Vortioxetine (Trintellix) The TOP 5 things you need to know

[@LevelheadedMind]

www.levelheadedmind.com/contact Not sure if this medication is right for you? Contact me so we can discuss treatment options for your unique needs.

[@lolak7438]

Hi - I watch you all of the time. My depression/anxiety has been so bad I am now facing eviction and that, in turn, is triggering worse depression/anxiety. Mt psych disappeared after covid ( I lost a sister to covid and before that, a brother to suicide0. but before that he told me Buproprion would help with my 'motivation". I just became worse. I was on Effexor before and only having mild results after slightly raising the dose). so mt new psych - who reired last year- just kept rasing the Buproprion. I was not getting better. (Yes, I was in therapy, not much help- no modalites- just talk, used, also grief therapy- when depression doesn't lift, it just doesn't help much). So now I have a nurse who tries, but seems to fill what I suggest (?). So- that's why I ask so many questions. I'm really afraid I won't ave the time to go through the side effects again. And with so many commercials making depression seem to be cured with one pill while still coping byhiding behind a smiley face (how are these people getting out of bed?)!adding to the stigma and people close to me noot understanding/believing me and what I'm going through (major MDD with an anxiety disorder) I have bottles laying around- still good? I would love to call for a free consult but I don't have much money after that. Please- I'll take any suggestions (on Obamacare/Medicaid so hard to find a doc/other treatments) right now.

[@AdeedumdooLin]

I was actually good on escitalopram in terms of mood BUT the cognitive delay was soooo bad that I cannot even speak without pausing to remember what I was saying. I've been on vortioxetine for more than a month and I can really feel the results 🥰

[@PilarBorrellaSalas]

Hi, I'm on escitalopram too but do miss better cognitive functioning. Do you take both or switched from one to the other?

[@AdeedumdooLin]

@@PilarBorrellaSalas i was switched by my psychiatrist and have been on it for 6 months. So far so good. Glad my insurance covers for it but if not it will be too costly 🙈

[@dakotaharrell9098]

Love Trintellix! I take it in combination with 100 mgs of Amitriptyline, and my EMDR sessions and I’m not just surviving but thriving now a days!

[@DivinityRedd]

Thank you for this video. I was recently prescribed this medication and had some reservations after experiencing some nausea. This video provided so much clarity.

[@paulj0557tonehead]

If you take any other med with Trintellix then the nausea can be intense. So I just take it by itself with 3/4 cups of water of so between breakfast and lunch midway. One thing the interaction did help me with was I tool Lamotrigine/Lamictal for bipolar and it really shortened my cycles. Once on Trintellix I immediately discovered I could not take them together. So I would take Trintellix first and midday take the Lamotrigine. Well after a couple months I noticed I forgetting to take the Lamotrigine. I'd correct myself, but after 6 months I was beginning to realize I didn't really need the Lamotrigine. That's been 8-9 months ago now. I told my doctor, but continue to get the Lamotrigine. On my next visit I'm going to discuss discontinuing Lamotrigine. Okay I spelled all this out for the reader because I realize self diagnosis and even self withdrawal of a med can be detrimental to whole objective. As you can tell I'm going about it wrong. Here's another thing. Cost. Lamotrigine is a $4 med, whereas Trintellix is about $500-$600 med. So here I am, thinking it's okay to self regulate a $4 med. WRONG! lol Yeah it's time to make that appointment. I am methadone patient for 20 years, and it's the only other thing I take. This video is helpful.

[@Medusa5885]

I have been using this medication for 3 months now. I was becoming suicidal after being on Wellbutrin for many years. I like it so far, it has helped my anxiety tremendously. the only side effect was severe sedation for the first month., but i think it was due to the other medication i take, Prazosin and Lamotrigine. I haven’t noticed any improved focus though. I’m grateful to have Medicaid and dont have to pay $500. Highly recommend.

[@justmadeit2]

Did you sleep ok on it?

[@straightwhiteandproud9643]

Thank the lord for medicaid

[@straightwhiteandproud9643]

​@@justmadeit2 I cannot sleep on it, it speeds my mind and thoughts up to the point I cannot shut my mind down

[@jhambrick27]

Thank you so much for honoring my request!!! ❤️❤️❤️❤️

[@LevelheadedMind]

You are so welcome! 😊

[@OrangeMicMusic]

My psychiatrist changed my antidepressants many times (one of them being Trintellix) over 4 years period, trying to find "the one that is working". Now, I started thinking if the chemical imbalance is real, after so many major studies in the last few years showing almost no difference between antidepressants and placebo.

[@radioguy8662]

This is the best video on Trintellix on KZbin!

[@Liopleurodon09]

2nd day on this pill. I am excited to get better! Going through a very rough patch.

