TWiV 1050: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19-associated hospitalizations in infants aged less than 6 months during SARS-CoV-2 Omicron predominance, COVID-19 vaccination recommendations and practices for women of reproductive age by health care providers, molnupiravir for intra-household prevention of COVID-19, delayed peak SARS-CoV-2 viral loads relative to symptom onset and implications for COVID-19 testing programs, viral kinetics of sequential SARS-CoV-2 infections, FDA authorizes updated Novavax COVID-19 vaccine formulated to better protect against currently circulating variants, antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, long-term cardiovascular, cerebrovascular, and other thrombotic complications in COVID-19 survivors, SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels, and the efficacy of gabapentin For post-COVID-19 olfactory dysfunction.
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[@lesfaby8997]

KZbin timestamps by Les 01:55 Quotation 02:26 Malaria in US 04:00 CoViD status 06:10 the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19-associated hospitalizations in infants aged less than 6 months during SARS-CoV-2 Omicron predominance 09:26 COVID-19 vaccination recommendations and practices for women of reproductive age by health care providers 11:32 molnupiravir for intra-household prevention of COVID-19 14:46 delayed peak SARS-CoV-2 viral loads relative to symptom onset and implications for COVID-19 testing programs 21:40 viral kinetics of sequential SARS-CoV-2 infections 22:49 mRNA Nobel Prize 23:32 FDA authorizes updated Novavax COVID-19 vaccine formulated to better protect against currently circulating variants 24:55 antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 39:33 Long CoViD 40:07 Long-term cardiovascular, cerebrovascular, and other thrombotic complications in COVID-19 survivors 42:36 SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels 47:07 the efficacy of gabapentin For post-COVID-19 olfactory dysfunction. 47:46 Please donate 48:23 Doctor answers your questions Livestream questions 49:47 Livestream question 2 51:39 Alana 53:21 Roxanne 56:37 Roxanne 56:52 Jen 57:58 Will Audio Podcast Timestamps by Jolene. Thanks.

[@crystaldragonwoman]

Thanks so much for the time line 🎉

[@tonaruch8623]

Thanks

[@francesschaefer]

I appreciate the review of studies and trends, these are complex times.

[@dturner6611]

I greatly appreciate these programs. Thank you both for educating us.

[@jonnash5196]

What is the efficacy of the (corbevax ?) Vaccine developed by Dr Peter Hotez and his group ? How does it compare to the mRNA vaccines ? It is much cheaper to manufacturer and does not have a patent on it . Why is it not being rolled out in the US ? Is it because there is no money for studies to get it approved ? Wouldn't it save everyone a lot of money ? Does his team have a plan for similar vaccines for new variants ?

[@regbhyyu]

Thank you!!!!!!!

[@justwhistlinpixie]

I'm so glad I was able to get vaccinated while pregnant. Nine times higher risk of ventilation in babies from unvaccinated mothers!

[@Invitational2]

Sounds like a contrived number. Have you actually read the study he is referencing? Did you see how they came up with those numbers?

[@christopherrobinson7541]

Previous numbers, with pregnancy:- 8x on hospitalization 20x death. And the risk of being unvaccinated were on top.

[@coda2475]

Would you mind citing the number of ventilated infants with a COVID diagnosis in 2023? Thanks so much for the help. "%900" is a useless number without a baseline. I appreciate your valuable time.

[@coda2475]

@@christopherrobinson7541 Relative risk, no actual numbers. Thanks.

[@m.moseley1964]

Dr. Griffin hasn't aged a bit over the last 3 years of the Covid pandemic. Everybody else I know has shown the wear and tear of these tough years. Remarkable, considering how much in the thick of things he has been.

[@katiehettinger7857]

I love Daniel being salty, but still kind. 😄👍🕊

[@doreeno3792]

Awake with jetlag...it just got better. HELLO EVERYONE!

[@lesfaby8997]

Hi Doreen

[@doreeno3792]

​@lesfaby8997 hello Les! Hope all is well...good to be back. Cheers.

[@Idahomie]

Thx Dr Griffith for doing these talks...very informative. Gt ...ps..i have passed this channel along to my appreciative primary doc.

[@MZ-mn9fl]

Thanks again!

[@rouxbe3595]

Hope your ⛵️through the 🌧️ is smooth, thanks for the update!

[@niftytubeman]

Wow, since early 2020. The collection can illuminate the “if we knew then what we know now” perspective. That frames planning for future outbreaks, HIV, MPX, parasites, polio, things to not forget.

[@4everyoung24]

To the breast feeding mom-what about getting donated milk from a milk bank while you take Paxlovid?

