TWiV 1035: Poxvirus wars, warp speed COVID-19 vaccine rollout

[@lesfaby8997]

KZbin timestamps by Les MicrobeTV Discord Server MicrobeTV store at Cafepress 01:51 Research assistant position in Rosenfeld Lab CBER/FDA (pdf) 03:43 Impact of COVID-19 vaccination trends (Sci Adv 29:51 Poxvirus-activated anticodon nuclease (Sci Adv) 1:23:47 Letters read see www.microbe.tv/twiv/twiv-1035-letters/ 2:00:15 Timestamps by Jolene. Thanks! 1:43:13 Weekly Picks Brianne - Project Hail Mary 1:45:21 Rich - Bird Buddy 1:48:58 Alan - Blood, Sweat, and Pixels and Press Reset 1:51:23 Vincent - Are microplastics spreading infectious disease? 1:53:20 Listener Picks Tom - Henrietta Lacks family settles lawsuit Kathleen - Why Insect Memories May Not Survive Metamorphosis

[@msjellybelly55]

Most of the people who I know that chose not to vaccinate, lost their job. So yes, in our case a lower vax rate does equate to a lower socio-economic status.

[@winniecash1654]

And how many small family owned businesses went out of business because sales were down, or they were deemed non-essential and so were forced to close their doors? A lot.

[@mariacristinavelezmatta1833]

I do my best to join you kon twiv, I'm no scientist, and find myself drowning in for me strange terminology, but it's prefectly ok, I stay with the show! Thank you, i I particularly enjoyed tonight. Thank you

[@janakingking3022]

I’m so happy to find a new episode tonight. Can’t sleep and it’s like listening to a group of friends talk science. Thank you!

[@charlottehammond8975]

You used an exclamation point! Stop " yelling.

[@mariacristinavelezmatta1833]

I agree I feel the same - listening to a group of friends. Thank you TWIV❤

[@janakingking3022]

@@charlottehammond8975 wait, what?

[@charlottehammond8975]

@@janakingking3022 watch the episode.

[@juhichaturvedi8098]

Thank you for covering our paper in your discussions (SAMD9) at 29:51 pox virus activated anticodon nuclease.

[@pathakprabhat]

Congratulations on such a wonderful work!

[@andylewis248]

You guys can have my boosters 😂

[@Invitational2]

31:13 perhaps their sponsors didn’t like the initial title: “All the vaccinated people got pox viruses now!”

[@Virusesluna]

Science explains how things happen not why. Thank you Vincent and microbetv team for everything you do!

[@christopherrobinson7541]

Israel will be an outlier because there are two groups, one where almost 100% are vaccinated and the other (group) where the vaccination rate is 0%. With these groups they have declined the vaccine for ethnic and religious reasons.

[@1247.cccccc]

Will Pfizer share accurate data on the ratio of genuine mRNA doses and saline placebo?

[@tuberroot1112]

Vaccination coverage vs GDP: "it's practically a straight line". Yeah a scatter plot with massive spread is practically a straight line when you fit a straight line. You can fit a linear regression to any dataset. At what point is a cloud of data not a straight line then?

[@stormwalker321]

great show guys,thx! Off to wrk...See ya!

[@Invitational2]

You know who refused his vaccine in protest to rich countries getting more vaccines? WHO leader Tedros.

[@gerardaygun2115]

We should all be concerned with the endless lying about the consequences of the “vaccine”-induced myocarditis/ pericarditis occurring in young males. A recent study demonstrated that even though the child appears to recover from the myocarditis, special scans demonstrated permanent damage to the heart muscle. Several cardiologists have stated that these young men could be in danger of further heart issues later in life, which is supported by real science and clinical experience. Long-term studies are needed to truly evaluate the effects of these cases of vaccine-induced heart damage. There is a real possibility, according to some cardiologists, that such damage could years later include progressive heart failure, arrhythmias, and an imposed reduction in physical activity.

[@charlottehammond8975]

citation pls? not being sarcastic. i like citations so i can read for myself always and others prob want to as well

[@traianliviudanciu8665]

May be blood spread of lyposoms with mRNA can be avoided ,If after vaccination shoulder are not use some hours. To avoid deltoid muscle contraction,forearm can be suport like after shoulder sprain.