[@DivinelyTimed]

How is it going? I start my first dose today

[@Liopleurodon09]

@@DivinelyTimed 2 and 1/2 weeks in and my appetite is back! I still get anxiety attacks at night and sudden lows throughout my day, but not as much and I have a more positive outlook in life. I am also getting more focus on my studies. Slowly getting there, not perfect yet. Hoping to feel the full effects of the pill on my 4th week! I am wishing you all the best! I am sorry you are going through a tough time. I know you’ll do great! How was your first day?

[@DivinelyTimed]

@@Liopleurodon09 thank you for responding! I haven’t taken it yet. Just glancing at the bottle every now and then lol….. I’ve tried so many medications. I just want to wake up and not dread the day. Dare I say I hope to smile genuinely and have meaningful interactions with people! Also improve my self care and energy level. I have high hopes every time I start a new med but as of late that initial excitement isn’t there anymore because nothing has worked thus far.

[@xxf1able]

Good luck ​@@Liopleurodon09

[@matthewscott1091]

Trintellix is the only anti-depressant that has ever really worked for me in what seems like a lifetime of trying different meds. *The problem is the cost.* There is no generic available in the US so a one month supply is over $400. I’ve literally been living off of samples from my doctor but this leads to missed dosages when I can’t rely on prescriptions. The patents to Trintellix don’t expire until *June of 2027.* Meaning there won’t be a generic version of the drug available until then (over 4 years from now). 😢

[@LevelheadedMind]

Have you tried getting a prescription savings card? us.trintellix.com/savings-support?showmg=true&BRSavings&gclid=CjwKCAiArNOeBhAHEiwAze_nKCdUVI0BV9BopRMfzdsW2Y-PrD4Ut5xYqCbwn6TUcoNHHIMlRYyEjxoCAJQQAvD_BwE&gclsrc=aw.ds

[@sleezuskryst1246]

Damn! I don’t feel so bad now having to pay 120.00 in Canada

[@lorikasheimer3231]

Would love a video feedback on taking 2 medications together. Trintellix and Wellbutrin. Pros and Cons using together.

[@pianosenzanima1]

400$??? WTF?? I take it for free in Italy from pharmacy with my psychiatrist prescription

[@puddifoots41]

I tried also a lot of medications....even Parnate. Some TCA. 3 SRRI. SNRI. Still feel low. Whats the difference you felt?

[@nawafpsy]

Most informative video I ever seen about Vortioxetine! Just an important point you didn't mention which is Vortioxetine and emotional blunting. How it is less likely to cause it in comparison with SSRIs/SNRIs

[@LevelheadedMind]

Great point! Thanks for sharing 👍

[@blessieyang8070]

Does it cause emotional blunting? I was about to start it for feeling of apathy…

[@LevelheadedMind]

@@blessieyang8070 it doesn't cause it, but any medication that increases serotonin may cause this, vortioxetine is less likely to cause this due to its multimodal effect. If serotonin causes emotional bunting it is a clue that low serotonin is not your problem.

[@blessieyang8070]

@@LevelheadedMind thank you for the response - I’m actually starting vortioxetine *for* emotional blunting and apathy - do you think this is a good idea?

[@LevelheadedMind]

@@blessieyang8070 It wouldn't hurt to try. Bupropion can also help with that as well. Typically emotional blunting is a result of low dopamine and norepinephrine.

[@daliamendez9792]

I'm starting a treatment with Vortioxetine next week, is the second antidepressant i try as Citalopram didn't work for me. Your video made me feel so much better and secure about taking this medication. Thank you so much for sharing this info! ❤️

[@LevelheadedMind]

You're welcome, I hope this medication works well for you.

[@GianlucaMurru]

Hey, how is it going?

[@ImGoodThankYou]

How did it go for you?

[@emanyaghmour504]

Please tell us if if works of u? and the side effects

[@macyfiscus4491]

I’m in the exact same boat. I was also taking Citalophram. I had to stop it because it was making me very irritable and angry. I start my first dose of Trentellix tomorrow morning. How has your experience with it been so far?

[@777MNM]

I need to start taking this but keep holding it off or i will start for a few days then stop! But im rather depressed and i know i need help i fight with myself daily to not take it its so frustrating 😢 reading everyone's comments is giving me hope ❤

[@davidswift1644]

Maybe useful if your suffering from Dementia of some form as for it's value in treating MDD from my experience it's an awful drug causing emotional paralysis and suicidal tape loop ideation. I guess all you can do is try it and cross your fingers just like any other current anti depressant..not a game changer.

[@hamzaalikhan1563]

taking for few days will not work u should take it for long time without any fear.then it will work for u

[@TotalBlackoutPainting]

I switched from this to Viibryd for 3 months. That stuff made my brain feel like mush. I'm finally a month back on Trintellix and I feel like a fog has been lifted from my brain. I wish it was more affordable. It's really putting me up against the wall, even with the savings card. It's seriously killing me, but the alternative is being a zombie or being a suicidal basket case. I finally feel like making content again instead of it just being performative, I feel so much better. I can't even put a price on it. I'm grateful my guy will give me samples if I need them, but I just wish they'd drop the price. I can't go back to effexor or anything like that, I won't do the brain zaps again. I'll just have the find it in the budget.

