TWiV 1127: Giving prions the (zinc) finger

TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor's subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor.
Show notes at www.microbe.tv/twiv/twiv-1127/
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[@lesfaby8997]

_KZbin timestamps by Les_ 03:28 microbe TV contributions are US tax deductible 27:03 Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints (Nature Comm) www.nature.com/articles/s41467-024-49758-0 44:17 Why we need to know what viruses are in nature 45:31 Brainwide silencing of prion protein by AAV delivered epigenetic editor (Science) www.science.org/doi/10.1126/science.ado7082 *Your correspondence answered by scientists* see microbe.tv/twiv/twiv-1127-letters/ 1:12:15 Mifi 1:22:56 Anthony 1:24:00 Walt 1:30:15 Craig 1:31:06 Sarah 1:33:40 Anil 1:35:39 John 1:51:08 John 1:40:15 *Picks of the Week* Dickson - Mars Odyssey Orbiter is about to make its 100,000th orbit Alan - Local animal shelters and “kitten season.” Vincent - Supreme Court allows cities to ban homeless people sleeping outside, even when shelter space is lacking 1:50:46 *Listener Picks* Blog design - Trump vows to defund schools requiring vaccines for students Jon - Detections of highly pathogenic avian influenza in mammals 1:52:30 please support science edutainment _Audio podcast timestamps by Jolene. Thank you!_

[@lesfaby8997]

Also, there is a news segment before the first paper is discussed. 1:34:56 en.wikipedia.org/wiki/Duryea_Motor_Wagon_Company Dr Paul Offit interviewed (PBS NewsHour) kzbin.info/www/bejne/eoOtf3ptj6mHY6M

[@LisaMartinez-ri6ve]

Thank you Les

[@lobby5t]

This is huge. I am so amazed. I’ve been reading and following prion disease since the early books on Kuru. I’m stunned that the likely connections with Huntingtons, Parkinson’s, etc, creates unbelievable advances in treatment of so many neuro-degenerative ailments. Getting up tomorrow will very exciting! Thank you so much❤💕

[@DudeFun-yi7nu]

Nothing better for the health of my brain than a TWiV session, thank you

[@queenofshebapractitioner9587]

Excellent just found you n subscribed with alerts. ❤🙏🙂 thanks good job.

[@kahae9858]

The Pentagon's actions were just shocking. Completely unprincipled. I'm grateful to Microbe TV for highlighting this news. What else is going on that the public don't know about? What sort of country is the US becoming?

[@fyang1429]

Just another intelligence agency thing. The US and lots of other countries have been doing those when they have the means for decades if not centuries.

[@stormwalker321]

Thank you...Allan , Dixon and Vincent - you guys are cool cats...:) smart too!!

[@WillNewcomb]

I'm a member of the great unwashed - retired engineer with zero medical background. But I listen to TWIV & some others (Dan Wilson & Susan Oliver). Could I be better informed about the pandemic than most GOP Congress people?

[@gferraro8353]

Great Twiv episode !

[@MZ-mn9fl]

So interesting!

[@ehfik]

that fish soup joke at the beginning, chefs kiss!

[@WillNewcomb]

'Gain of function': Vincent's first Virology Lecture explained that virtually all virus research involves GOF.

[@alijawad2042]

Thank you very much . I suggest Dr P Hotez for the next guest.

[@Rene-uz3eb]

Prions: it could also be reduced expression of heat shock proteins that help in folding prions

[@mrvzhao]

Wow, silencing the promoter of the prion gene sounds so much like commenting out a snippet of computer code.

[@WillNewcomb]

Returned to China after a month in UK. 28°C and raining everyday.

[@Northcountry1926]

A ban on Gain of Function ? … Nuts 🤪

[@millieortiz-vk5qq]

It is all about making a cure for all mRNA vaccine, including cancer, which is a noble reason; apparently, they have forgotten that cancer is not caused by a foreign pathogen and training our immune system to attack our own cells causes immunodeficiency, unfortunately.

[@stanleysokolow]

Another potential application for this targeted gene silencing technology could be for turning off the gene that causes the human liver to produce the Apo(a) protein that binds to LDL particles. The resulting particle is called Lp(a). Estimates say that about 20% to 30% of the population has this adverse lipoprotein particle. Lp(a) is highly atherogenic and thrombogenic which causes some heart attacks and ischemic strokes. Statins don't lower Lp(a) concentration and may increase it. Primates and hedgehogs apparently are the only mammals that make this perverse Lp(a) particle.

[@anthonyrstrawbridge]

The opthalmologist was both clear and concise.

[@jpaynter149]

Could the warming climate and change in atmosphere affect these viruses and their ability to infect other species that had been resistant to a virus?

[@ehfik]

the pentagon did what? im afraid humanity is past any rescue...

[@CraigCounterman]

AAV as Adeno-associated viruses always glitches the parser in my brain because other podcasts I listen to talk often about African-American Vernacular English (AAVE)

[@traianliviudanciu8665]

Curiosity and dreams without responsability are childish features

[@lohphat]

With every passing day, Idiocracy is becoming policy. I look forward to my offshore retirement in Europe.

[@nottooherbal]

Hannibal Lector might be hiding behind the mask.

[@traianliviudanciu8665]

If dreams prevale and precaution decrease catastrofic effects can occur

[@jpaynter149]

Blame the movies. People buy into the narratives presented on screen regarding labs and virial infection, etc.and think this is proof surrounding science that there is a ‘conspiracy’ or danger to humanity…labs are a result of humanity wanting to understand and protect humans through knowledge…do better…and see it coming. Let’s keep the headlights on and keep sci-fi out of labs and studies.

[@millieortiz-vk5qq]

The gain of function, I understand, is to use the normal functions of DNA synthesis to carry a chosen genomic sequence into the cells' cytoplasm. The end results are SARS Cov. 1 and Cov-19.

[@PifflePrattle]

37:56 Surely not Dr. Racaneillo. I'm sorry but I just do not believe you.

[@JimbeauxGo]

New government administered IQ test: U.S. Food and Drug Administration officials, acting on advice from their advisers, recently directed vaccine manufacturers to produce COVID-19 vaccines with updated formulations. CDC advisers earlier Thursday unanimously advised the CDC to recommend the forthcoming vaccines to virtually all Americans, even though no clinical efficacy or safety data are available for them.

[@helengarrett6378]

I grew up in a time when women who were intelligent and showed it were told they would remain unmarried for life. Yes, I was told that men prefer docile, simple women and should not take a science course. Anti-intellectualism is nothing new in America. It has taken many form, sometimes misogynistic and sometimes religious, often both. With the rise of Christian Nationalism in our country antiscience norms have become common again. What I am trying to say is that a modern variation of the dark ages is not inconceivable if some beliefs become more generally accepted than provable information. What is taught in our public schools is constrained in some areas of the country and in some communities. I was taught in a public school that though the curriculum in my basic biology class required teaching about Darwin, that it was just an incorrect theory. My science teacher taught creationism as a viable alternative theory. She continued to teach this dual theories curriculum until retirement. That kind of deliberate antiscientific and belief based thinking is again a growing phenomenon and it affects all of our lives in many ways. Anti-gain of function legislation is just another manifestation of dangerous social engineering by the growing Christian Nationalist trend in America. It's dangerous! Science cannot be isolated from politics in this day and age. Activist scientists are essential to our survival as the environment changes and research is throttled by politicians who don't have any idea what they are doing. Activist Supreme Court Justices have just hamstrung various alphabet governmental regulatory agencies that employ scientists and other experts who have regulatory authority. Scientists must become activists to remain free to inquire in these more strident anti-intellectual times.