Vortioxetine (Trintellix) The TOP 5 things you need to know

[@LevelheadedMind]

www.levelheadedmind.com/contact Not sure if this medication is right for you? Contact me so we can discuss treatment options for your unique needs.

[@lolak7438]

Hi - I watch you all of the time. My depression/anxiety has been so bad I am now facing eviction and that, in turn, is triggering worse depression/anxiety. Mt psych disappeared after covid ( I lost a sister to covid and before that, a brother to suicide0. but before that he told me Buproprion would help with my 'motivation". I just became worse. I was on Effexor before and only having mild results after slightly raising the dose). so mt new psych - who reired last year- just kept rasing the Buproprion. I was not getting better. (Yes, I was in therapy, not much help- no modalites- just talk, used, also grief therapy- when depression doesn't lift, it just doesn't help much). So now I have a nurse who tries, but seems to fill what I suggest (?). So- that's why I ask so many questions. I'm really afraid I won't ave the time to go through the side effects again. And with so many commercials making depression seem to be cured with one pill while still coping byhiding behind a smiley face (how are these people getting out of bed?)!adding to the stigma and people close to me noot understanding/believing me and what I'm going through (major MDD with an anxiety disorder) I have bottles laying around- still good? I would love to call for a free consult but I don't have much money after that. Please- I'll take any suggestions (on Obamacare/Medicaid so hard to find a doc/other treatments) right now.

[@radioguy8662]

This is the best video on Trintellix on KZbin!

[@DivinityRedd]

Thank you for this video. I was recently prescribed this medication and had some reservations after experiencing some nausea. This video provided so much clarity.

[@paulj0557tonehead]

If you take any other med with Trintellix then the nausea can be intense. So I just take it by itself with 3/4 cups of water of so between breakfast and lunch midway. One thing the interaction did help me with was I tool Lamotrigine/Lamictal for bipolar and it really shortened my cycles. Once on Trintellix I immediately discovered I could not take them together. So I would take Trintellix first and midday take the Lamotrigine. Well after a couple months I noticed I forgetting to take the Lamotrigine. I'd correct myself, but after 6 months I was beginning to realize I didn't really need the Lamotrigine. That's been 8-9 months ago now. I told my doctor, but continue to get the Lamotrigine. On my next visit I'm going to discuss discontinuing Lamotrigine. Okay I spelled all this out for the reader because I realize self diagnosis and even self withdrawal of a med can be detrimental to whole objective. As you can tell I'm going about it wrong. Here's another thing. Cost. Lamotrigine is a $4 med, whereas Trintellix is about $500-$600 med. So here I am, thinking it's okay to self regulate a $4 med. WRONG! lol Yeah it's time to make that appointment. I am methadone patient for 20 years, and it's the only other thing I take. This video is helpful.

[@jhambrick27]

Thank you so much for honoring my request!!! ❤️❤️❤️❤️

[@LevelheadedMind]

You are so welcome! 😊

[@jasonbowman6931]

im starting this today im excited after watching this video thank you!

[@repe0]

Only antidepressant that actually works!

[@Medusa5885]

I have been using this medication for 3 months now. I was becoming suicidal after being on Wellbutrin for many years. I like it so far, it has helped my anxiety tremendously. the only side effect was severe sedation for the first month., but i think it was due to the other medication i take, Prazosin and Lamotrigine. I haven’t noticed any improved focus though. I’m grateful to have Medicaid and dont have to pay $500. Highly recommend.

[@justmadeit2]

Did you sleep ok on it?

[@straightwhiteandproud9643]

Thank the lord for medicaid

[@straightwhiteandproud9643]

​@@justmadeit2 I cannot sleep on it, it speeds my mind and thoughts up to the point I cannot shut my mind down

[@daliamendez9792]

I'm starting a treatment with Vortioxetine next week, is the second antidepressant i try as Citalopram didn't work for me. Your video made me feel so much better and secure about taking this medication. Thank you so much for sharing this info! ❤️

[@LevelheadedMind]

You're welcome, I hope this medication works well for you.

[@GianlucaMurru]

Hey, how is it going?

[@ImGoodThankYou]

How did it go for you?

[@emanyaghmour504]

Please tell us if if works of u? and the side effects

[@macyfiscus4491]

I’m in the exact same boat. I was also taking Citalophram. I had to stop it because it was making me very irritable and angry. I start my first dose of Trentellix tomorrow morning. How has your experience with it been so far?