[@golovskin5917]

Using trintellix again make you happy again after how many weeks?

[@VictorMerryweather]

You feel like you can be productively creative again?

[@DanielSRosehill]

If you're looking for tough questions then I have one for you: taking two SSRIs concurrently is generally considered to be an absolute contraindication. But some docs seem to be happy combining Trintellix with SSRIs. Why is that considered safe but the other not?

[@LevelheadedMind]

I wouldn't consider it completely safe. You would still need to watch for serotonin syndrome. Risk is less than with SSRIs since it has many antagonist actions on different serotonin receptors, which account for increases in the different neurotransmitters, and not just serotonin.

[@pootube2024]

​@@LevelheadedMind I have a problem on PRISTIQ I'm still feeling so lethargic.😪

[@lindacarol5982]

​@@pootube2024I had to quit taking prestiq after a year it quit working months before I quit

[@anthonybenash3457]

Thank you for the video. I have been on Alprazolam for ten years and a new doctor just prescribed Tintellex and I was a bit nervous until I watched this. 🙏

[@LevelheadedMind]

Thank you, I hope it works out well for you.

[@tonymccarthy5624]

I’m shocked that you say you used alrazolam for 10 years as I’m a recovering Xanax addict who went on withdrawals and lost the plot due to alprzolam Xanax yes it’s a great medication to take for feeling amazingly good but i got addicted and went crazy and ruined my life and lost the people I love around me it messes up your head the next day when u wake up your just so moody also depends on dose I was taking 7 1mg a day

[@anthonybenash3457]

@@tonymccarthy5624 it hasn’t seemed to affect me like that. I have always taken it as prescribed and I’m only on the .5 mg twice a day. I did forget to take my trintellex for about a week and felt horrible though.

[@tonymccarthy5624]

@@anthonybenash3457 I just started on trintellix would you believe I’m on trintellix and quetipine because of addiction to Xanax and weed for years I was abusing the Xanax tho I take 7 maximum pills everyday like I was a super high all the time so whatever. I did to my brain now I’m ruined and have to take anti depressants and Phycotits due to having anxiety and phycosis and literally losing the plot because of Xanax and yes 2 .5 mg twice a day sound like it wouldn’t do much I’ve taken that much before 1 mg in day and I noticed it made me have nice feeling too any amount gives you kinda good calm euphoric buzz

[@anthonybenash3457]

@@tonymccarthy5624 sorry to hear that man, I went through alcohol rehab years ago so I can somewhat relate. I have dealt with general anxiety disorder for years and I’ve been doing way better with the Xanax personally. I know the risks of addiction so I have never asked to have my dosage increased.

[@StenellaFr]

My experience with this drug is superb..

[@OneDanae]

Can you expand please? What were your symptoms and how it has helped?

[@StenellaFr]

@@OneDanae yes I had much stress with living with an emotionally unstable person. After the drug I could calm myself down. Also it doesn't have particular negative effect on intellectual performance during the day. Only problem with the drug is having slightly less libido.

[@jmoss2543]

@@StenellaFr I live with an emotionally unstable person which has greatly affected me over the past 6 years. I started bupropion xl 4 days ago. I’m having bad headaches as worst symtom. If it doesn’t improve maybe I’ll try Trintellix. I’m always in a daze it seems and having memory issues and I’m only 44. You recommend Trintellix? How long it take to work for you?

[@StenellaFr]

@@jmoss2543 first ~10 days i started with 5 mg, then have taken 10 mg constantly for the last months. In the drug description it says it takes 3-4 weeks to have the effect , but I could feel the difference after a few days. I didnt have any experience with anti-depressants before, but I really liked this one and I'm happy that it works for me. Anti depressents' effects might be different for each person, but I had some luck on this one.

[@Juuanaa2014]

How long did you took it until you saw full effects? I am taking it 10 weeks now and nothing

[@bogse]

2:22 If something improves memory, attention and processing speed I can quarentee you it will raise the overall IQ since all those three are in major role when measuring IQ. So it would basically be impossible that it wouldnt improve IQ.

[@LevelheadedMind]

You would think so, but we don't have any studies to confirm this, so can't claim it. As well as don't want people taking psychoactive drugs just to try and raise IQ. These drugs cam cause more harm than good for some people.

[@binarybob0010]

I agree. If they make those claims and can’t back it with IQ tests, they’re full of you know what.

[@rcalabais]

Not to be argumentative, but memory and attention/processing speed and IQ are completely unrelated. But if the meds make you FEEL BETTER that's all that counts right. You seem like a smart person anyway so just go with it my friend. Peace 😊

[@bogse]

@@rcalabais " memory and attention/processing speed and IQ are completely unrelated." as doing 20 years of neurocognitive testing and beind doctor in neuroscience.... I dont know where you get that but it sure aint science.

