TWiV 977: Ageing is infectious

[@lesfaby8997]

KZbin Timestamps by Les (under construction) 02:28 Job with Dr. Amy Rosenfeld 03:10 ASV meeting deadlines 04:15 Discord Channel see shownotes 06:13 Sars-CoV-2 infection and persistance in the human body and brain at autopsy (Nature) 29:51 paper 31:56 Humans and others have retroviruses integrated into our DNA (8% of it!) ERVs(endogenous retroviruses), in humans HERVs, in pigs called PERVs Progeroid means "resembling premature aging" Werner syndrome (WS) is an example 36:30 Brianne: senescence cells general epigenetic de-repression so demethylated 39:17 FISH defined 40:19 a HERV gene getting taken out of storage and activated HGPS is Progeria, also known as Hutchinson-Gilford syndrome Progeria is premature aging RVLP is a retrovirus-like particle Website audio timestamps by Jolene. Thanks.

[@camresearch5120]

Thanks Les

[@TheButterflyGirl7]

Thank you! 😊

[@StoryThyme100]

So appreciated!!!

[@tonaruch8623]

Thanks!

[@erik_carter_art]

This was such an interesting episode! I never told you this, but before I became interested in viruses, I actually thought I wanted to go into aging research (I still follow the field closely because it's so exciting). Actually, David Sinclair's lab at Harvard Med just released a paper this month outlining a new 'Information Theory of Aging'. The proposal is that epigenetic changes in the genome may be a main cause of aging, rather than mutation. They set up a mouse model in which they could induce systemic non-mutagenic epigenetic changes, and these mice age considerably faster than littermates that didn't have these changes induced. It seems to me that endogenous retroviruses could be contributing to aging in this manner.

[@nancyhope2205]

Here in Quebec, -2C is really not bad. Once you have been through really awful cold weather it seems balmy. Every year we go through the adjustment to cold so much that a 5C makes us think of shorts and bathing suits. It really seems warm!

[@lismartinez5363]

Thank you as always TWiV team. Snowing here on this Sunday morning which is Lovely. Lis

[@JohnAMozzer]

Loved your report on “Resurrection of endogenous retroviruses during aging reinforces senescence”. And may your ERVs remain silenced in this New Year!

[@briancase6180]

I've been away from twiv for a few weeks, but I just have to comment that Dixon seems to be feeling back to his old self. Thanks to the twiv crew and supporters. 👋✅

[@aaronshure3723]

This is like jazz to me, I can't make it, don't understand most of it, but I enjoy it

[@lismartinez5363]

That was great- made me smile.. I need to remember that. I too love jazz .

[@Turtledove2009]

Excellent analogy!

[@dmwgoogled]

From or with Covid-19-- complicated situation: Have seen patients who fell and had a fracture followed by surgery but post onset symptom of weakness with GI/urinary symptoms or upper respiratory symptoms and weakness found in hospital to be RAT or PCR positive. The illness that setoff the sequence was Covid-19.

[@lesfaby8997]

IMHO, you must be looking at the paper to understand this episode.

[@silentrunner3067]

Autopsy are required in some circumstances, depending on the state. It can depend on location of death, not necessarily on any other factor.

[@minRef]

8:35 -21:55 Oh how the turns have tabled.

[@Turtledove2009]

Vincent, PASC is brought up because active research is being done to investigate this troubling situation. It is not a laughing matter. This research must continue.

[@lisalisa20907]

Nature Favors the Young: post-reproductive pressures explanation really helped me understand this paper. Thank you! Super interesting. Also, good to know, vampirism isn’t a realistc plan.

[@sbartdbarcelona44]

Brilliant episode! Thx you

[@v.johnson1810]

Autopsies are automatic below a certain age - 47 or 50, I can't remember.

[@luismatheu4226]

Hi. Great episode. b galactosidase known as lactase....as mammals we do digest lactose...but some as age or get older are lactose intolerant. Not all but Nice example for studyng getting old. Do virus scenece? Are there epigenetic signals in viruses?

[@tonaruch8623]

Interesting

[@dx5018]

I still wasn't infected with Covid-19. I would like to be protected from this disease when I have to go to hospital for another reason. I hope that there is a kind of protected area in the hospitals for people like me!

[@patriciagiles5833]

The last protocol in place for my local hospital in the US is test every patient on admission. Unsure if inpatients are tested during their admission. Separate all positives, asymptomatic or mildly symptomatic *with* COVID from the negative population & use respiratory droplet precautions. The few negative pressure rooms are only in the specialty units in our local hospitals.