[@redhen689]

Did you happen to read about what percentage of young athletes who were found to have myocarditis after diagnosis with Covid-19? There was at least one based in Germany and one done on athletes from Ohio State University if I remember correctly. It was quite shocking.

[@christopherrobinson7541]

@@redhen689 The German study was very poor.

[@AlbertMark-nb9zo]

@@charlottehammond8975 - NIH pre-covid rate per 100k 1.9, from the vaccine 2.0, with covid 4.0, with covid and hospitalization, 226.

[@Jedi_Australia]

Two comments: (1) Transmission: You mention the study showing that vaccination early reduces infection. It would have been helpful for you to have discussed how that fits (if it does) with the general acknowledgement that vaccines do not prevent transmission. If they reduce (2) Even if early vaccination of a percentage of the population may reduce bad outcomes, the likely scenario is that elderly and vulnerable would be prioritised. On that basis you would protect the most at risk, but have less impact on those most likely to be walking around spreading the virus. So it’s not just important how quickly you vaccinate but also who you vaccinate first.

[@christopherrobinson7541]

The vaccines reduce the spread of the virus by reducing the period when the host is infectious. This has the same effect as other interventions. It reduces the time related effective R number Rt = R0 x (1 - i) where i the the intervention. During a pandemic it is unlikely that vaccines will be available immediately, hence the only tool available to reduce infection, is mitigation measures to reduce contact, eg; travel restrictions and lock-downs. The lesson is that such measure should be strict and introduced quickly.

[@1247.cccccc]

@@christopherrobinson7541 Get used to hearing the word NO.

[@TheChipMcDonald]

CDC numbers for new hospitalizations are higher than April 2022, June 2021. Positivity rate way higher. The ascendant curve looks like surges before. But we're not distancing, masking in groups?

[@FrancoisMouton-iu7jt]

I live in South Africa. We had low vaccination rates. It is estimated that only 28% of the country was vaccinated. We had a very low covid death rate.

[@christopherrobinson7541]

The low mortality is because of the low median age.With COVID-19 the Infection Fatality Rate (IFR) is a log function of age.

[@FrancoisMouton-iu7jt]

The highest mortality were those at 70+ with several severe complications which could have resulted in death and in many instances were falsely attributed to covid.

[@berylarmitage6930]

We should also remember that SA has a high HIV rate across the age board. I think SA did well because they did low vaccines.

[@WillNewcomb]

Recommended books: recently a mathematician and member of the UK Independent SAGE group, Dr Kit Yates, published the entitled "How to Expect the Unexpected". Goes into lots of detail about how we are prone to follow unreliable expectations about how things change, with particular reference to the pandemic. Peppered with practical illustrations. Also available as an Audible book. I'm on the second time around because it's so engaging and enlightening.

[@JillC]

On kindle it’s not out yet. I’ll read it when it comes out in October. Thanks!

[@christopherrobinson7541]

There is an ongoing study by the WHO/UN to estimate the number of COVID-19 deaths. This is reported at Our World in Data. The current estimate is 24M excess deaths.

[@hime273]

Not Covid Deaths.

[@christopherrobinson7541]

@@hime273 This includes both direct and indirect deaths caused by infection with SARS-CoV-2.

[@nemoest0]

Off topic: As a person fascinated with the weather (I live in Sweden so I can only dream of >25° C) I love that the guests always tell the temperature were there are. It makes me want to move/travel south.

[@maxheadrom3088]

Does anybody know if they have an episode about the Japanese Dengue Fever vaccine? Thanks!

[@WillNewcomb]

Speed of vaccine roll out: It is reputed that the UK had one of the fastest rollouts of the Covid jabs but it also has one of the highest deaths/million of most major Western European countries according to Worldometer tables.

[@dogblessamerica]

Can you take off the pre vaccine rollout deaths, it's obviously only post rollout that are relevant

[@WillNewcomb]

@@dogblessamerica Ah yes! UK pre vax deaths probably v high because of delayed lockdown and govt 'herd immunity' preference.

[@williamverhoef4349]

Antivaxxers like this little guy have great difficulty when there is more than one variable leading to a result. Poor things.

[@Ramiiam]

About a thousand Britons are dying unexpectedly each week, and not from COVID.

[@WillNewcomb]

@@Ramiiam Many probably Covid sequelae.

[@coronavirus831]

Hello Sir, May I ask you question related to Small Pox?