[@rcalabais]

That's what I said . ​@@bogse

[@jaydenyounger6496]

Thanks for making this video - super helpful information! Just a little bit of feedback, I found the background music to be quite distracting as it's pretty loud in the mix, which made it difficult to take in all the info. Outside of that this was brilliant :)

[@LevelheadedMind]

Sorry about that, I'll take that into consideration next time.

[@marwanalamoodi8420]

Thanks for making this video, but my question does it effect the cholesterol level?

[@tanakkusai]

I have Bipolar 2. I take Trintellix on top of a mood stabilizer called Lamictal. Can you do a video on how Lamictal works for Bipolar and treatment resistant depression? Thank you so much for all that you do! The information you've shared has been so helpful.

[@LevelheadedMind]

Thank you. Yes, I have Lamictal om my videos list so stay tuned. 😉

[@KT-fm7dt]

Are you happy with The Trintellix/Lamictal combination?

[@artgreg2296]

Thanks for your comments. I am french colombian living in france with bipolar 2 trouble. Thanksfully medicine are taken in charge by the medical insurance. I would say i feel better during the day with the trintellix but I have nausea 1/3 and strange dreams.

[@MariaTeresa-b7w]

I really need emotional blunting...two months ago I have lost my mother and my husband in a fortnight...I have no kids or relatives so I'm alone and heartbroken. I have been taking vortioxetine for 8 days so far. I hope it can help me..

[@muslimdad983]

May God give you patience 😢

[@MariaTeresa-b7w]

Thank you, brother, peace be on you. I accept God's will with patience and humility. He gives, He takes away...thank you for your compassionate words..🌺 @@muslimdad983

[@rcalabais]

I pray it helps you and my heart aches for your loss. Blessings 🙏

[@MariaTeresa-b7w]

@@muslimdad983 ❤️

[@MariaTeresa-b7w]

@@rcalabais ❤️

[@user-ed1fr3qs8z]

Hello, I like the way you speak, I can understand everything even if my english is not fluent 👍

[@oliveb2o]

it's because of the trintellix that makes your brain smarter

[@BruderAdrian]

Thanks for making this video. It was very helpful ❤

[@LevelheadedMind]

You're so welcome!

[@umairsiddiqui3204]

can you please compare the vortioxetine with duloxetine. thanks

[@sharonpeters6826]

Thank you for this video. Help me to understand this medicine better.

[@realitywinner7582]

notice significant triggering of 'flight' mode ! on it 2 weeks ..heard on another channel this happens for a while . God Bless !

[@rajeevtaneja5153]

Thanks for such a valuable info ❤ love you May God bless you ❤️

[@nickytmorris]

I would love a video about SSRIs, SNRIs, and SARI’s. The differences/similarities and can you take them together?

[@LevelheadedMind]

Thank you for the video idea, I will consider it.

[@barbarabaker8118]

I was given samples of this medication and was so happy with the results. I have been on many different anti-depression meds for yrs. After a period of time they seemed to have lost their effect. Unfortunately the cost, even with my Medicare part D insurance is not in my budget!

[@thinksatheesh]

Try to source it from India. A strip of 10 tabs costs just one dollar

[@comradeharley]

Was there significant nausea? Can you share your experience with the side effects on this medication?

[@MountainAirOrganicBeds]

What is serotonin overload? Can you make a video about it?

[@nikkibpainting]

Please make a video about serotonin syndrome. Thank you!

[@LevelheadedMind]

Here is the video I did on serotonin syndrome kzbin.info/www/bejne/opmxiZR9lNCisKc

[@christianc1551]

Excellent video. I am a PMHNP student graduating in December. I still struggle with choosing the best antipsychotics for my patients. Could you go over a topic over first generation and second generation antipsychotics ? Thanks you!

[@LevelheadedMind]

That's a great video idea. When choosing between them I look at the side effect profile and risk/benefit for my patient. There are many choices so I can understand the confusion. Also good to look at what they are FDA approved for and clinical guidelines. Good luck with your studies and thanks for watching the videos.

[@christianc1551]

@@LevelheadedMind Thank you for the information. Glad I found your channel!

[@tangtang2223]

​@@LevelheadedMindf冫😮

[@ratheeshpnarayanan9440]

Can you make a video for comparing the sedation of antidepressants

[@DanielSRosehill]

Thanks - this was excellent and makes me feel a lot more empowered and informed starting this medication!

[@Chacals-n5g]

Ce médicament est parfait 🙏🙏🙏

[@mitch8237]

I just started on this medicine two days ago

[@leemurray9497]

How do you find the medicine im two weeks into 5mg but increased it to 10mg today to see will it sort out my anxiety!Came back out of the blue.

[@toddwilliams4493]

So....why is this not prescribed more?

[@repe0]

Only antidepressant that actually works!