[@OrangeMicMusic]

My psychiatrist changed my antidepressants many times (one of them being Trintellix) over 4 years period, trying to find "the one that is working". Now, I started thinking if the chemical imbalance is real, after so many major studies in the last few years showing almost no difference between antidepressants and placebo.

[@nawafpsy]

Most informative video I ever seen about Vortioxetine! Just an important point you didn't mention which is Vortioxetine and emotional blunting. How it is less likely to cause it in comparison with SSRIs/SNRIs

[@LevelheadedMind]

Great point! Thanks for sharing 👍

[@blessieyang8070]

Does it cause emotional blunting? I was about to start it for feeling of apathy…

[@LevelheadedMind]

@@blessieyang8070 it doesn't cause it, but any medication that increases serotonin may cause this, vortioxetine is less likely to cause this due to its multimodal effect. If serotonin causes emotional bunting it is a clue that low serotonin is not your problem.

[@blessieyang8070]

@@LevelheadedMind thank you for the response - I’m actually starting vortioxetine *for* emotional blunting and apathy - do you think this is a good idea?

[@LevelheadedMind]

@@blessieyang8070 It wouldn't hurt to try. Bupropion can also help with that as well. Typically emotional blunting is a result of low dopamine and norepinephrine.

[@nichecambal4657]

2nd day on this pill. I am excited to get better! Going through a very rough patch.

[@AdeedumdooLin]

I was actually good on escitalopram in terms of mood BUT the cognitive delay was soooo bad that I cannot even speak without pausing to remember what I was saying. I've been on vortioxetine for more than a month and I can really feel the results 🥰

[@user-em2kn1fs7o]

Hi, I'm on escitalopram too but do miss better cognitive functioning. Do you take both or switched from one to the other?

[@AdeedumdooLin]

@@user-em2kn1fs7o i was switched by my psychiatrist and have been on it for 6 months. So far so good. Glad my insurance covers for it but if not it will be too costly 🙈

[@user-ed1fr3qs8z]

Hello, I like the way you speak, I can understand everything even if my english is not fluent 👍

[@oliveb2o]

it's because of the trintellix that makes your brain smarter

[@JustinUrban1]

Trintellix seemed to make my memory worse…

[@charbar1360]

Same here, and my focus, attention and processing speed. It's done the exact opposite and now I'm experiencing horrendous withdrawals tapering off of it.

[@JustinUrban1]

@@charbar1360 I quit a few months back. If you noticed a drop in food cravings for salty foods that might play a partial role in it. Talk with your doctor as soon as possible though. I got off of it and in a matter of a few days I was clear headed and able to remember items I was studying for. There needs to be more attention brought to this side effect.

[@matthewscott1091]

Trintellix is the only anti-depressant that has ever really worked for me in what seems like a lifetime of trying different meds. *The problem is the cost.* There is no generic available in the US so a one month supply is over $400. I’ve literally been living off of samples from my doctor but this leads to missed dosages when I can’t rely on prescriptions. The patents to Trintellix don’t expire until *June of 2027.* Meaning there won’t be a generic version of the drug available until then (over 4 years from now). 😢

[@LevelheadedMind]

Have you tried getting a prescription savings card? us.trintellix.com/savings-support?showmg=true&BRSavings&gclid=CjwKCAiArNOeBhAHEiwAze_nKCdUVI0BV9BopRMfzdsW2Y-PrD4Ut5xYqCbwn6TUcoNHHIMlRYyEjxoCAJQQAvD_BwE&gclsrc=aw.ds

[@sleezuskryst1246]

Damn! I don’t feel so bad now having to pay 120.00 in Canada

[@lorikasheimer3231]

Would love a video feedback on taking 2 medications together. Trintellix and Wellbutrin. Pros and Cons using together.

[@pianosenzanima1]

400$??? WTF?? I take it for free in Italy from pharmacy with my psychiatrist prescription

[@puddifoots41]

I tried also a lot of medications....even Parnate. Some TCA. 3 SRRI. SNRI. Still feel low. Whats the difference you felt?

[@jaydenyounger6496]

Thanks for making this video - super helpful information! Just a little bit of feedback, I found the background music to be quite distracting as it's pretty loud in the mix, which made it difficult to take in all the info. Outside of that this was brilliant :)

[@LevelheadedMind]

Sorry about that, I'll take that into consideration next time.

[@TotalBlackoutPainting]

I switched from this to Viibryd for 3 months. That stuff made my brain feel like mush. I'm finally a month back on Trintellix and I feel like a fog has been lifted from my brain. I wish it was more affordable. It's really putting me up against the wall, even with the savings card. It's seriously killing me, but the alternative is being a zombie or being a suicidal basket case. I finally feel like making content again instead of it just being performative, I feel so much better. I can't even put a price on it. I'm grateful my guy will give me samples if I need them, but I just wish they'd drop the price. I can't go back to effexor or anything like that, I won't do the brain zaps again. I'll just have the find it in the budget.

