What is dose response, and what's a dose response model? | Andrew Maynard

[@mariasaraiva9675]

This came in time for my students. They asked me to explain dose-response last lecture. And here we go together with the models too , begining this week.

[@riskbites]

Perfect timing :-)

[@OAlem]

This is perfect and so is the other video about models! I'm compiling a top ten video of scientific models and this is compelling. It should at least get an honorary mention but I honestly hadn't thought of this one. Can I have your permission to use small bits of these two videos? I'm still compiling my list and expect to release it in the next few days. I will provide links to your originals if you like.

[@BusManTravelGroupGMBH]

Also . Car accidents are caused by Speed. DUIs proportionate. These are known as Independent Variables. However correlation does not always equate to causation

[@ahmedabuali6768]

Dear Professor, I am trying to implement the work done by Suyu Liu, “A Bayesian Phase I/II Trial Design for Immunotherapy”, using R, since the code attached with that work takes a lot of time (more than 20 hours and the code not complete, I do not know how it produced the tables and the figures). So that I tried to use trialr package trying to get similar or approximate results using the utility functions for sensitivity analysis in table 1 (picture below), but this package allowed me to use just two outcomes ( toxicity, efficacy ) and the work of Liu used three outcomes (immune response, toxicity, and efficacy). I want to see if I used the correct utility (table 1 below) and to see how to add a third outcome ( immune response ) to the model? (Question 1) I attached to you the code and the output for 50 iterations and 60 patients from the work of Liu and Yuan ( I cannot do more, it took around 12 hours), if you know how he produced the results, (Question 2) I hope you can feed me back. My goal is: to use their idea to select the best dose in the first stage and to continue in a second stage with only 2 arms clinical trial and the best dose. (may there is another way to do that?) Table 1 ### My code trying to get similar results using trialr package ### rm(list = ls()) library(trialr) ## Utility from table 1 and Liu and Yuan work. Uti

[@ahmedabuali6768]

Hi, I have a problem to simulate a scenario in clinical trial phase I/II, with R, where I can ask people to help me even for paid consultancy?

[@xrhsavgh]

Thank you 🙏🏽🙏🏽🙏🏽

[@alinashahid2744]

MSPH 🙌

[@es5248]

I couldn’t get past the guitar and focus.

[@binra3788]

Risk models offer trojan for fear, funding and controls to operate a self replicating and reinforcing loop by which 'defenceses or protections are not only destructive but recognised and used as such by private interests controlling 'regulators'. Insurance is a casino based an odds arrived at from data set into models. Predictive models become repurposed to predictive control. Control of a model or massaged and shaped data can and does operate backstage as the use of regulations to crush rivals, or defend against litigation or critical reevaluation. Especially once 'settled science' is protected as 'too big to fail'.

[@Mentocthemindtaker]

But...but...hormesis says that consistent low dose exposure _strengthens_ my cells and _decreases_ my risk of getting something like cancer. That's why every morning I slap on a low-dose fentanyl patch, suck on a lead-paint chip and make sure at least one item of my breakfast has just a little bit of E. coli "contamination". As a result I feel confident enough to take on anything that the world can throw at me!

[@riskbites]

... and I'm sure your body will rise to the challenge magnificently for as long as it lasts, which may not be as long as you might hope :)

[@Mentocthemindtaker]

@@riskbites Thanks! Hopefully the SARI lobbyists and members on the EPA get their way and reduce the safety requirements for worker's radiation exposure limits. Then I can get a job doing nuclear clean-up (they're always recruiting) so I can get _even stronger_ through radiation exposure! Life sure does look good!

[@chummychimchim]

Lmao!

[@binra3788]

If you want a disease to prove you right you are more than capable of manifesting it. Living life is key to adaptive capacity. You are in any case exposed to or imbibing similar toxins some by choice and some as unavoidable environmental exposures. Devious people can and do manipulate selected fears (real or imagined) to generate narratives, funding, and control over others. But not least because of attitudes like your sarcasm reveal, people trust their abusers, and actively seek toxic or destructive outcomes as belief they are 'made safe'. I think it depends. BTW. Some heavy metals are cumulative and not easily eliminated - especially if injected. But the LNT for radiation has been shown to be false.