[@patriciahoke4722]

Thank you for asking and answering the question on dialysis and tx for Covid - this is more or less what I already knew. I was hoping to hear Daniel fill in the blanks a bit more about challenges and solutions. Seems Paxlovid is still in the experimental stage for this group. Thanks again.

[@RiDankulous]

It's nice to hear Dr. Griffin. It's either that or creepypasta so please keep doing this.

[@Logotic]

Thank you for this comment! I've never heard the term "creepypasta" before, but I love it! It's the kind of thing old boomers like myself used to call "urban legends", and man, there's sure been a crapton of it lately!

[@TrinitySure-b9e]

Dna manipulation for my winnings for money laundering Denver Colorado cop's access for failure violation of my 4th amendment right microbiology weapon useage .And I just wanted what I won and the been trying to hurt me for the October 2nd 2023 power ball money .I have been injury they gave me autoimmune through auditing me and manslaughtering me saying I didn't win for winning.

[@janineforrest7723]

Recently developed covid symptoms while on a trip to Europe. Started with sore throat, sinus congestion and headache. Tested 3 times in four days since I was most concerned about my fellow travelers. My husband tested positive on my Day 4 but I was still negative. On Day 6 I tested again when I was home before going to a group gathering (had mild head congestion and cough) but was still negative. At this point I assumed I didn’t have covid. My symptoms improved until day 12 when my sore throat returned. That was when I tested positive for Covid. My first question is what could explain these results? Secondly, was I automatically ineligible for Paxlovid due to the delayed positive?

[@patriciahoke4722]

Excellent question. I hope you post again during office hours (in 2 or three weeks). I would say that one of those earlier tests you did might have returned a positive had it been PCR. Also, I'm not sure that during the nasal swabs, people are going slowly and long enough.

[@RiDankulous]

I'm no doctor or scientist but if it was me Id assume I got it later.

[@katiehettinger7857]

Perhaps the question is did you have a cold and did your husband give you Covid. As Daniel says you can have as many diagnosis as you need. Or as my sister a neurologist says there were diseases before Covid. Hope you and your husband have full recovered. 😉👍

[@janineforrest7723]

@@katiehettinger7857 That's very possible. I never had a fever but my husband did. I will say though that I never had a fever at all for the duration of my symptoms.

[@williamhesbach4072]

I can't figure out exactly when "symptom onset" occurs. It seems critical to know since it determines when to take Paxlovid. For example, I recently woke up with a slight sore throat and a mild background headache. I had no reason to suspect I had anything going on since those symptoms are typical for mild infections and allergies or can be totally meaningless. If five days later, I test positive for the first time, was that day when I woke with those mild symptoms my onset date or is my onset date the first time I tested positive?

[@patriciahoke4722]

I think in the video, they say symptom onset is the day you feel symptoms, which technically counts as day 0. Then, they say, test the NEXT day. I did not do this (I tested the same day I felt symptoms) nor will I do it in the future. The reason is that I want to start Paxlovid as soon as possible. I tested + on a Friday night. If I were to wait like is recommended, getting Pax would have been far more complicated.

[@williamhesbach4072]

Thank you. But why did you test? Did you know you were exposed? @@patriciahoke4722

[@williamhesbach4072]

If it's true that very mild symptoms count as the first day, then to use Paxlovid within its 5-day efficacy timeframe, one would need to suspect every slight headache or minor throat irritation as being a COVID-19 infection onset. But if repeated antigen tests are negative during the early mild symptom stage, why would anyone suspect they have COVID? I didn't test positive until after 5 days from early symptoms, and the only reason I now know those early symptoms were COVID-related is hindsight after I eventually tested positive. The guidelines need work. @@tunneling-nanotubes

[@patriciahoke4722]

@@williamhesbach4072 I tested because one, I felt some symptoms (sore throat, congestion, some general malaise). Couple that with some stress I was feeling for various reasons including lack of sleep, meaning I knew my immune system was not functioning on all four like it usually is, so I decided to test. Boom, positive came up right away. Yes, I work with patients one of whom I knew at the time had Covid.

[@Logotic]

I was a bit surprised about the hospitalist who thought paxlovid was a prohylaxis against covid. Or maybe I misunderstood that? Was he just being gently facetious? Whatever, thanks for yet another thought-provoking episode!

[@coda2475]

I dont think one should take Paxlovid before an actual positive test... A Hospital Doctor being facetious? Go to a different hospital. If I am wrong then our medical professionals and researchers have failed us. Thanks so much.

[@Logotic]

@@coda2475 I agree about the paxlovid but disagree about the facetious doctor. The hospital workers I know have such a dry sense of humor they could make a cop blush. It helps them cope with the stress.

[@coda2475]

@@Logotic Is it good bed manner to be facetious in front of a patient I wonder? 🤔

[@Logotic]

@@coda2475 Depends on the patient.