[@golovskin5917]

Using trintellix again make you happy again after how many weeks?

[@DanielSRosehill]

Thanks - this was excellent and makes me feel a lot more empowered and informed starting this medication!

[@zahidhusain7589]

I'm in weak English but you wrote in side to explain is very helpful

[@LevelheadedMind]

Thank you. I'm glad you found the video to be helpful.

[@rajeevtaneja5153]

Thanks for such a valuable info ❤ love you May God bless you ❤️

[@StenellaFr]

My experience with this drug is superb..

[@OneDanae]

Can you expand please? What were your symptoms and how it has helped?

[@StenellaFr]

@@OneDanae yes I had much stress with living with an emotionally unstable person. After the drug I could calm myself down. Also it doesn't have particular negative effect on intellectual performance during the day. Only problem with the drug is having slightly less libido.

[@jmoss2543]

@@StenellaFr I live with an emotionally unstable person which has greatly affected me over the past 6 years. I started bupropion xl 4 days ago. I’m having bad headaches as worst symtom. If it doesn’t improve maybe I’ll try Trintellix. I’m always in a daze it seems and having memory issues and I’m only 44. You recommend Trintellix? How long it take to work for you?

[@StenellaFr]

@@jmoss2543 first ~10 days i started with 5 mg, then have taken 10 mg constantly for the last months. In the drug description it says it takes 3-4 weeks to have the effect , but I could feel the difference after a few days. I didnt have any experience with anti-depressants before, but I really liked this one and I'm happy that it works for me. Anti depressents' effects might be different for each person, but I had some luck on this one.

[@Juuanaa2014]

How long did you took it until you saw full effects? I am taking it 10 weeks now and nothing

[@tanakkusai]

I have Bipolar 2. I take Trintellix on top of a mood stabilizer called Lamictal. Can you do a video on how Lamictal works for Bipolar and treatment resistant depression? Thank you so much for all that you do! The information you've shared has been so helpful.

[@LevelheadedMind]

Thank you. Yes, I have Lamictal om my videos list so stay tuned. 😉

[@KT-fm7dt]

Are you happy with The Trintellix/Lamictal combination?

[@artgreg2296]

Thanks for your comments. I am french colombian living in france with bipolar 2 trouble. Thanksfully medicine are taken in charge by the medical insurance. I would say i feel better during the day with the trintellix but I have nausea 1/3 and strange dreams.

[@anthonybenash3457]

Thank you for the video. I have been on Alprazolam for ten years and a new doctor just prescribed Tintellex and I was a bit nervous until I watched this. 🙏

[@LevelheadedMind]

Thank you, I hope it works out well for you.

[@tonymccarthy5624]

I’m shocked that you say you used alrazolam for 10 years as I’m a recovering Xanax addict who went on withdrawals and lost the plot due to alprzolam Xanax yes it’s a great medication to take for feeling amazingly good but i got addicted and went crazy and ruined my life and lost the people I love around me it messes up your head the next day when u wake up your just so moody also depends on dose I was taking 7 1mg a day

[@anthonybenash3457]

@@tonymccarthy5624 it hasn’t seemed to affect me like that. I have always taken it as prescribed and I’m only on the .5 mg twice a day. I did forget to take my trintellex for about a week and felt horrible though.

[@tonymccarthy5624]

@@anthonybenash3457 I just started on trintellix would you believe I’m on trintellix and quetipine because of addiction to Xanax and weed for years I was abusing the Xanax tho I take 7 maximum pills everyday like I was a super high all the time so whatever. I did to my brain now I’m ruined and have to take anti depressants and Phycotits due to having anxiety and phycosis and literally losing the plot because of Xanax and yes 2 .5 mg twice a day sound like it wouldn’t do much I’ve taken that much before 1 mg in day and I noticed it made me have nice feeling too any amount gives you kinda good calm euphoric buzz

[@anthonybenash3457]

@@tonymccarthy5624 sorry to hear that man, I went through alcohol rehab years ago so I can somewhat relate. I have dealt with general anxiety disorder for years and I’ve been doing way better with the Xanax personally. I know the risks of addiction so I have never asked to have my dosage increased.

[@BruderAdrian]

Thanks for making this video. It was very helpful ❤

[@LevelheadedMind]

You're so welcome!

