This video explains how voltage-gated sodium channels work in neurons, and how they influence the shape of an action potential graph. Animation and voice-over by Laura Slusser.
Пікірлер: 91
@kevinbaker1253Ай бұрын
Neuroscience student here. Very well explained. I didn't quite understand what was causing the directionality of an action potential so I'm glad I watched this.
@ayeshajameel7263 жыл бұрын
OMGG THIS VIDEO IS SUCH A SAVIOUR. THANKYOU SO MUCH FOR YOUR EFFORTS. PLEASE MAKE MORE VIDEOS!!
@abolfazlmahdavifar59966 ай бұрын
Very clearly explained. Thank you ❤
@iNireus7 ай бұрын
I’d like to see more. Love seeing how they worked. Trying to visualise how densely packed they are with each other and if there is differing density’s on the axon, maybe more near the end?
@thesixthcourier5 ай бұрын
Great animation and explanation - thank you for spreading your knowledge!:)
@ziemekz23033 жыл бұрын
Yes! I would like to see more videos, especially about different types of Ca2+ (low threshold and high threshold) and K+ channels :)
@amolharsh73753 жыл бұрын
Easy and simple explanation. A1 quality animation 👍
@medicostudy1012 жыл бұрын
Please please if possible make a video on Class 1 anti arrythmics too. With all the details of how they act on open and close state of sodium channels in myocardium. much needed!!!
@hookem37682 жыл бұрын
This video was crystal clear. Thanks.
@fidosa83823 жыл бұрын
this animation has helped me a lot. thanks!
@user-jj1pw1cz9p Жыл бұрын
thank you , please make more videos .. All my respect for what you are doing..
@saicharansaini69092 жыл бұрын
Every professor should you this video in their class
@soranary12822 жыл бұрын
It was such a unique incredible and amazing explanation can't say how much impressed by this video well done ✅
@djbslectures3 жыл бұрын
Beautifully done and explained! Thanks!
@mixtomanner88942 ай бұрын
Thank you and yes please more of this. I would like to know more about theee other channels!
@_DR._ABHAY Жыл бұрын
Very nice
@prabhakarmanikantan60582 ай бұрын
So it's basically Electrical Engineering Control System. It's amazing to see that engineering starts from the human body itself or otherwise a Human body is a perfectly engineered system
@s.u.k.k.u87652 жыл бұрын
This video is absolutely amazing…thank you so much 🙏🏻
@munimulislam59383 жыл бұрын
It is very helpful and comprehensive vedio as I was confused about Na+ voltage gated channel
@ece24712 жыл бұрын
A Great Explanation
@s.papadatos67113 жыл бұрын
I can't believe that, 2 years already in medicine and it's the first time i come across with such a complete and comprehensive illustration of those channels. Thank you...and please make more videos. Instantaneous subscription!
@JalalOsamaa2 жыл бұрын
absolutely agree
@Bizblitz282 жыл бұрын
great video, very helpful
@YanivKadosh553 жыл бұрын
Thank you, very informative in a 4 min video !
@onii-chan486 Жыл бұрын
I always knew there was a gap in my knowledge regarding how the membrane potential is initiated. Textbooks do a bad job explaining that there are actually sensors that can sense changes in membrane potential... Thank you for your complete explanation!
@raenxyoung3 жыл бұрын
Best explanation
@syncole773 жыл бұрын
1st time seen a video with 0 dislikes, and never dislike this video
@Muuip2 жыл бұрын
Improvement suggestion to this visualization: - Positively charged pink voltage sensor are insensitive to positive sodium ions concentration outside the neuron but sensitive to sodium ions concentration inside the neuron. If the pink voltage sensor are sensitive to both the outside the neuron and inside the neuron of the sodium concentration, then when the channel is open the sodium ions concentration could not flow against its concentration gradient. If the higher sodium ions concentration inside the neuron opens the channel then the sodium ions could flow out but not in! Solution to this is when pink voltage sensor are sensitive only to sodium concentration inside the neuron and opens the channel when there is a stimuli, allowing higher concentration of sodium ions outside the neuron to flow inside, down its gradient concentration, not against it.
