TWiV 1108: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, and H51 influenza infection of birds, poultry and cows before and SARS-CoV-2 circulation, before discussing if the original monovalent SARS-CoV-2 vaccine was effective in children and adolescents, how to use words to properly describe respiratory pathogens the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of remdesivir reduces mortality, long COVID, persistence of virus infection during long COVID and it prevalence. For more information about this body of work, listen to TWiV 1088.
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[@WillNewcomb]

Ah! No Saturday is complete without Vincent and Daniel! Thank you!

[@DrTonyaBreauxShropshire]

@WilNewcomb very true 😊

[@kathrynmcgrew8173]

Agreed. This is what I'm listening to on my birthday.

[@WillNewcomb]

@@kathrynmcgrew8173 祝你生日快乐 Zhu ni sheng ri kuai le. Happy Birthday 🌹 🌹 🌹 Keep safe!

[@tonaruch8623]

Thank you Dr. Griffin for sharing your time with us even on your family vacation

[@WillNewcomb]

Cost of installation of ventilation and masks etc: How about following the old tradition of opening the windows and enabling patients to be outside if appropriate? In January 2023, my 91 year old mother-in-law was hospitalised (ER/ICU) here in China with C19 where EVERYONE was wearing N95 AND most windows were open despite it being the middle of winter. Patients kept warm with quilts/duvets.

[@WillNewcomb]

@@gferraro8353 Brilliant! Same here! The problem comes when it's so warm we need to put the a/c on. But we do have an air purifiier on 24/7.

[@DeannaPiercy]

I recently purchased a Co2 monitor and what an eye opener it has been. I discovered that our upstairs bedroom has very poor ventilation even though it is a large room and the downstairs is fine. Turns out that those elevated Co2 levels were contributing to my restless sleep and morning headaches. Leaving the balcony door open a few inches as well as our bedroom door (we used to close it at night) helped a lot.

[@circa1890]

Yeah, N95s and great ventilation has stopped me and my friends from being infected thus far. Important as we learn the ever-increasing issues that Covid 19 presents after infection. 😢

[@olgatuzkov4882]

Hi The music is too loud

[@MrKaidman]

Ty for keep doing theese ones

[@WillNewcomb]

AMA just put out a fascinating interview with Akiko Iwasaki on the potential origins of Long Covid. Not heard from her directly before.

[@randmorf]

A grackle is a black bird (picture a thin crow) that is native to the southern States like Texas. We had them in Houston Texas when I lived there as a kid.

[@wednesdayschild3627]

The oldest tree is there in Yosemite. It is a bristlecone pine called the Methuseleh tree. The Location is secret.

[@traianliviudanciu8665]

Even intramuscular injection must be relearned,to avoid blood spread of liposomes with mRNA

[@razerginn]

Yosemite is an awesome place!, is this Dr Gs first trip?

[@WillNewcomb]

I have happy memories of visiting Yosemite back in 1975 when I was hitch-hiking around the US/Canada. I was younger then haha!!!

[@stonecookie]

Cooking should kill H5N1 in cow meat but not everyone has the same culinary practices. Some people like raw meat. I hope @CDC and @FDA consider an advisory against steak tartare and uncooked meat, and undercooked meats. The thicker steaks take longer to cook. Temperature exposure times for thermal deactivation of H5N1 in cow and other meats for consumption are still not clearly spelled out.

[@5955yt]

I have had 3 Pfizer shots, primary series in 2021 and 1 booster. However as time has gone on and we learn more and more the potential dangers and now as we see, low effectiveness I have changed my view 180 degrees. These shots should never be given to children, and this study reinforces this view.

[@WillNewcomb]

For further comment: today I read about a study showing Covid virus survival lasted longer in the air where CO2 levels were high!!!

[@riok6234]

@@gferraro8353 Please provide a link to the study you are describing.. I would like to check it out. Thank you

[@Rene-uz3eb]

Here is an old paper with the interesting observation that a sars coronavirus flourished in a low humidity AC type environment. Low humidity is also common in heated homes during winter. The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus, 2011 But in general different viruses survive better at different humidities and temps.