[@christianc1551]

Excellent video. I am a PMHNP student graduating in December. I still struggle with choosing the best antipsychotics for my patients. Could you go over a topic over first generation and second generation antipsychotics ? Thanks you!

[@LevelheadedMind]

That's a great video idea. When choosing between them I look at the side effect profile and risk/benefit for my patient. There are many choices so I can understand the confusion. Also good to look at what they are FDA approved for and clinical guidelines. Good luck with your studies and thanks for watching the videos.

[@christianc1551]

@@LevelheadedMind Thank you for the information. Glad I found your channel!

[@tangtang2223]

​@@LevelheadedMindf冫😮

[@melanie98d]

Trintellix tanked my mood so fast. It was terrifying

[@nickytmorris]

I would love a video about SSRIs, SNRIs, and SARI’s. The differences/similarities and can you take them together?

[@LevelheadedMind]

Thank you for the video idea, I will consider it.

[@DanielSRosehill]

If you're looking for tough questions then I have one for you: taking two SSRIs concurrently is generally considered to be an absolute contraindication. But some docs seem to be happy combining Trintellix with SSRIs. Why is that considered safe but the other not?

[@LevelheadedMind]

I wouldn't consider it completely safe. You would still need to watch for serotonin syndrome. Risk is less than with SSRIs since it has many antagonist actions on different serotonin receptors, which account for increases in the different neurotransmitters, and not just serotonin.

[@pootube2024]

​@@LevelheadedMind I have a problem on PRISTIQ I'm still feeling so lethargic.😪

[@lindacarol5982]

​@@pootube2024I had to quit taking prestiq after a year it quit working months before I quit

[@varnishyourboard]

Concise and informative. Subscribed. (Very minor edit to consider for future videos is to change the spelling of St. John's Wort). Thanks!

[@LevelheadedMind]

Thanks for the tip!

[@barbarabaker8118]

I was given samples of this medication and was so happy with the results. I have been on many different anti-depression meds for yrs. After a period of time they seemed to have lost their effect. Unfortunately the cost, even with my Medicare part D insurance is not in my budget!

[@thinksatheesh]

Try to source it from India. A strip of 10 tabs costs just one dollar

[@comradeharley]

Was there significant nausea? Can you share your experience with the side effects on this medication?

[@MountainAirOrganicBeds]

What is serotonin overload? Can you make a video about it?

[@Shelby-cf1sc]

Your videos are the best! Thanks for posting so I can learn more. You should do 5 things about venlafaxine xr next.

[@LevelheadedMind]

Thanks. I'll make sure to do one on Venlafaxine soon. 😉

[@20081980bert]

You beat me to it! I’ve just started Venlafaxine XR

[@erwinmega3573]

Thank you for this amazing review. Does nicotine influence when taking with vortioxetine? (nicotine pouches)

[@leekasmar7508]

I disagree that you can taper off it more easily than antidepressants with a shorter half-life. A longer half life for vortioxetine means that it takes longer to taper off it without ill effect.

[@realitywinner7582]

notice significant triggering of 'flight' mode ! on it 2 weeks ..heard on another channel this happens for a while . God Bless !

[@nikkibpainting]

Please make a video about serotonin syndrome. Thank you!

[@LevelheadedMind]

Here is the video I did on serotonin syndrome kzbin.info/www/bejne/opmxiZR9lNCisKc

[@marwanalamoodi8420]

Thanks for making this video, but my question does it effect the cholesterol level?

[@souravkumarmukherjee496]

Hi, Thank you for presenting an insightful video about Vortioxetine. Which of the medications can be combined with it to treat GAD, Anxiety disorder, Panic attacks and social phobia ?

[@LevelheadedMind]

You can add medications such as clonidine, propranolol, or hydroxyzine. You would need to be careful with any serotonin medications as these can increase risk of serotonin syndrome. Buspar can also be added but with caution, since it is a partial serotonin agonist.

[@mikejudd7922]

So it is Safe to take Clonidine with Trintellix on a Daily Basis for Sleep?

[@ratheeshpnarayanan9440]

Can you make a video for comparing the sedation of antidepressants

[@sabirmirza6606]

Dear mam, I have two questions 1) does taking antidepressants for long time harm any organ of our body like heart kidney etc 2) can one really stop antidepressants after the treatment or is it just a false hope because I have seen people taking it even since 30 years .

[@LevelheadedMind]

Yes you can stop these medications if done correctly under the direction of a provider. As for organ damage it is fairly rare but liver damage can occur with some of these medications, typically in higher dosages risks of side effects are increased.