@Lifein60seconds19 Жыл бұрын
Thank you so much for this video!!! It was soo helpful💖
@davidallen5282 Жыл бұрын
Please make a video of inward rectifier K channels. Med students have a super hard time with this channel, and it would be super useful!
@mohamadaljrad73443 жыл бұрын
Amazing
@sidrakadhim51022 жыл бұрын
Thank u so much It's really helpful!
@syncole773 жыл бұрын
thank u so much, its very much helpful to me
@parvanehbehnam94247 ай бұрын
please make more nervous system videos!
@candyandrew5115 Жыл бұрын
Realy clear thank you!!! Can you make a video about the K+ voltage dependent channal?
@ovyf64648 ай бұрын
Why does the number of sodium ions increase within the cell when the neuron is receiving an excitatory signal? Isn’t that a result of the gated channels opening?
@nantia592 жыл бұрын
that is an amazing animation!!! which program did you use to create this animation?
@أبوجابر-ظ7م2و Жыл бұрын
Thanks
@hookem37682 жыл бұрын
I would like to have that more comprehensive video of other channels, please.
@GGG-gf1wf Жыл бұрын
How do you make this complex consepts very clear and easy to understand. What is your technique?
@tayoneumann95332 жыл бұрын
I was never sure how to imagine the AP to travel along the axon on a molecular level. Are individual sodium ions simply traveling along the whole length of the axon? This helped me understand that ion channels at every node of Ranvier open and just gradually fill up the axon - very helpful, thanks! ♡
@Muuip2 жыл бұрын
Excellent presentation/visualization of the mechanism responsible for Na channel opening and closing. 👍 Question: What triggers the inactivation gate to close the channel at -30 mV? Is it also positively charged and gets repelled upwards by higher Na concentration inside the neuron therefore blocking the Na channel?🤔
@venkatramanan65183 жыл бұрын
my humble request , please upload more videos mam.
@Blankity2 ай бұрын
So how does this get affected by pyrethrins? Like why would the channels be kept open? I was reading about shock dope lol I’m just curious as to what is happening in the brain that ordinary flowers can’t derive the same compound from, like how chrysanthemums can make pyrethrum for pesticides after undergoing a process
@ZainAli-mb3ye2 жыл бұрын
How the number of sodium ions increase within cell on receiving stimulus even the voltage sensors are closed??
@magbtr89573 жыл бұрын
thanks a lot, please make more video... :)
@Abdulrahman-lp7dz Жыл бұрын
from where does the sodium come after the excitatory sginal ? Please reply :)
@beatrizlope83402 жыл бұрын
And which is the interaction with mobile phones & wifi?
@Ihavetruth22 Жыл бұрын
what software was used to make the graphics?
@lauraslusser8710 Жыл бұрын
Blender 3D. It’s a free and open-source animation software. Good luck with your endeavors!
@Ihavetruth22 Жыл бұрын
@@lauraslusser8710 Good job !👍
@rakshnirakshni46162 жыл бұрын
Audio not clear
@hollyrule78623 жыл бұрын
I teach physiology, and this will be a must for my students. To echo others, YES, please make more videos!!!
@leokch2009 Жыл бұрын
Thank you so much, your video is very helpful. I am studying how DDT, insecticide, affects insect evolution. Namaste :)
@DrinkColdWater Жыл бұрын
i am a med student and this is one of the best videos who explain it very comprehensive and intuative i appreciate it a lot what i would like to see more if its possible like a time line of what exactly happen from the post synaptic cleft to the action potential itself that go through the axon and axon terminal but really thank you so much incredible video!!
@anitamendeman5999 Жыл бұрын
Thank you for explaining this concept for my biology course. I am an environmental science student. Sometimes these courses are not fully explained to us because we are not med students. But we do need to understand the content just as well!
@Martin_Z5554 жыл бұрын
make more videos!
@studytuberrohan29983 жыл бұрын
Ah beautiful stuff! You explanation is so vivid, it's amazing. Please upload more videos in the future! I have one question though: How does the inactivation gate work? I mean, how does it know when to close? Is it voltage dependent too? Does it carry some charge as well?