[@valmardon1183]

Any chapter about hpv?

[@WillNewcomb]

Choral singing: one of the most dangerous activities that you can participate in! We canceled our group singing classes when infections shot up in November 2020. Pity I know but I want to be able to sing again some time!

[@lw1zfog]

you’ve been mugged off

[@doroparker1702]

Why did you not go back one year ago? Which country are you in? Any pandemic ends after 18 months so I was told by a professor. A few very long time for something with the survival rate of 99,98 percent. 18 months are long over. Go back to your choir and sing as loud as you can.

[@nemoest0]

1:34:18 Sometimes patients want someone else to blame for their misfortune. I have fallen into that trap once, albeit less dramatic. Concerning anti-vaccine movement/people. I remember when the paper about a link between the triple vaccine (I live in Sweden, maybe it's called something else in other part's of the world) / the measles vaccine and autism in children exploded in the media. I was still in high-school so I don't have a complete recollection of the situation. What I do remember was media talk shows full of angry mothers waving stacks of papers and making angry accusations against the government and/or health care providers. -I can certainly understand the trauma of having a child that's autistic. Unfortunately there's no cure at the present time. I don't think there's a complete understanding of the etiology, the cause? Probably it's no one's fault? In a vulnerable situation you're looking for answers, it's understandable that you would want to blame some outside force or organisation - even when there might be no answer. People have been hurt by the SARS-CoV2 pandemic. Unfortunately some of them is misdirecting their frustration against the vaccine, backed up by this eclectic movement. What would have been the alternative response? Don't develop vaccines! In my opinion the US situation was aggravated by a less than optimal health care system, costing twice per capita (to compatible countries) with worse outcome - but that's another discussion.

[@Invitational2]

Why doesn’t your podcast ever compare vaccinated vs unvaccinated? Why do you always use contrived, manipulated, and misleading data and info. For your podcast?

[@deborahhebblethwaite1865]

Statists in 🇨🇦, a country of 39 million people are as follows. We have had 54,000 covid deaths to date of which 81 percent of these deaths were in care homes. That means 44,000 deaths I believe rounded off. That leaves the death rate of all,other people at .25 percent I believe. If we just concentrate on these elderly people improving their housing conditions I would hardly call this a pandemic. I was shocked to hear this because my country is falling apart from all these closures and paying people to stay home when we could have simply focused on these elderly people. Clean up the air with hepa and uv filters and pay people well to stay with these people during a pandemic say for a time period and having strict monitoring of,the new shift coming in to care for these people. And understanding these elderly folk are not the healthiest to begin with and trying your best to protect them and accepting life as it comes and stopping the blame game. I am done with covid. Dont even think about it and i am 70 and have had it twice. No need for further shots for me at this point. I wanted to listen to the poxvirus part of your podcast, enough of covid

[@F2a0bi0an5o]

The math is right, I checked

[@AlbertMark-nb9zo]

Which is what the great Barrington declaration was about and it's a fail. The population had no immunity in the first place. How many people were kept alive just because the passage of the virus was slowed. That services were maintained without heightening exposure. Think about momentum and kinetic energy.

[@1247.cccccc]

You possess a functioning brain and are not afraid to use it. Bravo. These malevolent creeps want covid back in earnest.

[@doroparker1702]

Yes, exactly. They make a thumbnail for clickbait and talk about covid. Again...

[@kevt6151]

Well your lying to us so you get what you get!

[@LS-kl6bj]

BTW, I don't know who made up the phrase "grace under pressure," but it at least goes back to 1984, when the (Canadian) rock band Rush released a studio album -- entitled "Grace Under Pressure."

[@markdawson3500]

i hope one day they invent search engines so you can find out where it came from.

[@MsJoaniesgarden]

Love the bird feeder pick. Reminds me of the "perfect" squirrel-proof feeder I made. I put a platform feeder bracketed to a pole with a funnel underneath. Four dowel rods fitted on the platform that would accommodate a five-gallon plastic water bottle. When I turned it upside down I would put a stick on the mouth that would trickle seed out. I made sure to keep it 12 ft. away from anything they could jump from.....Little did I realize I had "flying" squirrels. This must have been how they evolved?