[@WillNewcomb]

@@gferraro8353 Yes it was a study. Unfortunately I didn't save the link.

[@WillNewcomb]

Uni Bristol Physics Dept, 26 April 2024 "A new study has revealed for the first time the vital role carbon dioxide (CO2) plays in determining the lifespan of airborne viruses-namely SARS-CoV-2, the virus that causes COVID-19. It clearly showed keeping CO2 levels in check helps to reduce virus survival, and therefore the risk of infection."

[@HeatherOrdover-CraftLit]

Does that mean if HVAC systems add a “CO2” chamber/filter/wash, that could help remove active virus from indoor air? I’m interested-what are the ways this info can be applied?

[@CraigCounterman]

To me "droplet" = liquid, while particle is solid but could include liquid. Certainly I'm used to pollution stated in particles and particle sizes. So particle sounds more general a term to use.

[@Ahm.nae-fou]

Sorry if this is a dumb question but does cheese made from raw milk carry the same risk as unpasteurised milk?

[@gribbler1695]

There are many cheeses made from raw milk, such as camembert and roquefort. It's an FDA requirement that they be aged for at least 60 days, which prevents listeria, salmonella, E. coli and other harmful types of bacteria from growing.

[@DrTonyaBreauxShropshire]

Thanks!

[@simongordon8182]

Nearly to episode 1111

[@WillNewcomb]

What? No bowtie???

[@luismatheu4226]

Ok would the pausterized milk serves As a oral vaccine?

[@luismatheu4226]

How about also. Look for viral proteínas?

[@traianliviudanciu8665]

May be, warmed oxigen mix can be more effective If SARS COV2 infection and if Covid19 occur at patients with cryoglobuline ?

[@justleif7]

You *sorta* touched on this, but isn't it true that ANY human infection from a virus of domestic animal origin GREATLY increases its ability to make the jump to a much greater degree of virulence. Viruses are programmed to mutate rapidly and only require an environment that favors adaptations that enable spread? [ps. the recent JAMA has a bit on H5N1 human infection from cattle.]

[@MNP208]

Black is a good color on Daniel! We are used to seeing him in white!

[@kathrynmcgrew8173]

Nice John Muir quotation here.

[@KOSTASTSATSARIS]

Black makes everyone including Daniel look slimmer lol

[@traianliviudanciu8665]

May be hyjaked cell with SARS COV2 use more Zn ? May be decreasing level of Zn using chelating agents can mitigate SARS COV2 infection ?

[@justleif7]

this is already well researched: in short "no."

[@traianliviudanciu8665]

@@justleif7 did You know that some vitC vials for parenteral use can contain EDTA ?

[@traianliviudanciu8665]

CaEDTA was used to chelate metals also

[@traianliviudanciu8665]

Only injected vit C had some effects in Covid19. Why? May be because some chelating substances used to preserve ascorbic acid for parenteral use

[@traianliviudanciu8665]

If hyjaked by virus cells use more Zn to replicate viruses ,interstițial Zn level decrease

[@proudchristian77]

Hi & good morning, ☕️🍯🍶💝🏝

[@donnamunro2090]

When you read XKCD, don't forget to check the alt text by mousing over the comic - there is always one more joke in there.

[@traianliviudanciu8665]

Can learn to boil milk

[@karenkaren3189]

Just buy pasteurized milk which means milk in grocery stores! No need to boil it

[@georgeharrison6022]

​@@karenkaren3189no need to drink pasteurized milk. If your gonna drink milk (for nutrition) drink raw milk or don't bother

[@sobraine123]

you do not have to boil milk to pasteurise it

[@traianliviudanciu8665]

Boil can be better ,but must learn to boil milk

[@sirloin869]

r they, to...

[@cyberbob4111]

Daniel should forget his bow tie more often, looks much better!

[@traianliviudanciu8665]

Pasive immunisation sound better

[@Zeden2010]

I heard Chicken Pox was also on the rise... 🥺