[@beeathome1064]

Thank you so much for your videos. I watch a lot! Can you tell me if you think virtioxetine causes weight gain? And can it help PMDD? I take Prozac for PMDD and don’t love it. I was wanting to try trintellix for PMDD and anxiety

[@LevelheadedMind]

This would not be my first choice for those symptoms. As far as weight gain, it is considered weight neutral. Have you tried sertraline or escitalopram?

[@beeathome1064]

@@LevelheadedMind I have tried Zoloft and citalopram … and Prozac.. I don’t think I handle the other SSRIs very well. But I’ve been researching the Trintellix and all SNRIs .. it’s such a trial and error. Thank you so much

[@umairsiddiqui3204]

can you please compare the vortioxetine with duloxetine. thanks

[@randycushman1669]

Can you please expand on how Vortioxetine increases norepinephrine, dopamine, glutamate, acetylcholine and histamine? Everything I have read says it absolutely does not have any affect on anything other than serotonin. Is it an indirect action? I am considering giving this med a try and am wanting to understand it as best I can. Thanks.

[@LevelheadedMind]

No direct actions but by antagonistic and agonism on various serotonin receptors and pathways, it leads to actions on those multiple neurotransmitters. Stahls Psychopharmacology text book explains this very well if you want to learn more about down stream effects.

[@toddwilliams4493]

So....why is this not prescribed more?

[@markallman418]

While i like the idea of it helping me think faster and better, but what i most want from it is ED relief.....

[@marieb9961]

I d like to Thank you really for me you ha e made a big difference with your info ℹ️ thanks 🌺

[@LevelheadedMind]

You are so welcome, I am glad to help!

[@kingcarisma]

Memory and processing speed is considered part of the IQ

[@DanielSRosehill]

I'd be interested to see a comparison between vortioxetine and the couple of other newer serotonin modulators in its drug class - which I believe is really just Viibryd

[@LevelheadedMind]

Great video idea, thanks.

[@viktoriakarypidou181]

I have been taking vortioxetine 1 month now. I have reached the dose of 20 mg starting with 5 mg. Although i have less anxiety i have noticed less connection to my emotions and all senses overall, is this a side effect? It feels like emptiness and numbness....does it get better as the time goes by?

[@LevelheadedMind]

This is a flattening affect that cam occur due to too much serotonin, which lowers dopamine. Have your doctor lower the dose, or add Bupropion if tolerated and no contraindications exist.

[@Allanwify]

Im planning to shift from Sertraline til this drug.

[@genialshape]

Every person is different, for example; the sertraline worked well in the past for me, but now doesnt work. Im doing the change for Vortioxetine, I feel so bad, I hope that this medication can help me.

[@baronluigi2738]

It worked great for me. But it still makes me dizzy, gassy ans nauseousm

[@Tony-lo1gv]

Could this medication help with ADHD? PLEASE GET BACK TO ME THANKS.

[@zxaj]

I was going to pull my hair out if I didn't find this video. I remember reading the thumbnail nail and getting excited about this med. I searched it on Google so I could read later, but I somehow I couldn't find it in my search history. I tried so many things to find your video. I ended up using chatgpt and now in hear.

[@zxaj]

Hopefully it can do something for my OCD and ADHD(self-diagnosed)

[@LevelheadedMind]

I'm so glad you found the video.

[@Ooooia]

@@zxajI have adhd too

[@nikimclaren1838]

Thank you for the great information. Does this medication interact with any ADHD medication, in particular, dexamphetamine?

[@LevelheadedMind]

Yes, it can increase your risk for serotonin syndrome so you and your provider will need to monitor for this risk and symptoms of serotonin syndrome.

[@AbdulRehman-ox9ld]

Please make video on paroxetine

[@martialfan36]

Does Trintellix and Clonidine work well together for panic disorders and social anxiety? I have tried so many others in the past with no benefit at all.

[@daemon_zero]

Good video, the background music made it a little hard to follow though. A little too loud and agitated.

[@bogse]

2:22 If something improves memory, attention and processing speed I can quarentee you it will raise the overall IQ since all those three are in major role when measuring IQ. So it would basically be impossible that it wouldnt improve IQ.

[@LevelheadedMind]

You would think so, but we don't have any studies to confirm this, so can't claim it. As well as don't want people taking psychoactive drugs just to try and raise IQ. These drugs cam cause more harm than good for some people.

[@binarybob0010]

I agree. If they make those claims and can’t back it with IQ tests, they’re full of you know what.