[@LisaMartinez-ri6ve]

I am thinking of purchasing Bird Buddy as a birthday gift . Wish I had more info from Rich . Time to read the online reviews😎

[@eageralto]

@MsJoaniesgarden they are highly motivated problem-solvers! We had put a tube feeder with inverted cone beneath, on a 6' pole which we stuck into top of 3' fence post well apart from building and trees. Enter the Diligent Squirrel: it climbed about 30' up an oak (which was at least 15' away) and jumped down toward the feeder. Fell far short and went WHAP on the lawn. Climbed up again, jumped, WHAP. This went on sporadically for a couple days; the WHAPs continued but the squirrel was landing ever closer... then at last there was a CLANG - squirrel had succeeded in hitting the feeder but then fell off. A few more tries and it managed to CLING after the CLANG; and the feasting began :-D (The pole cracked open the wood post after a few more jumps - the repeated impact of even a very small weight can be significant given enough time)

[@lesfaby8997]

Hilarious Squirel Wrecking Ball short kzbin.infoRupUMJOEMO8 Rich was referring to Mark Rober's kzbin.info/www/bejne/nne9d52ljZeWfck

[@LisaMartinez-ri6ve]

Love those videos Les

[@WillNewcomb]

So much thanks to you all for communicating your expertise on these matters to the general public like me.

[@charlottehammond8975]

we have now diacussed methylation for a half hoir and no one has said what methylation is. methylatiin is adding a carbon (and ita hydrogens) to a molecule. acetylation is addinf two. methylation is an offswitch for DNA replication and an onswitch for some b (read: bacterially derived) vitamins and other enzymes that are called methyltransferases. yes, it is more complexthan that. but if you think of mwthylation as a +1 tag that signals a possible event, that is great foe thia lvl of discourse. example: HNMethyltransferase gets a methyl group from.folate that goes to b12 that goes to SAMethionine to methylate histamine in the lungs and marks it for degradation. then you breathe easier. hope that helps y'all who program

[@keithrobinson2941]

Fascinating discussion on the country analysis. Thanks for another great episode.

[@patriciahoke4722]

so glad to hear Vincent mention his interview with Desiree Townsend! As Rich notes, those stories are very powerful. Well done, guys.

[@maxheadrom3088]

9:30 And don't forget Cape Verde (Cabo Green ... hehehe)! It's really beautiful, the capital is called Beach (Praia) and the people are amazing and really beautiful.

[@patriciahoke4722]

That was a very nice letter from the artist!

[@jact8350]

I always appreciate the podcasts. I listen to at least 4 a week. Thank-you

[@tinobemellow]

I really wish I didn't see that thumbnail, but thanks.

[@donnamunro2090]

I keep hearing that sixties dance video voice...TRNA...TRNA...

[@DonedHiga]

If the facts don't fit the theory, change the facts.

[@ledaswan5990]

If you’ve ever heard Bret Weinstein and his Darkhorse Podcast you’ll here a classic example of that. No matter what facts he is presented with he will twist it to fit his theory’s . He’s a 3rd rate ex college professor and wouldn’t even be worth mentioning except that he’s extremely popular.

[@TubbyYoungbrosArmy]

What are you referring to?

[@kenmfrancis]

@@TubbyYoungbrosArmy they just troll TWIV’s somewhat regularly. I wouldn’t expect a clear answer.

[@1247.cccccc]

@@ledaswan5990 Read your comment again in a week, numbnuts. You have a problem with Weinstein's theories?

[@Sceince01]

@@TubbyYoungbrosArmy Donedhiga is a member of the association of the dumbest and the dishonest - the antivaxers . Don’t expect reason or facts .

[@terenzo50]

Is there a scientific/toy manufacturer pumping out little colored plastic amino acid components for use in classrooms in the style of Lego?

[@maxheadrom3088]

I have a question: in the COVID19 pandemic, wealthier countries got the vaccine first. Based on the little I know about optimization, I think poorer countries should receive them firstly. Also, among the poorer countries, the ones with the worst public health system should receive them before the others - but their governments should not be in charge of the immunization process. My reasoning is that viruses spread faster in poorer countries and kill more in badly managed poorer countries - and since most of the world population is poor, the chances of variants arising is greater.

[@jedadruled984]

Richer countries have the vaccine first and poorer countries have them later. Richer countries have the most covid death, while poorer countries have less death. How could that be ?