[@namehere1861]

The mosquitoes who carry malaria moving north in the habitat is a factor. The New York is geographic outlier. I wonder if the cases are tied to shipping and if the US develop a summertime pattern. Infecting humans on a ship, then flying around port and maybe even into a delivery vehicle. A pregnant mother or large enough group could provide a generation or two before dying out inside someone's home or workplace. Has there been an uptick in local malaria in places that export? Arkansas is a bit of an outlier but Wal-Mart HQ is there, so its a bigger risk area than you'd expect given the travel involved with their private airport.

[@ruthmcbride1778]

Were the moms vaccinated in the third trimester as with Tdap?

[@jonnash5196]

The pregnant individual ? Did Dr Griffin mean to say the pregnant woman ? "Follow the science" ?

[@michaelr5606]

Imagine thinking virology isn’t a psyop. Keeping getting those injections folks. 😵‍💫

[@traianliviudanciu8665]

At TWiV 659 at min29 virologist Christian Drosten suggest that SARS COV2 better replicate at very low tissue temperature. Did we know at what tissue temperature new variants did replicate better?

[@katiehettinger7857]

National Institute of Health, Virology Journal and PLOS reframe the findings as, Elevated temperature inhibits SARS-CoV-2. 😉👍

[@traianliviudanciu8665]

May be must use more warmed oxigen mix at patients with SARS COV2 infection ,to avoid decrease lung temperature (?) May be ,even,,mask wearing,, increase upper respiratory temperature and theoretically diminish SARS COV2 infection (?)

[@Invitational2]

25:52. You mentioned the Thai Princess. Is this the same princess that was vaccine injured per chance?

[@afterbabel]

Has Doctor Griffin ever tested positive for Covid? I've been wondering for a long time...

[@DB-su5qp]

Has he ever tested positive for common sense is what bothers me

[@redhen689]

I don’t think he has.

[@theironslady3063]

He always sounds bunged up with a snotty cold

[@davidcottrell1308]

everyone's a critic. please. @@theironslady3063

[@robertabarnum9189]

What about RSV?

[@christopherrobinson7541]

Cases will appear later.

[@Invitational2]

So it’s not safe for 4 month olds, but it’s safe for babies yet to be born?

[@redhen689]

Absolutely. It’s antibodies from the mom that get passed through the placenta.

[@karenkaren3189]

Yes

[@Invitational2]

@@redhen689 why did they recently end the trial in pregnant women receiving the RSV? vaccine due to premature and still births? Same platform…

[@christopherrobinson7541]

@@Invitational2 The trial was not halted for those reasons, it wa so successful continuing the trial was unnecessary.

[@Invitational2]

@@christopherrobinson7541 is that the reason they gave that you chose to believe while ignoring all the premature and stillborn? Good on you.

[@wednesdayschild3627]

Heart attacks went way up in 2019 pror to vaccinations. Heart attacks had been increasing for the last 20 years. I think smog causes heart disease.

[@gribbler1695]

Obesity is ever rising too. Ref: State of Obesity 2022: Better Policies for a Healthier America

[@stormwalker321]

I experienced it. myself...cytokine. storm...heart comp;ications...otherwise healthy and young enough ...

[@markpetters9064]

Show notes 404 error

[@TheAtt22]

hello ... I've never commented this early. oooho

[@Invitational2]

This guy just his 7th or 8th injection people! I’ll be surprised if he doesn’t stroke out before the end of this podcast.

[@Henry-fk7cq]

I've had 8 vaccines. 2 Az, 5 pfizer & 1 moderna. You are wrong. The vaccines do not create clotting & strokes. That's the eventual fate of antivaxxers post covid. Your comment does not reflect reality.

[@karenkaren3189]

I’ve had six shots over the last 18 months and feel fine. As do everyone I know who is vaccinated

[@marklemont3735]

I have had seven vaccinations for COVID and since early 2020 and have been well.

[@wednesdayschild3627]

Do you count all your vaccinations? DO you count every illness you get?

[@georgeharrison6022]

​@@karenkaren3189do you remember them saying if you get the 2 shots you'll be fine

[@Invitational2]

2:38 malaria in Arkansas? Or just in the vaccinated?

[@marklemont3735]

With climate change the mosquitoes who carry malaria are moving more north over time.

[@wednesdayschild3627]

​@@marklemont3735Arkansas, Florida and Texas had malaria before ddt. When ddt is banned malaria comes back.

[@wednesdayschild3627]

How creative. Colorado has a high covid vax rate and no malaria. It is almost like miquotos like lots of water and hot weather. Who knew?

[@coda2475]

Lol what? Show evidence or get the fuck out. Thanks so much.