[@RGL01]

I’ve never been very impressed with it for my patients, and the cost tends to be prohibitive. I’ll use it more when it goes generic.

[@lemieuxlara2724]

Is setraline better ?

[@rajeevtaneja5153]

Very helpful ❤

[@HugOCovers]

Hi Dra. I'm seeing you from Portugal, I started with vortioxetina a week ago, in my case I fell a little social anxiety, to sing in public, to eat with stranger, be a centre of attention is not a good thing for me, even with my friends. So I start to avoid parties, sing in public, and even be with my group of friends. Because I started to feel, sensations of panic. Is this drug or substance the most suitable for this clinical condition?

[@fabiogarcia3455]

Então hugo como estas agora?

[@jayseagal3681]

Has anyone ever used it for chronic nerve pain

[@GianlucaMurru]

I'm 1 week into it and the only side effect is a mild tinnitus since day 2. Should I worry? Also, there's any interaction with ashwagandha?

[@LevelheadedMind]

Hi, I didn't see any interaction with Ashwaghanda according to UPtoDate interaction checker. As for the tinnitus, this can cause issues with balance and dizziness. So if it doesn't resolve, I would first make sure it is a side effect and see an ENT then consider switching treatments if it is indeed from vortioxetine.

[@GianlucaMurru]

@@LevelheadedMind Thank you for taking your time to reply

[@jazzyreyes6921]

my daughter is experiencing mania with this med!!

[@xshavox]

Hi dr! Do you find it weird if a neurologist prescribed me 10mg for 2 weeks then 10mg every 12 hrs (for a total of 20mg a day) for JUST 3 months? Suppose to regulate 4 hormones (serotonine, norepinephrine, melatonine and other) bc I have physiological stress and then I can continue with a treatment from a psychiatrist? (Which I believe would switch to lexapro cause I was on it some years ago)

[@LevelheadedMind]

I've never heard of Trintellix used in this way. Did you ask for a rationale to this type of treatment plan? Perhaps they have some research paper or study about this use that I am unfamiliar with. Always speak up if you don't understand your treatment plan, it's your right.

[@xshavox]

@@LevelheadedMind yes he told me that there are 4 main hormones that get imbalanced when you have physiological stress and that vortioxetina will help me regulate that. I too was kinda skeptical that's why I asked. Aside from if it's true or not from the neurologic pov could someone switch from vortioxetine to Escitalopram and get something good from it or is it a waste of time and money psychiatrically speaking since vorti it's gonna be only 3-4 months? Thank you for reading and I like the channel so far.

[@edapen9829]

Would you say its better for anxiety than Lexapro? I take 15 mg per day and I am doing well on it but I also at times feel a bit numb/or like I can’t focus.

[@LevelheadedMind]

In my opinion Lexapro is better at treating generalized anxiety and even panic disorder. If you have depression as a dominating illness and some underlying anxiety, Trintellix would help. Check out my comparison video on these meds if you haven't done so already. kzbin.info/www/bejne/fIa0gmOwft6Andk

[@edapen9829]

@@LevelheadedMind yes I’m in it for GAD. Thanks for replying

[@jonharry6293]

It’s useless for anxiety, I have lots of friends who switch to Zoloft which is much better.

[@KennethNordin]

The nurse's role is to follow the doctor's orders. There is, of course, a great deal of room for one's own opinions and, not least, to remind doctors of new or increasing symptoms and side effects, and to generally look out for the patient's best interests in a role similar to that of a medium between patient and doctor. But precisely when it comes to pharmacology, nurses have limited knowledge of pharmacology. Superficially, you can understand certain basic mechanisms of action, but at the end of the day, a nurse has extremely limited knowledge of pharmacology/psychopharmacology. That is why we have different professional roles. A doctor or clinical pharmacologist like myself has the most knowledge. It is not about devaluing nurses, but just as a pure fact. Doctors are doctors and nurses are nurses

[@AP-nx6xo]

Well done!

[@whosaysitmatters]

you misundertand the meaning of the word substrate.

[@essakhan6969]

Does agomelatine treat emotional numbness please reply

[@despiertanmuchos7837]

Vortioxetine does not work for me....6 months on 20mg...energy zero, motivation zero...a waste of time, probablly less side effects but if depression dont goes away, you are not able to do nothing. I hope work for someone...

[@LevelheadedMind]

I'm sorry to hear it hasn't helped you. Not every medication is going to be the right fit for everyone. Also make sure to look at other causes, such as poor diet, inflammation, methylation issues, autoimmune disease and gut dysbiosis are some of the few causes of depressive symptoms to explore. I hope you find the right treatment for you and get to the root cause of your symptoms.