[@souravkumarmukherjee496]

Hi, Thank you for presenting an insightful video about Vortioxetine. Which of the medications can be combined with it to treat GAD, Anxiety disorder, Panic attacks and social phobia ?

[@LevelheadedMind]

You can add medications such as clonidine, propranolol, or hydroxyzine. You would need to be careful with any serotonin medications as these can increase risk of serotonin syndrome. Buspar can also be added but with caution, since it is a partial serotonin agonist.

[@mikejudd7922]

So it is Safe to take Clonidine with Trintellix on a Daily Basis for Sleep?

[@Jasminethebestofc]

Could this medication help with ADHD? PLEASE GET BACK TO ME THANKS.

[@beeathome1064]

Thank you so much for your videos. I watch a lot! Can you tell me if you think virtioxetine causes weight gain? And can it help PMDD? I take Prozac for PMDD and don’t love it. I was wanting to try trintellix for PMDD and anxiety

[@LevelheadedMind]

This would not be my first choice for those symptoms. As far as weight gain, it is considered weight neutral. Have you tried sertraline or escitalopram?

[@beeathome1064]

@@LevelheadedMind I have tried Zoloft and citalopram … and Prozac.. I don’t think I handle the other SSRIs very well. But I’ve been researching the Trintellix and all SNRIs .. it’s such a trial and error. Thank you so much

[@picklesooz]

How does it interact with plant medicines like CBD & THC ?

[@LevelheadedMind]

There are studies that suggest CBD is an inhibitor of CYP2D6 which Trintellix is metabolized by, so it may increase the percentage of available Trintellix in your system leading to increased side effects. THC is not on the CYP2D6, but induces CYP1A2, which has no effect on Trintellix.

[@ambrakaur2499]

​@@LevelheadedMindThank you for answering folks' questions. I am someone who tends to self-medicate and have had a lot of reservations with wanting to try an actual psychiatric medication (I had a bad experience with side effects to a medication years ago). But I'm a little bit desperate. However, I am currently taking kratom almost every day. My gut feeling is that I should stop it before going on a med like this... Do you agree?

[@randycushman1669]

Can you please expand on how Vortioxetine increases norepinephrine, dopamine, glutamate, acetylcholine and histamine? Everything I have read says it absolutely does not have any affect on anything other than serotonin. Is it an indirect action? I am considering giving this med a try and am wanting to understand it as best I can. Thanks.

[@LevelheadedMind]

No direct actions but by antagonistic and agonism on various serotonin receptors and pathways, it leads to actions on those multiple neurotransmitters. Stahls Psychopharmacology text book explains this very well if you want to learn more about down stream effects.

[@essakhan6969]

Does agomelatine treat emotional numbness please reply

[@nermenelkhamisy4315]

I would like to know does it make my migraine worse 😢 Can it helps me in menopausal hot flashes

[@DoItWrightRo]

I would like to know how it impacts peri menopause

[@varnishyourboard]

Concise and informative. Subscribed. (Very minor edit to consider for future videos is to change the spelling of St. John's Wort). Thanks!

[@LevelheadedMind]

Thanks for the tip!

[@fdkh517]

My doctor prescribed me this drug with fluoxetine +olanzapine is ok to take with vortioxetine

[@LevelheadedMind]

Watch out for serotonin syndrome, that is a risk with this combo.

[@Shelby-cf1sc]

Your videos are the best! Thanks for posting so I can learn more. You should do 5 things about venlafaxine xr next.

[@LevelheadedMind]

Thanks. I'll make sure to do one on Venlafaxine soon. 😉

[@20081980bert]

You beat me to it! I’ve just started Venlafaxine XR

[@giacomograndi5527]

Can be potentially effective also a low dose like 5 mg? 5mg can be potentially sufficient?

[@mercyfulvickv2810]

No

[@marieb9961]

I d like to Thank you really for me you ha e made a big difference with your info ℹ️ thanks 🌺

[@LevelheadedMind]

You are so welcome, I am glad to help!

[@hayesAlexa]

Can this medication be taken in combination with wellbutrin and Adderall

[@LevelheadedMind]

Bupropion will reduce metabolism of Trintellix making you have adverse toxic effects. If this combo is being given it must done under expert guidance, many risks as well as serotonin syndrome risks.

[@edapen9829]

Would you say its better for anxiety than Lexapro? I take 15 mg per day and I am doing well on it but I also at times feel a bit numb/or like I can’t focus.

[@LevelheadedMind]

In my opinion Lexapro is better at treating generalized anxiety and even panic disorder. If you have depression as a dominating illness and some underlying anxiety, Trintellix would help. Check out my comparison video on these meds if you haven't done so already. kzbin.info/www/bejne/fIa0gmOwft6Andk

[@edapen9829]

@@LevelheadedMind yes I’m in it for GAD. Thanks for replying

[@jonharry6293]

It’s useless for anxiety, I have lots of friends who switch to Zoloft which is much better.

