Voltage Gated Calcium Channels Part 1

[@danielmcelroy3]

This really is amazing ... thanks a lot!

[@haiderahmed9074]

do you know anything about r type channels? i am trying to find out more about it but dont seem to be finding any luck.

[@jackson32]

Does magnesium block these VGCC's? Which type does it work for?

[@curtiskline8214]

Bay K 8644 is in fact a Calcium channel agonist, I think L-type selective. It also increases the tail current amplitude.

[@curtiskline8214]

Okay did abit of digging and Bay K 8644 is both a DHP agonist and antagonist, but dependent on the isomer (S-) is the potent activator and (R+) the potent antagonist.

[@johnstillman2935]

another know it all heard from .

[@johnstillman2935]

why have you changed the playlist ? it's a little confusing .

[@MsTommyknocker]

I don't understand, if there is always a battery restoring the electrical potential how can the voltage gated channels be activated??

[@christinedonohue7555]

There is a stimulus that temporarily depolarizes it, the battery then takes some time to restore the potential back to -65

[@MsTommyknocker]

If there is no net current, then the voltage must also be zero according to V = I*R

[@tamkakit1233]

Bay K8644 is a calcium channel opener

[@romeolhk1008]

Thankyou, clearly presented. btw are you from England?

[@gayathrijinesh3004]

Of course he is.

[@MsTommyknocker]

Wouldn't the electrons just "try" to restore the electrical potential to zero??

[@a1sharp65]

I think that the electrons will try to restore the equilibrium potential for the cell (found using Nernst/GHK equations, considering concentration gradients and electrical gradients together) - usually around 65mV

[@wobina]

Thank you!!

[@zuhair1952]

bad presentation.