[@L0kEcITyY]

@@LevelheadedMind how would someone fix methylation issues?

[@ARolls-dd2zd]

@@L0kEcITyY B vitamins, B12, B6, B1, B2, B3, Folic acid, or eat lots of salads.

[@iamthefiremanjj]

@@LevelheadedMind this is the best way to go first

[@LevelheadedMind]

@Jeff you would need methylated forms of B vitamins in high doses to correct the deficiencies. Check homocysteine, B12 and Folate levels.

[@kevinfogarty5081]

I take one low dose aspirin a day and I just started taking 10mg vortioxetine. What bleeding are these docs referring to exactly?

[@LevelheadedMind]

Serotonin can affect platelets ability to clot. Therefore there is in an increased risk of bleeding. Watch out for signs such as bruising easily, nose bleeds, blood in stool, etc. It would be prudent to have your blood levels checked at least every 6 months to monitor as well.

[@kevinfogarty5081]

@@LevelheadedMind interesting thank you

[@Phoenix-ov5gg]

Are there any supplements or activities you can do to increase the therapeutic effect without increasing the dose of the medication? I currently use a TDCS headset from flow and try to exercise because I read they can help improve the results. I also take a fish oil tablet every day. I am on 10mg but I don’t want to go higher due to risk of increased side effect.

[@LevelheadedMind]

Yes, eat anti-inflammatory diet, increase foods high in tryptophan and phenylalanine.

[@nermenelkhamisy4315]

I would like to know does it make my migraine worse 😢 Can it helps me in menopausal hot flashes

[@DoItWrightRo]

I would like to know how it impacts peri menopause

[@nicoleboie3794]

Video on vraylar!!

[@LevelheadedMind]

Thank you Nicole, I am making a video on Vraylar very soon!

[@BooksCoffeeLife]

It helps so much, but eats at my ulcer.

[@helenfoster7073]

Why isn't your Ulcer being treated? I'm sure you know this already but some Ulcers are caused by a bacteria & can be treated easily. I have GERD (acid reflux) so I'm prescribed Omeprazole anyway but it really helps wi acidity Vortioxetine can cause in titration period.

[@rocketlegs6933]

How effective is vortioxetine with anxiety?

[@pallvisharma4824]

Mam I am having functional disorder dr.prescribed me vortioxetine ten mg....l took for one month...my symptoms improved ....then halfed the dose to five mg .....I took that for one month more ...now I started having buzzing sound in my ear ...mam why this ringing in my ear it was no there before

[@datbtrue]

Why did you reduce your dosage upon symptom improvement? This is an indication that the medication is starting to work ! Never, ever do this! unless it's causing a serious adverse reaction. The tinnitus is most likely from a slight withdrawal from 10 to 5 mgs . Please see your doctor and Never self-medicate or play doctor . You keep messing around like this and you run the risk of Treatment resistant Depression/GAD etc..

[@Nazzereno100]

are there any drug to drug interactions if i take trintellix with adderall,concerta or vyvanse?

[@captainlux409]

Is it good to combine aripiprazole with vortioxetine for people who have mild depression cause negative symptoms of psychosis? Thank you!

[@RealTrueHorrorStories]

If I am taking Bupropion currently, and just prescribed Trintellix, what’s the best way to cross these over safely. I feel like my doctor was not very clear. She said to take one, one day, and then the other the next day, for a week then go only Trintellix. Is this right, or what’s the best way? I want to be safe.

[@baron2161]

Metformin, is this really good for you, because I have to now take other supplements to fix what Metformin depleted, like Vitamin B12 and Folic acid is there nothing else to replace this with?

[@LevelheadedMind]

As a Psychiatric Nurse Practitioner prescribing a medication like metformin is out of my scope of practice. I really can't comment on whether it is good or bad. However, for type 2 diabetes with proper diet and exercise some patients can come off of this medication. So discuss your concerns with your provider and develop an action plan to start working towards a goal of coming off this medication.

[@sulochanakotary106]

Vortioxtine taking 15 mg daily divided 3 times a day. Is it okay this medication takes 3 times a day? Or it takes only once in a day? My doctor prescribed morning, afternoon and night 5 mg daily.( Total 15 mg)

[@LevelheadedMind]

It is typically only once daily. Ask your provider why it is beign prescribed in this frequency, perhaps there is a metabolism issue?