[@viktoriakarypidou181]

I have been taking vortioxetine 1 month now. I have reached the dose of 20 mg starting with 5 mg. Although i have less anxiety i have noticed less connection to my emotions and all senses overall, is this a side effect? It feels like emptiness and numbness....does it get better as the time goes by?

[@LevelheadedMind]

This is a flattening affect that cam occur due to too much serotonin, which lowers dopamine. Have your doctor lower the dose, or add Bupropion if tolerated and no contraindications exist.

[@zahidhusain7589]

I'm in weak English but you wrote in side to explain is very helpful

[@LevelheadedMind]

Thank you. I'm glad you found the video to be helpful.

[@JohnBarrylizard]

I was put on this following a near death experience. I never thought I felt very depressed but do have anxiety and PSTD. So far, I notice it has improved the rapidity of my thoughts, given me vivid dreams, and seems to have increased the clarity of my thoughts. I've yet to see an improvement in anxiety, but every incremental dosage had a difficult period where I was ferociously angry. Currently, I'm at 10mg and feel less aggressive. My doctor plans to increase me to 20mg. I wonder if it decreases empathy?

[@erwinmega3573]

Thank you for this amazing review. Does nicotine influence when taking with vortioxetine? (nicotine pouches)

[@AbdulRehman-ox9ld]

Please make video on paroxetine

[@mikejudd7922]

So what is the Timeline for Feeling Better when taking Trintellix?

[@LevelheadedMind]

6 to 8 weeks max if on a therapeutic dose.

[@mikejudd7922]

5 Weeks on this Medication & it Seems like it Doing Nothing for My Anxiety?😢...Does Trintellix Actually Address Anxiety Dr Mark's?

[@sophiestein7568]

@@LevelheadedMind what is a therapeutic dose?

[@kevinfogarty5081]

I take one low dose aspirin a day and I just started taking 10mg vortioxetine. What bleeding are these docs referring to exactly?

[@LevelheadedMind]

Serotonin can affect platelets ability to clot. Therefore there is in an increased risk of bleeding. Watch out for signs such as bruising easily, nose bleeds, blood in stool, etc. It would be prudent to have your blood levels checked at least every 6 months to monitor as well.

[@kevinfogarty5081]

@@LevelheadedMind interesting thank you

[@vilsujami]

5 mg atleast from the beginning felt alright after couple of weeks. 10 mg almost paralyzed me, I was so tired, horrible brain fog and my anxiety just got worse by the day. I had to stop it after 2,5 weeks I had to work and continue on living which wqs impossible. I wonder if this stuff is too strong on me, I dont suffer from depression, I take it for pretty bad general anxiety disorder.

[@nadiazakaria8601]

I have internal parkinson tre.mors ca. I TAKE Trentellix any side affect. With. Carpadooa/Le adopa. Or. Citrate Magnizium pleaselet me know

[@LevelheadedMind]

Discuss this with your provider and check Web MDs drug interaction checker for any possible interactions.

[@melanie98d]

Trintellix tanked my mood so fast. It was terrifying

[@PharmacologySimplifiedRx]

Make a video on Vilazodone vs Vortioxitine???

[@LevelheadedMind]

Thanks for the video idea, I will consider it.

[@MidniteSon]

@@LevelheadedMind Yes, can you please create one comparing the multimodular class? Perhaps each may treat symptoms slightly differently.

[@DanielSRosehill]

I'd be interested to see a comparison between vortioxetine and the couple of other newer serotonin modulators in its drug class - which I believe is really just Viibryd

[@LevelheadedMind]

Great video idea, thanks.

[@baron2161]

Metformin, is this really good for you, because I have to now take other supplements to fix what Metformin depleted, like Vitamin B12 and Folic acid is there nothing else to replace this with?

[@LevelheadedMind]

As a Psychiatric Nurse Practitioner prescribing a medication like metformin is out of my scope of practice. I really can't comment on whether it is good or bad. However, for type 2 diabetes with proper diet and exercise some patients can come off of this medication. So discuss your concerns with your provider and develop an action plan to start working towards a goal of coming off this medication.

[@RahulThakur-jo6kx]

My dr. Prescribed me bupropion 150 xl in morning and vortioxetine 10 mg in night. Is it good to take?

[@LevelheadedMind]

No, this is not considered safe. Bupropion can significantly increase the blood concentration of Trintellix making you more susceptible to the side effects. Please talk with your doctor about this concern.

[@madbuttcollage5067]

What do you think of this with Agomelatine?

[@LevelheadedMind]

Agomelatine is not approved in the US due to causing Liver toxicity, so don't have experience with it.

[@jazzyreyes6921]

my daughter is experiencing mania with this med!!

[@Hassan3hunna]

Can it provide relief for sexual dysfunction (PSSD) symptoms? caused by antipsychotic medicines prescribed for schizophrenia? Although the condition name is Post SSRI sexual dysfuction & SSRIs are antidepressants but this conidition is caused by both antidepressants and antipsychotics both.