[@christopherrobinson7541]

@@jedadruled984 The poorer countries have much younger populations and the Infection Fatality Rate (IFR) of COVID-19 is a log function of age.

[@jedadruled984]

@@christopherrobinson7541Yo, but natural immunity works better.

[@highlandbob2470]

Can you really expect an honest answer to that question? I’m serious. So much bias on both sides of the argument.

[@jedadruled984]

@@highlandbob2470 Poorer countries were lucky to escape the attck with sum genetics in lipifs going every where in the body. Lipid nanos enter the brain, the liver, heart, ovaria and testis and start producing their toxic spikes. Spreading the spike army of destruction. Nice.

[@PawPancha]

Nev ADD A. Not Nev VAH Da. Thank you!

[@maxheadrom3088]

44:20 Stephen Jay Gould and his friend are feeling happy up there in Heaven.

[@donnamunro2090]

Baron Samedi...Nine?

[@markgivens3225]

What are the chances Rich’s favorite paper was generated by an AI author?

[@jeanineh1035]

The part about why people believe antivaxers and what is the benefit to them. Starts about 1 he 36 mins . Can you have your girl name a tiktok about it. This is GOLD!! I have never heard it this well summarized. Thank you ❤

[@CKWong-jk5st]

Great talk and discussion as usual. The speaker from Austin, Texas misidentified UT Southwestern as from San Antonio. UT Southwestern is at Dallas. How could an Austin scientist make that mistake! I am scratching my head. I am afraid that some people from UT Southwestern might be offended.

[@methanial73]

People aren't perfect?

[@CKWong-jk5st]

@@methanial73 Of course, people are not perfect. I guess you are not a Texan, or a Texan who is not in the science and medicine community. UTSW has a towering status and reputation. They were called "the Harvard of the South", which they justifiably resent. They would say, "Harvard is the UTSW of the north." Researchers at that institute have received 6 Nobel Prizes in the last 35 years, and at least 3 more Nobel Laureats had performed trsearch and taught there. Its medicine department has produced head of departments and facutlies now spread out all over USA. If one is in the science and medicine community in Texas, it is no way that one would not know about UTSW. Maybe his brain got cross-fired that day twice. Who knows. BTW, I am not and have not been associated with UT Southwestern and do not have relatives or friends associated with that institution. No potential conflict of interest.

[@methanial73]

@@CKWong-jk5st making a mistake has what to do with being Texan? Don't you think that's a silly argument? 🤔

[@CKWong-jk5st]

@@methanial73 The speaker being a scientist from Austin, Capital city of Texas, one of the 4 major cities in Texas (Houston, San Antonio, Dallas, Austin.) Everyone in the science and medicine community, everyone knows about the other institutions in the state, and frequently has friends, accquintances, or colleagues in other instutions in the state. Researchers and doctors from all these institutions would meet in state conferences and regional conferences. Scholars and investigators from different institutions frequently collaborate with each other. There are always guest lecturers and visiting professors from other institutions in the state. Many graduates from one institution go on to do research or practice in another institution in the state. It is a very vibrant, competitve, yet very cordial community, a lot of inter-institutional competition and exchange. How do I know? I was in this community before I retired several years ago. No one from UT Houstom or Baylor College of Medicine in Houston would not know of UT San Antonio, UTSW...etc. and vice versa. I have no connection to UTSW and I am certainly not partial to Texas for various reasons. My education and training were all over the place in USA.

[@luismatheu4226]

Float my boat... Dude you got me laughing all Day 1 hr 20.min.

[@WillNewcomb]

Oh dear... I've used exclamation marks too often. Didn't mean to shout...

[@F2a0bi0an5o]

Don't worry, nowadays shouting IS WHEN YOU TYPE LIKE THIS

[@maxheadrom3088]

Very august commentators! The fact the comments were recorded in August has nothing to do with that, btw. (the word is more common in Portuguese and is in the Hymn to the Flag. I should check some English Dictionary becore clicking comment, though ... done)

[@onisillossekkides9005]

On the point of hoarding vaccines, many of us were pushing the argument of enlightened self-interest from the outset. But high-income countries weren't listening. And, given political cycles favouring short-term thinking, I think it's unlikely that they'll listen even with the study you highlight.

[@MsSherryl01]

The kind the govt creates and rolls out for the people.

[@fyouman7]

Jaja

[@patriciagiles5833]

What virus did the government create?