[@datbtrue]

Once a day is preferred , especially since it has a long half-life. It is sedating for most, so I recommend the total dosage to be taken before sleep. If others are aroused or stimulated, then you should take in the morning. Make sure you always communicate with your doctor before you leave his office, so that you dont have uncertanties which can delay your treatment and therapeutic benefits 👍💯

[@christabelleborg5042]

anyone use this with welbutrin

[@picklesooz]

How does it interact with plant medicines like CBD & THC ?

[@LevelheadedMind]

There are studies that suggest CBD is an inhibitor of CYP2D6 which Trintellix is metabolized by, so it may increase the percentage of available Trintellix in your system leading to increased side effects. THC is not on the CYP2D6, but induces CYP1A2, which has no effect on Trintellix.

[@ambrakaur2499]

​@@LevelheadedMindThank you for answering folks' questions. I am someone who tends to self-medicate and have had a lot of reservations with wanting to try an actual psychiatric medication (I had a bad experience with side effects to a medication years ago). But I'm a little bit desperate. However, I am currently taking kratom almost every day. My gut feeling is that I should stop it before going on a med like this... Do you agree?

[@bjchannel849]

Plz video make on trazodone vs vilazodone.

[@Hassan3hunna]

Can it provide relief for sexual dysfunction (PSSD) symptoms? caused by antipsychotic medicines prescribed for schizophrenia? Although the condition name is Post SSRI sexual dysfuction & SSRIs are antidepressants but this conidition is caused by both antidepressants and antipsychotics both.

[@LevelheadedMind]

I haven't used this as a treatment for PSSD, not sure it would work. Talk to your doctor about it.

[@Hassan3hunna]

@@LevelheadedMind Would be hard finding a Doctor that acknowledges this condition because very few Doctors are even aware of it most are of the believe once the medication is stopped everything goes normal if it doesn't ''it's in your head'' as in you're thinking about it ( placebo). The condition got recognized in 2019 by the European medical agency. Anyhow from what I am aware theirs no treatment currently for it some medicines like Wellbutrin (Bupropion) which is a NDRI provide relief for some, Viagra (Sildenafil), and Cialis (Tadalafil) for some.

[@RahulThakur-jo6kx]

My dr. Prescribed me bupropion 150 xl in morning and vortioxetine 10 mg in night. Is it good to take?

[@LevelheadedMind]

No, this is not considered safe. Bupropion can significantly increase the blood concentration of Trintellix making you more susceptible to the side effects. Please talk with your doctor about this concern.

[@mrgoalieman711]

Can we get a video on Wellbutrin (Bupropion) and also comparing Wellbutrin to other similar options such as Trintellix

[@joesmith1830]

This is an advertisement for Trintellix.👍🏻

[@invinciblefarhan2698]

Is there any prescription saving program for vortixetine for financial needy patients in India?

[@nadiazakaria8601]

I have internal parkinson tre.mors ca. I TAKE Trentellix any side affect. With. Carpadooa/Le adopa. Or. Citrate Magnizium pleaselet me know

[@LevelheadedMind]

Discuss this with your provider and check Web MDs drug interaction checker for any possible interactions.

[@entertainmenteducavlogs9717]

As you know that, I am suffering from schizoaffective disorder, OCD. I have used all SSRI's, but nothing tolerable/ ineffective. Will vortioxetine be a good medicine for OCD without exacerbating psychosis/ schizophrenia? Mam kindly reply , I shall be very grateful to you

[@user-yh5wk1ve4z]

i have taken brintellix for 10 months ended in nov 2023 but after a few months i am experencing the same iam again in a depressive state and and iam having a hard time is there any effect if i will take brintellix again?

[@harmcity9934]

is Vortioxetine safe for people with multiple sclerosis?

[@giacomograndi5527]

Can be potentially effective also a low dose like 5 mg? 5mg can be potentially sufficient?

[@mercyfulvickv2810]

No

[@Daydreamermallu]

No use waste med for treatment resistance

[@vickinoseworthy-wi7if]

How does this drug affect new borns breastfeeding?

[@optical76]

My dr is taking me off Wellbutrin and on trintellix. I’m on 300mg bupropion and he has me going down to 150mg but at the same time start taking 5mg trintellix for one week. At week 2 I’m going off bupropion completely and up to 10 mg trintellix. Should I be worried about drug interactions? Or just be aware of changes and re asses as needed. Thanks!

[@DrRahu-77]

Make a video on Vilazodone vs Vortioxitine???

[@LevelheadedMind]

Thanks for the video idea, I will consider it.

[@MidniteSon]

@@LevelheadedMind Yes, can you please create one comparing the multimodular class? Perhaps each may treat symptoms slightly differently.