[@LevelheadedMind]

I haven't used this as a treatment for PSSD, not sure it would work. Talk to your doctor about it.

[@Hassan3hunna]

@@LevelheadedMind Would be hard finding a Doctor that acknowledges this condition because very few Doctors are even aware of it most are of the believe once the medication is stopped everything goes normal if it doesn't ''it's in your head'' as in you're thinking about it ( placebo). The condition got recognized in 2019 by the European medical agency. Anyhow from what I am aware theirs no treatment currently for it some medicines like Wellbutrin (Bupropion) which is a NDRI provide relief for some, Viagra (Sildenafil), and Cialis (Tadalafil) for some.

[@ajomshah1668]

Which medicine do you prescribe for pssd?

[@ΦΑΙΗΑΒΡΑΜΙΩΤΗ]

I started this medicine 4 mounths ago. It helped me very much, i couldn't breathe attal from my anxiety... but since 20 days my appetite has opened very much, and now i want to stop it, because i dont want to get weight... Any advice, please?

[@rcalabais]

Are you saying you feel it has CAUSED you to gain weight?

[@natakijean-baptiste1746]

Can I get this in the uk 🇬🇧?

[@denydeni144]

Yes you can :)

[@matthewcallaghan1512]

Does it help ptsd

[@LevelheadedMind]

It's not my choice for PTSD. Try good therapy before medication.

[@RoystonLewars]

Do you have to do prior authorization for this medication for most insurances?

[@trailurparkgurl3167]

Although on its website it says most insurances doesn’t require prior authorization, mine did. I’m stuck this weekend without it cause it was 500 dollars

[@vickinoseworthy-wi7if]

How does this drug affect new borns breastfeeding?

[@GianlucaMurru]

I'm 1 week into it and the only side effect is a mild tinnitus since day 2. Should I worry? Also, there's any interaction with ashwagandha?

[@LevelheadedMind]

Hi, I didn't see any interaction with Ashwaghanda according to UPtoDate interaction checker. As for the tinnitus, this can cause issues with balance and dizziness. So if it doesn't resolve, I would first make sure it is a side effect and see an ENT then consider switching treatments if it is indeed from vortioxetine.

[@GianlucaMurru]

@@LevelheadedMind Thank you for taking your time to reply

[@macyfiscus4491]

Is it safe to take this with remeron?

[@LevelheadedMind]

There is a risk for serotonin syndrome so monitor for that.

[@macyfiscus4491]

@@LevelheadedMind I have it in 7.5 milligrams

[@Phoenix-ov5gg]

Are there any supplements or activities you can do to increase the therapeutic effect without increasing the dose of the medication? I currently use a TDCS headset from flow and try to exercise because I read they can help improve the results. I also take a fish oil tablet every day. I am on 10mg but I don’t want to go higher due to risk of increased side effect.

[@LevelheadedMind]

Yes, eat anti-inflammatory diet, increase foods high in tryptophan and phenylalanine.

[@rocketlegs6933]

How effective is vortioxetine with anxiety?

[@edapen9829]

Does it interact w/ Buspar at all?

[@LevelheadedMind]

If you are taking Buspar and Vortioxetine you will need to monitor for serotonin syndrome, as their would be a risk. Check out this video that details this kzbin.info/www/bejne/opmxiZR9lNCisKc

[@sabirmirza6606]

Dear mam, I have two questions 1) does taking antidepressants for long time harm any organ of our body like heart kidney etc 2) can one really stop antidepressants after the treatment or is it just a false hope because I have seen people taking it even since 30 years .

[@LevelheadedMind]

Yes you can stop these medications if done correctly under the direction of a provider. As for organ damage it is fairly rare but liver damage can occur with some of these medications, typically in higher dosages risks of side effects are increased.

[@Allanwify]

Im planning to shift from Sertraline til this drug.

[@genialshape]

Every person is different, for example; the sertraline worked well in the past for me, but now doesnt work. Im doing the change for Vortioxetine, I feel so bad, I hope that this medication can help me.

[@martialfan36]

Does Trintellix and Clonidine work well together for panic disorders and social anxiety? I have tried so many others in the past with no benefit at all.

[@nikimclaren1838]

Thank you for the great information. Does this medication interact with any ADHD medication, in particular, dexamphetamine?

[@LevelheadedMind]

Yes, it can increase your risk for serotonin syndrome so you and your provider will need to monitor for this risk and symptoms of serotonin syndrome.

[@dirt_reborn]

Produces glutamate? That causes anxiety correct?

[@LevelheadedMind]

Overproduction of glutamate can, yes. But you need glutamate for attention, focus, and energy, which is what this medication provides to some patients and the benefits of stimulating this system.

[@invinciblefarhan2698]

Is there any prescription saving program for vortixetine for financial needy patients in India?

[@MrRizon83]

In Australia it’s $83.00 for 14 tablets is that normal worldwide?

