johnmchale83088 9 and 10 can be local and regional as well

[@TOMMYSURIA]

😇Ready for war... Just got my first injection to block testosterone, today.

[@johng8082]

Started my ADT treatment Jan 2019 and it’s been on/off since then. PSA up (2>) = treatment resumes (6mth Inj), PSA (

[@robwells230]

I hope your ADT is easier on you than mine was. I also hope that you were fully informed about ALL the horrific side effects and possible long term full or partial castration the often occurs after ADT. It is a lot easier to cope with the side effects if you are forewarned and prepared Best wishes for a cure