[@patriciagiles5833]

You might want to see about using a properly fitted N95 or higher type PPE respirator just in case you need hospitalized.

[@allcoppedout]

Vince and all - thanks . Helped me stay moderately sane during the official advice of "wash you hands" and other duck and cover patronisation buffoonery [we're brits].

[@zyzzyva303]

So, can we CRISPR out those sequences if the HERVs are a mechanism for inducing senescence?

[@simoncelt5590]

Oh lord, there’s discord now. Party time coming

[@robertcox14]

Could advancing "neuropathy" start with dropping things and clumsy fingers?

[@robertcox14]

Adding, could advancing neuropathy be contagious from other seniors losing their flexibility and micro-muscle movements?

[@doreeno3792]

Fun title!

[@traiandanciu8139]

If SARS COV2 better replicate at very low tissue temperature,may be hypothermia must be avoided at Covid19 patients,to avoid persistent infection? May be even oxigenotherapy must use more warmed oxigen mix in case of SARS COV2 infection?

[@simontemplar404]

Some interesting stuff 3/4 of the way through

[@francescachristy8761]

I know several people who developed long term ME after flu.

[@Bogusuap]

-9 c Front Rage Colorado we are getting lots of snow

[@shipswithoutsails]

Great work, but who has 1hr45mins available to listen to this?

[@Kannot2023]

Can you put some captions, for a layman, it is not interesting to know the minutia of work with viruses.

[@Clem62]

You can autopsy me as long as you tell me the results.

[@vaxman8328]

I don’t recall seeing Dr. Rich Condit lately. What’s up?

[@silentrunner3067]

CDC has a table listing, by state, what situations require an autopsy.

[@anymoose6685]

Nah, the spleen and liver and head and heart pain was terrible in that deadly 3rd week.

[@anymoose6685]

Also, watched a covid patient die with terrible spleen pain early on, not respiratory distress. It gets other organs too. Everyone has been distracted by the respiratory failure.

[@PLERF]

Baritone sax? OMG Serge Chaloff was the Bird of Bari. No shade on Mulligan.

[@norman_5623]

If you had windows, you would hear trucks and sirens in the background.

[@stormwalker321]

Canada is ..the True North...:)..Right on!...Great Show...!Thank you!

[@OldOneTooth]

Good form Dixon.

[@drunkensquirrel7545]

Infectious, and darned sure not for scaredy cats! 🤣

[@jackiechance795]

The spirit is in the blood.

[@tonaruch8623]

I’d like some abracadabra on my stiff and painful hands

[@biologySoon]

Look at the people already taking the drug.

[@rogerplumer6331]

I refuse to tune and give over time in my life to hear any further announcements of Dr. Rosenfeld's job openings - you utterly offend my sensibilities. I doubt I'm alone in feeling this way, Eh?

[@bourgoisereader]

Can't say it bothers me for a few seconds

[@vaxman8328]

Maybe you should ask for a full refund.

[@Henry-fk7cq]

You aren't the only one.

[@patriciagiles5833]

Utterly offended over less than a minute of your time? Lol okay drama queen. Keep your fainting couch nearby incase you get the vapors.🙄

[@bourgoisereader]

You can skip it if you want

[@indianasb59]

Is this a drunk challenge? Some of the panel seem to need some help.

[@sallystubbs7417]

While I appreciate the valuable information you provide, I STRONGLY suggest you shorten your podcasts. I have forwarded to friends, who say “Thanks, but I don’t have anywhere NEAR that much time!” For example, on this program, it was SIX MINUTES before you got to the subject. You talked about snow, snow removal, temperature, windows, research assistant, Amy’s text message, etc…all nice chitchat but totally unnecessary for your AUDIENCE. Save the chitchat until the end so the audience is spared the wasted time. (Sorry, but everyone I know is BUSY and RUSHED.) I also suggest you break up programs into shorter segments when possible, recording 2 or more related programs. I’m interested in the information you provide, but most days, don’t have 1+ uninterrupted hours…and I’m RETIRED!!

[@MihaelaFroehlich]

Use Timestamps! See the pinned comment.

[@Everybodylies13]

Timestamps pinned at the top.

[@lismartinez5363]

I would like to respectfully disagree. I listen in sections. Love the chit chat and then science. I use the time stamps also.

[@patriciagiles5833]

Moderator posts the timestamps in comments shortly after upload for those who want to skip over the chit chat and whatever doesn't interest them.

[@tonaruch8623]

I disagree. I have come to think of these scientists as my pals. I appreciate the chit chat. How about you listen to the beginning at double speed?

[@jpenneymrcoin6851]

that baritone just sounds faked.