[@LevelheadedMind]

No, that's very cheap compared to U.S. It's 4 to $500 for 1 month supply without insurance.

[@Zenboy23]

@@LevelheadedMind That's insane. It's $70 for 28 10mg tabs here in Mexico.

[@Naat_Bayan]

Vertioxetine 20 mg arround 3 to 4 usd in india

[@iancampbell9297]

That is awful in the UK it is free

[@pianosenzanima1]

Here in Italy it's free

[@kratos8529]

Does vortioxetine treat hallucinations ?

[@LevelheadedMind]

No, it does not.

[@kratos8529]

​@@LevelheadedMind at various websites on internet it is labelled as both antipsychotic and antidepressant

[@LevelheadedMind]

@Suhail Shaikh that's interesting, according to the FDA label it is an antidepressant not an antipsychotic.

[@pallvisharma4824]

Mam I am having functional disorder dr.prescribed me vortioxetine ten mg....l took for one month...my symptoms improved ....then halfed the dose to five mg .....I took that for one month more ...now I started having buzzing sound in my ear ...mam why this ringing in my ear it was no there before

[@datbtrue]

Why did you reduce your dosage upon symptom improvement? This is an indication that the medication is starting to work ! Never, ever do this! unless it's causing a serious adverse reaction. The tinnitus is most likely from a slight withdrawal from 10 to 5 mgs . Please see your doctor and Never self-medicate or play doctor . You keep messing around like this and you run the risk of Treatment resistant Depression/GAD etc..

[@despiertanmuchos7837]

Vortioxetine does not work for me....6 months on 20mg...energy zero, motivation zero...a waste of time, probablly less side effects but if depression dont goes away, you are not able to do nothing. I hope work for someone...

[@LevelheadedMind]

I'm sorry to hear it hasn't helped you. Not every medication is going to be the right fit for everyone. Also make sure to look at other causes, such as poor diet, inflammation, methylation issues, autoimmune disease and gut dysbiosis are some of the few causes of depressive symptoms to explore. I hope you find the right treatment for you and get to the root cause of your symptoms.

[@L0kEcITyY]

@@LevelheadedMind how would someone fix methylation issues?

[@ARolls-dd2zd]

@@L0kEcITyY B vitamins, B12, B6, B1, B2, B3, Folic acid, or eat lots of salads.

[@iamthefiremanjj]

@@LevelheadedMind this is the best way to go first

[@LevelheadedMind]

@Jeff you would need methylated forms of B vitamins in high doses to correct the deficiencies. Check homocysteine, B12 and Folate levels.

[@sulochanakotary106]

Vortioxtine taking 15 mg daily divided 3 times a day. Is it okay this medication takes 3 times a day? Or it takes only once in a day? My doctor prescribed morning, afternoon and night 5 mg daily.( Total 15 mg)

[@LevelheadedMind]

It is typically only once daily. Ask your provider why it is beign prescribed in this frequency, perhaps there is a metabolism issue?

[@datbtrue]

Once a day is preferred , especially since it has a long half-life. It is sedating for most, so I recommend the total dosage to be taken before sleep. If others are aroused or stimulated, then you should take in the morning. Make sure you always communicate with your doctor before you leave his office, so that you dont have uncertanties which can delay your treatment and therapeutic benefits 👍💯

[@MissSandralicious]

You can’t take Advil or naproxen with this medication? At all?

[@LevelheadedMind]

You can, you just have to be aware that it can increase your risk for bleeding or bruising easily.

[@taqihaider456]

Is it useful for brain fog

[@HugOCovers]

Hi Dra. I'm seeing you from Portugal, I started with vortioxetina a week ago, in my case I fell a little social anxiety, to sing in public, to eat with stranger, be a centre of attention is not a good thing for me, even with my friends. So I start to avoid parties, sing in public, and even be with my group of friends. Because I started to feel, sensations of panic. Is this drug or substance the most suitable for this clinical condition?

[@fabiogarcia3455]

Então hugo como estas agora?

[@nawafpsy]

Thank you so much! Could you speak about Hydroxyzine?

[@LevelheadedMind]

Thanks for the video idea.

[@bjchannel849]

Plz video make on trazodone vs vilazodone.

[@baronluigi2738]

It worked great for me. But it still makes me dizzy, gassy ans nauseousm

[@harmcity9934]

is Vortioxetine safe for people with multiple sclerosis?

[@thethirdgeneration1738]

I'm here because my VA doctor is about to switch me to this medication possibly. I am currently taking Lithium, and Cymbalta. But, I think that want to take me off the Cymbalta. I've been on the Lithium for years, however. Do you know how lithium acts with this medication?

[@kathleenveronesi2755]

How do I titrate 75 Effexor x day, to 20 mg. Of Trintellex over time? I tried going from Effexor to Trintellex from one day to the next and and I got very depressed. Thank you.

[@LevelheadedMind]

Checkout switchrx.com for some guidance and discuss with your provider.