@bebotawfik72763 жыл бұрын
You are amazing! please make more videos on the action potential
@scratnoisette99632 жыл бұрын
thank you you are amazing
@camm93974 ай бұрын
Hi Laura this REALLY helped me understand the AP firing line and how it works I hope you make many many more..... Kind regards
@surajsajjala28572 жыл бұрын
Thank you so much
@ninastopa76632 жыл бұрын
We NEED more animations! Greetings from Poland, thanks to you we are gonna pass our physiology exam on Medical University of Silesia.
@adam13322 жыл бұрын
Seeing it animated helps so much! Keep it up!!
@Sam-nb1rm3 жыл бұрын
Subbed. It is very useful. Thank you very much!
@rahmaabdelkafy72033 жыл бұрын
Thanks alot for your great efforts .. your video helped me to understand well in very short time
@dannichols62613 жыл бұрын
Cartoon animations are extremely helpful, thank you for making it! For Na v-gated channel, could you explain/demonstrate the actions of: Selectivity filter (by which sodium is allowed & passed through & K is rejected), and Fast inactivation (how opening of the pore gate closes the inactivation gate)? (And how these parts derive from the 6 segments of the 4 domains of the channel?) And isn't the actual pore gate at the bottom of the pore (intracellular side), rather than at the top on the extracellular side that you showed?
@getinspired3499 Жыл бұрын
Yeah that’s absolutely fantastic animation. It is easy to visualise and understand. I have the same comment about the flowing of the Na+ ion. It looks the concentration of the Na+ ion is less outside than inside before opening. Which I think is the opposite and that will make sense as the transport system has to be diffusion ( from an area of high concentration to low concentration. Thank you for all your efforts Xxx
@Illkacirma11 ай бұрын
thanks for this great explanation
@michaelmuller1362 жыл бұрын
Good visualization, well explained, thank you!
@surajsajjala28572 жыл бұрын
Bruh mind boggling easy explain
@funkystyle7249 Жыл бұрын
This is really good explanation
@keerthikayalakaturi7383 жыл бұрын
what is resting-state blockade?
@uzomauzoma7749 Жыл бұрын
Just Wonderful! 👏👏👏
@حسينعناد-و8ه3 жыл бұрын
Thank you very much ❤️🙏 From university of muthanna, Iraq 💜
@user-rn4jh8qx6w3 жыл бұрын
هلا والله باهل العراق ❤️🤚🤝🤝
@حسينعناد-و8ه3 жыл бұрын
@@user-rn4jh8qx6w حبيبي والله 😍
@medicostudy1012 жыл бұрын
is this applicable to sodium channels in working myocardium? as anti arrythmic application?
@MonishR967 күн бұрын
Wow!
@subhambose63732 жыл бұрын
thank u so much
@s.papadatos67113 жыл бұрын
An idea for future video: Explain how the MET channels at the tip of the hair cells in the Organ of Corti work.
@lukekim70123 жыл бұрын
Wow, I have like one week left till the exam and I finally get it!! Please make more videos!!
@aftermath73 жыл бұрын
Best of luck for ur exams
@lukekim70123 жыл бұрын
@@aftermath7 already had two more big exams after that..
@aftermath73 жыл бұрын
@@lukekim7012 how did they go?
@lukekim70123 жыл бұрын
Semester ended last week, and I got 3.73 😊😃
@aftermath73 жыл бұрын
@@lukekim7012 3.73? Good bro👍
@soliangmanyu28643 жыл бұрын
At resting potential, there is more sodium ions outside and less inside . And you added ,on arrival of impulse , Na+ ions increase inside. How does it happen ? Or what cause increase in Na+ ions before the actual influx of Na+ from outside ?
@lauraslusser87103 жыл бұрын
The first Na+ ions enter the cell via some kind of stimulation at the synapse. For many neurons, this happens via ligand-gated channels that open in response to neurotransmitters. But you can also have an electrical synapse, where the graded potential arrives through a gap junction. Alternatively, in the hair cells of the ear, there are ion channels that open in response to vibration. In the skin, there are sensory neurons with channels that open in response to pressure or heat. It all depends on the type of neuron.